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Oligodendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics

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Neural Regeneration Research 2025年第11期20卷 3179-3192页

作者： Pieter-Jan Serneels Julie D.De Schutter Lies De Groef Lieve Moons Steven Bergmans KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionNeural Circuit Development&Regeneration Research GroupLeuvenBelgium KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionCellular Communication&Neurodegeneration Research GroupLeuvenBelgium

Decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and ***,recent studies employing single-cell RNA sequencing techniques have uncovered novel cell states,prompting a revision of the existing *** forward,the oligodendroglial lineage should be delineated into five distinct cell states:oligodendrocyte precursor cells,committed oligodendrocyte precursor cells,newly formed oligodendrocytes,myelin-forming oligodendrocytes,and mature *** new classification system enables a deeper understanding of the oligodendroglia in both physiological and pathological *** this uniform terminology will facilitate comparison and integration of data across ***,including the consolidation of findings from various demyelinating models,is essential to better understand the pathogenesis of demyelinating ***,comparing injury models across species with varying regenerative capacities can provide insights that may lead to new therapeutic strategies to overcome remyelination ***,by standardizing terminology and synthesizing data from diverse studies across different animal models,we can enhance our understanding of myelin pathology in central nervous system disorders such as multiple sclerosis,Alzheimer's disease,and amyotrophic lateral sclerosis,all of which involve oligodendroglial and myelin dysfunction.

关键词： animal models demyelination fish mammals multiple sclerosis myelin neurodegeneration oligodendrocytes oligodendroglial lineage remyelination

Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： Chao Tan Junling Lü Chunchi Zhang Dong Liang Lei Yang Zegao Wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of China Electronics Technology group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

The Dynamic Set-up of a Hydrogen Infrastructure in Integrated Consideration of the Whole Chain "Well-to-Tank"

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The Dynamic Set-up of a Hydrogen Infrastructure in Integrate...

2004年国际氢能大会

作者： Dr.R.Stromberger bmw group MunichGermany

＜正＞This presentation is based on the results of a dissertation that has been made in cooperation with bmw group, Munich, Germany. The work is analyzing a possible dynamic development of the hydrogen filling station network, until a complete adaptation of all conventional filling stations in Germany in order to supply the estimated hydrogen fuel demand is achieved. Due to the view of the whole period from market introduction to completely adaptation of all conventional filling stations the cost-important influences like the utilization rate of some components in the whole chain "Well-to-Tank", the economies of scale or the learning curve have been demonstrated. The overall view of the discounted total costs （Well-to-Tank） in dependency on time, realizable CO2-reduction by the German road-transportation （by the means of conventional fuel substitution by hydrogen） and hydrogen production process results optima due to management analysis.

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来源： cnki会议评论

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闹市中的秘境花园纽约鼎泰丰餐厅

室内设计与装修 2025年第1期 146-147页

作者：无麦子(编译) ROCKWELL group 不详

纽约鼎泰丰餐厅位于百老汇大街1633号,设计团队与业主希望将鼎泰丰品牌的美食文化及其戏剧化的表达方式带入当地人的生活。餐厅设计灵感源自于曼哈顿剧院区充满活力的街区氛围。为了捕捉这一风格特点,设计团队结合了引人注目的形状、鲜... 详细信息

纽约鼎泰丰餐厅位于百老汇大街1633号,设计团队与业主希望将鼎泰丰品牌的美食文化及其戏剧化的表达方式带入当地人的生活。餐厅设计灵感源自于曼哈顿剧院区充满活力的街区氛围。为了捕捉这一风格特点,设计团队结合了引人注目的形状、鲜艳的色彩和戏剧性的灯光,将每个餐区都设计得像舞台一般。

关键词：美食文化戏剧化餐厅设计团队设计灵感百老汇风格特点曼哈顿

Advancing healthcare through laboratory on a chip technology:Transforming microorganism identification and diagnostics

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World Journal of Clinical Cases 2025年第3期13卷 9-19页

作者： Carlos M Ardila Department of Basic Sciences Biomedical Stomatology Research GroupUniversidad de Antioquia U de AMedellín 0057Colombia

In a recent case report in the World Journal of Clinical Cases,emphasized the crucial role of rapidly and accurately identifying pathogens to optimize patient treatment ***-on-a-chip(LOC)technology has emerged as a transformative tool in health care,offering rapid,sensitive,and specific identification of *** editorial provides a comprehensive overview of LOC technology,highlighting its principles,advantages,applications,challenges,and future *** studies from the field have demonstrated the practical benefits of LOC devices in clinical diagnostics,epidemiology,and food *** studies have underscored the superiority of LOC technology over traditional methods,showcasing improvements in speed,accuracy,and *** future integration of LOC with biosensors,artificial intelligence,and data analytics promises further innovation and *** call to action emphasizes the importance of continued research,investment,and adoption to realize the full potential of LOC technology in improving healthcare outcomes worldwide.

关键词： Laboratory-on-a-chip Microorganism identification Diagnostics Point-ofcare testing Biosensors

Transfer learning from synthetic data for open-circuit voltage curve reconstruction and state of health estimation of lithium-ion batteries from partial charging segments

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Energy and AI 2024年第3期17卷 80-97页

作者： Tobias Hofmann Jacob Hamar Bastian Mager Simon Erhard Jan Philipp Schmidt Chair of Systems Engineering for Electrical Energy Storage University of BayreuthWeiherstraße 26Bayreuth95448BavariaGermany bmw group Petuelring 130Munich80809BavariaGermany

Data-driven models for battery state estimation require extensive experimental training data,which may not be available or suitable for specific tasks like open-circuit voltage(OCV)reconstruction and subsequent state of health(SOH)*** study addresses this issue by developing a transfer-learning-based OCV reconstruction model using a temporal convolutional long short-term memory(TCN-LSTM)network trained on synthetic data from an automotive nickel cobalt aluminium oxide(NCA)cell generated through a mechanistic model *** data consists of voltage curves at constant temperature,C-rates between C/30 to 1C,and a SOH-range from 70%to 100%.The model is refined via Bayesian optimization and then applied to four use cases with reduced experimental nickel manganese cobalt oxide(NMC)cell training data for higher use *** TL models’performances are compared with models trained solely on experimental data,focusing on different C-rates and voltage *** results demonstrate that the OCV reconstruction mean absolute error(MAE)within the average battery electric vehicle(BEV)home charging window(30%to 85%state of charge(SOC))is less than 22 mV for the first three use cases across all *** SOH estimated from the reconstructed OCV exhibits an mean absolute percentage error(MAPE)below 2.2%for these *** study further investigates the impact of the source domain on TL by incorporating two additional synthetic datasets,a lithium iron phosphate(LFP)cell and an entirely artificial,non-existing,cell,showing that solely the shifting and scaling of gradient changes in the charging curve suffice to transfer knowledge,even between different cell chemistries.A key limitation with respect to extrapolation capability is identified and evidenced in our fourth use case,where the absence of such comprehensive data hindered the TL process.

关键词： Lithium-ion battery State of health estimation Transfer learning OCV curve Partial charging Synthetic data

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès Sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

Relation between half-cell and fuel cell activity and stability of FeNC catalysts for the oxygen reduction reaction

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SusMat 2022年第5期2卷 630-645页

作者： Janik Scharf Markus Kübler Vladislav Gridin William David Zacharias Wallace Lingmei Ni Stephen Daniel Paul Ulrike Ingrid Kramm Department of Chemistry Catalysts and ElectrocatalystsTechnical University of DarmstadtDarmstadtGermany Department of Materials and Earth Sciences Catalysts and ElectrocatalystsTechnical University of DarmstadtDarmstadtGermany bmw group Munich MunichGermany

FeNC catalysts are promising substitutes of platinum-type catalysts for the oxygen reduction reaction(ORR).While previous research disclosed that high pyrolysis temperatures are required to achieve good stability,it was identified that a trade-off needs to be made regarding the active site *** central question is,if a good stability can also be reached at milder pyrolysis conditions but longer duration retaining more active sites,while enabling the defect-rich carbon to heal during a long residence time?To address this,a variation of pyrolysis temperatures and durations is used in FeNC *** morphology and iron species are characterized by Raman spectroscopy and Mössbauer spectroscopy,*** cell(FC)activity and stability data are *** results are compared to ORR activity and selectivity data from rotating ring disc electrode experiments and resulting durability in accelerated stress tests mimicking the load cycle and start-up and shut-down cycle *** is discussed how pyrolysis temperature and duration affect FC activity and ***,more important,the results connect the pyrolysis conditions to the required accelerated stress test protocol combination to enable a prediction of the catalyst stability in fuel cells.

关键词： accelerated stress tests FeNC catalysts fuel cells Mössbauer spectroscopy oxygen reduction reaction

Traffic Signal Information in a Real Residential Area

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Traffic Signal Information in a Real Residential Area