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Measurement of very low-molecular weight metabolites by traveling wave ion mobility and its use in human urine samples

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Journal of Pharmaceutical Analysis 2024年第5期14卷 733-743页

作者： Alongkorn Kurilung Suphitcha Limjiasahapong Khwanta Kaewnarin Pattipong Wisanpitayakorn Narumol Jariyasopit Kwanjeera Wanichthanarak Sitanan Sartyoungkul Stephen Choong Chee Wong Nuankanya Sathirapongsasuti Chagriya Kitiyakara Yongyut Sirivatanauksorn Sakda Khoomrung Siriraj Center of Research Excellent in Metabolomics and systems biology(SiCORE-MSb) Faculty of Medicine Siriraj HospitalMahidol UniversityBangkok10700Thailand Siriraj Metabolomics and Phenomics Center Faculty of Medicine Siriraj HospitalMahidol UniversityBangkok10700Thailand Department of biomedical Informatics University of Arkansas for Medical SciencesLittle RockAR72205USA SingHealth Duke-NUS Institute of biodiversity Medicine National Cancer Centre Singapore168583Singapore Waters pacific pte. Ltd.Singapore117528Singapore Program in Translational Medicine Faculty of Medicine Ramathibodi HospitalMahidol UniversityBangkok10400Thailand Chakri Naruebodindra Medical Institute Faculty of Medicine Ramathibodi HospitalMahidol UniversitySamut Prakan10540Thailand Department of Medicine Ramathibodi HospitalMahidol UniversityBangkok10400Thailand Department of biochemistry Faculty of Medicine Siriraj HospitalMahidol UniversityBangkok10700Thailand Center of Excellence for Innovation in Chemistry(PERCH-CIC) Faculty of ScienceMahidol UniversityBangkok10400Thailand

The collision cross-sections(CCS)measurement using ion mobility spectrometry(IMS)in combination with mass spectrometry(MS)offers a great opportunity to increase confidence in metabolite ***,owing to the lack of sensitivity and resolution,IMS has an analytical challenge in studying the CCS values of very low-molecular-weight metabolites(VLMs250 Da).Here,we describe an analytical method using ultrahigh-performance liquid chromatography(UPLC)coupled to a traveling wave ion mobility-quadrupole-time-of-flight mass spectrometer optimized for the measurement of VLMs in human urine *** experimental CCS values,along with mass spectral properties,were reported for the 174 *** experimental data included the mass-to-charge ratio(m/z),retention time(RT),tandem MS(MS/MS)spectra,and CCS *** the studied metabolites,263 traveling wave ion mobility spectrometry(TWIMS)-derived CCS values(TWCCSN2)were reported for the first time,and more than 70%of these were CCS values of *** TWCCSN2 values were highly repeatable,with inter-day variations ofbe IMS(DTIMS)and TWIMS CCS *** complexity of the urine matrix did not affect the precision of the method,as evidenced by DCCS within±1.92%.According to the Metabolomics Standards Initiative,55 urinary metabolites were identified with a confidence level of *** these 55 metabolites,53(96%)were *** larger number of confirmed compounds found in this study was a result of the addition of TWCCSN2 values,which clearly increased metabolite identification confidence.

关键词： Very low-molecular-weight metabolites Traveling wave ion mobility Collision cross-section Human urine

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Effects of a multi-enzyme complex on growth performance,nutrient utilization and bone mineralization of meat duck

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Journal of Animal Science and biotechnology 2015年第4期6卷 402-409页

作者： Qiufeng Zeng Xueqin Huang Yuheng Luo Xuemei Ding Shiping bai Jianping Wang Yue Xuan Zhuowei Su Yonggang Liu Keying Zhang Institute of Animal Nutrition Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of EducationSichuan Agricultural University Adisseo asia pacific pte ltd

background： Previous studies with broiler have shown dietary supplementation with multi-enzyme complex containing non-starch polysaccharides （NSP） degrading enzymes and phytase is efficient in releasing phosphorus （P）, calcium （Ca）, energy and amino acids from corn-soybean meal diets or corn-sorghum diets, hence compensating considerable levels of nutrients in formulation. Notwithstanding, such potentials have not been well defined in duck nutrition. Giving China being the largest duck producing country, we conducted this study to establish adequate specifications of major nutrients along with multi-enzyme complex to meat duck from day-old to slaughter, focusing on performance, utilization of nutrients and bone mineralization. Five dietary treatments were： Positive control （PC,T1）： the nutrients concentration of diet for 1 to 14 d of age were apparent metabolizable energy（AME） 2,800 kcal/kg, crude protein （CP）1 9.39%, Ca 0.85%, available phosphorus （avP） 0.42%; for 15 to 35 d of age these parameters were AME 2,900 kcal/kg, CP 16.47%,Ca 0.76%,avP 0.38%; Negative control 1（NC1,7-2）, the AME and digestible amino acids （DAA） were reduced by 70 kcal/kg and 2.0%, avP and Ca by 1.0 g/kg from PC diet; Negative control 2（NC2,T4）, the down- spec from PC diet was AME 100 kcal/kg, DAA 2.5%, avP 1.5 g/kg and Ca 1.2 g/kg; The enzyme complex was added at the same dosage （200 mL/1,000 kg） on NC1 （T3） and NC2 （T5） diets. Results： Comparing with the ducks fed on T1, T3 and T5 diets, the birds fed on NC2 diet showed the lowest （P 〈 0.05） body weight （ d 14 and 35）, feed intake （d 35）, tibia ash, Ca and P contents （d 14 and 35）, and the utilization of nutrients （P 〈 0.05）. The supplementation with the enzyme complex to the NC diets restored growth rate, utilization of nutrients and bone mineralization to the level of the PC diet, and increased AME by 60 kcal/kg and 117 kcal/kg, respectively for the NC1 and NC2 diets. Conclusion： These results suggest that down-spec AME by 100 kcal/kg,

关键词： Formulation specification Growth Phytase Meat duck Non-starch polysaccharides enzyme

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纺织工业中火花探测熄灭系统的应用

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中国安全生产科学技术 2012年第2期8卷 102-105页

作者：汪秀清石建中王正纲武汉纺织大学环境工程学院武汉430073 bs&b safety systems asia pacific pte ltd.

纺织行业的火灾和粉尘爆炸的发生,点火源是导致事故发生的条件之一,若能在事故发生前检测到火花并灭之,完全可以预防事故的发生。火花探测熄灭系统能够胜任此项任务。本文介绍了火花探测熄灭系统的工作原理和管道火花探测熄灭系统的基... 详细信息

纺织行业的火灾和粉尘爆炸的发生,点火源是导致事故发生的条件之一,若能在事故发生前检测到火花并灭之,完全可以预防事故的发生。火花探测熄灭系统能够胜任此项任务。本文介绍了火花探测熄灭系统的工作原理和管道火花探测熄灭系统的基本组成,分析了纺织厂火花源的产生,探讨了火花探测熄灭系统的安装位置,以及该技术在纺织行业大力推广还要做的大量试验实践工作。本火花探测熄灭系统的最大优点是发现火花立即熄灭,而不会影响生产的继续运行,属于预防纺织行业粉尘爆炸的积极方式。但是,目前国内纺织工业企业中使用该技术的较为少见,那么建立相应产品的国内生产标准和安装规范迫在眉睫,它是该技术统一、规范和推广的法规性保障。

关键词：火花探测熄灭纺织应用

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化学隔离抑爆系统在纺织行业的应用

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武汉纺织大学学报 2011年第6期24卷 37-39页

作者：石建中汪秀清王正纲武汉纺织大学环境工程学院湖北武汉430073 bs&b safety systems asia pacific pte ltd.USA

介绍化学隔离抑爆系统的工作原理及其基本组成,以及典型的化学隔离抑爆系统产品,探讨在纺织行业化学隔离抑爆系统的安装位置。指出设备安装化学隔离抑爆系统后,不仅可预防和抑制其爆炸的发生,而且可以降低对其强度的要求,从而节省设备... 详细信息

介绍化学隔离抑爆系统的工作原理及其基本组成,以及典型的化学隔离抑爆系统产品,探讨在纺织行业化学隔离抑爆系统的安装位置。指出设备安装化学隔离抑爆系统后,不仅可预防和抑制其爆炸的发生,而且可以降低对其强度的要求,从而节省设备的经济投入。最后,为更全面更安全的保护过程设备,建议化学隔离抑爆系统应与更多的保护方案组合使用。

关键词：化学隔离抑爆纺织应用

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