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OsNPF3.1,a nitrate,abscisic acid and gibberellin transporter gene,is essential for rice tillering and nitrogen utilization efficiency

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Journal of Integrative Agriculture 2024年第4期23卷 1087-1104页

作者： Junnan Hang Bowen Wu Diyang Qiu Guo Yang Zhongming Fang Mingyong Zhang institute of Rice Industry Technology research/Key Laboratory of Functional Agriculture Guizhou Provincial Department of Education/Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous RegionMinistry of Education/Key Laboratory of Molecular Breeding for Grain and Oil Crops in Guizhou Province/College of Agricultural SciencesGuizhou UniversityGuiyang 550025China Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement/Guangdong Provincial Key Laboratory of Applied Botany/South China Botanical Garden Chinese Academy of SciencesGuangzhou 510650China institute of Fruit Tree research Guangdong Academy of Agricultural SciencesGuangzhou 510640China

Low-affinity nitrate transporter genes have been identified in subfamilies 4-8 of the rice nitrate transporter 1(NRT1)/peptide transporter family(NPF),but the OsNPF3 subfamily responsible for nitrate and phytohormone transport and rice growth and development remains *** this study,we described OsNPF3.1 as an essential nitrate and phytohormone transporter gene for rice tillering and nitrogen utilization efficiency(NUtE).OsNPF3.1 possesses four major haplotypes of its promoter sequence in 517 cultivars,and its expression is positively associated with tiller *** expression was higher in the basal part,culm,and leaf blade than in other parts of the plant,and was strongly induced by nitrate,abscisic acid(ABA)and gibberellin 3(GA_3)in the root and shoot of *** experiments demonstrated that OsNPF3.1 is a pH-dependent low-affinity nitrate transporter,with rice protoplast uptake assays showing it to be an ABA and GA_3 ***3.1 overexpression significantly promoted ABA accumulation in the roots and GA accumulation in the basal part of the plant which inhibited axillary bud outgrowth and rice tillering,especially at high nitrate *** NUtE of OsNPF3.1-overexpressing plants was enhanced under low and medium nitrate concentrations,whereas the NUtE of OsNPF3.1 clustered regularly interspaced short palindromic repeats(CRISPR)plants was increased under high nitrate *** results indicate that OsNPF3.1 transports nitrate and phytohormones in different rice tissues under different nitrate *** altered OsNPF3.1 expression improves NUtE in the OsNPF3.1-overexpressing and CRISPR lines at low and high nitrate concentrations,respectively.

关键词： rice tillering grain yield phytohormone nitrate transporter nitrogen utilization efficiency

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Mn-modified nitrogen-doped Pt-based electrocatalyst for efficient oxygen reduction in aluminum-air batteries

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Nano research 2024年第8期17卷 7126-7135页

作者： Li Gao Yang Song Xuebing Xu Chang Li Chaoquan Hu State Key Laboratory of Mesoscience and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Zhongke Nanjing institute of Green Manufacturing Industry Nanjing 211135China

In this study,a Mn-modified Pt-based catalyst loaded on nitrogen-doped Ketjen black(Mn-Pt/NKB)is prepared using a simple ethylene glycol reduction *** size of Pt nanoparticles(NPs)is effectively controlled by doping with Mn and *** the smallest average particle size of 1.7 nm,Mn-Pt/NKB demonstrates half-wave potentials of 0.890 and 0.688 V in the alkaline and neutral electrolytes,respectively,which are superior to those of commercial platinum on activated carbon(Pt/C).When applied as an air cathode in aluminum-air battery,it exhibits ultra-high power densities of 190(alkaline)and 26.2 mW·cm^(−2)(neutral).Moreover,the voltage remains stable after 5 h of *** practical application performance of the Mn-Pt/NKB catalyst in an aluminum-air battery is better than that of commercial Pt/***,the oxygen reduction reaction(ORR)mechanism on surfaces with different particle sizes is analyzed using density functional *** cracking is the major pathway on the surface of the small particles with lower energy consumption of 0.5 eV,while water molecule cleavage is the major pathway on the surface of the large particles with higher energy consumption of 0.97 *** lower energy consumption of the oxygen cracking pathway further confirms the ORR mechanism for higher activity on small-sized *** study provides a direction for the rational design of Pt-based catalysts for ORR and sheds light on the commercial development of aluminum-air batteries.

关键词： oxygen reduction reaction precious metal catalysts aluminum-air battery density functional theory(DFT)calculations reaction pathway

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Hybrid channeling of Cu-Al cold plates for thermal management devices

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China Welding 2024年

作者：胡胜男谢聿铭王胜龙孟祥晨黄永宪 State Key Laboratory of Precision Welding & Joining of Materials and Structures Harbin Institute of Technology Zhengzhou research institute Harbin Institute of Technology Beijing Hangxing Machinery Manufacturing Co.Ltd.

Cu-Al cold plates, as a novel type of cold plate that combines the high thermal conductivity of copper with the low production cost of aluminum, are among the best options for enhancing the heat dissipation capacity of battery thermal management systems. Hybrid channeling of Cu-Al cold plates was proposed for thermal management devices with the combination of friction stir welding + *** highest flexural strength of the Cu-Al interfaces reached 127.5 MPa with the optimized parameters. Due to the close-row welds adjacent to the channels, high-efficiency heat dissipation was realized with the fully bonded interfaces. No leakage of coolants occurred under the pressure of 0.85 MPa during the hydrostatic tests, indicating a sound sealing performance of the channels. Compared to the conventional Al cold plates, the heat sink capacity of the Cu-Al cold plates was enhanced by 16.3%. The results indicated that hybrid channeling not only enhanced the interfacial strength of Cu-Al cold plates but also significantly improved the heat dissipation capacity, offering a new technical pathway for optimizing battery thermal management systems.

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The switch triggering the invasion process:Lipid metabolism in the metastasis of hepatocellular carcinoma

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Chinese medical Journal 2024年第11期137卷 1271-1284页

作者： Jiaqian Zhang Zhicheng Zhang Zhangfan Wu Yufei Wang Zerui Zhang Limin Xia Department of Gastroenterology Institute of Liver and Gastrointestinal DiseasesHubei Key Laboratory of Hepato-Pancreato-Biliary DiseasesTongji Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical research Center for Digestive Diseases Xijing Hospital of Digestive DiseasesFourth Military Medical UniversityXi’anShaanxi 710032China

In humans,the liver is a central metabolic organ with a complex and unique histological *** carcinoma(HCC),which is a highly aggressive disease with a poor prognosis,accounts for most cases of primary liver *** an emerging hallmark of cancers,metabolic reprogramming acts as a runaway mechanism that disrupts homeostasis of the affected organs,including the ***,rewiring of the liver metabolic microenvironment,including lipid metabolism,is driven by HCC cells,propelling the phenotypes of HCC cells,including dissemination,invasion,and even metastasis in *** resulting formation of this vicious loop facilitates various malignant behaviors of HCC ***,few articles have comprehensively summarized lipid reprogramming in HCC ***,we have reviewed the general situation of the liver microenvironment and the physiological lipid metabolism in the liver,and highlighted the effects of different aspects of lipid metabolism on HCC metastasis to explore the underlying *** addition,we have recapitulated promising therapeutic strategies targeting lipid metabolism and the effects of lipid metabolic reprogramming on the efficacy of HCC systematical therapy,aiming to offer new perspectives for targeted therapy.

关键词： Hepatocellular carcinoma Invasion Metastasis Lipid metabolism Tumor microenvironment

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Rational management of the plant microbiome for the Second Green Revolution

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Plant Communications 2024年第4期5卷 1-15页

作者： Xiaofang Li Xin Zheng Nikita Yadav Shouvik Saha El-Sayed Salama Xiangkai Li Likun Wang Byong-Hun Jeon Center for Agricultural Resources research Institute of Genetics and Developmental BiologyChinese Academy of SciencesShijiazhuang 050021China Department of Earth Resources and Environmental Engineering Hanyang UniversitySeoul 04763South Korea Natural Resources research institute University of Minnesota DuluthHermantownMN 55811USA Department of Biotechnology Brainware UniversityBarasatKolkata 700125West BengalIndia Department of Occupational and Environmental Health School of Public HealthLanzhou UniversityLanzhouGansu 730000China Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations School of Life ScienceLanzhou UniversityLanzhouGansu 730000China

The Green Revolution of the mid-20th century transformed agriculture worldwide and has resulted in envi-ronmental challenges.A new approach,the Second Green Revolution,seeks to enhance agricultural pro-ductivity while minimizing negative environmental *** microbiomes play critical roles in plant growth and stress responses,and understanding plant–microbiome interactions is essential for developing sustainable agricultural practices that meet food security and safety challenges,which are among the United Nations Sustainable Development *** review provides a comprehensive exploration of key deterministic processes crucial for developing microbiome management strategies,including the host effect,the facilitator effect,and microbe–microbe interactions.A hierarchical framework for plant mi-crobiome modulation is proposed to bridge the gap between basic research and agricultural *** framework emphasizes three levels of modulation:single-strain,synthetic community,and in situ mi-crobiome ***,rational management of plant microbiomes has wide-ranging applications in agriculture and can potentially be a core technology for the Second Green Revolution.

关键词： Second Green Revolution plant microbiome rational management host effect microbiome heritability

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Active Magnetic Compensation Based on Parametric Resonance Magnetometer

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Journal of Shanghai Jiaotong university(Science) 2024年第2期29卷 280-289页

作者：郭阳李绍良黄艺明骆曼箬刘华 School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Shanghai institute of Spacefight Control Technology Shanghai Key Laboratory of Space Intelligent Control TechnologyShanghai Engineer Research Center of InertiaShanghai 201109China

Based on the parametric resonance magnetometer(PRM)theory,this paper establishes an experimen-tal system of *** experimental results are consistent with the theoretical predictions.A PRM has been developed with sensitivity of 0.5 pT/Hz^(1/2),which can detect the magnitude of residual magnetic field;furthermore,a proportion-integration-differentiation(PID)closed-loop magnetic compensation system of the residual magnetic field also has been *** with open-loop compensation,the PID closed-loop compensation reduces the average value of the residual magnetic field in the z-axis direction from 0.0244nT to-0.0023nT,and the mean-square error from 0.2083 nT to 0.0691 *** the same way,the average value of the residual magnetic field in the y-axis direction is reduced from 0.0816nT to-0.0042nT,and the mean-square error from 0.1316nT to 0.0461 *** magnitude of residual magnetic fields in both directions is decreased to the order of picotesla(pT).In addition,based on the signal waveforms of the magnetometer,a method of verifying the effect of magnetic compensation is proposed.

关键词： magnetometer parametric resonance nuclear magnetic resonance gyroscope magnetic compensa-tion proportion-integration-differentiation(PID)

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Cancer treatment with biosimilar drugs:A review

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Cancer Innovation 2024年第2期3卷 45-62页

作者： Shilpa Malakar Emmanuel Nuah Gontor Moses YDugbaye Kamal Shah Sakshi Sinha Priya Sutaoney Nagendra Singh Chauhan Department of Microbiology Kalinga UniversityRaipurChhattisgarhIndia institute of Pharmaceutical research GLA UniversityMathuraUttar PradeshIndia Drug Testing Laboratory Avam Anusandhan KendraRaipurChhattisgarhIndia

Biosimilars are biological drugs created from living organisms or that contain living *** share an identical amino-acid sequence and *** drugs are considered to be cost-effective and are utilized in the treatment of cancer and other endocrine *** primary aim of biosimilars is to predict biosimilarity,efficacy,and treatment costs;they are approved by the Food and Drug Administration(FDA)and have no clinical *** involve analytical studies to understand the similarities and dissimilarities.A biosimilar manufacturer sets up FDA-approved reference products to evaluate *** contribution of next-generation sequencing is evolving to study the organ tumor and its progression with its impactful therapeutic approach on cancer patients to showcase and target rare *** study shall help to understand the future perspectives of biosimilars for use in gastro-entero-logic diseases,colorectal cancer,and thyroid *** also help target specific organs with essential mutational categories and drug prototypes in clinical practices with blood and liquid biopsy,cell treatment,gene therapy,recombinant therapeutic proteins,and personalized *** derivatives such as monoclonal antibodies like trastuzumab and rituximab are common drugs used in cancer *** coli produces more than six antibodies or antibody-derived proteins to treat cancer such as filgrastim,epoetin alfa,and so on.

关键词： biologics biosimilars cancer Escherichia coli monoclonal antibody next-generation sequencing pharmacovigilance

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A folic acid-decorated nanoparticles loaded JQ1 for oral squamous cell carcinoma therapy

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Chinese Chemical Letters 2024年第3期35卷 332-336页

作者： Dequan Zeng Zhongkai Ma Xin Zan Ting Luo Xiang Wang Xiang Gao Xianghui Fu School of Health Management Xihua UniversityChengdu 610039China State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China College of StomatologySichuan UniversityChengdu 610041China Department of Neurosurgery and institute of Neurosurgery State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalWest China Medical SchoolSichuan University and Collaborative Innovation Center for BiotherapyChengdu 610041China Breast Disease Center Cancer CenterWest China HospitalSichuan UniversityChengdu 610041China

Oral squamous cell carcinoma(OSCC)is known as one of the most malignant tumors with high recurrence and fatality *** poor tumor-targeting ability of traditional chemotherapeutic drugs has been a grand challenge for anti-OSCC *** that,a large quantity of tumor associated macrophages in OSCC tissues further diminish the anti-tumor effects of these ***,we produced a therapeutic nano drug delivery system(FA-PEG-PLA-JQ1)through encapsulating JQ1[a small-molecule inhibitor of bromodomain containing protein 4(BRD4)]into the folic acid(FA)-modified nanoparticle(PEG-PLA),which could prolong the half-life of JQ1 and target the tumor *** then,JQ1 released from this nanoparticle could prevent OSCC growth inducing tumor cell apoptosis,inhibiting tumor angiogenesis and the polarization of M2 type *** conclusion,our date demonstrated the therapeutic benefits of FA-PEG-PLA-JQ1 against OSCC in vivo or in vitro,which could be a novel treatment strategy for OSCC in coming days.

关键词： Folic acid Nanoparticles JQ1 Oral squamous cell carcinoma Macrophages

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A regular MOG black hole's impact on shadows and gravitational weak lensing in the presence of a quintessence field

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Communications in Theoretical Physics 2024年第8期76卷 91-102页

作者： Ahmad Al-Badawi Sanjar Shaymatov Mirzabek Alloqulov Anzhong Wang Department of Physics Al-Hussein Bin Talal UniversityPO Box:2071111Ma’anJordan institute for Theoretical Physics and Cosmology Zhejiang University of TechnologyHangzhou 310023China Tashkent State Technical University Tashkent 100095Uzbekistan University of Tashkent for Applied Sciences Str.Gavhar 1Tashkent 100149Uzbekistan New Uzbekistan University Movarounnahr Street 1Tashkent 100000Uzbekistan institute of Fundamental and Applied research National Research University TIIAMEKori Niyoziy 39Tashkent 100000Uzbekistan GCAP-CASPER Physics DepartmentBaylor UniversityWacoTX 76798-7316United States of America

We investigate the impact of the modified gravity(MOG)field and the quintessence scalar field on horizon evolution,black hole(BH)shadow and the weak gravitational lensing around a static spherically symmetric *** first begin to write the BH metric associated with the MOG parameter and quintessence scalar *** then determine the BH shadow and obtain numerical solutions for the photon sphere and shadow *** show that the MOG(α)and the quintessence(c)parameters have a significant impact on the BH shadow and photon *** on the analysis,we further show that the combined effects of the MOG parameter and quintessence field can increase the values of BH shadow and photon sphere *** also obtain constraints on the BH parameters by applying the observational data of Sgr A^(★)and M87^(★).Finally,we consider the weak deflection angle of BH within the context of the Gauss-Bonnet theorem(GBT)and show that the combined effects of the MOG and quintessence parameters do make the value of the deflection angle increase,and find this remarkable property is in good agreement with the physical meaning of both parameters that can maintain the strong gravitational field in the surrounding environment of a BH.

关键词： modified gravity shadows gravitational weak lensing quintessence field

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Application of different fiber structures and arrangements by electrospinning in triboelectric nanogenerators

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Chinese Journal of Chemical Engineering 2024年第5期69卷 177-191页

作者： Hebin Li Zifei Meng Dehua Wang Ye Lu Longlong Jiang Le Zhang Hanbin Wang Xiaoxiong Wang College of Physics Qingdao UniversityQingdao 266071China School of Physics and Electronic Engineering Jiangsu Normal UniversityXuzhouJiangsu 221000China Microsystem&Terahertz research Center China Academy of Engineering Physics(CAEP)Chengdu 610200China institute of Electronic Engineering China Academy of Engineering Physics(CAEP)Mianyang 621900China University-Industry Joint Center for Ocean Observation and Broadband Communication College of PhysicsQingdao UniversityQingdao 266071China Weihai Innovation research institute of Qingdao University Weihai 264200China Collaborative Innovation Center for Eco-Textiles of Shandong Province and State Key Laboratory of Bio-Fibers and Eco-TextilesQingdao UniversityQingdao 266071China

In recent years,nanogenerators(NGs)have attracted wide attention in the energy field,among which triboelectric nanogenerators(TENGs)have shown superior *** reports of electrospinning(ES)-based TENGs have been reported,but there is a lack of deep analysis of the designing method from microstructure,limiting the creative of new ES-based *** TENGs use polymer materials to achieve corresponding design,which requires structural design of polymer *** existing polymer molding design methods include macroscopic molding methods,such as injection,compression,extrusion,calendering,etc.,combined with liquid-solid changes such as soluting and melting;it also includes micro-nano molding technology,such as melt-blown method,coagulation bath method,ES method,and nanoimprint *** fact,ES technology has good controllability of thickness dimension and rich means of nanoscale structure *** present,these characteristics have not been ***,in this paper,we combine recent reports with some microstructure regulation functions of ES to establish a more general TENGs design *** on the rich microstructure research results in the field of ES,much more new types of TENGs can be designed in the future.

关键词： Triboelectric nanogenerators Electrospinning Fiber microstructure regulation Nanomaterials Membranes Global optimization

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