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Follow-up in patients with a burn-related emergency department visit:a feasibility study

burns & Trauma 2017年第4期5卷 260-267页

作者： H. Goei B. F. M. Wijnen S. Mans M. A. C. de Jongh C. H. van der Vlies S. Polinder N. E. E. van Loey M. E. van Baar association of dutch burn centres Burn Centre Maasstad Hospital PO Box 9100 3007 AC Rotterdam the Netherlands Department of Plastic Reconstructive and Hand Surgery MOVE Research Institute VU University Medical Centre Amsterdam the Netherlands association of dutch burn centres Burn Centre Maasstad Hospital PO Box 9100 3007 AC Rotterdam the Netherlands Department of Health Services Research CAPHRI School of Public Health and Primary Care Maastricht University 6200 MD Maastricht the Netherlands Trauma Centre Brabant Elisabeth-TweeSteden Hospital Tilburg the Netherlands burn Centre Maasstad Hospital Rotterdam the Netherlands Department of Public Health Erasmus Medical Centre Rotterdam the Netherlands association of dutch burn centres Red Cross Hospital Beverwijk the Netherlands association of dutch burn centres Burn Centre Maasstad Hospital PO Box 9100 3007 AC Rotterdam the Netherlands Department of Public Health Erasmus Medical Centre Rotterdam the Netherlands

Background:Data on epidemiology, costs, and outcomes of burn-related injuries presenting at emergency departments (EDs) are scarce. To obtain such information, a questionnaire study with an adequate response rate is imperative. There is evidence that optimized strategies can increase patient participation. However, it is unclear whether this applies to burn patients in an ED setting. The objective of this feasibility study was to optimize and evaluate patient recruitment strategy and follow-up methods in patients with burn injuries presenting at EDs. Methods:In a prospective cohort study with a 6-month follow-up, patients with burn-related injuries attending two large EDs during a 3-month study period were included. Eligible patients were quasi-randomly allocated to a standard or optimized recruitment strategy by week of the ED visit. The standard recruitment strategy consisted of an invitation letter to participate, an informed consent form, a questionnaire, and a franked return envelope. The optimized recruitment strategy was complemented by a stamped returned envelope, monetary incentive, sending a second copy of the questionnaire, and a reminder by telephone in non-responders. Response rates were calculated, and questionnaires were used to assess treatment, costs, and health-related quality of life. Results:A total of 87 patients were included of which 85 were eligible for the follow-up study. There was a higher response rate at 2 months in the optimized versus the standard recruitment strategy (43.6%vs. 20.0%;OR=3.1 (95%CI 1.1–8.8)), although overall response is low. Non-response analyses showed no significant differences in patient, burn injury or treatment characteristics between responders versus non-responders. Conclusions:This study demonstrated that response rates can be increased with an optimized, but more labor-intensive recruitment strategy, although further optimization of recruitment and follow-up is needed. It is feasible to assess epidemiology, tr

关键词： burns Emergency department Recruitment strategy Response rate Health care survey methods

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Skin bioprinting:the future of burn wound reconstruction?

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burns & Trauma 2019年第1期7卷 25-36页

作者： Mathew Varkey Dafydd O.Visscher Paul P.Mvan Zuijlen Anthony Atala James J.Yoo Wake Forest Institute for Regenerative Medicine Wake Forest School of MedicineMedical Center BoulevardWinston-SalemNC 27101USA Department of Plastic Reconstructive and Hand SurgeryAmsterdam University Medical Center1081HVAmsterdamThe Netherlands Amsterdam Movement Sciences AmsterdamThe Netherlands burn Center Red Cross Hospital1942LEBeverwijkThe Netherlands association of dutch burn centres 1942LEBeverwijkThe Netherlands

burns are a significant cause of trauma,and over the years,the focus of patient care has shifted from just survival to facilitation of improved functional ***,burn treatment,especially in the case of extensive burn injuries,involves surgical excision of injured skin and reconstruction of the burn injury with the aid of skin *** skin substitutes do not contain all skin cell types and do not facilitate recapitulation of native skin ***-dimensional(3D)bioprinting for reconstruction of burn injuries involves layer-by-layer deposition of cells along with scaffolding materials over the injured *** bioprinting can be done either in situ or in *** these approaches are similar except for the site of printing and tissue *** are technological and regulatory challenges that need to be overcome for clinical translation of bioprinted skin for burn ***,the use of bioprinting for skin reconstruction following burns is promising;bioprinting will enable accurate placement of cell types and precise and reproducible fabrication of constructs to replace the injured or damaged ***,3D bioprinting is a very transformative technology,and its use for wound reconstruction will lead to a paradigm shift in patient *** this review,we aim to introduce bioprinting,the different stages involved,in vitro and in vivo skin bioprinting,and the various clinical and regulatory challenges in adoption of this technology.

关键词： Bioprinting Skin burns Reconstruction

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NEW STUDY FINDS ACCIDENTAL ALTERATION OF WATER TEMPERATURE AT THE TAP WHILST BATHING WAS INVOLVED IN MORE THAN 55% OF INJURIES IN PEOPLE ADMITTED WITH TAP WATER SCALDS TO AUSTRALIAN AND NEW ZEALAND burn CENTERS

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水务世界 2022年第5期 29-30页

作者： Yvonne Singer The Alfred Asia Pacific Representative International Society of burn Injuries Prevention Committee International Society of burn Injuries American burn association Quality and Registry Committee

Scalds caused from hot tap water can have devastating outcomes and lifelong consequences for survivors.A 2020 study conducted by the Australian and New Zealand professional burns community using data from the burn Registry of Australia and New Zealand highlighted the frequency,demographic profile and in-hospital outcomes of people with tap water scalds admitted to Australian and New Zealand burn services between 2010,and 2018.

关键词： admitted consequences Zealand

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burns in the elderly:a nationwide study on management and clinical outcomes

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burns & Trauma 2020年第1期8卷 71-81页

作者： Harold Goei Margriet E.van Baar Jan Dokter J Vloemans Gerard I.J.M.Beerthuizen Esther Middelkoop Kees H.van der Vlies the dutch burn Repository group association of dutch burn centres Burn CentreMaasstad HospitalRotterdamthe Netherlands Department of Plastic Reconstructive and Hand SurgeryAmsterdam Movement SciencesVU University Medical CentreAmsterdamthe Netherlands burn Centre Maasstad Hospital Rotterdamthe Netherlands burn Centre Red Cross Hospital Beverwijkthe Netherlands burn Centre Martini HospitalGroningenthe Netherlands association of dutch burn centres Burn Centre Red Cross HospitalBeverwijkthe Netherlands Department of Public Health Erasmus Medical CentreRotterdamthe Netherlands 不详

Background:In modern-day burn care,advanced age remains an important predictor for mortality among burn *** this study,we compared the complete treatment trajectory(including prehospital and surgical treatment)and the outcomes between an elderly burn population and a younger adult burn ***:In this nationwide study,data from the dutch burn Repository were *** is a uniform national registration for dutch specialized burn *** adult patients that were admitted to one of the three dutch burn centres from the period 2009 to 2015 were included in the *** patients were considered as elderly when≥65 years of age,and were then further subdivided into three age categories:65–74,75–85 and 85+*** adults in the age category 18–64 years were used as the reference *** managementwas studied comprehensively and included timing of surgery,the number of procedures and details on the surgical technique,especially the technique used for debridement and the grafting technique that was *** the comparison of clinical outcome,the following parameters were included:mortality,wound infections,length of stay/TBSA(total body surface area)burned,discharge disposition and secondary ***:During the study period,3155 adult patients were included(elderly,n=505).burn severity,reflected by the median TBSA,varied between 3.2–4.0%and was comparable,but aetiology and pre-hospital care were different between elderly and the younger adult reference *** treatment was initiated significantly faster in elderly burn patients(pburns patients(hydrosurgery,42.0%vs 23.5–22.6%),and on the other hand more avulsion(5.3%vs 7.3–17.6%)and primary wound closure(6.7%vs 24.5%).The most frequently used grafting technique was meshed skin grafts(79.2–88.6%);this was not related to *** increased rapidly with a higher age and showed a h

关键词： burns Nationwide study Elderly Surgical management Clinical outcomes

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Citrus fruits are rich in flavonoids for immunoregulation and potential targeting ACE2

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Natural Products and Bioprospecting 2022年第1期12卷 41-50页

作者： Wenting Liu Weikang Zheng Liping Cheng Ming Li Jie Huang Shuzheng Bao Qiang Xu Zhaocheng Ma College of Horticulture and Forestry Sciences Key Laboratory of Horticultural Plant BiologyMinistry of EducationHuazhong Agricultural UniversityWuhan 430070China Network of Aquaculture centres in Asia-Pacific Bangkok 10903Thailand China association of Agricultural Science Societies Beijing 100125China

The most recent outbreak of 2019 novel coronavirus,named as COVID-19,caused pneumonia epidemic in Wuhan with 2121 deaths cases as of February 20th *** of effective antiviral agents to combat the novel coronavirus is urgently *** fruit peel or wild citrus are rich in flavonoids,and clinically documented for roles in relief of cough and promotion of digestive ***,citrus fruits are assumed to possess antivirus activities or enhance the host immunity.A previous study found that hesperetin could act as a high potent inhibitor of SARS-CoV *** determined six flavonoid compounds’content in three citrus species by using LC-MS *** content of naringin and naringenin was at higher levels in *** and hesperidin were highly accumulated in mandarin and sweet *** subsequent in vitro and in vivo experiments indicated that naringin could inhibit the expression of the proinflammatory cytokines(COX-2,iNOS,IL-1βand IL-6)induced by LPS in Raw macrophage cell line,and may restrain cytokine through inhibiting HMGB1 expression in a mouse *** results revealed that naringin may have a potential application for preventing cytokine *** simulated molecular docking to predict the binding affinity of those flavonoids to bind Angiotensin-converting enzyme 2(ACE 2),which is a receptor of the *** of the potential anti-coronavirus and anti-inflammatory activity of flavonoids,the citrus fruit or its derived phytochemicals are promising in the use of prevention and treatment of SARS-CoV-2 infection.

关键词： Citrus flavonoids Naringin Immunoregulation ACE2 SARS-CoV-2

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Tissue engineering in burn scar reconstruction

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burns & Trauma 2015年第3期3卷 122-132页

作者： PPM van Zuijlen KLM Gardien MEH Jaspers EJ Bos DC Baas AJM van Trier E Middelkoop burn Center Red Cross HospitalBeverwijkThe Netherlands Department of Plastic Reconstructive and Hand SurgeryRed Cross HospitalBeverwijkThe Netherlands association of dutch burn Centers BeverwijkThe Netherlands Department of Plastic Reconstructive and Hand SurgeryMOVE Research InstituteVU University Medical CenterAmsterdamThe Netherlands

Nowadays,most patients with severe burns will survive their *** evolution is accompanied by the challenge to cover a large percentage of total body surface area ***,more and more patients have to deal with the sequelae of burn scars and require(multiple)*** review provides a gross overview of developments in the field of tissue engineering for permanent burn wound coverage and reconstructive burn surgery,focusing on usage and clinical *** only skin substitutes will be discussed but also the replacement of subcutaneous fat tissue and cartilage.

关键词： burns Tissue engineering Scar Contracture Substitute Subcutaneous fat tissue Cartilage Reconstruction

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New techniques in the tissue diagnosis of gastrointestinal neuromuscular diseases

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World Journal of Gastroenterology 2009年第2期15卷 192-197页

作者： Charles H Knowles Joanne E Martin Neurogastroenterology Group Centres for Academic Surgery and Pathology Institute of Cellular and Molecular Science Barts and the London Queen Mary's School of Medicine and Dentistry Whitechapel London United Kingdom

Gastrointestinal neuromuscular diseases are a clinically heterogeneous group of disorders of children and adults in which symptoms are presumed or proven to arise as a result of neuromuscular (including interstitial cell of Cajal) dysfunction. Common to most of these diseases are symptoms of impaired motor activity which manifest as slowed or obstructed transit with or without evidence of transient or persistent radiological visceral dilatation. A variety of histopathological techniques and allied investigations are being increasingly applied to tissue biopsies from such patients. This review outlines some of the more recent advances in this fi eld, particularly in the most contentious area of small bowel disease manifesting as intestinal pseudo-obstruction.

关键词：肠疾病肠神经疾病间隙细胞内脏疼痛

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Post electrical or lightning injury syndrome: a proposal for an American Psychiatric association's Diagnostic and Statistical Manual formulation with implications for treatment

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Neural Regeneration Research 2017年第9期12卷 1405-1412页

作者： Christopher J.Andrews Andrew D.Reisner Mary Ann Cooper Medicine The University of Queensland Lightning and Electrical Injuries Mt Ommaney Family Practice Forensic Diagnostic Center of District Nine Lightning Injury Research Program University of Illinois at Chicago African centres for Lightning and Electromagnetics Network

In the past, victims of electrical and lightning injuries have been assessed in a manner lacking a system- atic formulation, and against ad hoc criteria, particularly in the area of neuropsychological disability. In this manner patients have, for example, only been partially treated, been poorly or incorrectly diagnosed, and have been denied the full benefit of compensation for their injuries. This paper contains a proposal for diagnostic criteria particularly for the neuropsychological aspects of the post injury syndrome. It pays attention to widely published consistent descriptions of the syndrome, and a new cluster analysis of post electrical injury patients. It formulates a proposal which could be incorporated into future editions of the American Psychiatric association＇s Diagnostic and Statistical Manual （DSM）. The major neuropsycholog- ical consequences include neurocognitive dysfunction, and memory subgroup dysfunction, with ongoing consequences, and sometimes including progressive or delayed psychiatric, cognitive, and/or neurological symptoms. The proposed diagnostic criteria insist on a demonstrated context for the injury, both specifying the shock circumstance, and also physical consequences. It allows for a certain delay in onset of symptoms. It recognizes exclusory conditions. The outcome is a proposal for a DSM classification for the post electrical or lightning injury syndrome. This proposal is considered important for grounding patient treatment, and for further treatment trials. Options for treatment in electrical or lightning injury are summarised, and future trials are foreshadowed.

关键词： electrical injury lightning injury neuropsychology neuropsychiatry injury American Psychiatric association's Diagnostic and Statistical Manual

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Identification of factors predicting scar outcome after burn injury in children:a prospective case-control study

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burns & Trauma 2017年第3期5卷 186-198页

作者： Hilary J. Wallace Mark W. Fear Margaret M. Crowe Lisa J. Martin Fiona M. Wood burn Injury Research Unit Faculty of Health and Medical Sciences University of Western Australia Perth WA Australia burn Injury Research Unit Faculty of Health and Medical Sciences University of Western Australia M318 35 Stirling Highway Crawley 6009 WA Australia burn Injury Research Unit Faculty of Health and Medical Sciences University of Western Australia Perth WA Australia burns Service of Western Australia Princess Margaret Hospital for Children and Fiona Stanley Hospital Perth WA Australia burn Injury Research Unit Faculty of Health and Medical Sciences University of Western Australia Perth WA Australia burns Service of Western Australia Princess Margaret Hospital for Children and Fiona Stanley Hospital Perth WA Australia

Background:There is a lack of rigorous research investigating the factors that influence scar outcome in children. Improved clinical decision-making to reduce the health burden due to post-burn scarring in children will be guided by evidence on risk factors and risk stratification. This study aimed to examine the association between selected patient, injury and clinical factors and the development of raised scar after burn injury. Novel patient factors were investigated including selected immunological co-morbidities (asthma, eczema and diabetes type 1 and type 2) and skin pigmentation (Fitzpatrick skin type). Methods:A prospective case-control study was conducted among 186 children who sustained a burn injury in Western Australia. Logistic regression was used to explore the relationship between explanatory variables and a defined outcome measure:scar height measured by a modified Vancouver Scar Scale (mVSS). Results:The overall correct prediction rate of the model was 80.6%;80.9%for children with raised scars (>1 mm) and 80.4%for children without raised scars (≤1 mm). After adjustment for other variables, each 1%increase in%total body surface area (%TBSA) of burn increased the odds of raised scar by 15.8%(95%CI=4.4-28.5%). Raised scar was also predicted by time to healing of longer than 14 days (OR=11.621;95%CI=3.727-36.234) and multiple surgical procedures (OR=11.521;1.994-66.566). Conclusions:Greater burn surface area, time to healing of longer than 14 days, and multiple operations are independently associated with raised scar in children after burn injury. Scar prevention strategies should be targeted to children with these risk factors.

关键词： burns Wound healing Hypertrophic scar Risk factors Children

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Epidemiology of foot burns in a dutch burn centre

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burns & Trauma 2015年第1期3卷 29-34页

作者： Tülay Kilic Pieta Krijnen Wim E Tuinebreijer Roelf S Breederveld Department of Surgery Leiden University Medical Center University Leiden2300 RC LeidenThe Netherlands Acute burn Care&Trauma Surgery Department Surgery/Burn CentreRode Kruis ZiekenhuisVondellaan 131942 LE BeverwijkThe Netherlands

Background:Although the feet involve a small percentage of the total body surface area,they can have major effects in daily life,caused by prolonged bed rest,hospitalization and high risk of both early and late *** aim of this study was to define the aetiology,treatment and outcomes of foot burns,with special interest in paediatric patients,patients with diabetic disease and burns acquired at the ***:This is a retrospective cohort study of 82 patients who were admitted to one of the three burn centres in the Netherlands during the period 2004 to *** patients had a median age of 43.5 years(range 0.01–85.9),and included 14 children and 8 *** were collected from the hospital ***:Scalding was the most common cause of the *** all patients required surgical *** is notable that most of hospitalized patients(82%)were not admitted on the day of *** had a significantly shorter length of stay compared to adults(p=0.01).The eight patients with diabetes had a significantly longer length of hospital stay,more complications and more often residual defects compared to the non-diabetic *** 13 patients,the injury took place at *** of these burns were caused by scalding,and foot burns caused by chemicals at work were rare(two patients).Conclusions:Although the incidence of foot burns is low,there is a significant morbidity due to complications and long hospital *** following three points are *** referral to a burn centre is *** is important to educate diabetic patients on the risk of complications and adverse outcomes after burn *** measures at the workplace are worth considering.

关键词： burns admitted centre

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