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Overall Survival with Adjuvant Pembrolizumab in Renal-Cell Carcinoma

四川生理科学杂志 2024年第4期46卷 872-872页

作者： Toni K Choueiri From Dana-Farber Cancer Institute and Harvard medical School (T.K.C.) and Beth Israel Deaconess medical Center (D.F.M.) - all in Boston Poznan University of medical Sciences Poznan (P.T.) and Provincial Hospital in Torun Torun (P.S.) - both in Poland Samsung medical Center Sungkyunkwan University School of Medicine (S.H.P.) and Asan Medical Center University of Ulsan College of Medicine (J.-L.L.) - both in Seoul South Korea Beatson West of Scotland Cancer centre and the University of Glasgow Glasgow (B.V.) Edinburgh Cancer Centre and the University of Edinburgh Edinburgh (S.N.S.) and Imperial College Healthcare NHS Trust (N.S.) Barts Health NHS Trust and the Royal Free NHS Foundation Trust Barts Cancer Institute (T.P.) and Queen Mary University of London (T.P.) London - all in the United Kingdom Fiona Stanley Hospital Perth WA (T.F.) and Maquarie University Sydney (H.G.) - both in Australia Fakultní Nemocnice Ostrava Ostrava (J.H.) and Palacký University and University Hospital Olomouc Olomouc (B.M.) - all in the Czech Republic Taipei Veterans General Hospital Taipei Taiwan (Y.-H.C.) Abramson Cancer Center Penn Medicine Philadelphia (N.B.H.) Fundación Arturo López Pérez Santiago Chile (M.M.) University Hospital Bordeaux-Hôpital Saint-André Bordeaux (M.G.-G.) Hôpital Européen Georges Pompidou Université Paris Cité Paris (S.O.) and Centre Hospitalier Universitaire de Montpellier Montpellier (D.T.) - all in France the University of Texas Southwestern medical Center Dallas (T.Z. H.H.) and Texas Oncology-Houston Houston (G.D.) Rocky Mountain Cancer Centers Aurora CO (J.M.B.) Omsk Clinical Oncology Dispensary Omsk Russia (E.K.) the University of Michigan Ann Arbor (A.A.) the University of Toyama Toyama Japan (H.K.) Instituto de Cancer e Transplante de Curitiba Curitiba Brazil (A.S.) the London Regional Cancer Program London Health Sciences Centre Western University London ON Canada (E.W.) and Merck Rahway NJ (J.C. A.E. J.E.B. R.F.P.).

Background:Adjuvant pembrolizumab therapy after surgery for renal-cell carcinoma was approved on the basis of a significant improvement in disease-free survival in the KEYNOTE-564 *** the results regarding overall survival from the third prespecified interim analysis of the trial would also favor pembrolizumab was ***:In this phase 3,double-blind,placebo-controlled trial,we randomly assigned(in a 1:1 ratio)participants with clear-cell renal-cell carcinoma who had an increased risk of recurrence after surgery to receive pembrolizumab(at a dose of 200 mg)or placebo every 3 weeks for up to 17 cycles(approximately 1 year)or until recurrence,the occurrence of unacceptable toxic effects,or withdrawal of consent.A significant improvement in disease-free survival according to investigator assessment(the primary end point)was shown *** survival was the key secondary end *** was a secondary end point.

关键词： Carcinoma Survival specified

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Engineering Geometric Electrodes for Electric Field-Enhanced High-Performance Flexible In-Plane Micro-Supercapacitors

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Energy & Environmental Materials 2023年第4期6卷 114-120页

作者： Jihong Kim Sung Min Wi Jong-Guk Ahn Sangjun Son Hee Young Lim Yeonsu Park Hye Ji Eun Jong Bae Park Hyunseob Lim Sangyeon Pak A-Rang Jang Young-Woo Lee Department of Energy Engineering Soonchunhyang UniversityAsan 31538Korea Department of Chemistry Gwangju Institute of Science and TechnologyGwangju 61005Korea Jeonju centre Korea Basic Science InstituteJeonju 54907Korea Prof.S.Pak School of Electronic and Electrical Engineering Hongik UniversitySeoul 04066Korea Division of Electrical Electronic and Control EngineeringKongju National UniversityCheonan 31080Korea

In plane micro-supercapacitors that are miniaturized energy storage components have attracted significant attention due to their high power densities for various ubiquitous and sustainable device systems as well as their facile integration on various flexible/wearable *** implement the micro-supercapacitors in various practical applications that can accompany solid state or gel electrolyte and flexible substrates,ions must be readily transported to electrodes for achieving high power ***,we show large enhancement in electrochemical properties of flexible,inplane micro-supercapacitor using sharp-edged interdigitated electrode design,which was simply fabricated through direct laser scribing *** sharp-edged electrodes allowed strong electric field to be induced at the corners of the electrode fingers which led to the greater accumulation of ions near the surface of electrode,significantly enhancing the energy storage performance of *** electric field-enhanced in-plane micro-supercapacitor showed the volumetric energy density of 1.52 Wh L^(−1)and the excellent cyclability with capacitive retention of 95.4%after 20000 *** further showed various practicability of our sharp-edged design in micro-supercapacitors by showing circuit applicability,mechanical stability,and air *** results present an important pathway for designing electrodes in various energy storage devices.

关键词： electric field enhancement flexible energy storage device microsupercapacitors sharp electrodes

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Utilizing hybrid faradaic mechanism via catalytic and surface interactions for high-performance flexible energy storage system

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能源化学:英文版 2023年第8期83卷 541-548,I0013页

作者： Dong-Gyu Lee Hyeonggeun Choi Yeonsu Park Min-Cheol Kim Jong Bae Park Suok Lee Younghyun Cho Wook Ahn A-Rang Jang Jung Inn Sohn John Hong Young-Woo Lee Department of Energy Engineering Soonchunhyang UniversityAsan 31538Republic of Korea Division of Physics and Semiconductor Science Dongguk University-SeoulSeoul 04620Republic of Korea Jeonju centre Korea Basic Science InstituteJeonju 54907Republic of Korea Division of Electrical Electronic and Control EngineeringKongju National UniversityCheonan 31080Republic of Korea School of Materials Science and Engineering Kookmin UniversitySeoul 02707Republic of Korea

Improving the capacitance and energy density is a significant challenge while developing practical and flexible energy storage system(ESS).Redox mediators(RMs),as redox-active electrolyte additives,can provide additional energy storing capability via electrochemical faradaic contribution on electrodes for high-performance flexible ***,determining effective material combinations between electrodes and RMs is essential for maximizing surface faradaic redox reactions for energy-storage *** this study,an electrode-RM system comprising heterostructured hybrid(carbon fiber(CF)/MnO_(2)) faradaic electrodes and iodine RMs(I-RMs) in a redox-active electrolyte is *** CF/MnO_(2)with the 1-RMs(CF/MnO_(2)-I) induces dominant catalytic faradaic interaction with the I-RMs,significantly enhancing the surface faradaic kinetics and increasing the overall energy-storage *** CF/MnO_(2)-I ESSs show a 12.6-fold(or higher) increased volumetric energy density of 793.81 mWh L^(-1)at a current of 10 μA relative to ESSs using CF/MnO_(2)without I-RMs(CF/MnO_(2)).Moreover,the CF/MnO_(2)-I retains 93.1% of its initial capacitance after 10,000 cycles,validating the excellent ***,the flexibility of the ESSs is tested at different bending angles(180° to 0°),demonstrating its feasibility for flexible and high-wear ***,CF/MnO_(2)electrodes present a practical material combination for high-performance flexible energy-storage devices owing to the catalytic faradaic interaction with I-RMs.

关键词： Energy storage system Redox mediators Faradaic electrodes Catalytic interactions Mechanical stability

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病毒性肝炎:乙型肝炎和丁型肝炎-临床(治疗、新化合物、耐药性) 一项在HBeAg阴性、慢性乙型肝炎(CHB)患者中比较磷丙替诺福韦(TAF)与富马酸替诺福韦二吡呋酯(TDF)的3期研究:96周时疗效和安全性结果

病毒性肝炎:乙型肝炎和丁型肝炎-临床(治疗、新化合物、耐药性) ...

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第九届全国疑难及重症肝病大会

作者： Maurizia Brunetto Young Suk Lim Ed Gane Wai Kay Seto Marina Osipenko Sang Hoon Ahn Harry L.Janssen Akash Shukla Wan Long Chuang Huy Trinh Mustafa K.Celen John F.Flaherty Audrey H.Lau Anuj Gaggar Vithika Suri Neeru Bhardwaj Kyungpil Kim G Mani Subramanian Calvin Pan Namiki Izumi Patrick Marcellin Henry Chan Maria Buti University Hospital of Pisa asan medical centre Erasmus medical Center

背景和目的:TAF是替诺福韦(TFV)的一种新型前体药,在血浆中比TDF更稳定,增强了TFV进入肝细胞的给药,且循环TFV水平降低。这项在HBeAg阴性患者中比较TAF与TDF的随机双盲研究显示,之前在48周时,在HBV DNA小于29IU/mL的患者比例方面,TAF的...

背景和目的:TAF是替诺福韦(TFV)的一种新型前体药,在血浆中比TDF更稳定,增强了TFV进入肝细胞的给药,且循环TFV水平降低。这项在HBeAg阴性患者中比较TAF与TDF的随机双盲研究显示,之前在48周时,在HBV DNA小于29IU/mL的患者比例方面,TAF的疗效并不劣于TDF,且骨骼和肾脏影响改善。本文摘展示了96周治疗后的结果。方法:425例患者被随机分配到接受TAF 25mg QD(n=285)或TDF 300mg QD(n=140),且治疗144

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Incidence and Outcome of Prostate Cancer after Transurethral Resection of the Prostate and Photoselective Vaporization of the Prostate for Benign Prostatic Enlargement

Incidence and Outcome of Prostate Cancer after Transurethral...

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第十七届全国泌尿外科学术会议

作者： Tai Young Ahn Dalsan You Jun Hyuk Hong Choung-Soo Kim Hanjong Ahn Department of Urology Asan Medical CentreUniversity of Ulsan College of Medicine

Objective Despite the current widespread use of prostate-specific antigen(PSA) testing and prostate biopsy,several recent reports reveal that incidental prostate cancer(CaP) detected at transurethral resection of the ...

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Treatment preferences in men with erectile dysfunction： an open label study in Korean men switching from sildenafil citrate to tadalafil

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Asian Journal of Andrology 2007年第6期9卷 760-770页

作者： Tai Young Ahn Sung Won Lee Sae-Woong Kim Dae Yul Yang Nam Cheol Park Kweon-Sik Min Kwangsung Park Jae-Seung Paick Yulia Dyachkova Trisha Dwight Myung-Sea Luke Lee asan medical centre Seoul 138-736 Korea Samsung medical centre Seoul 135-710 Korea Youido St Marys Hospital Seoul 150-713 Korea Kang Dong Sacred Heart Hospital Seoul 134-701 Korea Pusan National University Hospital Pusan 602-739 Korea Pusan lnje University Paik Hospital Pusan 614-735 Korea Chonnam National University Hospital Gwangju 501-757 Korea Seoul National University Hospital Seoul 110-744 Korea Area medical centre Vienna Eli Lilly Austria Sydney A-1030 Australia Intercontinental Information Sciences Eli Lilly Australia Sydney 2113 Australia Eli Lilly Korea Seoul 135-280 Korea

To evaluate patient preferences for sildenafil citrate or tadalafil （PDE-5 inhibitors available for the treatment of erectile dysfunction [ED]） and assess potential reasons for these preferences. Methods： This open-label study was conducted on Korean men taking sildenafil, at least 6 weeks prior to study entry, for ED. Following screening, patients continued sildenafil treatment for 4 weeks, then after a 1-week washout period, switched to tadalafil for 8 weeks. Patients then continued with their treatment of choice during an extension phase. Psychosocial factors （time concern, spontaneity, sexual self-confidence） were evaluated using Psychological and Interpersonal Relation- ship Scales （PAIRS）, while timing of dose to sexual attempt patterns were assessed from patient diaries. Results： The present study enrolled 160 Korean men （mean age 55 years） with prior median sildenafil use of 585 days. During the extension phase, 73.7% of patients elected to take tadalafil, whereas 26.3% chose sildenafil （P 〈 0.001）. After switching from sildenafil to tadalafil, mean PAIRS time concern scores decreased from 2.54 to 2.42 （P = 0.002）, with no statistically significant differences observed between the sildenafil and tadalafil assessment phases in sexual spontaneity and self-confidence scores. Sexual attempts made 〉 4 h to 〈 36 h post-dose occurred in 4.5% of patients during the sildenafil assessment phase compared with 17.5% during the tadalafil assessment phase. Conclusion： After experiencing both sildenafil and tadalafil, the majority of patients exhibited a preference for tadalafil. This preference might be influenced by psychosocial factors, such as decreased time concerns, and a broader window of opportunity available for sexual activity.

关键词： erectile dysfunction tadalafil sildenafil citrate Psychological and Interpersonal Relationship Scales preference

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medical Feature Selection Approach Based on Generalized Normal Distribution Algorithm

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Computers, Materials & Continua 2021年第12期69卷 2883-2901页

作者： Mohamed Abdel-Basset Reda Mohamed Ripon K.Chakrabortty Michael J.Ryan Yunyoung Nam Mohamed Abouhawwash Faculty of Computers and Informatics Zagazig UniversityZagazig44519Egypt Capability Systems centre School of Engineering and ITUNSWCanberraAustralia Department of Computer Science and Engineering Soonchunhyang UniversityAsan31538Korea Department of Mathematics Faculty of ScienceMansoura UniversityMansoura35516Egypt Department of Computational Mathematics Scienceand Engineering(CMSE)Michigan State UniversityEast Lansing48824MIUSA

This paper proposes a new pre-processing technique to separate the most effective features from those that might deteriorate the performance of the machine learning classifiers in terms of computational costs and classification accuracy because of their irrelevance,redundancy,or less information;this pre-processing process is often known as feature *** technique is based on adopting a new optimization algorithm known as generalized normal distribution optimization(GNDO)supported by the conversion of the normal distribution to a binary one using the arctangent transfer function to convert the continuous values into binary ***,a novel restarting strategy(RS)is proposed to preserve the diversity among the solutions within the population by identifying the solutions that exceed a specific distance from the best-so-far and replace them with the others created using an effective updating *** strategy is integrated with GNDO to propose another binary variant having a high ability to preserve the diversity of the solutions for avoiding becoming stuck in local minima and accelerating convergence,namely improved GNDO(IGNDO).The proposed GNDO and IGNDO algorithms are extensively compared with seven state-of-the-art algorithms to verify their performance on thirteen medical instances taken from the UCI *** is shown to be superior in terms of fitness value and classification accuracy and competitive with the others in terms of the selected *** the principal goal in solving the FS problem is to find the appropriate subset of features that maximize classification accuracy,IGNDO is considered the best.

关键词： Generalized normal distribution optimization feature selection transfer function novel restarting strategy UCI repository

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An Improved Jellyfish Algorithm for Multilevel Thresholding of Magnetic Resonance Brain Image Segmentations

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Computers, Materials & Continua 2021年第9期68卷 2961-2977页

作者： Mohamed Abdel-Basset Reda Mohamed Mohamed Abouhawwash Ripon K.Chakrabortty Michael J.Ryan Yunyoung Nam Faculty of Computers and Informatics Zagazig UniversityZagazig44519Egypt Department of Mathematics Faculty of ScienceMansoura UniversityMansoura35516Egypt Department of Computational Mathematics Scienceand Engineering(CMSE)Michigan State UniversityEast LansingMI48824USA Capability Systems centre School of Engineering and ITUNSW CanberraAustralia Department of Computer Science and Engineering Soonchunhyang UniversityAsan31538Korea

Image segmentation is vital when analyzing medical images,especially magnetic resonance(MR)images of the ***,several image segmentation techniques based on multilevel thresholding have been proposed for medical image segmentation;however,the algorithms become trapped in local minima and have low convergence speeds,particularly as the number of threshold levels ***,in this paper,we develop a new multilevel thresholding image segmentation technique based on the jellyfish search algorithm(JSA)(an optimizer).We modify the JSA to prevent descents into local minima,and we accelerate convergence toward optimal *** improvement is achieved by applying two novel strategies:Rankingbased updating and an adaptive ***-based updating is used to replace undesirable solutions with other solutions generated by a novel updating scheme that improves the qualities of the removed *** develop a new adaptive strategy to exploit the ability of the JSA to find a best-so-far solution;we allow a small amount of exploration to avoid descents into local *** two strategies are integrated with the JSA to produce an improved JSA(IJSA)that optimally thresholds brain MR *** compare the performances of the IJSA and JSA,seven brain MR images were segmented at threshold levels of 3,4,5,6,7,8,10,15,20,25,and *** was compared with several other recent image segmentation algorithms,including the improved and standard marine predator algorithms,the modified salp and standard salp swarm algorithms,the equilibrium optimizer,and the standard JSA in terms of fitness,the Structured Similarity Index Metric(SSIM),the peak signal-to-noise ratio(PSNR),the standard deviation(SD),and the Features Similarity Index Metric(FSIM).The experimental outcomes and the Wilcoxon rank-sum test demonstrate the superiority of the proposed algorithm in terms of the FSIM,the PSNR,the objective values,and the SD;in terms of the SSIM,IJSA was competitive with

关键词： Magnetic resonance imaging brain image segmentation artificial jellyfish search algorithm ranking method local minima Otsu method

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International experts consensus guidelines on robotic liver resection in 2023

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世界胃肠病学杂志:英文版 2023年第32期29卷 4815-4830页

作者： Rong Liu Mohammed Abu Hilal Go Wakabayashi Ho-Seong Han Chinnusamy Palanivelu Ugo Boggi Thilo Hackert Hong-Jin Kim Xiao-Ying Wang Ming-Gen Hu Gi Hong Choi Fabrizio Panaro Jin He Mikhail Efanov Xiao-Yu Yin Roland S Croner Yu-Man Fong Ji-Ye Zhu Zheng Wu Chuan-Dong Sun Jae Hoon Lee Marco V Marino Iyer Shridhar Ganpati Peng Zhu Zi-Zheng Wang Ke-Hu Yang Jia Fan Xiao-Ping Chen Wan Yee Lau Faculty of Hepato-Pancreato-Biliary Surgery The First Medical Center of Chinese PLA General HospitalBeijing 100000China Hepatobiliary Pancreatic Robotic&Laparoscopic SurgeryPoliambulanza Foundation HospitalBrescia 25100Italy Center for Advanced Treatment of HBP Diseases Ageo Central General HospitalSaitama 362-0075Japan Department of Surgery Seoul National University Bundang HospitalSeoul National University College of MedicineSeoul 03080South Korea GEM Hospital&Research centre GEM Hospital&Research CentreCoimbatore 641045India Division of General and Transplant Surgery University of PisaPisa 56126Italy Department of General Visceral and Thoracic SurgeryUniversity Hospital Hamburg-EppendorfHamburg 20251Germany Department of Surgery Yeungnam University HospitalDaegu 42415South Korea Department of Liver Surgery and Transplantation Liver Cancer InstituteZhongshan HospitalFudan UniversityShanghai 200032China Division of Hepato-Biliary-Pancreatic Surgery Department of SurgerySeverance HospitalYonsei UniversityCollege of MedicineSeoul 03722South Korea Department of Surgery/Division of Robotic and HBP Surgery Montpellier University Hospital-School of MedicineMontpellier 34090France Department of Surgery Johns Hopkins University School of MedicineBaltimoreMD 21218United States Department of Hepato-Pancreato-Biliary Surgery Moscow Clinical Scientific CenterMoscow 111123Russia Department of Pancreatobiliary Surgery The First Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510080Guangdong ProvinceChina Department of General VisceralVascular and Transplant SurgeryUniversity Hospital MagdeburgMagdeburg 39120Germany Department of Surgery City of Hope Medical CenterDuarteCA 91010United States Department of Hepatobiliary Surgery Peking University People’s HospitalBeijing 100000China Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Hepatobiliary and Pancreatic Surgery The Affiliated Ho

The robotic liver resection(RLR)has been increasingly applied in recent years and its benefits shown in some aspects owing to the technical advancement of robotic surgical system,however,controversies still *** on the foundation of the previous consensus statement,this new consensus document aimed to update clinical recommendations and provide guidance to improve the outcomes of RLR clinical *** guideline steering group and guideline expert group were formed by 29 international experts of liver surgery and evidence-based medicine(EBM).Relevant literature was reviewed and analyzed by the evidence evaluation *** to the WHO Handbook for Guideline Development,the Guidance Principles of Development and Amendment of the Guidelines for Clinical Diagnosis and Treatment in China 2022,a total of 14 recommendations were *** them were 8 recommendations formulated by the GRADE method,and the remaining 6 recommendations were formulated based on literature review and experts’opinion due to insufficient EBM *** international experts consensus guideline offered guidance for the safe and effective clinical practice and the research direction of RLR in future.

关键词： Robotic liver resection Laparoscopic liver resection Guidelines Expert consensus

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POLYMER SCIENCE AND TECHNOLOGY IN THE PAST AND THE FUTURE:HEROISM,EXPLORATION AND ENLIGHTENMENT

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Chinese Journal of Polymer Science 2000年第3期18卷 189-193页

作者： RobertG.Gilbert Key centre for Polymer Colloids Sydney University Sydney NSW 2006 Australia

The scientific and technical history of polymerization can be divided into three periods, which will be illustratedfor emulsion polymerization. The first period was when emulsion polymers were originally produced, and was developed asan attempt to copy natural rubber latex. Indeed, the natural process is quite different from the synthetic process of emulsionpolymerization, which in fact does not even need an emulsion to be present: the term is a misnomer! The results werefunctional but limited. In the second period, the first theories appeared, and a huge range of products was madefor surface coatings, adhesives, commodity polymers such as SBR, neoprene, etc. The work of the outstanding pioneers wasbased on limited types of experimental data, and some suppositions are now seen to be incorrect. Nevertheless, manyexcellent products were made and have evolved to many materials currently in everyday use. The third period of emulsionpolymerization is now dawning. The scientific efforts of many teams over previous decades, aided by the advent of newphysical techniques for investigation, have resulted in better understanding of the fundamentals of emulsion *** examples from the author's group involve creating novel materials using controlled seeded emulsion polymerizationfrom natural rubber latex and other polyenes. Latex topology and controlled free-radical chemistry can be combined toproduce a) a comb polymer with hydrophobic backbone and hydrophilic 'teeth', or b) with sufficient in situ compatibilizerbetween two otherwise incompatible polymers to yield a spatially uniform material down to the nanostructure level, and c) toproduce controlled nanostructures.

关键词： Polymer rubber Emulsion polymerization Natural rubber DMAEMA Polybutadiene polyisoprene grafting

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