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Antimicrobial resistance characteristics and phylogenetic relationships of pleuromutilin-resistant Enterococcus isolates from different environmental samples along a laying hen production chain

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Journal of Environmental Sciences 2024年第3期137卷 195-205页

作者： Cong Lin Yuxuan Feng Xianjun Xie Haoyu Zhang Jie Wu Yixiao Zhu Jing Yu Jingyi Feng Wen Su Shanming Lai Anyun Zhang Animal Disease Prevention and Food Safety Key laboratory of Sichuan Province Key Laboratory of Bio-Resource and Eco-Environment of Ministry of EducationCollege of Life SciencesSichuan UniversityChengdu 610065China

Antimicrobial resistance in the laying hen production industry has become a serious public health *** antimicrobial resistance and phylogenetic relationships of the common conditional pathogen Enterococcus along the laying hen production chain have not been systematically clarified.105 Enterococcus isolates were obtained from 115 environmental samples (air,dust,feces,fies,sewage,and soil) collected along the laying hen production chain (breeding chicken,chick,young chicken,and commercial laying hen).These Enterococcus isolates exhibited resistance to some clinically relevant antibiotics,such as tetracycline (92.4%),streptomycin (92.4%),and erythromycin (91.4%),and all strains had multidrug resistance *** genome sequencing characterized 29 acquired antibiotic resistance genes (ARGs) that conferred resistance to 11 classes of antibiotics in 51pleuromutilin-resistant Enterococcus isolates,and lsa(E),which mediates resistance to pleuromutilins,always co-occurred with lnu(B).Alignments with the Mobile Genetic Elements database identified four transposons (Tn554,Tn558,Tn6261,and Tn6674) with several ARGs(erm(A),ant(9)-la,fex(A),and optrA) that mediated resistance to many clinically important ***,we identified two new transposons that carried ARGs in the Tn554 family designated as Tn7508 and Tn7492.A complementary approach based on conventional multi-locus sequence typing and whole genome single nucleotide polymorphism analysis showed that phylogenetically related pleuromutilin-resistant Enterococcus isolates were widely distributed in various environments on different production *** results indicate that environmental contamination by antimicrobial-resistant Enterococcus requires greater attention,and they highlight the risk of pleuromutilin-resistant Enterococcus and ARGs disseminating along the laying hen production chain,thereby warranting effective disinfection.

关键词： Antimicrobial resistance Enterococcus Laying hen production chain Pleuromutilin

Opportunities and challenges in studies of mammalian hybrid speciation

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Science China(Life Sciences) 2024年第3期67卷 614-617页

作者： Hong Wu Yuxing Zhang Li Yu State Key laboratory for Conservation and Utilization of bio-Resource in Yunnan School of Life SciencesYunnan UniversityKunming 650091China

Revealing the mechanisms of speciation remains one of the most attractive and challenging issues in the field of evolutionary biology, and is also key to understanding the biodiversity present in nature.

关键词： biodiversity attractive evolutionary

Structural Engineering of Hierarchical Magnetic/Carbon Nanocomposites via In Situ Growth for High-Efficient Electromagnetic Wave Absorption

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Nano-Micro Letters 2024年第9期16卷 262-278页

作者： Xianyuan Liu Jinman Zhou Ying Xue Xianyong Lu Key laboratory of bio‑Inspired Smart Interfacial Science and Technology of Ministry of Education School of ChemistryBeihang UniversityBeijing 100191People’s Republic of China

Materials exhibiting high-performance electromagnetic wave absorption have garnered considerable scientific and technological attention,yet encounter significant *** new materials and innovative structural design concepts is crucial for expanding the application field of electromagnetic wave ***,hierarchical structure engineering has emerged as a promising approach to enhance the physical and chemical properties of materials,providing immense potential for creating versatile electromagnetic wave absorption ***,an exceptional multi-dimensional hierarchical structure was meticulously devised,unleashing the full microwave attenuation capabilities through in situ growth,selfreduction,and multi-heterogeneous interface *** hierarchical structure features a three-dimensional carbon framework,where magnetic nanoparticles grow in situ on the carbon skeleton,creating a necklace-like ***,magnetic nanosheets assemble within this *** impedance matching was achieved by precisely adjusting component proportions,and intelligent integration of diverse interfaces bolstered dielectric *** obtain Fe_(3)O_(4)-Fe nanoparticles/carbon nanofibers/Al-Fe_(3)O_(4)-Fe nanosheets composites demonstrated outstanding performance with a minimum reflection loss(RLmin)value of−59.3 dB and an effective absorption bandwidth(RL≤−10 dB)extending up to 5.6 GHz at 2.2 *** notable accomplishments offer fresh insights into the precision design of high-efficient electromagnetic wave absorption materials.

关键词： Electromagnetic wave absorption Hierarchical structure In situ growth Self-reduction

Synergy Between Soft Feet and an Active Tail to Enhance the Climbing Ability of a bio-inspired Climbing Robot

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Journal of bionic Engineering 2024年第2期21卷 729-739页

作者： Pongsiri Borijindakul Tachadol Suthisomboon Alihong Ji Zhendong Dai Poramate Manoonpong Institute of bio-inspired Structure and Surface Engineering College of Mechanical and Electrical EngineeringNanjing University of Aeronautics and AstronauticsNanjing210016China bio-inspired Robotics and Neural Engineering laboratory School of Information Science and TechnologyVidyasirimedhi Institute of Science and TechnologyRayong21210Thailand

Lizards use the synergy between their feet and tail to climb on slopes and vertical *** use their soft adhesive feet with millions of small hairs to increase their contact area with the terrain surface and press their tails against the terrain to actively maintain stability during *** by this,we propose a bio-inspired climbing robot based on a new approach wherein the synergy between soft feet and an active tail with a soft adhesive tip allows the robot to climb stably on even and uneven terrains at different slope *** evaluate and compare the climbing performance of the robot on three different terrains(hard,soft,and fluffy)at different slope *** robot configurations are employed,including those with standard hard feet and soft feet in combination with an active tail-with and without a soft *** experimental results show that the robot having soft feet and a tail with the soft tip achieves the best climbing performance on all terrains,with maximum climbing slopes of 40°,45°,and 50°on fluffy,soft,and hard terrains,*** payload capacity depends on the type of terrain and the inclination ***,our robot performs multi-terrain transitions(climbing from horizontal to sloped terrains)on three different terrains of a *** approach can allow a climbing robot to walk and climb on different terrains,extending the operational range of the robot to areas with complex terrains and slopes,e.g.,in inspection,exploration,and construction.

关键词： bio-inspired climbing robots Climbing robots Soft foot Active tail Soft terrain Terrain transitions

ACBP4-WRKY70-RAP2.12 module positively regulates submergence-induced hypoxia response in Arabidopsis thaliana

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Journal of Integrative Plant biology 2024年第6期66卷 1052-1067页

作者： Mengyun Guo Yingjun Yao Kangqun Yin† Luna Tan Meng Liu Jing Hou Han Zhang Ruyun Liang Xinran Zhang Heng Yang Xiaoxiao Chen Jinrui Tan Yan Song Shangling Lou Liyang Chen Xuejing Liu Si Tang Yongqi Hu Jin Yan Wensen Fu Kai Yang Ruijia Zhang Xuerui Li Yao Liu Zhen Yan Wei Liu Yu Han Jianquan Liu Kangshan Mao Huanhuan Liu Key laboratory for bio‐resources and eco‐environment&State Key Lab of Hydraulics&Mountain River Engineering Sichuan Zoige Alpine Wetland Ecosystem National Observation and Research StationKey Laboratory for Bio‐resource and Eco‐environment of Ministry of EducationCollege of Life SciencesSichuan UniversityChengdu 610065China

ACYL-CoA-BINDING PROTEINs(ACBPs)play crucial regulatory roles during plant response to hypoxia,but their molecular mechanisms remain poorly *** study reveals that ACBP4 serves as a positive regulator of the plant hypoxia response by interacting with WRKY70,influencing its nucleocytoplasmic shuttling in Arabidopsis ***,we demonstrate the direct binding of WRKY70 to the ACBP4 promoter,resulting in its upregulation and suggesting a positive feedback ***,we pinpointed a phosphorylation site at Ser638 of ACBP4,which enhances submergence tolerance,potentially by facilitating WRKY70's nuclear ***,a natural variation in this phosphorylation site of ACBP4 allowed *** to adapt to humid conditions during its historical demographic *** further observed that both phosphorylated ACBP4 and oleoyl-Co A can impede the interaction between ACBP4 and WRKY70,thus promoting WRKY70's nuclear ***,we found that the overexpression of orthologous Bna ***4and Bna ***70 in Brassica napus increases submergence tolerance,indicating their functional similarity across *** summary,our research not only sheds light on the functional significance of the ACBP4 gene in hypoxia response,but also underscores its potential utility in breeding flooding-tolerant oilseed rape varieties.

关键词： ACBP4 Arabidopsis thaliana humid adaptation natural variation RAP2.12 WRKY70

An intelligent DNA nanodevice for precision thrombus therapy

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Science China Chemistry 2024年第10期67卷 3195-3197页

作者： Yihao Zhou Qiangbin Wang CAS Key laboratory of Nano-bio Interface Division of Nanobiomedicine and i-LabSuzhou Instiute of Nano-Tech and Nano-BionicsChinese Academy of Sciences

Obstruction of blood vessels(thrombosis) due to blood clots is one of the main causes of death worldwide and is associated with many cardiovascular diseases, such as myocardial infarction, ischemic stroke, and pulmonary embolism[1]. Thrombolytic therapy is currently the preferred treatment for acute thrombosis and is administered intravenously with thrombolytic drugs, such as tissue plasminogen activator(tPA) [2].

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Enzyme-driven Nanorobots Walking Along Predesigned Tracks on the DNA Origami for Cargo Transport and Catalysis

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Chemical Research in Chinese Universities 2024年第2期40卷 333-342页

作者： NIE Cunpeng MA Tianran CHEN Tingting CHU Xia State Key laboratory of Chemo/bio-Sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha410082P.R.China

In molecular engineering,designing and synthesizing molecular machines with capable of performing complex tasks,remains a formidable *** is an excellent candidate for building molecular robots because it is highly ***,we present an artificial nanorobot,in which a DNA cube serves as the inert‘body’,and nucleic acid catalysts based on an enzymatic nicking reaction act as the‘legs’for *** nanorobot can execute a series of actions,such as‘start’,‘turn’,and‘stop’when it walks along a predefined *** performance could be confirmed and monitored by using an atomic force microscope(AFM)and fluorescence *** by biological machines,we artificially designed a series of specialized tasks that combined walking with control of cargo transport and ***-time fluorescence kinetics curves provide monitoring signals for cargo transport and catalytic *** work can enrich the toolbox of DNA machinery and has great potential for engineering molecular nanofactories.

关键词： DNA origami DNA nanorobot Controlled cargo transport DNAzyme catalysis

The NAC Transcription Factor ANAC089 Modulates Seed Vigor through the ABI5-VTC2 Module in Arabidopsis thaliana

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Phyton-International Journal of Experimental Botany 2024年第6期93卷 1101-1116页

作者： Yuan Tian Lulu Zhi Ping Li Xiangyang Hu Shanghai Key laboratory of bio-Energy Crops School of Life SciencesShanghai UniversityShanghai200444China

Seed viability is an essential feature for genetic resource conservation as well as sustainable crop ***-term storage induces seed viability deterioration or seed aging,accompanied by the accumulation of toxic reactive oxygen species(ROS)to suppress seed *** deterioration treatment(CDT)is a gen-eral approach for mimicking seed *** transcription factor ANAC089 was previously reported to modulate seed primary *** this study,we evaluated the ability of ANAC089 to control seed viability during *** with that in the wild-type line,the mutation of ANAC089 signiﬁcantly increased H_(2)O_(2),thereby reducing seed viability after CDT,while the overexpression of ANAC089 reduced H_(2)O_(2) and improved seed long-evity,indicating a critical role for ANAC089 in maintaining seed viability through H_(2)O_(2) signaling.A series of stu-dies have shown that ANAC089 targets and negatively regulates the level of ABI5,an important transmitter of abscisic acid(ABA)signals,to affect seed viability after ***,ABI5 negatively regulated the expres-sion of VTC2,which is involved in the biosynthesis of the antioxidant ascorbic acid and H_(2)O_(2) *** a result,ANAC089 attenuates the generation of H_(2)O_(2),thereby enhancing seed viability through the ABI5-VTC2 module during the seed aging *** together,our results reveal a novel mechanism by which ANAC089 enhances seed viability by coordinating ABI5 and VTC2 expression,ultimately preventing the overac-cumulation of H_(2)O_(2),which would have led to reduced seed viability.

关键词： Arabidopsis seed aging ANAC089 ABI5 VTC2 H_(2)O_(2)

Trace Cobalt Doping and Defect Engineering of High Surface Area α-Ni(OH)2 for Electrocatalytic Urea Oxidation

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能源与环境材料（英文） 2024年第2期7卷 111-118页

作者： Yi Liu Zhihui Yang Yuqin Zou Shuangyin Wang Junying He School of Metallurgy and Environment Central South UniversityChangsha 410083China State Key laboratory of Chem/bio-Sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

Owing to the intrinsically sluggish kinetics of urea oxidation reaction(UOR)involving a six-electron transfer process,developing efficient UOR electrocatalyst is a great challenge remained to be ***,by taking advantage of 2-Methylimidazole,of which is a kind of alkali in water and owns strong coordination ability to Co2+in methanol,trace Co(1.0 mol％)addition was found to induce defect engineering on α-Ni(OH)2 in a dual-solvent system of water and *** characterization results revealed that the synthesized electrocatalyst(WM-Ni0.99Co0.01(OH)2)was a kind of defective nanosheet with thickness around 5-6 nm,attributing to the synergistic effect of Co doping and defect engineering,its electron structure was finely altered,and its specific surface area was tremendously enlarged from 68 to 172.3 m2 *** all these merits,its overpotential to drive 10 mA cm-2 was reduced by 110 ***,the interfacial behavior of UOR was also well deciphered by operando electrochemical impedance spectroscopy.

关键词： defect engineering electrocatalysis small molecule oxidation