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Minimalistic approach to left atrial appendage occlusion guided by cardiac computed tomography angiography

Journal of Geriatric Cardiology 2024年第4期21卷 431-442页

作者： Xian-Sai MENG Qing-Song WANG Xin-Yan WANG Xu LU Yang MU Jing WANG Ting-Ting SONG Yun-Dai CHEN Tao CHEN Jun GUO Graduate School of Chinese PLA medical College BeijingChina Senior Department of Cardiology the Sixth Med-ical CenterChinese PLA General HospitalBeijingChina

OBJECTIVE To assess the feasibility and safety of the minimalistic approach to left atrial appendage occlusion(LAAO) guided by cardiac computed tomography angiography(CCTA).METHODS Ninety consecutive patients who underwent LAAO, with or without CCTA-guided, were matched(1:2). Each step of the LAAO procedure in the computed tomography(CT) guidance group(CT group) was directed by preprocedural CT planning. In the control group, LAAO was performed using the standard method. All patients were followed up for 12 months, and device surveillance was conducted using *** A total of 90 patients were included in the analysis, with 30 patients in the CT group and 60 matched patients in the control group. All patients were successfully implanted with Watchman devices. The mean ages for the CT group and the control group were 70.0 ± 9.4 years and 68.4 ± 11.9 years(P = 0.52), respectively. The procedure duration(45.6 ± 10.7 min vs. 58.8 ± 13.0 min,P < 0.001) and hospital stay(7.5 ± 2.4 day vs. 9.6 ± 2.8 day, P = 0.001) in the CT group was significantly shorter compared to the control group. However, the total radiation dose was higher in the CT group compared to the control group(904.9 ± 348.0 m Gy vs.711.9 ± 211.2 m Gy, P = 0.002). There were no significant differences in periprocedural pericardial effusion(3.3% vs. 6.3%, P = 0.8) between the two groups. The rate of postprocedural adverse events(13.3% vs. 18.3%, P = 0.55) were comparable between both groups at 12 months *** CCTA is capable of detailed LAAO procedure planning. Minimalistic LAAO with preprocedural CCTA planning was feasible and safe, with shortened procedure time and acceptable increased radiation and contras consumption. For patients with contraindications to general anesthesia and/or transesophageal echocardiography, this promising method may be an alternative to conventional LAAO.

关键词： anesthesia matched approach

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Hemodynamic changes with serial balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension

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China medical Abstracts(Internal medicine) 2024年第2期41卷 99-100页

作者：汪薇 Dept Respir&Critical Care med Beijing Chaoyang HospCapital Med UnivBeijing Instit Respir MedBeijing 100020

Objective To monitor hemodynamic changes during serial balloon pulmonary angioplasty (BPA) for chronic thromboembolic pulmonary hypertension (CTEPH).Methods General clinical data of CTEPH patients diagnosed from October 2017 to January 2022 in beijing Chaoyang Hospital were collected,and 83 patients who underwent at least 1 BPA treatment were included to analyze their 6 min walking distance,WHO functional class,N-terminal B-type natriuretic peptide precursor(NT-proBNP),troponin I (cTnI) and haemodynamic indices.

关键词： balloon hypertension angioplasty

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Risk factors and prognosis of aspiration pneumonia in the elderly

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China medical Abstracts(Internal medicine) 2024年第2期41卷 102-103页

作者：原源 Dept Geriatr Beijing Jishuitan HospCapital Med UnivBeijing 100035

Objective To analyze the disease characteristics of aspiration pneumonia and its risk *** In thisretrospective case-control study,analysis was conducted on data from 92 patients aged≥60 years admitted to beijing Jishuitan Hospital,Capital medical university between June 1,2018 and July 31,2022,with aspiration pneumonia(AsP)as the primary diagnosis at the time of hospital discharge and from non-AsP patients admitted during the same *** number of participants was matched at a 1:1 *** The average age of the AsP group was(80.88±9.41)years and 57(62.0%)were *** average age of the control group was(77.74±10.98)years and 52(56.5%)were *** was no statistically significant difference in age and sex ratio(age:t=1.973,P=0.060;sex ratio:X^(2)=0.661,P=0.416).univariate analysis showed that,at admission,body mass index(BMI)and activities of daily living(ADL)scores of the AsP group were lower than those of the non-AsP group.

关键词： admitted diagnosis matched

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Clinical heterogeneity and cluster analysis of multiple system atrophy

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China medical Abstracts(Internal medicine) 2024年第2期41卷 124-125页

作者：王雪梅 Dept Neurol Beijing Luhe HospCapital Med UnivBeijing 101149

Objective To examine the clinical subtypes of patients with multisystem atrophy(MSA)that may indicate the prognosis of ***,we aim to compare the ability to perform daily activities among patients of each subtype using cluster *** The retrospective analysis included demographic data,clinical symptoms and signs,scale scores,and ancillary examinations of 94 patients diagnosed with multisystem atrophyatXuanwu Hospital of Capital medical *** study aimed to analyze the clinical characteristicssofeachhsubtype obtained through ***,acomparison was'made between patients with traditional motor subtypes and those with new subtypes in terms of activities of daily *** study consisted of 94 MSA patients,with an average age of 61 years and a female representation of 51.1%.Using the data collected on the continuum,a full linkage hierarchical cluster analysis was performed to classify MSA patients into four clinical subtypes:gait disorder(17 cases,18.1%),malignant tonic hyperkinetic with premature haircut(25 cases,26.6%),intermediate(43 cases,45.7%)。

关键词： atrophy cluster analysis

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Association of body mass index and waist circumference with risk of all-cause mortality in middle-aged and elderly patients receiving maintenance hemodialysis

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China medical Abstracts(Internal medicine) 2024年第1期41卷 54-55页

作者：石志华 Dept Nephrol Beijing Shijitan HospCapital Med UnivBeijing 100038

Objective To investigate the association between body mass index (BMI) and waist circumference (WC)with all-cause mortality in middle-aged and elderly patients receiving maintenance hemodialysis (MHD).Methods The clinical data of MHD patients aged≥50years old from eleven hemodialysis centers from April to June 2017 in beijing were analyzed.

关键词： patients hemodialysis index

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Evaluation of the efficacy of urine-based lipoarabinomannan antigen test in the diagnosis of pulmonary tuberculosis

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China medical Abstracts(Internal medicine) 2024年第2期41卷 100-101页

作者：张天辉 1st Dept Thoracic Surg Beijing Chest HospCapital Med UnivBeijing 101149

Objective To analyze the diagnostic efficacy of urinary lipoarabinomannan (LAM) antigen detection method in tuberculosis patients,and to provide an experimental basis for the clinical application of urinary LAM kit in *** From March to May 2023,228 patients with lung diseases [134 male,94 female,age 20-82 (44.8±16.7) years] were prospectively collected in beijing Chest Hospital,Capital medical university,including 143 pulmonary tuberculosis patients and 85 non-tuberculosis patients.

关键词： tuberculosis diagnosis urine

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Risk analysis of gastrointestinal bleeding in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

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China medical Abstracts(Internal medicine) 2024年第1期41卷 35-36页

作者：叶明 Coronary Artery Dis Center Div CardiolBeijing Anzhen HospCapital Med UnivBeijing 100029

Objective To investigate the in-hospital incidence,associated outcomes,and predictors of UGIB after *** In this retrospective study,we analyzed the records of 2 791 patients with acute STEMI admitted to beijing Anzhen... 详细信息

关键词： admitted patients acute

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Study on the efficacy of beat chemotherapy in treating non-small cell lung cancer

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China medical Abstracts(Internal medicine) 2024年第2期41卷 98-99页

作者：王雪 Peking univ 5th Clin med Sch Beijing 100730

Objective To assess the effectiveness and safety of beat chemotherapy in treating non-small cell lung cancer,and to investigate its anti-tumor molecular *** In this study,we developed a subcutaneous tumor model of lung cancer in *** mice were subsequently divided into two groups:the beat chemotherapy group and the placebo group(negative control group).Throughout the treatment period,we monitored the changes in body weight and tumor size of the *** the conclusion of the treatment,we collected blood samples from the mice to conduct blood routine and biochemical ***,we obtained tumor tissues from the mice to perform immunohistochemical staining and sequencing of the *** The study found that beat chemotherapy could effectively delay the growth of lung *** tumor tissues in the beat chemotherapy group were significantly smaller compared to the placebo *** resultsof routineblood and blood biochemistry tests showed that the levels of red blood cells(RBCs),white blood cells(WBCs),alanine aminotransferase(ALT).

关键词： routine chemotherapy cancer

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RPRD1B/CREPT facilitates the progression of diffuse large B-cell lymphoma by inhibiting apoptosis through the NF-κB signaling pathway

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Asian Pacific Journal of Tropical Biomedicine 2024年第7期14卷 307-318页

作者： Lu Xu Zhi-Hao Xie Jun Li Shi Tao Fang-Li Ren Yin-Yin Wang Zhi-Jie Chang Xin-Bao Hao Department of Hematology The First Affiliated Hospital of Hainan Medical UniversityHaikou570102China State Key Laboratory of Membrane Biology School of MedicineTsinghua UniversityBeijing 100084China Heya beijing med-Biotech Inc. Beijing 100084China Department of Hematology Roswell Park Comprehensive Cancer CenterNY 14263USA

Objective:To investigate the role of RPRD1B in the progression of diffuse large B-cell lymphoma(DLBCL)and its potential as a therapeutic ***:This study analyzed RPRD1B expression in DLBCL and normal tissues using public databases and assessed its prognostic impact through survival *** vitro and in vivo experiments were conducted to explore the mechanisms by which RPRD1B influences tumor growth and ***:RPRD1B expression was significantly elevated in DLBCL compared to normal tissues and was associated with poor *** vitro and in vivo experiments demonstrated that RPRD1B promoted lymphoma cell proliferation and inhibited apoptosis through the NF-κB signaling ***:RPRD1B plays a critical role in the progression of DLBCL by modulating apoptosis and cellular *** RPRD1B may offer a novel therapeutic strategy for DLBCL,suggesting its potential as a prognostic marker and therapeutic target in hematological malignancies.

关键词： RPRD1B RNAPⅡ Diffuse large B-cell lymphoma NF-κB Apoptosis

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Efficacy and adverse effects of first-line immunotherapy combined with chemotherapy in real world elderly patients with small cell lung cancer

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China medical Abstracts(Internal medicine) 2024年第1期41卷 44-45页

作者：别志欣 Dept Oncol Beijing HospNatl Gerontol CenterInstit Geriatr MedCAMSBeijing 100730

Objective To investigate the efficacy and adverse effects of first-line immunotherapy combined with chemotherapy in elderly patients with small cell lung cancer(SCLC) in population of real *** A total of 148 elderly SCLC patients (age≥65 years old)underwent pathological diagnosis were retrospectively analyzed from January 2013 to June 2023.

关键词： chemotherapy diagnosis SCLC

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