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Human dental pulp stem/stromal cells in clinical practice

World Journal of Stem Cells 2024年第2期16卷 54-57页

作者： Mohammed E Grawish Department of Oral biology Faculty of DentistryMansoura UniversityMansoura 35561Egypt Department of Oral biology Faculty of Oral and Dental MedicineDelta University for Science and TechnologyMansoura 11152Egypt

Dental pulp stem/stromal cells(DPSCs)are fibroblast-like,neural crest-derived,and multipotent cells that can differentiate into several *** are relatively easy to isolate from healthy and inflamed pulps,with little ethical concerns and can be successfully cryopreserved and *** therapeutic effects of DPSCs derived from animal or human sources have been extensively studied through in-vitro and in-vivo animal experiments and the findings indicated that DPSCs are effective not only for dental diseases but also for systemic *** that translational research is a critical step through which the fundamental scientific discoveries could be translated into applicable diagnostics and therapeutics that directly benefit humans,several clinical studies were carried out to generate evidence for the efficacy and safety of autogenous or allogeneic human DPSCs(hDPSCs)as a treatment modality for use in cell-based therapy,regenerative medicine/dentistry and tissue *** clinical medicine,hDPSCs were effective for treating acute ischemic stroke and human exfoliated deciduous teeth-conditioned medium(SHED-CM)repaired vascular damage of the corpus cavernous,which is the main cause of erectile *** in clinical dentistry,autologous SHED was able to rege-nerate necrotic dental pulp after implantation into injured teeth,and micrografts enriched with autologous hDPSCs and collagen sponge were considered a treatment option for human intrabony *** contrast,hDPSCs did not add a significant regenerative effect when they were used for the treatment of post-extraction ***-scale clinical studies across diverse populations are still lacking to provide robust evidence on the safety and efficacy of hDPSCs as a new treatment option for various human diseases including dental-related problems.

关键词： Dental pulp stem/stromal cells Human clinical studies Regenerative medicine Regenerative dentistry Cell-based therapy

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Effects of the fertilizer and water management on amino acids and volatile components in Cabernet Sauvignon grapes and wines

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International Journal of Agricultural and Biological Engineering 2024年第1期17卷 69-79页

作者： Kui Zhang Wenhuai Kang Weihua Han Haijun Ma Daozhi Gong Ling Qin College of Food science and biology Hebei University of Science and TechnologyShijiazhuang 050018China Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agricultural SciencesBeijing 100081China College of Biological science and Engineering North Minzu UniversityYinchuan 750021China

The amino acids and the volatile substances in grapes and wines play important roles in their quality,and the concentrations of these substances can be changed by how a vineyard is managed,e.g.,irrigation and fertigation *** study aimed to evaluate the effect of fertilizer and water management on the distribution of amino acids,the volatile component profiles,and the sensory characteristics of Cabernet Sauvignon grapes and *** results showed that the amino acid concentration in grape berries was the highest under the 100%local fertilizer rate(HF)and 100%water irrigation quota(HW)treatment,and the volatile component concentration in wine was the highest under HF and 80%water irrigation quota(MW)*** effect of irrigation on the amino acid content in grapes was greater than that of *** synergistic effect of fertilizer and water on arginine,serine,and glutamine in grape berries was *** interactive effect of fertigation and irrigation on the volatile substance in grapes was greater than that of fertigation and irrigation *** influence of irrigation on volatile substances in wines was greater than that of *** addition,there was also a correlation between the concentrations of multiple amino acids in grapes and volatile components in *** component analysis showed that the wine from the HFMW treatment had the best quality among all treatments.

关键词： fertilizer and water management grape ine amino acids volatile components

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A new diatom genus Spargeria ***.(Bacillariophyceae)from Xizang,China,and the description of two new species

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Journal of Oceanology and Limnology 2024年第1期42卷 291-303页

作者： Yan LIU John Patrick KOCIOLEK Li WANG Xinxin LU Huan ZHU Guoxiang LIU Fengyang SUI Yawen FAN College of Life science and Technology Harbin Normal UniversityHarbin 150025China Museum of Natural History and Department of Ecology and Evolutionary biology University of ColoradoBoulder CO 80309USA Key Laboratory of Algal biology Institute of HydrobiologyChinese Academy of SciencesWuhan 430072China

During our investigation of diatom biodiversity in Xizang,two species exhibited unique morphological features discriminative from all previously known *** we describe these two species and describe as new the genus,Spargeria *** new genus features narrow to wide rectangular valves,narrow valve mantles,filiform raphe branches that occur on the valve face only,terminal raphe fissures straight or slightly deflected to same side,bow-tie shaped central areas,chambered striae present on the valve face only,being absent from the mantle,wider striae near the axial area and very narrow near the margin,multiseriate striae with small and round areolae that are occluded ***,Spargeria zhuii *** larger and robust valves,radiate striae,with one divergent stria near the apices,while Spargeria chenia *** smaller,with narrow valves,striae slightly radiate in the middle,becoming convergent or parallel near *** new genus belongs to the family Pinnulariaceae,and it was compared and contrasted with other genera of this *** work suggests the need for continued studies to document the biodiversity of diatoms in Xizang.

关键词： Spargeria new genus Pinnulariaceae morphology Xizang

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Defining two subpopulations of marginal zone B cells

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Cellular & Molecular Immunology 2024年第4期21卷 412-413页

作者： Xiaojing Liu Fei-Long Meng Key Laboratory of RNA science and Engineering Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai200031China

Marginal zone(MZ)B cells,which are composed of heterogeneous subpopulations,are participate in the rapid response to *** et *** that MZ B cells can be divided into two distinct subpopulations based on CD80 *** two sub... 详细信息

关键词： expression. subpopulations al.

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Multistep continuous flow synthesis of Erlotinib

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Chinese Chemical Letters 2024年第4期35卷 371-375页

作者： Hui Jin Qin Cai Peiwen Liu Yan Chen Derong Wang Weiping Zhu Yufang Xu Xuhong Qian State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of Chemical BiologySchool of PharmacyEast China University of Science and TechnologyShanghai 200237China

Erlotinib is an orally administered, highly effective, specific epidermal growth factor receptor tyrosine kinase inhibitor, used to treat non-small cell lung cancer and pancreatic cancer. The traditional synthetic methods for Erlotinib exhibit long reaction time and safety concern. Herein, we describe a novel five-step route for the synthesis of Erlotinib in flow. These five steps comprise etherification, nitration, reduction,addition and cyclization reactions. All steps were optimized and converted to continuous flow process,which drastically reduces the reaction time and considerably improves the process safety as well as the total yield. Enabled by five continuous flow units, Erlotinib is efficiently afforded with an E-factor of 38,an overall yield of 83%, and a total residence time of 25.1 min. Majority steps in this process have been optimized for quantitative conversion, which offers the possibility of telescoping the entire process.

关键词： Erlotinib Continuous flow synthesis Microchannel flow reactor Process optimization Continuous nitration Continuous hydrogenation

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Simple and robust 3D MINFLUX excitation with a variable phase plate

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Light(science & Applications) 2024年第7期13卷 1354-1363页

作者： Takahiro Deguchi Jonas Ries European Molecular biology Laboratory Cell Biology and BiophysicsHeidelbergGermany. Max Perutz Labs Vienna Biocenter Campus(VBC)ViennaAustria. University of Vienna Center for Molecular BiologyDepartment of Structural and Computational BiologyViennaAustria. University of Vienna Faculty of PhysicsViennaAustria

MINFLUX has achieved extraordinary resolution in superresolution imaging and single fluorophore *** is based on localizing single fluorophores by rapid probing with a patterned beam that features a local intensity *** implementations,however,are complex and expensive and are limited in speed and ***,we show that a combination of an electro-optical modulator with a segmented birefringent element such as a spatial light modulator produces a variable phase plate for which the phase can be scanned on the MHz *** or top-hat phase patterns generate high-contrast compact excitation point-spread functions for MINFLUX localization in the x,y,and z-direction,respectively,which can be scanned across a fluorophore within a microsecond,switched within 60 microseconds and alternated among different excitation *** discuss how to compensate for non-optimal performance of the components and present a robust 3D and multi-color MINFLUX excitation module,which we envision as an integral component of a high-performance and cost-effective open-source MINFLUX.

关键词： excitation phase switched

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Low-density lipoprotein receptor-related protein 2(LRP2)is required for lipid export in the midgut of the migratory locust,Locusta migratoria

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Journal of Integrative Agriculture 2024年第5期23卷 1618-1633页

作者： Yiyan Zhao Weimin Liu Xiaoming Zhao Zhitao Yu Hongfang Guo Yang Yang Hans Merzendorfer Kun Yan Zhu Jianzhen Zhang Research Institute of Applied biology Shanxi Key Laboratory of Nucleic Acid BiopesticidesShanxi UniversityTaiyuan 030006China College of Life science Shanxi UniversityTaiyuan 030006China Interfaculty Institute of Cell biology University of TubingenTubingen 72076Germany Institute of biology University of SiegenSiegen 57076Germany Department of Entomology Kansas State UniversityManhattanKS 66506USA

Low-density lipoprotein receptor-related protein 2(LRP2)is a multifunctional endocytic receptor expressed in epithelial *** mammals,it acts as an endocytic receptor that mediates the cellular uptake of cholesterol-containing apolipoproteins to maintain lipid ***,little is known about the role of LRP2 in lipid homeostasis in *** the present study,we investigated the function of LRP2 in the migratory locust Locusta migratoria(LmLRP2).The mRNA of LmLRP2 is widely distributed in various tissues,including integument,wing pads,foregut,midgut,hindgut,Malpighian tubules and fat body,and the amounts of LmLRP2 transcripts decreased gradually in the early stages and then increased in the late stages before ecdysis during the nymphal developmental *** immunohistochemistry revealed that the LmLRP2 protein is mainly located in cellular membranes of the midgut and *** RNAi to silence LmLRP2 caused molting defects in nymphs(more than 60%),and the neutral lipid was found to accumulate in the midgut and surface of the integument,but not in the fat body,of dsLmLRP2-treated *** results of a lipidomics analysis showed that the main components of lipids(diglyceride and triglyceride)were significantly increased in the midgut,but decreased in the fat body and ***,the content of total triglyceride was significantly increased in the midgut,but markedly decreased in the fat body and hemolymph in dsLmLRP2-injected *** results indicate that LmLRP2 is located in the cellular membranes of midgut cells,and is required for lipid export from the midgut to the hemolymphand fat body in locusts.

关键词： Locusta migratoria low-density lipoprotein receptor-related protein 2 midgut lipids transport RNAi

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Inhibition of Defect-Induced Ice Nucleation, Propagation, and Adhesion by Bioinspired Self-Healing Anti-Icing Coatings

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Research 2024年第1期2023卷 237-246页

作者： Shu Tian Ruiqi Li Xinmeng Liu Jiancheng Wang Junyu Yu Sijia Xu Yunqing Tian Jing Yang Lei Zhang Department of Biochemical Engineering Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(MOE)School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300350China Binzhou Institute of Technology Weiqiao-UCAS Science and Technology ParkBinzhou CityShandong Province 256606China

Anti-icing coatings on outdoor infrastructures inevitably suffer from mechanical injuries in numerous icing scenarios such as hailstorms,sandstorms,impacts of foreign objects,and icing–deicing ***,the mechanisms of surface-defect-induced icing are *** the defects,water molecules exhibit stronger adsorption and the heat transfer rate increases,accelerating the condensation of water vapor as well as ice nucleation and ***,the ice–defect interlocking structure increases the ice adhesion ***,a self-healing(at−20℃)antifreeze-protein(AFP)-inspired anti-icing coating is *** coating is based on a design that mimics the ice-binding and non-ice-binding sites in *** enables the coating to markedly inhibit ice nucleation(nucleation temperature<−29.4℃),prevent ice propagation(propagation rate<0.00048 cm^(2)/s),and reduce ice adhesion on the surface(adhesion strength<38.9 kPa).More importantly,the coating can also autonomously self-heal at−20℃,as a result of multiple dynamic bonds in its structure,to inhibit defect-induced icing *** healed coating sustains high anti-icing and deicing performance even under various extreme *** work reveals the in-depth mechanism of defect-induced ice formation as well as adhesion,and proposes a self-healing anti-icing coating for outdoor infrastructures.

关键词： coating defect clarified

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Dendritic mesoporous silica nanoparticles for enzyme immobilization

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Green Chemical Engineering 2024年第2期5卷 173-186页

作者： Shuling Zhang Jing Bai Weixi Kong Haolei Song Yunting Liu Guanhua Liu Li Ma Liya Zhou Yanjun Jiang School of Chemical Engineering and Technology Hebei University of TechnologyTianjin300130China College of Food science and biology Hebei University of Science&TechnologyShijiazhuang050018China Hebei Yanuo Bioscience Co. Ltd.Shijiazhuang052165China

Dendritic mesoporous silica nanoparticles(DMSNs)are a new class of solid porous materials used for enzyme immobilization support due to their intrinsic characteristics,including their unique open central-radial structures with large pore channels and their excellent *** this review,we review the recent progress in research on enzyme immobilization using DMSNs with different structures,namely,flower-like DMSNs and tree-branch-like *** DMSN synthesis methods are briefly compared,and the distinct characteristics of the two DMSN types and their effects on the catalytic performance of immobilized enzymes are comprehensively *** directions for future research on enzyme immobilization using DMSNs are also proposed.

关键词： Dendritic mesoporous silica nanoparticles Enzyme immobilization Flower-like Tree-branch-like Central-radial structure

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An efficient and safe strategy for germ cell-specific automatic excision of foreign DNA in F1 hybrid transgenic silkworms

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Insect science 2024年第1期31卷 28-46页

作者： Dingpei Long Rongpeng Liu Yang Huang Anyao Fu Yuli Zhang Zhanzhang Hao Qiang Li Hanfu Xu Zhonghuai Xiang Aichun Zhao State Key Laboratory of Resource Insects Institute of Sericulture and Systems BiologySouthwest UniversityChongqingChina Department of biology Georgia State UniversityAtlantaGeorgiaUSA Guangxi Institute of Sericulture science NanningGuangxiChina Department of Mathematics and Statistics Georgia State UniversityAtlantaGeorgiaUSA

The safety of transgenic technology is a major obstacle in the popularization and use of transgenic silkworms and their *** sericulture,only the first filial generation(F1)hybrid eggs produced by cross-breeding Japanese and Chinese original strains are usually used for the large-scale breeding of silkworms,but this may result in uncontrolled transgene dispersal during the popularization and application of the F1 hybrid transgenic *** address this issue,we developed a safe and efficient strategy using the GAL4/Upstream activating sequence(UAS)system,the FLP/flippase recognition target(FRT)system,and the gonad-specific expression gene promoters(RSHP1p and Nanosp)for the germ cell-specific automatic excision of foreign DNA in the F1 hybrid transgenic *** established 2 types of activator strains,R1p::GAL4-Gr and Nsp::GAL4-Gr,containing the testis-specific GAL4 gene expression cassettes driven by RSHP1p or Nanosp,respectively,and 1 type of effector strain,UAS::FLP-Rg,containing the UAS-linked FLP gene expression *** FLP recombinase-mediated sperm-specific complete excision of FRT-flanked target DNA in the F1 double-transgenic silkworms resulting from the hybridization of R1p::GAL4-Gr and UAS::FLP-Rg was 100%,whereas the complete excision efficiency resulting from the hybridization of Nsp::GAL4-Gr and UAS::FLP-Rg ranged from 13.73%to 80.3%.Additionally,we identified a gene,sw11114,that is expressed in both testis and ovary of Bombyx mori,and can be used to establish novel gonad-specific expression systems in transgenic *** strategy has the potential to fundamentally solve the safety issue in the production of F1 transgenic silkworm eggs and provides an important reference for the safety of transgenic technology in other insect species.

关键词： Bombyx mori FLP/FRT system GAL4/UAS system germ cell-specific excision safety of transgenic technology transgenic silkworm

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