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Unraveling the role of long non‑coding RNAs in chronic heat stress‑induced muscle injury in broilers

Journal of Animal Science and Biotechnology 2025年第1期16卷 206-217页

作者： Zhen Liu Yingsen Liu Tong Xing Jiaolong Li Lin Zhang Liang Zhao Yun Jiang Feng Gao College of Animal Science and Technology Key Laboratory of Animal Origin Food Production and Safety Guarantee of Jiangsu ProvinceJiangsu Collaborative Innovation Center of Meat Production and ProcessingQuality and Safety ControlNanjing Agricultural UniversityNanjing 210095People’s Republic of China Anhui Key Laboratory of Livestock and Poultry Product Safety Engineering Institute of Animal Husbandry and Veterinary MedicineAnhui Academy of Agricultural SciencesHefei 230031China Institute of Agro‑Products Processing Jiangsu Academy of Agricultural SciencesNanjing 210014People’s Republic of China School of Food Science and Pharmaceutical Engineering Nanjing Normal UniversityNanjing 210023People’s Republic of China

Background Chronic heat stress(CHS)is a detrimental environmental stressor with a negative impact on the meat quality of ***,the underlying mechanisms are not fully *** study investigates the effects of CHS on long non-coding RNA(lncRNA)expression and muscle injury in broilers,with a focus on its implications for meat *** The results showed that CHS diminished breast muscle yield,elevated abdominal fat deposition,induced cellular apoptosis(P<0.05),and caused *** analysis revealed 151 differentially expressed(DE)lncRNAs when comparing the normal control(NC)and HS groups,214 DE lncRNAs when comparing the HS and PF groups,and 79 DE lncRNAs when comparing the NC and pair-fed(PF)*** eliminating the confounding effect of feed intake,68 lncRNAs were identified,primarily associated with cellular growth and death,signal transduc-tion,and metabolic ***,the apoptosis-related pathway P53,lysosomes,and the fibrosis-related gene TGF-β2 were significantly upregulated by *** These findings indicate that chronic heat stress induces cellular apoptosis and muscle injury through lncRNA,leading to connective tissue accumulation,which likely contributes to reduced breast muscle yield and meat quality in broilers.

关键词： Apoptosis Broiler Chronic heat stress LncRNA Muscle

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Correcting on-chip distortion of control pulses with silicon spin qubits

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Chinese Physics B 2025年第1期34卷 265-271页

作者： Ming Ni Rong-Long Ma Zhen-Zhen Kong Ning Chu Wei-Zhu Liao Sheng-Kai Zhu Chu Wang Gang Luo Di Liu Gang Cao Gui-Lei Wang Hai-Ou Li Guo-Ping Guo CAS Key Laboratory of Quantum Information University of Science and Technology of China(USTC)Hefei 230026China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Integrated Circuit Advanced Process Research and Development Center Institute of MicroelectronicsChinese Academy of Sciences(CAS)Beijing 100029China Hefei National Laboratory Hefei 230088China Beijing Superstring Academy of Memory Technology Beijing 100176China origin Quantum Computing Company Limited Hefei 230026China

In semiconductor quantum dot systems,pulse distortion is a significant source of coherent errors,which impedes qubit characterization and ***,we demonstrate two calibration methods using a two-qubit system as the detector to correct distortion and calibrate the transfer function of the control *** methods are straightforward to implement,robust against noise,and applicable to a wide range of qubit *** two methods differ in correction accuracy and *** first,coarse predistortion(CPD)method,partially mitigates *** second,all predistortion(APD)method,measures the transfer function and significantly enhances exchange oscillation *** methods use exchange oscillation homogeneity as the metric and are suitable for any qubit driven by a diabatic *** believe these methods will enhance qubit characterization accuracy and operation quality in future applications.

关键词： quantum computation quantum dot pulse distortion

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64-qubit quantum circuit simulation

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Science Bulletin 2018年第15期63卷 964-971页

作者： Zhao-Yun Chen Qi Zhou Cheng Xue Xia Yang Guang-Can Guo Guo-Ping Guo CAS Key Laboratory of Quantum information University of Science and Technology of China Hefei 230026 China origin Quantum Computing Company Limited Hefei 230026 China

Classical simulations of quantum circuits are limited in both space and time when the qubit count is above 50, the realm where quantum supremacy reigns. However, recently, for the low depth circuit with more than 50 qubits, there are several methods of simulation proposed by teams at Google and IBM. Here,we present a scheme of simulation which can extract a large amount of measurement outcomes within a short time, achieving a 64-qubit simulation of a universal random circuit of depth 22 using a 128-node cluster, and 56-and 42-qubit circuits on a single PC. We also estimate that a 72-qubit circuit of depth 23 can be simulated in about 16 h on a supercomputer identical to that used by the IBM team. Moreover, the simulation processes are exceedingly separable, hence parallelizable, involving just a few inter-process communications. Our work enables simulating more qubits with less hardware burden and provides a new perspective for classical simulations.

关键词： Simulation of quantum circuits Universal random circuit Quantum supremacy Partitioning Parallel computing

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An Evaluation on the Ratio of Plant to Animal Protein in the Diet of Juvenile Sea Cucumber(Apostichopus japonicus):Growth,Nutrient Digestibility and Nonspecific Immunity

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Journal of Ocean University of China 2018年第6期17卷 1479-1486页

作者： BAO Pengyun LI Xiaoyu XU Yongping School of Life Sciences and Biotechnology Dalian University of TechnologyDalian 116024China School of Fisheries and Life Sciences Dalian Ocean UniversityDalian 116023China Ministry of Education Center for Food Safety of Animal origin Dalian 116620China Liaoning Food Safety of Animal origin Innovation Team Dalian 116024China

This study was conducted to evaluate the effects of plant/animal(P/A) protein ratios(viz.1:4, 1:3, 1:2, 1:1,2:1, 3:1, 4:1) on growth performance, body composition, apparent digestibility of diets, and nonspecific immunity of juvenile sea cucumber(Apostichopus japonicus). Sea cucumbers were divided into 21 plastic tanks, and each tank was stocked with 15 individuals(initial weight: about 23.73 g). Each feed was allocated to three replicates of sea cucumbers. The feeding experiment lasted for 50 days. Results indicated that weight gain rate(WGR) and body wall weight(BWW) significantly increased as dietary ratio of P/A increased from 1:4 to 3:1, and then decreased significantly with further increase of this ratio(P 0.05). The apparent digestibility of dry matter, protein and lipid increased with ratio of P/A increasing from 1:4 to 2:1(P < 0.05), and then decreased with further increase of this ratio. Correspondingly, activities of trypsin and amylase were significantly increased as P/A increased from 1:4 to 2:1(P < 0.05). The activities of SOD and CAT showed a similar trend with WGR, with the highest value observed in the ratio of 1:2 and 1:1, respectively. Results above showed that moderate or relatively higher ratio of P/A protein(1:1-3:1) significantly increased the growth performance, apparent digestibility, and nonspecific immunity of sea cucumber. This will contribute to improving the feed formulation for juvenile cucumbers.

关键词： Apostichopus japonicus plant protein animal protein growth digestibility nonspecific immunity

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Research Progress in the Application of Chinese Herbal Medicines in Aquaculture： A Review

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Engineering 2017年第5期3卷 731-737页

作者： Hongyu Pu Xiaoyu Li Qingbo Du Hao Cui Yongping Xu School of Life Sdences and Biotechnology Dalian University of Technology Dalian 116024 China College of Fisheries and Life Science Dalian Ocean University Dalian 116023 China Ministry of Education Center for Food Safety of Animal origin Dalian 116620 China Liaoning Food Safety of Animal origin Innovation Team Dalian 116024 China

Due to increasing safety concerns regarding human consumption of fish products, an increasing number of medicinal chemicals are prohibited from use in aquaculture. As a result, Chinese herbal medicines are being increasingly used, coining the use of the term ＂green medicine.＂ Research shows that Chinese herbal medicines have many beneficial effects on fish, including growth promotion, enhancement of disease resistance, and improvement in meat quality. Many effective ingredients have been discovered in Chinese herbal medicines, which function to promote feed intake, improve meat flavor, and increase digestive enzyme activity. They also regulate and participate in processes that improve the specific and non-specific immunity of fish; however, the composition of Chinese herbal medicines is very complex and it is often difficult to identify the effective ingredients. This article reviews the latest research and application progress in Chinese herbal medicines regarding growth and feed utilization, immunity and disease resistance, and the meat quality of cultured fish. It also discusses research on the chemical constituents of classical Chinese medicinal herbs and problems with the application of Chinese herbal medicines in fish culture. This article concludes by proposing that future studies on Chinese herbal medicines should focus on how to cheaply refine and extract the effective ingredients in classical Chinese medicinal herbs, as well as how to use them efficiently in aquaculture.

关键词： Aquaculture Chinese herbal medicines Fish farming Research progress

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Anisotropic thermal expansion in high-entropy multicomponent AlB_(2)-type diboride solid solutions

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International Journal of Extreme Manufacturing 2023年第1期5卷 331-343页

作者： Frédéric Monteverde Mattia Gaboardi Federico Saraga Lun Feng William Fahrenholtz Gregory Hilmas National Research Council of Italy Institute of Science Technology and Sustainability for CeramicsFaenza 48018RAItaly Elettra—Sincrotrone Trieste S.C.P.A Strada Statale 14—Km 1635 in AREA Science ParkBasovizza 34149TriesteItaly Missouri University of Science and Technology RollaMO 65409United States of America AUREL Spa I-47015(ModiglianaItaly) blue origin 98302(KentWashington US).

High-entropy(HE)ultra-high temperature ceramics have the chance to pave the way for future applications propelling technology advantages in the fields of energy conversion and extreme environmental *** others,HE diborides stand out owing to their intrinsic anisotropic layered structure and ability to withstand ultra-high ***,we employed in-situ high-resolution synchrotron diffraction over a plethora of multicomponent compositions,with four to seven transition metals,with the intent of understanding the thermal lattice expansion following different composition or synthesis *** a result,we were able to control the average thermal expansion(TE)from 1.3×10^(−6)to 6.9×10^(−6)K^(−1)depending on the combination of metals,with a variation of in-plane to out-of-plane TE ratio ranging from 1.5 to 2.8.

关键词： ultra-high temperature ceramics borides high-entropy ceramics spark plasma sintering synchrotron diffraction anisotropic thermal expansion

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Effects of Quantum Noise on Quantum Approximate Optimization Algorithm

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Chinese Physics Letters 2021年第3期38卷 7-11页

作者： Cheng Xue Zhao-Yun Chen Yu-Chun Wu Guo-Ping Guo Key Laboratory of Quantum Information Chinese Academy of SciencesSchool of PhysicsUniversity of Science and Technology of ChinaHefei 230026China origin Quantum Computing Hefei Hefei 230026China

The quantum-classical hybrid algorithm is a promising algorithm with respect to demonstrating the quantum advantage in noisy-intermediate-scale quantum(NISQ) devices. When running such algorithms, effects due to quantum noise are inevitable. In our work, we consider a well-known hybrid algorithm, the quantum approximate optimization algorithm(QAOA). We study the effects on QAOA from typical quantum noise channels, and produce several numerical results. Our research indicates that the output state fidelity, i.e., the cost function obtained from QAOA, decreases exponentially with respect to the number of gates and noise strength. Moreover,we find that when noise is not serious, the optimized parameters will not deviate from their ideal values. Our result provides evidence for the effectiveness of hybrid algorithms running on NISQ devices.

关键词： strength. quantum exponentially

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Study of Cell Behaviors on Anodized TiO_2 Nanotube Arrays with Coexisting Multi-Size Diameters

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Nano-Micro Letters 2016年第1期8卷 61-69页

作者： Yifan Chen Jiahua Ni Hongliu Wu Ruopeng Zhang Changli Zhao Wenzhi Chen Feiqing Zhang Shaoxiang Zhang Xiaonong Zhang State Key Laboratory of Metal Matrix Composites School of Material Science and Engineering Shanghai Jiao Tong University Suzhou origin Medical Technology Co. Ltd.

It has been revealed that the different morphologies of anodized TiO_2 nanotubes, especially nanotube diameters, triggered different cell behaviors. However, the influence of TiO_2 nanotubes with coexisting multi-size diameters on cell behaviors is seldom reported. In this work, coexisting four-diameter TiO_2 nanotube samples, namely,one single substrate with the integration of four different nanotube diameters(60, 150, 250, and 350 nm), were prepared by repeated anodization. The boundaries between two different diameter regions show well-organized structure without obvious difference in height. The adhesion behaviors of MC3T3-E1 cells on the coexisting fourdiameter TiO_2 nanotube arrays were investigated. The results exhibit a significant difference of cell density between smaller diameters(60 and 150 nm) and larger diameters(250 and 350 nm) within 24 h incubation with the coexistence of different diameters, which is totally different from that on the single-diameter TiO_2 nanotube arrays. The coexistence of four different diameters does not change greatly the cell morphologies compared with the singlediameter nanotubes. The findings in this work are expected to offer further understanding of the interaction between cells and materials.

关键词： Coexisting multi-size TiO2 nanotubes Repeated anodization MC3T3-E1 cells Cell adhesion behaviors Cell-material interaction

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Wireless Sensing: A New Sixth Sense to Deciphering our World

Wireless Sensing: A New Sixth Sense to Deciphering our World

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2024年全国微波毫米波会议（中国微波年会）

作者： K.J.Ray Liu origin Research

With more and more bandwidth readily available for the next generation of wireless applications, many intelligent products/services by leveraging the ambient radio waves unimaginable before are now possible. What impact will it bring to our lives? Many may wonder or even speculate if it is science fiction or real? In this talk, we will show that with more bandwidth, one can see many multi-paths, which can serve as hundreds of virtual sensors around us that can be readily leveraged as new degrees of freedom readily for our use(but we never realized that before!). We discovered for the first time that the time-reversal focusing spot is not a point but exhibiting a stationary power distribution of Bessel function which enabled accurate/reliable speed estimation under non-line-of-sight, severe multipath conditions, uncovering a new physical principle ideal for indoor applications. Together with the use of machine learning, a revolutionary wireless AI platform can be built to enable many IoT applications that have been dreamed for a long time but have never been possibly achieved. Such a technology forms the core of a wireless sensing AI platform that can be applied to many device-free, non-obtrusive applications. We will show the world's first ever centimeter-accuracy wireless indoor positioning systems that can offer indoor tracking without any costly infrastructure, home/office monitoring and security, radio human biometrics, vital signs detection, sleep monitoring, gait recognition, and fall detection, without any wearable but sorely relying on ubiquitous commodity Wi-Fi. In essence, now and in the future, it is the wireless sensing that will forever change Wi-Fi as we know it today, as well as future 5G/6G systems, allowing us to decipher our surrounding world with a new "sixth sense". Some products/services of origin have been deployed worldwide and will be demonstrated to illustrate how such a fundamental discovery can make the world a better place..

关键词： A New Sixth Sense to Deciphering our World Wireless Sensing

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Genetic Analysis and QTL Mapping of Large Flag Leaf Angle Trait in Japonica Rice

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Rice science 2012年第4期19卷 277-285页

作者： HU Wen-de ZHANG Hong JIANG Jian-hua WANG Ying-ying SUN Da-yun WANG Xiao-shuai LIANG Kui HONG De-lin State Key Laboratory of Crop Genetics and Germplasm Enhancement Nanjing Agricultural University Beijing origin Seed Co.Ltd

Genetic segregation analysis for flag leaf angle was conducted using six generations of P1, P2, F1, B1, B2 and F2 derived from a cross of 863B （a maintainer line of japonica rice） and A7444 （a germplasm with large flag leaf angle）. Genotypes and phenotypes of flag leaf angle were investigated in 863B （P1）, A7444 （P2） and 141 plants in BC^F~ （863BIA744411863B） population. An SSR genetic linkage map was constructed and QTLs for flag leaf angle were detected. The genetic map containing 79 information loci was constructed, which covers a total distance of 441.6 cM, averaging 5.6 cM between two neighboring loci. Results showed that the trait was controlled by two major genes plus polygene and the major genes were more important. Fifteen markers showed highly significant correlations with flag leaf angle based on single marker regression analysis. Two QTLs （qFLA2 and qFLA8） for flag leaf angle were detected by both composite interval method in software WinQTLCart 2.5 and composite interval method based on mixed linear model in QTL Network 2.0. The qFLA2 explained 10.50% and 13.28% of phenotypic variation, respectively, and was located at the interval of RM300 and RM145 on the short arm of chromosome 2. The qFLA8 explained 9.59% and 7.64% of phenotypic variation, respectively, and was located at the interval flanking RM6215 and RM8265 on the long arm of chromosome 8. The positive alleles at the two QTLs were both contributed from A7444.

关键词： rice flag leaf angle out-crossing rate segregation analysis quantitative trait locus

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