检索结果-南通市图书馆

Targeting glial metabolism in neurodegenerative diseases:detail matters

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第11期18卷 2393-2394页

作者： Ruqayya Afridi Kyoungho Suk Department of Pharmacology School of MedicineKyungpook National UniversityDaeguSouth Korea Department of biomedical Sciences BK21 PLUS KNU Biomedical Convergence ProgramSchool of MedicineKyungpook National UniversityDaeguSouth Korea Brain Science and Engineering Institute Kyungpook National UniversityDaeguSouth Korea

Neurodegenerative diseases,a group of disorders associated with advanced age,are typified by the disease-specific accumulation of mutant proteins and *** decades,treatment modalities for these disorders have focused on addressing neuronal malfu nction,which has resulted in the failure of *** studies have identified the crucial role of glial cells in exacerbating neurodegenerative processes via the release of neuroinflammatory ***,the major immune component of the central nervous system (CNS),undergo numerous phenotypic transitions and regulate the outcomes of various pathologies (Afridi et al.,2022).

关键词： degenerative metabolism diseases

Application of extracellular vesicles from mesenchymal stem cells promotes hair growth by regulating human dermal cells and follicles

在线全文

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2022年第7期14卷 527-538页

作者： Ramya Lakshmi Rajendran Prakash Gangadaran Mi Hee Kwack Ji Min Oh Chae Moon Hong Young KwanSung Jaetae Lee Byeong-Cheol Ahn Department of Nuclear Medicine School of MedicineKyungpook National UniversityDaegu 41944South Korea bk21 FOUR knu convergence Educational program of biomedical Sciences for Creative Future Talents Department of Biomedical SciencesSchool of MedicineKyungpook National UniversityDaegu 41944South Korea Department of Immunology School of MedicineKyungpook National UniversityDaegu 41944South Korea Department of Nuclear Medicine Kyungpook National University HospitalDaegu 41944South Korea

BACKGROUND Dermal papillae(DP)and outer root sheath(ORS)cells play important roles in hair growth and regeneration by regulating the activity of hair follicle(HF)*** To investigate the effects of human mesenchymal stem cell-derived extracellular vesicles(hMSC-EVs)on DP and ORS cells as well as *** are known to regulate various cellular ***,the effects of hMSC-EVs on hair growth,particularly on human-derived HF cells(DP and ORS cells),and the possible mechanisms underlying these effects are *** hMSC-EVs were isolated and characterized using transmission electron microscopy,nanoparticle tracking analysis,western blotting,and flow *** activation of DP and ORS cells was analyzed using cellular proliferation,migration,western blotting,and real-time polymerase chain *** growth was evaluated ex vivo using human *** Wnt3a is present in a class of hMSC-EVs and associated with the EV ***-EVs promote the proliferation of DP and ORS ***,they translocateβ-catenin into the nucleus of DP cells by increasing the expression ofβ-catenin target transcription factors(Axin2,EP2 and LEF1)in DP *** with hMSC-EVs also promoted the migration of ORS cells and enhanced the expression of keratin(K)differentiation markers(K6,K16,K17,and K75)in ORS ***,treatment with hMSC-EVs increases hair shaft elongation in cultured human *** These findings suggest that hMSC-EVs are potential candidates for further preclinical and clinical studies on hair loss treatment.

关键词： Mesenchymal stem cells Extracellular vesicles Hair growth Dermal papillae Outer root sheath cells

Noninvasive in vivo cell tracking using molecular imaging:A useful tool for developing mesenchymal stem cell-based cancer treatment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2020年第12期12卷 1492-1510页

作者： Ramya Lakshmi Rajendran Manasi Pandurang Jogalekar Prakash Gangadaran Byeong-Cheol Ahn Department of Nuclear Medicine Kyungpook National UniversityDaegu 41944South Korea Brigham and Women’s Hospital Harvard Medical SchoolBostonMA 02115United States Department of Nuclear Medicine School of MedicineKyungpook National UniversityDaegu 41944South Korea bk21 plus knu biomedical convergence program Department of Biomedical ScienceSchool of MedicineKyungpook National UniversityDaegu 41944South Korea Department of Nuclear Medicine School of MedicineKyungpook National UniversityKyungpook National University HospitalDaegu 41944South Korea

Mounting evidence has emphasized the potential of cell therapies in treating various diseases by restoring damaged tissues or replacing defective cells in the *** therapies have become a strong therapeutic modality by applying noninvasive in vivo molecular imaging for examining complex cellular processes,understanding pathophysiological mechanisms of diseases,and evaluating the kinetics/dynamics of cell *** particular,mesenchymal stem cells(MSCs)have shown promise in recent years as drug carriers for cancer *** can also be labeled with different probes and tracked in vivo to assess the in vivo effect of administered cells,and to optimize *** exact role of MSCs in oncologic diseases is not clear as MSCs have been shown to be involved in tumor progression and inhibition,and the exact interactions between MSCs and specific cancer microenvironments are not *** this review,a multitude of labeling approaches,imaging modalities,and the merits/demerits of each strategy are *** addition,specific examples of the use of MSCs and in vivo imaging in cancer therapy are ***,present limitations and future outlooks in terms of the translation of different imaging approaches in clinics are discussed.

关键词： Cell therapy Mesenchymal stem cells In vivo molecular imaging Drug delivery Superparamagnetic iron oxide

Controlling hypoxia-inducible factor-2α is critical for maintaining bone homeostasis in mice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bone Research 2019年第2期7卷 210-223页

作者： Sun Young Lee Ka Hyon Park Hyung-Gu Yu Eunbyul Kook Won-Hyun Song Gyuseok Lee Jeong-Tae Koh Hong-In Shin Je-Yong Choi Yun Hyun Huh Je-Hwang Ryu Department of Pharmacology and Dental Therapeutics School of DentistryChonnam National UniversityGwangju 61186Korea Research Center for Biomineralization Disorders School of DentistryChonnam National UniversityGwangju 61186Korea Department of Oral Pathology and IHBR School of DentistryKyungpook National UniversityDaegu 41940Korea Department of Biochemistry and Cell Biology BK21 Plus KNU Biomedical Convergence ProgramSkeletal Diseases Analysis CenterKorea Mouse Phenotyping Center (KMPC)School of MedicineKyungpook National UniversityDaegu 41944Korea School of Life Sciences Gwangju Institute of Science and TechnologyGwangju 61005Korea

Pathological bone loss is caused by an imbalance between bone formation and *** bone microenvironments are hypoxic,and hypoxia-inducible factor (HIF) is known to play notable roles in bone ***,the relevant functions of HIF-2α are not well ***,we have shown that HIF-2α deficiency in mice enhances bone mass through its effects on the differentiation of osteoblasts and *** vitro analyses revealed that HIF-2α inhibits osteoblast differentiation by targeting Twist2 and stimulates RANKL-induced osteoclastogenesis via regulation of *** addition,HIF-2α appears to contribute to the crosstalk between osteoblasts and osteoclasts by directly targeting RANKL in osteoprogenitor *** performed with osteoblast- and osteoclast-specific conditional knockout mice supported a role of HIF-2α in this ***-2α deficiency alleviated ovariectomy-induced bone loss in mice,and specific inhibition of HIF-2α with ZINC04179524 significantly blocked RANKLmediated ***,our results suggest that HIF-2α functions as a catabolic regulator in bone remodeling,which is critical for the maintenance of bone homeostasis.

关键词： is RANKL its via

Intravenous morphine self-administration alters accumbal microRNA profiles in the mouse brain

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2018年第1期13卷 77-85页

作者： Juhwan Kim Heh-In Im Changjong Moon Department of Veterinary Anatomy and Animal Behavior College of Veterinary Medicine and BK21 Plus Project Team Chonnam National University Gwangju South Korea Center for Neuroscience Korea Institute of Science and Technology (KIST) Seoul South Korea convergence Research Center for Diagnosis Treatment and Care System of Dementia Korea Institute of Science and Technology (KIST) Seoul South Korea Division of biomedical Science & Technology KIST School Korea University of Science and Technology Seoul South Korea

A significant amount of evidence indicates that microRNAs （miRNAs） play an important role in drug addiction. The nucleus accumbens （NAc） is a critical part of the brain’s reward circuit and is involved in a variety of psychiatric disorders, including depression, anxiety, and drug addiction. However, few studies have examined the expression of miRNAs and their functional roles in the NAc under conditions of morphine addiction. In this study, mice were intravenously infused with morphine （0.01, 0.03, 0.3, 1 and 3 mg/kg/infusion） and showed inverted U-shaped response. After morphine self-administration, NAc was used to analyze the functional networks of altered miRNAs and their putative target mRNAs in the NAc following intravenous self-administration of morphine. We utilized several bioinformatics tools, including Kyoto Encyclopedia of Genes and Genomes （KEGG） pathway mapping and CyTargetLinker. We found that 62 miRNAs were altered and exhibited differential expression patterns. The putative targets were related to diverse regulatory functions, such as neurogenesis, neurodegeneration, and synaptic plasticity, as well as the pharmacological effects of morphine （receptor internalization/endocytosis）. The present findings provide novel insights into the regulatory mechanisms of accumbal molecules under conditions of morphine addiction and identify several novel biomarkers associated with morphine addiction.

关键词： nerve regeneration nucleus accumbens microRNA morphine self-administration bioinformatics neural regeneration

Development of novel gene carrier using modified nano hydroxyapatite derived from equine bone for osteogenic differentiation of dental pulp stem cells

在线全文

学校读者我要写书评

暂无评论

Bioactive Materials 2021年第9期6卷 2742-2751页

作者： Myung Chul Lee Hoon Seonwoo Kyoung Je Jang Shambhavi Pandey Jaewoon Lim Sangbae Park Jae Eun Kim Yun-Hoon Choung Pankaj Garg Jong Hoon Chung Department of Biosystems&Biomaterials Science and Engineering Seoul National UniversitySeoul08826Republic of Korea Department of Biosystems Engineering Seoul National UniversitySeoul08826Republic of Korea Department of Industrial Machinery Engineering Sunchon National University315 Maegok-dongSunchon57922Republic of Korea Interdisciplinary program in IT-Bio convergence System Sunchon National UniversitySuncheon57922Republic of Korea Division of Agro-system Engineering Gyeongsang National University501 Jinju-daeroJinju52828Republic of Korea Institute of Agriculture&Life Science Gyeongsang National UniversityJinju52828Republic of Korea Research Institute for Agriculture and Life Sciences Seoul National UniversitySeoul08826Republic of Korea Department of Otolaryngology Ajou University School of MedicineSuwon16499Republic of Korea Ajou University Graduate School of Medicine Bk21 Plus Research Center for Biomedical SciencesSuwon16499Republic of Korea bk21 Global Smart Farm Educational Research Center Seoul National UniversitySeoul08826Republic of Korea

Hydroxyapatite(HA)is a representative substance that induces bone *** research team extracted nanohydroxyapatite(EH)from natural resources,especially equine bones,and developed it as a molecular biological ***(PEI)was used to coat the EH to develop a gene *** verify that PEI is well coated in the EH,we first observed the morphology and dispersity of PEI-coated EH(pEH)by electron *** pEH particles were well distributed,while only the EH particles were not distributed and ***,the existence of nitrogen elements of PEI on the surface of the pEH was confirmed by EDS,calcium concentration measurement and fourier transform infrared spectroscopy(FT-IR).Additionally,the pEH was confirmed to have a more positive charge than the 25 kD PEI by comparing the zeta *** a result of pGL3 transfection,pEH was better able to transport genes to cells than 25 kD *** verification as a gene carrier for pEH,we induced osteogenic differentiation of DPSCs by loading the BMP-2 gene in pEH(BMP-2/pEH)and delivering it to the *** a result,it was confirmed that osteogenic differentiation was promoted by showing that the expression of osteopontin(OPN),osteocalcin(OCN),and runt-related transcription factor 2(RUNX2)was significantly increased in the group treated with BMP-2/*** conclusion,we have not only developed a novel nonviral gene carrier that is better performing and less toxic than 25 kD PEI by modifying natural HA(the agricultural byproduct)but also proved that bone differentiation can be effectively promoted by delivering BMP-2 with pEH to stem cells.

关键词： Nanocomposites biomedical applications Hydroxyapatite Polyethyleneimine Gene carrier Osteogenic differentiation

COVID-19-activated SREBP2 disturbs cholesterol biosynthesis and leads to cytokine storm

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2020年第1期5卷 910-920页

作者： Wonhwa Lee June Hong Ahn Hee Ho Park Hong Nam Kim Hyelim Kim Youngbum Yoo Hyosoo Shin Kyung Soo Hong Jong Geol Jang Chun Gwon Park Eun Young Choi Jong-Sup Bae Young-Kyo Seo Aging Research Center Korea Research Institute of Bioscience and BiotechnologyDaejeon 34141Republic of Korea Division of Pulmonology and Allergy Department of Internal MedicineCollege of MedicineYeungnam University and Regional Center for Respiratory DiseasesYeungnam University Medical CenterDaegu 42415Republic of Korea Department of Biotechnology and Bioengineering Kangwon National UniversityChuncheonGangwon-do 24341Republic of Korea Center for BioMicrosystems Brain Science InstituteKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolKorea University of Science and TechnologySeoul 02792Republic of Korea College of Pharmacy Chungnam National UniversityDaejeon 34134Republic of Korea Department of biomedical Engineering SKKU Institute for ConvergenceSungkyunkwan University(SKKU)SuwonRepublic of Korea biomedical Institute for convergence at SKKU(BICS) Sungkyunkwan University2066 Seobu-roJangan-guSuwon 16419Republic of Korea College of Pharmacy CMRIResearch Institute of Pharmaceutical SciencesBK21 Plus KNU Multi-Omics based Creative Drug Research TeamKyungpook National UniversityDaegu 41566Republic of Korea

Sterol regulatory element binding protein-2(SREBP-2)is activated by cytokines or pathogen,such as virus or bacteria,but its association with diminished cholesterol levels in COVID-19 patients is ***,we evaluated SREBP-2 activation in peripheral blood mononuclear cells of COVID-19 patients and verified the function of SREBP-2 in ***,we report the first observation of SREBP-2 C-terminal fragment in COVID-19 patients’blood and propose SREBP-2 C-terminal fragment as an indicator for determining *** confirmed that SREBP-2-induced cholesterol biosynthesis was suppressed by Sestrin-1 and PCSK9 expression,while the SREBP-2-induced inflammatory responses was upregulated in COVID-19 ICU *** an infectious disease mouse model,inhibitors of SREBP-2 and NF-κB suppressed cytokine storms caused by viral infection and prevented pulmonary *** results collectively suggest that SREBP-2 can serve as an indicator for severity diagnosis and therapeutic target for preventing cytokine storm and lung damage in severe COVID-19 patients.

关键词： cytokine diagnosis damage

Tumor microenvironment signaling and therapeutics in cancer progression

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Communications 2023年第5期43卷 525-561页

作者： Anshika Goenka Fatima Khan Bhupender Verma Priyanka Sinha Crismita C.Dmello Manasi PJogalekar Prakash Gangadaran Byeong-Cheol Ahn The Ken&Ruth Davee Department of Neurology The Robert H.Lurie Comprehensive Cancer CenterNorthwestern University Feinberg School of MedicineChicago60611ILUSA Department of Neurological Surgery Feinberg School of MedicineNorthwestern UniversityChicago60611ILUSA Department of Ophthalmology Schepens Eye Research InstituteMassachusetts Eye and Ear InfirmaryHarvard Medical SchoolBoston02114MAUSA Department of Neurology MassGeneral Institute for Neurodegenerative DiseaseMassachusetts General HospitalHarvard Medical SchoolCharlestown02129MAUSA Helen Diller Family Comprehensive Cancer Center University of California San FranciscoSan Francisco94143CAUSA bk21 FOUR knu convergence Educational program of biomedical Sciences for Creative Future Talents Department of Biomedical ScienceSchool of MedicineKyungpook National UniversityDaegu41944South Korea Department of Nuclear Medicine School of MedicineKyungpook National UniversityKyungpook National University HospitalDaegu41944South Korea

Tumor development and metastasis are facilitated by the complex interactions between cancer cells and theirmicroenvironment,which comprises stromal cells and extracellular matrix(ECM)components,among other *** cells can adopt new phenotypes to promote tumor cell *** understanding of the signaling pathways involved in cell-to-cell and cell-to-ECM interactions is needed to design effective intervention strategies that might interrupt these *** this review,we describe the tumor microenvironment(TME)components and associated *** discuss the clinical advances in the prevalent and newly discovered signaling pathways in the TME,the immune checkpoints and immunosuppressive chemokines,and currently used inhibitors targeting these *** include both intrinsic and non-autonomous tumor cell signaling pathways in the TME:protein kinase C(PKC)signaling,Notch,and transforming growth factor(TGF-β)signaling,Endoplasmic Reticulum(ER)stress response,lactate signaling,Metabolic reprogramming,cyclic GMP–AMP synthase(cGAS)–stimulator of interferon genes(STING)and Siglec signaling *** also discuss the recent advances in programmed Cell Death Protein 1(PD-1),Cytotoxic T-Lymphocyte Associated Protein 4(CTLA4),T-cell immunoglobulin mucin-3(TIM-3)and Lymphocyte Activating Gene 3(LAG3)immune checkpoint inhibitors along with the C-C chemokine receptor 4(CCR4)-C-C class chemokines 22(CCL22)/and 17(CCL17),C-C chemokine receptor type 2(CCR2)-chemokine(C-Cmotif)ligand 2(CCL2),C-C chemokine receptor type 5(CCR5)-chemokine(C-C motif)ligand 3(CCL3)chemokine signaling axis in the *** addition,this review provides a holistic understanding of the TME as we discuss the three-dimensional and microfluidic models of the TME,which are believed to recapitulate the original characteristics of the patient tumor and hence may be used as a platform to study new mechanisms and screen for various anti-cancer *** further discuss the systemic

关键词： 3D-model cancer therapy gut microbiota immune signaling metabolism signaling tumor microenvironment

Histone crotonylation in neurobiology:to be or not to be?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2022年第9期135卷 1036-1038页

作者： Cechuan Deng Jia-Hua Qu InKyeom Kim Xiaoqiang Tang Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE State Key Laboratory of BiotherapyWest China Second University HospitalSichuan UniversityChengduSichuan 610041China Department of Medical Genetics Prenatal Diagnostic CenterWest China Second University HospitalSichuan UniversityChengduSichuan 610041China Laboratory of Cardiovascular Science Intramural Research ProgramNational Institute on AgingNational Institutes of HealthBaltimoreMaryland 21224USA Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea Cardiovascular Research Institute School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of biomedical Science BK21 Plus KNU Biomedical Convergence ProgramSchool of MedicineKyungpook National UniversityDaeguRepublic of Korea

Epigenetic regulation is a pivotal mechanism that controls gene transcription and cell *** the past decades,it has been observed that histone,DNA,and RNA modifications participate in determining the fate of neural stem cells(NSCs).These modifications include histone acetylation and methylation,as well as DNA and RNA *** note,non-coding RNAs also participate in neural differentiation.[1]In addition to acetylation,many other types of acylations to histone lysines,including crotonylation,propionylation,succinylation,and malonylation,have been identified.[2]The roles of these histone acylations in neuroscience remain elusive.

关键词： neural differentiation. modification