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PGE2 receptor 3 subtype（EP3）regulates adipose metabolism in mice

PGE2 receptor 3 subtype（EP3）regulates adipose metabolism i...

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中国生理学会第24届全国会员代表大会暨生理学学术大会

作者：徐虎 Yifei Miao Sha Li Jialin Fu Shizheng Huang Shengnan Du Jia Liu Xiaoyan Zhang Youfei Guan 北京大学 Department of Physiology and Pathophysiology Peking University Health Science Center astra zeneca-shenzhen university joint institute of nephrology Shenzhen University Health Science Center

Preadipocyte and adipocyte are two major cell types that exist in white adipose tissue（WAT）.The differentiation of preadipocyte increases the number of mature adipocyte and governs fat ***（TG）in adipose tissue is the main energy storage form in *** breakdown of TG,termed lipolysis,in adipocyte produces glycerol and free fatty acid（FFA）,which is released to circulatory system to supply energy for various *** imbalance of adipogenesis and adipocyte lipolysis and hypertrophy in WAT account for the development of obesity under over-nutrition *** development of obesity also depends on the function of brown adipose tissue（BAT）.Prostaglandin E2（PGE2）is the predominant prostaglandin produced in adipose tissue and plays an important role in the regulation of adipose tissue functions through its four receptors,i.e.,EP1,EP2,EP3,and *** study showed that the EP3 receptor deficient mice exhibited increased night eating frequency and developed obesity and insulin ***,the underlying mechanism remains *** aimed to investigate the impact of EP3 receptor on both WAT and BAT functions and its contribution to the development of *** demonstrated that global EP3 receptor gene deficiency in mice（EP3-/-）resulted in reduced locomotion,increased food intake and spontaneous obesity,with an enhanced ***3-/-mice also exhibited increased adipocyte size,WAT mass and body weight,mainly due to enhanced preadipocyte ***,the lipolysis process was also activated in the WAT of EP3-/-mice via the stimulation of the c AMP/protein kinase A（PKA）/hormone sensitive lipase（HSL）pathway,which promoted excessive lipid ectopic deposition in liver and mild insulin *** the condition of 24h fasting,EP3-/-mice displayed higher serum glycerol level but less lipid deposition in liver than that in EP3+/+*** also found that EP3-/-mice exhibited more BAT content and lower respiratory quotient（R

关键词： PGE2 receptor 3 subtype adipose lipogenesis lipolysis

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