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Prevalence and risk factors associated with malaria infection among pregnant women in a semi-urban community of north-western Nigeria

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Infectious Diseases of Poverty 2015年第1期4卷 193-197页

作者： Sani Abdullahi Fana Mohammed Danladi Abubakar Bunza Sule Aliyu Anka Asiya Umar Imam Shehu Usman Nataala author details 1 department of medical microbiology Faculty of Medical Laboratory ScienceUsmanuDanfodiyo UniversitySokotoNigeria department of Biological Sciences UsmanuDanfodiyo UniversitySokotoNigeria

Background:Malaria during pregnancy remains a serious public health problem,with substantial risks for the mother,her foetus and the *** aim of this study was to determine the prevalence of malaria and possible risk factors for malaria infection among pregnant women in a semi-urban area in north-western *** women are among the most susceptible to malaria *** of their malaria infection status is an important yardstick to measure the effectiveness of any malaria control ***:We conducted a cross sectional study in the semi-urban area of Argungu,Kebbi State *** hundred and fifty five pregnant women were included in the study after informed verbal consent was *** each participant,the socio-demographic profile,stage of pregnancy and attitude to the use of insecticide-treated nets(ITNs)were investigated using a *** blood samples were collected and thick blood smears were prepared and stained with Giemsa stains to check for malaria *** associations between age,education level and use of ITNs with occurrence of malaria infection during pregnancy were analysed using the chi-square ***:One hundred and six(41.6%)out of 255 pregnant women were infected with malaria parasites,with a mean parasite density of 800 parasitesμl−*** was found that prevalence and parasite density decreased as age *** chi-square test indicated that a lack of education and non-usage of ITNs were significantly associated with malaria ***:Malaria is still a major public health issue among pregnant women mainly due to illiteracy and non-compliance to using *** awareness about malaria preventive measures and early attendance of antenatal care services will help to reduce malaria and,consequently,its associated morbidities and mortalities.

关键词： Malaria Pregnant women Mean parasite density Prevalence Risk factors Giemsa stain Argungu

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Insecticide resistance in phlebotomine sandflies in Southeast Asia with emphasis on the Indian subcontinent

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Infectious Diseases of Poverty 2016年第1期5卷 972-981页

作者： Ramesh C.Dhiman Rajpal S.Yadav author details 1 National Institute of Malaria Research(ICMR) Delhi 110077India department of Control of Neglected Tropical Diseases World Health OrganizationGenevaSwitzerland

Background:Visceral leishmaniasis,commonly known as kala-azar in India,is a global public health *** Southeast Asia,Bangladesh,Bhutan,India,Nepal,Sri Lanka and Thailand are endemic for visceral *** role of sandflies as the vector of kala-azar was first confirmed in 1942 in *** resistance in Phlebotomus argentipes Annandale and Brunetti,the vector of kala-azar in the Indian subcontinent,was first reported in 1987 in Bihar,*** article provides a scoping review of the studies undertaken from 1959 to 2015 on insecticide resistance in *** and ***(Scopoli),the vectors of visceral and cutaneous leishmaniasis respectively,in Southeast Asia,mainly in Bangladesh,India,Nepal and Sri ***:Studies undertaken in areas of Bihar and West Bengal in India where kala-azar is endemic have reported resistance of *** to DDT,while in non-endemic areas it has been reported to be *** areas of Nepal bordering India,there are indications of resistance to DDT;biochemical resistance has been reported in Sri *** laboratory studies have been undertaken in Bangladesh;however,the sandfly vector is reported to be still susceptible to pyrethroids in all kala-azar endemic areas in the aforementioned ***:Studies are needed to determine the resistance of sandfly vectors to all available classes of potential insecticides in kala-azar endemic *** is a need to assess the impact of indoor residual spraying with DDT and pyrethroids on the incidence of kala-azar in India where 54 districts remain endemic for the disease,strengthen entomological surveillance capacity,and develop and implement an insecticide management ***-cypermethrin indoor residual spraying has been introduced in 33 kala-azar endemic districts in Bihar State of India in a pilot trial;the outcomes should be used to inform decisions on expanding coverage with alpha-cypermethrin in all remaining endemic districts to achie

关键词： DDT Alpha-cypermethrin Indoor residual spraying Indian subcontinent Insecticide resistance Phlebotomus argentipes Phlebotomus papatasi Sandflies Visceral leishmaniasis

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Reprogramming cholesterol metabolism in macrophages and its role in host defense against cholesterol-dependent cytolysins

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Cellular & Molecular Immunology 2022年第3期19卷 327-336页

作者： Min-Sub Lee Steven J.Bensinger department of Molecular and medical Pharmacology University of CaliforniaLos AngelesCA90095USA department of microbiology Immunology and Molecular GeneticsUniversity of CaliforniaLos AngelesCA90095USA

Cholesterol is a critical lipid for all mammalian cells,ensuring proper membrane integrity,fluidity,and biochemical *** evidence indicates that macrophages rapidly and profoundly reprogram their cholesterol metabolism in response to activation signals to support host defense ***,our understanding of the molecular details underlying how and why cholesterol homeostasis is specifically reshaped during immune responses remains less well *** review discusses our current knowledge of cellular cholesterol homeostatic machinery and introduces emerging concepts regarding how plasma membrane cholesterol is partitioned into distinct *** then discuss how proinflammatory signals can markedly reshape the cholesterol metabolism of macrophages,with a focus on the differences between MyD88-dependent pattern recognition receptors and the interferon signaling *** also discuss recent work investigating the capacity of these proinflammatory signals to selectively reshape plasma membrane cholesterol *** examine how these changes in plasma membrane cholesterol metabolism influence sensitivity to a set of microbial pore-forming toxins known as cholesterol-dependent cytolysins that specifically target cholesterol for their effector *** also discuss whether lipid metabolic reprogramming can be leveraged for therapy to mitigate tissue damage mediated by cholesterol-dependent cytolysins in necrotizing fasciitis and other related *** expect that advancing our understanding of the crosstalk between metabolism and innate immunity will help explain how inflammation underlies metabolic diseases and highlight pathways that could be targeted to normalize metabolic homeostasis in disease states.

关键词： Cholesterol Macrophages Innate Immunity Metabolism

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Epidemiology of carbapenem-resistant Acinetobacter baumannii colonization in neonatal intensive care units:A systematic review and meta-analysis

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World Journal of Meta-Analysis 2024年第1期12卷 1-10页

作者： Donatien Serge Mbaga Sebastien Kenmoe Seraphine Nkie Esemu Arnol Bowo-Ngandji Nene Kaah Keneh Jane-Francis Tatah Kihla Akoachere Hortense Kamga Gonsu Roland Ndip Ndip Jean Thierry Ebogo-Belobo Cyprien Kengne-Ndé Nicholas Tendongfor Jean Paul Assam Assam Lucy Mande Ndip Jacky Njiki Bikoï Sara Honorine Riwom Essama department of microbiology The University of Yaounde IYaounde 00237Cameroon department of microbiology and Parasitology University of BueaBuea 00237Cameroon Faculty of Medicine and Biomedical Sciences The University of Yaounde IYaounde 00237Cameroon Center for Research in Health and Priority Pathologies Institute of Medical Research and Medicinal Plants StudiesYaounde 00237Cameroon Epidemiological Surveillance Evaluation and Research UnitNational AIDS Control CommitteeDouala 00237Cameroon

BACKGROUND The rising prevalence of carbapenem-resistant Acinetobacter baumannii(CRAB)in neonatal intensive care units(NICUs)represents an escalating challenge in healthcare settings,particularly in managing hospital-acquired infections(HAIs).Studies across various World Health Organization regions have documented a significant incidence of CRAB-related HAIs,with rates as high as 41.7 cases per 1000 patients in ICUs,accounting for 13.6%of all *** infections pose a doubled mortality risk compared to infections with carbapenem-susceptible Acinetobacter baumannii.A particularly concerning aspect of CRAB colonization is its asymptomatic nature,enabling its transmission through healthcare workers(HCWs)or the NICU environment to vulnerable neonates with developing immune *** To explore the prevalence of CRAB colonization in NICUs,focusing on neonates,healthcare workers,and the environmental samples,to enhance epidemiological understanding and inform targeted *** We conducted according to PRISMA 2020 checklist guidelines,a comprehensive literature search across multiple databases including MEDLINE(Ovid),EMBASE(Ovid),Global Health(Ovid),Web of Science,and Global Index *** were selected based on predetermined criteria,primarily involving neonates,HCWs,and environmental swabs,using culture or molecular methods to detect CRAB *** excluded studies that did not specifically focus on NICUs,were duplicates,or lacked necessary *** study selection and quality assessment were conducted independently by two *** extraction involved collecting comprehensive details about each *** statistical analysis used a random-effects model to calculate the pooled prevalence and confidence intervals,stratifying results by regional *** assessed study heterogeneity using Cochran's Q statistic and I²statistic,with regression tests employed to evaluate potential publication *** We analyzed 737 records from f

关键词： Colonization Carbapenem-resistant Acinetobacter baumannii Neonatal intensive-care unit

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author Correction:Distinct strengths of mTORC1 control T-cell memory via transcriptional FOXO1 and metabolic AMPKa1 pathways in linear cell differentiation and asymmetric cell division models

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Cellular & Molecular Immunology 2023年第3期20卷 311-312页

作者： Junqiong Huang Scot Leary Jim Xiang Cancer Research Cluster Saskatchewan Cancer Agency Saskatoon SK Canada department of Oncology College of Medicine University of Saskatchewan Saskatoon SK Canada department of Blood Transfusion Affiliated Hospital of Zunyi Medical University Zunyi Guizhou China department of Biochemistry Microbiology and Immunology College of Medicine University of Saskatchewan Saskatoon SK Canada

In the version of this article initially published,unintended typographical errors in the original version of Fig.1B were made during manuscript *** revised Fig.1,including the correct Fig.1B,isshown below.

关键词： FOXO1 mTORC1 initially

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Animal models for anti-neutrophil cytoplasmic antibody-associated vasculitis:Are current models good enough?

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Animal Models and Experimental Medicine 2023年第5期6卷 452-463页

作者： Fei Huang Yongman Lv Siyang Liu Hao Wu Qingquan Liu department of Geriatrics Tongji HospitalTongji Medical collegeHuazhong University of Science and TechnologyWuhanChina department of General Medicine Tongji HospitalTongji Medical collegeHuazhong University of Science and TechnologyWuhanChina department of Nephrology Tongji HospitalTongji Medical collegeHuazhong University of Science and TechnologyWuhanChina department of health management center Tongji HospitalTongji Medical collegeHuazhong University of Science and TechnologyWuhanChina Interdisciplinary Sciences Institute Huazhong Agricultural UniversityWuhanChina State Key Laboratory of Agricultural microbiology College of Veterinary MedicineHuazhong Agricultural UniversityWuhanChina

Antineutrophil cytoplasmic autoantibody(ANCA)-associated vasculitis(AAV)is a rare and severe systemic autoimmune disease characterized by pauci-immune necrotizing inflammation of small blood *** involves multiple organ systems throughout the *** knowledge of the pathogenesis of AAV has increased considerably in recent years,involving cellular,molecular and genetic *** of the controlled environment with no other confounding factors,animal models are beneficial for studying the mechanistic details of disease development and for providing novel therapeutic targets with fewer toxic side ***,the complexity and heterogeneity of AAV make it very difficult to establish a single animal model that can fully represent the entire clinical spectrum found in *** aim of this review is to overview the current status of animal models for AAV,outline the pros and cons of methods,and propose potential directions for future research.

关键词： antineutrophil cytoplasmic antibody experimental models pathogenesis vasculitis

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author Correction:A novel recombinant DNA vaccine encoding Mycobacterium tuberculosis ESAT-6 and FL protects against Mycobacterium tuberculosis challenge in mice

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The Journal of Biomedical Research 2022年第6期36卷 448-450页

作者： Qingtao Jiang Jing Zhang Xia Chen Mei Xia Yanlai Lu Wen Qiu Ganzhu Feng Dan Zhao Yan Li Fengxia He Guangyong Peng Yingwei Wang department of microbiology and Immunology Nanjing Medical UniversityNanjingJiangsu 211166China Division of Infectious Diseases Allergy and ImmunologyDepartment of Internal MedicineSaint Louis University School of MedicineSt.LouisMissouri 63104USA

Correction to:Journal of Biomedical Research https://***/10.7555/JBR.27.20120114,published on 30 September *** apologize for the misused images in Fig.7 in our article published on 30 September *** Fig.7 by HE staining and immunohistochemistry were partially misused because of our *** we couldn't find the original pictures acquired 11 years ago,thus HE and IHC experiments were repeated by our previously reserved wax ***,the pictures taken by microscope imaging system in each group were collected and combined,*** correct version of Fig.

关键词： tuberculosis immunohistochemistry picture

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Comparison of approaches to quantify SARS-CoV-2 in wastewater using RT-qPCR: Results and implications from a collaborative inter-laboratory study in Canada

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Journal of Environmental Sciences 2021年第9期33卷 218-229页

作者： Alex H.S.Chik Melissa B.Glier Mark Servos Chand S.Mangat Xiao-Li Pang Yuanyuan Qiu Patrick M.D’Aoust Jean-Baptiste Burnet Robert Delatolla Sarah Dorner Qiudi Geng John P.Giesy Jr Robert Mike McKay Michael R.Mulvey Natalie Prystajecky Nivetha Srikanthan Yuwei Xie Bernadette Conant Steve E.Hrudey Canadian SARS-CoV-Inter-Laboratory Consortium Consultant to Canadian Water Network Inc. KitchenerCanada Presently at Ontario Clean Water Agency MississaugaCanada Environmental microbiology BC Centre for Disease ControlVancouverCanada department of Biology University of WaterlooWaterlooCanada National microbiology Laboratory Public Health Agency of CanadaWinnipegCanada Public Health Laboratory Alberta Precision LaboratoryEdmontonCanada department of Laboratory Medicine&Pathology Faculty of Medicine and DentistryUniversity of AlbertaEdmontonAB T6G 2G3Canada Faculty of Engineering University of OttawaOttawaCanada Département des génies civil géologique et des minesPolytechnique MontréalMontréalCanada Veterinary Biomedical Sciences University of SaskatchewanSaskatoonCanada Toxicology Centre University of SaskatchewanSaskatoonCanada Great Lakes Institute for Environmental Research University of WindsorWindsorCanada department of medical microbiology University of ManitobaWinnipegCanada department of Pathology and Laboratory Medicine University of British ColumbiaVancouverCanada Canadian Water Network Inc. WaterlooCanada Group author details below

Detection of SARS-CoV-2 RNA in wastewater is a promising tool for informing public health decisions during the COVID-19 ***,approaches for its analysis by use of reverse transcription quantitative polymerase chain reaction(RT-q PCR)are still far from standardized *** characterize inter-and intra-laboratory variability among results when using various methods deployed across Canada,aliquots from a real wastewater sample were spiked with surrogates of SARS-CoV-2(gamma-radiation inactivated SARS-CoV-2 and human coronavirus strain 229E[HCoV-229E])at low and high levels then provided"blind"to eight *** estimates reported by individual laboratories were consistently within a 1.0-log_(10) range for aliquots of the same spiked *** laboratories distinguished between low-and high-spikes for both *** expected,greater variability was observed in the results amongst laboratories than within individual laboratories,but SARS-CoV-2 RNA concentration estimates for each spiked condition remained mostly within 1.0-log_(10) *** no-spike wastewater aliquots provided yielded non-detects or trace levels(<20 gene copies/mL)of SARS-CoV-2 *** appear linked to methods that included or focused on the solids fraction of the wastewater matrix and might represent in-situ SARS-CoV-2 to the wastewater ***-229E RNA was not detected in the no-spike ***,all methods yielded comparable results at the conditions *** behavior of SARS-CoV-2 and spiked surrogates in wastewater should be considered to evaluate method effectiveness.A consistent method and laboratory to explore wastewater SARS-CoV-2 temporal trends for a given system,with appropriate quality control protocols and documented in adequate detail should succeed.

关键词： COVID-19 Wastewater surveillance Public health Quality assurance Quality control

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PLGA nanodepots co-encapsulating prostratin and anti-CD25 enhance primary natural killer cell antiviral and antitumor function

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Nano Research 2020年第3期13卷 736-744页

作者： Elizabeth E.Sweeney Preethi B.Balakrishnan Allison B.Powell Allan Bowen Indra Sarabia Rachel A.Burga R.Brad Jones Alberto Bosque C.Russell Y.Cruz Rohan Fernandes The George Washington Cancer Center The George Washington UniversityWashingtonDC20052USA Center for Cancer and Immunology Research Children’s National Health SystemWashingtonDC20010USA department of microbiology Immunologyand Tropical MedicineThe George Washington UniversityWashingtonDC20052USA Infectious Disease Division Weill Cornell Medical CollegeNew YorkNY10065USA View author publications department of Medicine The George Washington UniversityWashingtonDC20052USA

Natural killer(NK)cells are attractive effector cells of the innate immune system against human immunodeficiency virus(HIV)and ***,NK cell therapies are limited by the fact that target cells evade NK cells,for example,in latent reservoirs(in HIV)or through upregulation of inhibitory signals(in cancer).To address this limitation,we describe a biodegradable nanoparticlebased“priming”approach to enhance the cytotoxic efficacy of peripheral blood mononuclear cell-derived NK *** present poly(lactic-co-glycolic acid)(PLGA)nanodepots(NDs)that co-encapsulate prostratin,a latency-reversing agent,and anti-CD25(aCD25),a cell surface binding antibody,to enhance primary NK cell function against HIV and *** utilize a nanoemulsion synthesis scheme to encapsulate both prostratin and aCD25 within the PLGA NDs(termed Pro-aCD25-NDs).Physicochemical characterization studies of the NDs demonstrated that our synthesis scheme resulted in stable and monodisperse *** NDs successfully released both active prostratin and anti-CD25,and with controllable release *** Pro-aCD25-NDs were administered in an in vitro model of latent HIV and acute T cell leukemia using J-Lat 10.6 cells,the NDs were observed to prime J-Lat cells resulting in significantly increased NK cell-mediated cytotoxicity compared to free prostratin plus anti-CD25,and other *** findings demonstrate the feasibility of using our Pro-aCD25-NDs to prime target cells for enhancing the cytotoxicity of NK cells as antiviral or antitumor agents.

关键词： poly(lactic-co-glycolic acid)(PLGA)nanodepots natural killer(NK)cells human immunodeficiency virus(HIV) cancer latency-reversing agent antibody

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Oncogenic viruses and cancer

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Virologica Sinica 2015年第2期30卷 83-84页

作者： Guangxiang George Luo Jing-hsiung James Ou department of microbiology University of Alabama at Birmingham School of Medicine Peking University Health Science Center department of Molecular microbiology and Immunology University of Southern California Keck School of Medicine

This special issue of the journal is dedicated to the important topic of oncogenic viruses and *** contains seven review articles covering all known oncogenic viruses except for human T-lymphotropic virus type1(HTLV-1).These review articles are contributed by experts on specific viruses and their associated human *** account for about 20%of total human cancer *** many viruses can cause various tumors in animals,only seven of

关键词： covering dedicated pathogenesis alterations herpesvirus details replication references specif carcinogenesis

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