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Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

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neural regeneration research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles méryl-Farelle Oye mintsa mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond martine Saint-Pierre Clémence rouxel Line Berthiaume Pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada axe neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(nutrineuro FranceINAFCanada)QuebecQCCanada axe Endocrinologie et néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Département de médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Département de Psychiatrie et neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal DOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

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Considerations for the clinical use of stem cells in genitourinary regenerative medicine

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World Journal of Stem Cells 2021年第10期13卷 1480-1512页

作者： Christophe Caneparo Luis Sorroza-martinez Stéphane Chabaud Julie Fradette Stéphane Bolduc Centre de recherche en Organogénèse Expérimentale de l'UniversitéLaval/LOEX Centre de Recherche du CHU de Québec-UniversitéLavalAxe Médecine RégénératriceQuebec G1J1Z4Canada Department of Surgery Faculty of MedicineUniversitéLavalQuebec G1V0A6Canada

The genitourinary tract can be affected by several pathologies which require repair or replacement to recover biological *** therapeutic strategies are challenged by a growing shortage of adequate ***,new options must be considered for the treatment of patients,with the use of stem cells(SCs)being *** different strategies can be derived from stem cell use:Cell therapy and tissue therapy,mainly through tissue *** recent advances using these approaches are described in this review,with a focus on stromal/mesenchymal cells found in adipose ***,the accessibility,high yield at harvest as well as anti-fibrotic,immunomodulatory and proangiogenic properties make adipose-derived stromal/SCs promising alternatives to the therapies currently offered to ***,an innovative technique allowing tissue reconstruction without exogenous material,the self-assembly approach,will be *** advances,more studies are needed to translate such approaches from the bench to clinics in *** the 21st century,cell and tissue therapies based on SCs are certainly the future of genitourinary regenerative medicine.

关键词： genitourinary tract Cell therapy Tissue engineering Stem cells

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Ultrastretchable and wearable conductive multifilament enabled by buckled polypyrrole structure in parallel

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npj Flexible Electronics 2022年第1期6卷 419-429页

作者： Yimeng Li Yaya gao Lizhen Lan Qian Zhang Leqian Wei mengqi Shan Lamei guo Fujun Wang Jifu mao Ze Zhang Lu Wang Key Laboratory of Textile Science&Technology of ministry of Education and College of Textiles Donghua UniversityShanghai 201620China Key Laboratory of Textile Industry for Biomedical Textile materials and Technology Donghua UniversityShanghai 201620China Département de chirurgie Facultéde médecineUniversitéLavalAxe médecine régénératriceCentre de recherche du CHU de Québec-UniversitéLavalQuébec(QC)G1V 0A6Canada

Stretchable conductive fibers have attracted much attention due to their potential use in wearable ***,the ultrahigh strain insensitive conductivity is hindered by mechanical mismatch in Young’s modulus and failure of stretchable structures under large *** challenge is addressed with a conductive and elastic multifilament made of the polyurethane monofilaments that are surface-coated with buckled polypyrrole(PPy)of which flexibility is improved by sodium *** parallel conductive monofilaments with PPy buckling on surface reduce the influence of cracks in the conductive coating on the overall conductivity,displaying an ultra-high strain insensitive behavior(quality factor Q=10.9).remarkably,various complex forms of wearable electronic textiles made by this conductive multifilament maintain the strain-insensitive behavior of the original multifilament,even upon the large deformation of human *** multifilament with wrinkled PPy has attractive advantages in the application of super-stretched wearable electronic devices.

关键词： conductive polypyrrole conductivity

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e-FILTErS OF mS-ALgEBrAS

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Acta mathematica Scientia 2013年第3期33卷 738-746页

作者： m. Sambasiva rAO Department of mathematics M.V.G.R. College of EngineeringChintalavalasa Vizianagaram Andhra Pradesh India-535005

The notion of e-filters is introduced in an mS-algebra and characterized. The concept of D-filters is introduced and a set of equivalent conditions under which every D-filter is an e-filter are given. The properties of the space of all prime e-filters of an mS-algebra are observed. The concept of D-prime filters is introduced and then a set of equivalent conditions axe derived for a prime e-filter to become a D-prime filter in topological terms.

关键词： mS-algebra e-filter dense element D-filter D-prime filter minimal prime filter Hausdorff space

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Influence of Cell Confluency on the Expression of the α4 Integrin Subunit of retinal Pigment Epithelial Cells

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Advances in Biological Chemistry 2015年第2期5卷 73-82页

作者： Jean-michel Bourget mohib morcos Karine Zaniolo Sylvain L. guérin Stéphanie Proulx Centre de recherche du CHU de Québec and Centre de recherche en organogénèse expérimentale de l’Université Laval/LOEX axe médecine régénératrice Hopital du Saint-Sacrement Québec Canada Département d’anatomie et de cytologie pathologiques CHU de Québec Hopital du Saint-Sacrement Québec Canada Département de biologie moléculaire biochimie médicale et pathologie Faculté de médecine Université Laval Québec Canada Département d’Ophtalmologie Faculté de médecine Université Laval Québec Canada

Integrins are a family of transmembrane glycoproteins that mediate cell-cell and cell-extracellular matrix interactions. The integrin α4 subunit is widely expressed by cells from the immune system and its expression by non-hematopoietic cells is scarce. In the present study, gene and protein expression of this integrin subunit was characterized in proliferating and quiescent human rPE cells. Immunofluorescent studies confirm that the α4 subunit is expressed in vitro by rPE cells, a result that has been validated by immunofluorescence and FACS analyses. The accumulation of the α4 integrin at cell-cell junctions in post-confluent rPE cell cultures negatively correlated with the level of expression of the mrnA transcript. Accordingly, transient transfection analyses reveal that the α4 promoter activity is considerably reduced when rPE cells form a confluent monolayer. moreover, transfection of recombinant constructs bearing 5’-deletions of the α4 promoter segment allows the localization of strong negative regulatory elements on the -76 to -300 region of the α4 gene suggesting that its expression is intimately linked to the proliferative state of primary cultured rPE cells.

关键词： retinal Pigment Epithelium Integrin Alpha 4 Subunit Cell Culture Confluency Promoter

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Association between genome-wide epigenetic and genetic alterations in breast cancer tissue and response to HEr2-targeted therapies in HEr2- positive breast cancer patients: new findings and a systematic review

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Cancer Drug resistance 2022年第4期5卷 995-1015页

作者： Daniela Furrer Dzevka Dragic Sue-Ling Chang Frédéric Fournier Arnaud Droit Simon Jacob Caroline Diorio Centre de recherche sur le cancer de l’UniversitéLaval 1050 Avenue de la MédecineQuébecQC G1V 0A6Canada axe Oncologie Centre de Recherche du CHU de Québec-UniversitéLavalQuébecQC G1S 4L8Canada Département de médecine sociale et préventive Facultéde MédecineUniversitéLavalQuébecQC G1V 0A6Canada UniversitéParis-Saclay UVSQInsermCESP U1018Exposome and Heredity TeamGustave RoussyVillejuif 94807France Département de médecine moléculaire Facultéde MédecineUniversitéLavalQuébecQC G1V 0A6Canada Département de biologie moléculaire de biochimie médicale et de pathologieFacultéde MédecineUniversitéLavalQuébecQC G1V 0A6Canada Centre des maladies du Sein Hôpital du Saint-SacrementQuébecQC G1S 4L8Canada

recent evidence suggests that genetic and epigenetic mechanisms might be associated with acquired resistance to cancer *** aim of this study was to assess the association of genome-wide genetic and epigenetic alterations with the response to anti-HEr2 agents in HEr2-positive breast cancer *** was screened for articles published until march 2021 on observational studies investigating the association of genome-wide genetic and epigenetic alterations,measured in breast cancer tissues or blood,with the response to targeted treatment in HEr2-positive breast cancer *** studies were included in the review along with ours,in which we compared the genome-wide DnA methylation pattern in breast tumor tissues of patients who acquired resistance to treatment (case group, n = 6) to that of patients who did not develop resistance (control group, n =6). Among genes identified as differentially methylated between the breast cancer tissue of cases and controls, oneof them, PrKACA, was also reported as differentially expressed in two studies included in the review. Althoughincluded studies were heterogeneous in terms of methodology and study population, our review suggests thatgenes of the PI3K pathway may play an important role in developing resistance to anti-HEr2 agents in breastcancer patients. genome-wide genetic and epigenetic alterations measured in breast cancer tissue or blood mightbe promising markers of resistance to anti-HEr2 agents in HEr2-positive breast cancer patients. Further studiesare needed to confirm these data.

关键词： Breast neoplasms epigenetics genetics HEr2 inhibitors treatment response biomarkers

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On Second Order Degree of graphs

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Acta mathematica Sinica,English Series 2012年第1期28卷 171-182页

作者： gabriela ArAUJO-PArDO Camino BALBUEnA mika OLSEn Pilar VALEnCIA Instituto de matemáticas rea de la Investigación CientíficaUniversidad Nacional Autónoma de MxicoCircuito ExteriorCiudad UniversitariaCoyoacan04510 MxicoD.F.Mxico Departament de matemàtica Aplicada III Universitat Politècnica de CatalunyaC/Jordi Girona 1-3(Edifici C2Despatx 302)08034-BarcelonaSpain Departamento de matemáticas Aplicadas y Sistemas Universidad Autónoma MetropolitanaCalle Artificios 402o pisoCol.Hidalgo Delegación lvaro Obregón01120 Mxico D.F.Mxico

given a vertex v of a graph g the second order degree of v denoted as d2（v） is defined as the number of vertices at distance 2 from v. In this paper we address the following question： What axe the sufficient conditions for a graph to have a vertex v such that d2（v） ≥ d（v）, where d（v） denotes the degree of v？ Among other results, every graph of minimum degree exactly 2, except four graphs, is shown to have a vertex of second order degree as large as its own degree. moreover, every K4^--free graph or every maximal planar graph is shown to have a vertex v such that d2（v） ≥ d（v）. Other sufficient conditions on graphs for guaranteeing this property axe also proved.

关键词： Second order degree K4^-free graph planar graphs

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J’ai grandi dans l’axe central de Beijing

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今日中国（法文版） 2022年第8期60卷 30-31页

作者： CAO JIngZHOU Centre de recherche sur la culture de l’axe central à l'Institut de recherche sur le développement urbain de Beijing

J’ai grandi à Beijing et j’ai vécu dans le lnitong(allée)de majuan,à l’angle nord-est de la Cité interdite,et en face de la cour,il y avait le hutong de *** sortant à l’ouest,vous voyez la tour d'angle nord-... 详细信息

关键词： les angle Beijing

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*** pattern of proteases secretion in Fuchs corneal endothelial dystrophy

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Annals of Eye Science 2019年第1期 202-202页

作者： Isabelle Xu mathieu Thériault Stéphanie Proulx Centre de recherche en Organogénèse Expérimentale de l’UniversitéLaval/LOEX QuébecQCCanada Centre de recherche du CHU de Québec-UniversitéLaval Axe Médecine RégénératriceQuébecQCCanada Département d’Ophtalmologie et d’OrL-Chirurgie Cervico-Faciale Facultéde MédecineUniversitéLavalQuébecQCCanada

Background:The goal of this project was to analyze the relationship between cell morphology and proteases/proteases inhibitors(PIs)secretion profile in fuchs endothelial corneal dystrophy(FECD)corneal endothelial cells(CECs).methods:Cell morphology was determined using a circularity index(4π×area/perimeter2)for each CECs population extracted from surgical FECD specimens(n=2)and healthy Eye bank corneas(n=3).CECs were cultured 28 days *** was collected and analysed using Proteome Profiler Array detecting 35 proteases and 32 PIs(r&D Systems).Proteome signal was analyzed using Image Studio Lite and correlated with the population’s circularity ***:Calculation of circularity index reported different morphologies among FECD populations(0.59±0.18 and 0.64±0.17)and healthy populations(0.44±0.18,0.66±0.13 and 0.71±0.11).Proteome arrays revealed the presence of 10 proteases(ADAmTS1,Cathepsin A,B,D,and X/Z/P,DPPIV/CD26,mmP-2,3 and 12,uPA/Urokinase)and 10 PIs(Protease nexin II,Cystatin B and C,EmmPrIn/CD147,Latexin,Lipocalin-1,Serpin E1,TFPI,TFPI-2,TImP-1,2 and 4).Healthy and FECD specimens showed similar variation patterns according to morphology for secretion of ADAmTS1,mmP-3 and ***,opposing patterns between healthy and FECD populations were observed for Cathepsin B and ***,some proteins did not show variation according to phenotype in healthy CECs,but did in FECD CECs:Cathepsin A,Cystatin C,TFPI-2 and total *** the other proteins,secretion did not vary according to morphology or no specific pattern was ***:To conclude,our results suggest that cell phenotype is linked to the secretion of certain proteases/PIs in both ***,there seems to be differences in secretion of particular proteases and PIs between FECD and healthy specimens as morphology did not have a similar *** differences might initiate an imbalance between proteases and PIs explaining the irregular thickening of the

关键词： Fuchs endothelial corneal dystrophy(FECD) cornea corneal endothelial cells(CECs) protease phenotype

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Improving the radiopacity of Fe-mn biodegradable metals by magnetron-sputtered W-Fe-mn-C coatings:Application for thinner stents

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Bioactive materials 2022年第6期7卷 64-70页

作者： Samira ravanbakhsh Carlo Paternoster gianni Barucca Paolo mengucci Sofia gambaro Theophraste Lescot Pascale Chevallier a marc-Andre Fortin Diego mantovani Laboratory for Biomaterials and Bioengineering Canada Research Chair I in Biomaterials and Bioengineering for the Innovation in SurgeryDepartment of Min-Met-Materials EngineeringResearch Center of CHU de QuebecDivision of Regenerative MedicineLaval UniversityQuebec CityQuebec G1V 0A6Canada Laboratory for Biomaterials in Imaging(BIm) Axe Medecine RegeneratriceCentre Hospitalier Universitaire(CHU)de Quebec-Universite Laval2705boul.Laurier(T1-61a)QuebecG1V 4G2Canada Department of materials Environmental Sciences and Urban PlanningUniversita Politecnica delle Marchevia Brecce Bianche 1260131AnconaItaly national research Council Institute of Condensed Matter Chemistry and EnergyCNR-ICMATEVia de Marini 616149GenovaItaly Departement de genie des mines de la Metallurgie et des MateriauxCentre de Recherche sur les Materiaux Avances(CERMA)Universite LavalQuebecG1V 0A6Canada axe medecine regeneratrice Centre Hospitalier Universitaire(CHU)de Quebec-Universite Laval2705boul.Laurier(T1-61a)QuebecG1V 4G2Canada

In this exploratory work,micrometric radiopaque W-Fe-mn-C coatings were produced by magnetron sputtering plasma deposition,for the first time,with the aim to make very thin Fe-mn stents trackable by *** power of Fe-13mn-1.2C target was kept constant at 400 W while that of W target varied from 100 to 400 W producing three different coatings referred to as P100,P200,*** effect of the increased W power on coatings thickness,roughness,structure,corrosion behavior and radiopacity was *** coatings showed a power-dependent thickness and W concentration,different roughness values while a similar and uniform columnar *** amorphous phase was detected for both P100 and P200 coatings while γ-Fe,bcc-W and W_(3)C phases found for ***,P200 and P400 showed a significantly higher corrosion rate(Cr)compared to *** presence of W,W_(3)C as well as the Fe amount variation determined two different micro-galvanic corrosion mechanisms significantly changing the Cr of coatings,0.26±0.02,59.68±1.21 and 59.06±1.16μm/year for P100,P200 and P400,*** P200 with its most uniform morphology,lowest roughness(rmS=3.9±0.4 nm)and good radiopacity(~6%)appeared the most suitable radiopaque biodegradable coating investigated in this study.

关键词： Fe-mn-Based alloys Degradable coatings W-Fe-mn-C coatings magnetron sputtering radiopacity Stent fluoroscopy

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