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Journal of Pharmaceutical Analysis 2011年第4期1卷 275-283页

作者： Deepak Bageshwar Vineeta Khanvilkar Vilasrao Kadam Bharati vidyapeeth's college of Pharmacy Sector-8CBD BelapurNavi Mumbai 400614India

A specific, precise and stability indicating high-performance thin-layer chromatographic method for simultaneous estimation of pantoprazole sodium and itopride hydrochloride in pharmaceutical formulations was developed and validated. The method employed TLC aluminium plates precoated with silica gel 60F254 as the stationary phase. The solvent system consisted of methanol：water：ammonium acetate; 4.0：1.0：0.5 （v/v/v）. This system was found to give compact and dense spots for both itopride hydrochloride （Rf value of 0.55__＋0.02） and pantoprazole sodium （Rf value of 0.85＋0.04）. Densitometric analysis of both drugs was carried out in the reflectance- absorbance mode at 289 nm. The linear regression analysis data for the calibration plots showed a good linear relationship with R2=0.9988___0.0012 in the concentration range of 100--400 ng for pantoprazole sodium. Also, the linear regression analysis data for the calibration plots showed a good linear relationship with R2=0.9990_＋0.0008 in the concentration range of 200-1200 ng for itopride hydrochloride. The method was validated for specificity, precision, robustness and recovery. Statistical analysis proves that the method is repeatable and selective for the estimation of both the said drugs. As the method could effectively separate the drug from its degradation products, it can be employed as a stability indicating method.

关键词： Gastroesophageal refluxdisease (GERD) Itopride hydrochtoride Pantoprazole sodium High performance thinlayer chromatography(HPTLC) Stability indicating Forced degradation

Real-Time Analysis of COVID-19 Pandemic on Most Populated Countries Worldwide

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Computer Modeling in Engineering & Sciences 2020年第12期125卷 943-965页

作者： Meenu Gupta Rachna Jain Akash Gupta Kunal Jain Department of Computer Science and Engineering Chandigarh UniversityPunjab140301India Department of Computer Science and Engineering Bharati Vidyapeeth’s College of EngineeringNew Delhi110063India

The spread of the Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)has already taken on pandemic extents,influencing even more than 200 nations in a couple of ***,regulation measures in China have decreased new cases by over 98%,this decrease is not the situation everywhere,and most of the countries still have been affected by *** objective of this research work is to make a comparative analysis of the top 5 most populated countries namely United States,India,China,Pakistan and Indonesia,from 1st January 2020 to 31st July *** research work also targets to predict an increase in the number of deaths and total infected cases in these five *** our research,the performance of the proposed framework is determined by using three Machine Learning(ML)regression algorithms namely Linear Regression(LR),Support Vector Regression(SVR),andRandom Forest(RF)*** proposed model is also validated upon the infected and death cases of further *** performance of these three algorithms is compared using the RootMean Square Error(RMSE)*** Forest algorithm shows best performance as compared to other proposed algorithms,with the lowest RMSE value in the prediction of total infected and total deaths cases for all the top five most populated countries.

关键词： COVID-19 SARS COV-2 country-wise analysis most populated countries pandemic mortality rate

Yoga as a complementary therapy for metabolic syndrome:A narrative review

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Journal of Integrative Medicine 2021年第1期19卷 6-12页

作者： Dastan M.Khoshnaw Abhijit A.Ghadge Department of Botany Fergusson CollegeSavitribai Phule Pune UniversityPuneMaharashtra 411004India Diabetes Laboratory Interactive Research School for Health AffairsBharati VidyapeethPuneMaharashtra 411043India

Metabolic syndrome(MS)is associated with a sedentary and stressful lifestyle and affects underactive people *** is considered to be a low-impact mind-body stress-relieving exercise,and researchers are increasing their focus on the benefits of yoga for managing metabolic *** is also important for physicians and health care professionals to understand the therapeutic efficacy of yoga intervention,in terms of its type,duration and frequency on various MS risk *** present review summarizes the current scientific understanding of the effects of yoga on MS risk factors such as glucose homeostasis markers,lipid profile,adipocytokines and cardiovascular risk factors,and discusses the possible mechanisms of ***,Pub Med,Scopus and Cochrane Library were searched from their inception up to December 2019,using the keywords“metabolic syndrome,”“diabetes,”“cardiovascular diseases,”“obesity”and“yoga.”The literature summarized in this review have shown mixed effects of yoga on MS risk factors and do not provide robust evidence for its *** rigorous research and well-designed trials that have a higher standard of methodology and evaluate yoga's long-term impacts on MS are *** yoga's biochemical and molecular mechanisms of action on various metabolic pathways is also needed.

关键词： Cardiovascular diseases Diabetes Metabolic syndrome Obesity Yoga

Highly sensitive assay for the determination of therapeutic peptide desmopressin in human plasma by UPLC–MS/MS

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Journal of Pharmaceutical Analysis 2017年第3期7卷 196-202页

作者： Shiva Kumar Gudlawar Nageswara Rao Pilli Sridhar Siddiraju Jaya Dwivedi Department of Chemistry Banasthali VidyapeethJaipur 304022India Wellquest Clinical Research Laboratories RamanthapurHyderabad 500013India Department of Pharmaceutical Chemistry Malla Reddy College of PharmacyMaisammagudaSecunderabad 5000100India

An analytical method based on ultra-performance liquid chromatography with positive ion electrospray ionization(ESI) coupled with tandem mass spectrometry(UPLC–MS/MS) was developed and validated for the determination of therapeutic peptide desmopressin in human plasma. A desmopressin stable labeled isotope(desmopressin d_8) was used as an internal standard. Analyte and the internal standard were extracted from200 μL of human plasma via solid-phase extraction technique using Oasis WCX cartridges. The chromatographic separation was achieved on an Aquity UPLC HSS T3 column by using a gradient mixture of methanol and 1 m M ammonium formate buffer as the mobile phase. The calibration curve obtained was linear(r^2≥0.99)over the concentration range of 1.01–200 pg/m L. Method validation was performed as per FDA guidelines and the results met the acceptance criteria. The results of the intra-and inter-day precision and accuracy studies were well within the acceptable limits. The proposed method was successfully applied to pharmacokinetic studies in humans.

关键词： Desmopressin Solid-phase extraction (SPE) Ultra performance liquid chromatography–tandem mass spectrometry Method validation Pharmacokinetics

Assess the Level of Occupational Stress and to Evaluate the Effectiveness of Planned Teaching Programme on Knowledge Regarding Occupational Stress and Its Management among Security Guards of a Selected Organization, Shimoga, Karnataka

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Open Journal of Nursing 2020年第2期10卷 87-100页

作者： M.Siddesh H.N.Ravindra Sumandeep vidyapeeth VadodaraGujaratIndia Sumandeep Nursing college Sumandeep VidyapeethVadodaraGujaratIndia

Background and aim: Occupational stress occurs when there is a disequilibrium between job demands and capabilities. Being employed as a security guard exposes the subject to potentially dangerous situations. Security guards are engaged in a profession that confronts violators of the law as well as violence and thus are more likely to be exposed to traumatic experiences. So it is very important to assess the level of stress they possess and make them aware of the harmful effects and how to manage it. Hence, there is a need to assess the level of occupational stress and to evaluate the effectiveness of PTP on knowledge regarding occupational stress and its management among security guards of a selected organization, Shimoga, Karnataka. Results: Demonstrated that the majority of the security guards were having a moderate level of occupational stress. Among 80 security guards, 59 (74%) were having a moderate level of occupational stress, 21 (26%) were having a severe level of occupational stress and none of them possessed a mild level of occupational stress. Conclusion: This study contributes to the emerging body of knowledge about occupational stress in their security profession and it is important to plan the healthy coping strategies to cope up with their occupational stress.

关键词： Occupational Stress Security Guards Planned Teaching Programme

Colorectal cancer cell growth inhibition by linoleic acid is related to fatty acid composition changes

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第12期11卷 923-930页

作者： Xiao-feng LU Guo-qing HE Hai-ning YU Qi MA Sheng-rong SHEN Undurti N. DAS Department of Food Science and Nutrition College of Biosystems Engineering and Food Science Zhejiang University Hangzhou 310029 China college of Pharmaceutical Sciences Zhejiang University of Technology Hangzhou 310032 China UND Life Sciences Shaker Heights OH 44120 USA college of Medicine Bharati Vidyapeeth University Pune 411030 India

Polyunsaturated fatty acids （PUFAs） possess anti-cancer action both in vitro and in vivo. In the present study, we detected cell viability with methyl thiazolyl tetrazolium （MTT） assay and cell membrane permeability with propidium iodide （PI） fluorescence dyeing, and calculated cell membrane fluidity change as fluorescence anisotropy. Fatty acid content in cells was measured by gas chromatography/mass spectroscopy （GC/MS）, and the relationship between fatty acid composition and cell viability was studied. We observed that n-6 PUFA linoleic acid （LA） inhibited tumor cell growth at high concentrations （〉300 μmol/L）, while low concentrations （100-200 μmol/L） seemed to promote cell proliferation. Analyses of cell membrane permeability, cell membrane fluidity, and cell fatty acid composition suggested that the anti-cancer action of LA could be related to changes in the ratio of n-6 to n-3 PUFAs. We observed that pre-incubation of cancer cells with 100 μmol/L LA for 24 h enhanced cell sensitivity to the cytotoxic action of LA, whereas undifferentiated cell line LoVo seemed to have a distinct path in LA-induced death. These results showed that one of the mechanisms by which supplementation of LA induces cancer cell death could be altering the ratio of n-6/n-3 PUFAs, and this may be related to celt differentiation status.

关键词： Anti-cancer Fatty acids composition Linoleic acid In vitro

Rice-wheat comparative genomics:Gains and gaps

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The Crop Journal 2024年第3期12卷 656-669页

作者： Akila Wijerathna-Yapa Ruchi Bishnoi Buddhini Ranawaka Manu Maya Magar Hafeez Ur Rehman Swati G.Bharad Michal T.Lorenc Vinita Ramtekey Sasha Gohar Charu Lata Md.Harun-Or-Rashid Maryam Razzaq Muhammad Sajjad Bhoja *** School of Agriculture and Food Sustainability The University of QueenslandSt LuciaQLD 4072Australia ARC Centre of Excellence for Plant Success in Nature and Agriculture The University of QueenslandSt LuciaQLD 4072Australia Department of Genetics and Plant Breeding College of AgricultureUmmedganj-KotaAgriculture UniversityKotaRajasthan 324001India Centre for Agriculture and the Bioeconomy Queensland University of Technology(QUT)2 George StreetBrisbaneQLD 4000Australia UWA School of Agriculture and Environment The University of Western Australia35 Stirling HighwayCrawleyWA 6009Australia Nepal Agriculture Research Council KhumaltarLalitpurNepal Department of Agronomy University of AgricultureFaisalabad 38040Pakistan Department of Agricultural Botany Dr Panjabrao Deshmukh Krishi VidyapeethAkola 444104MaharashtraIndia ICAR-Indian Institute of Seed Science MauUttar Pradesh 275103India School of Natural Sciences Macquarie UniversityMacquarie ParkNSW 2109Australia ICAR-Indian Institute of Wheat and Barley Research Flowrdale 54642ShimlaIndia International Maize and Wheat Improvement Center(CIMMYT)Bangladesh Office Gulshan-2Dhaka 1212Bangladesh Center for Seed Science University of AgricultureFaisalabad 38000Pakistan Department of Biosciences COMSATS University IslamabadPark RoadTarlai KalanIslamabad 45550Pakistan CGIAR’s Excellence in Breeding(EiB)Platform/Accelerated Breeding Initiative International Maize and Wheat Improvement Center(CIMMYT)El Batán 56237Mexico

Rice and wheat provide nearly 40%of human calorie and protein *** share a common ancestor and belong to the Poaceae(grass)*** their genetic homology is crucial for developing new cultivars with enhanced *** wheat genes and gene families have been characterized based on their rice ***–wheat orthology can identify genetic regions that regulate similar traits in both ***–wheat comparative genomics can identify candidate wheat genes in a genomic region identified by association or QTL mapping,deduce their putative functions and biochemical pathways,and develop molecular markers for marker-assisted breeding.A knowledge of gene homology facilitates the transfer between crops of genes or genomic regions associated with desirable traits by genetic engineering,gene editing,or wide crossing.

关键词： Comparative genomics Orthologs Genes Synteny Genetic engineering Molecular breeding

BACE1 inhibitors:A promising therapeutic approach for the management of Alzheimer’s disease

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Asian Pacific Journal of Tropical Biomedicine 2024年第9期14卷 369-381页

作者： Richa arya Smita Jain Sarvesh Paliwal Kirtika Madan Swapnil Sharma Achal Mishra Prashant Tiwari Sunil Kumar Kadiri Banasthali University Banasthali-304022(Raj.)India Department of Pharmacy Guru Ghasidas VishwavidyalayaBilaspurChhattisgarh-495009India Department of Pharmacology College of Pharmaceutical SciencesDayananda Sagar UniversityBengaluru-560111India

Alzheimer’s disease is a neurological disorder marked by the accumulation of amyloid beta(Aβ)aggregates,resulting from mutations in the amyloid precursor *** enzymeβ-secretase,also known asβ-site amyloid precursor protein cleaving enzyme 1(BACE1),plays a crucial role in generating Aβ*** no targeted therapy available for Alzheimer’s disease,inhibiting BACE1 aspartic protease has emerged as a primary treatment *** 1999,compounds demonstrating potential binding to the BACE1 receptor have advanced to human *** optimization of synthetically derived compounds,coupled with computational approaches,has offered valuable insights for developing highly selective leads with drug-like *** review highlights pivotal studies on the design and development of BACE1 inhibitors as anti-Alzheimer’s disease *** summarizes computational methods employed in facilitating drug discovery for potential BACE1 inhibitors and provides an update on their clinical status,indicating future directions for novel BACE1 *** promising clinical results of Elenbecestat(E-2609)catalyze the development of effective,selective BACE1 inhibitors in the future.

关键词： BACE1 inhibitors Amyloid precursor protein β-secretase Structure-based drug design 3D-QSAR β-amyloid precursor protein

Novel multistage solid-liquid circulating fluidized bed： Hydrodynamic characteristics

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Particuology 2018年第3期16卷 134-142页

作者： Prakash V. Chavan Manjusha A. Thombare Sandip B. Bankar Dinesh V. Kalaga Veena A. Patil-Shinde Department of Chemical Engineering College of Engineering Bharati Vidyapeeth Deemed University Pune 411 043. India Department of Biotechnology and Chemical Technology School of Chemical Technology Alto University P.O. Box 16100. FI-00076 Aalto Finland Department of Chemical Engineering City college of New York CUNY NY USA

The present work proposes a novel radially cross-flow multistage solid-liquid circulating fluidized bed （SLCFB）. The SLCFB primarily consists of a single multistage column （having an inner diameter of 100 mm and length of 1.40 m）, which is divided into two sections wherein both the steps of utilization or loading （e.g., adsorption and catalytic reaction） and regeneration of the solid phase can be carried out simulta- neously in continuous mode. The hydrodynamic characteristics were studied using ion exchange resin as the solid phase and water as the fluidizing medium. The loading and flooding states were determined for three particle sizes; i.e,. 0.30, 0,42, and 0.61 ram. The effects of the superficial liquid velocity and solid feed rate on the solid hold-up were investigated under loading and flooding conditions. The solid hold-up increases with an increase in the solid feed rate and decreases with an increase in the superficial liquid velocity. An artificial-intelligence formalism, namely the multilayer perceptron neural network （MLPNN）, was employed for the prediction of the solid hold-up. The input space of MLPNN-based model consists of four parameters, representing operating and system parameters of the proposed SLCFB. The developed MLPNN-based model has excellent prediction accuracy and generalization capability.

关键词： Solid-liquid fluidized bed Solid-liquid circulating fluidized bed Hydrodynamics Modeling

Genetic expression of Col-2A and Col-10A as a function of administration of IGF-1 &TGF-<i>β</i>with and without anterior mandibular repositioning appliance on the growth of mandibular condylar cartilage in young rabbit

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Open Journal of Stomatology 2013年第9期3卷 6-13页

作者： A. S. Patil R. B. Sable R. M. Kothari P. Nagarajan Deartment of Orthodontics and Dentofacial Orthopedics Bharati Vidyapeeth Dental College and Hospital Bharati Vidyapeeth Deemed University Pune India Rajiv Gandhi Institute of Biotechnology Bharati Vidyapeeth Deemed University Pune India

New Zealand (NZ) young rabbits with the administration of insulin-like growth factor (IGF-1) and transforming growth factor-β (TGF-β) with and without mandibular anterior repositioning appliances are explored for the growth of the mandibular condylar cartilage (MCC). 32 growing NZ and rabbits were divided into 4 groups: the group with saline injection in TMJ, the group which received growth factor injection in TMJ, the group which received anterior positioning appliance and the group which received growth factors injection as well as mandibular repositioning appliance. Gene expression was studied by real-time RT-PCR and cartilage growth by histomorphometry. Administration of growth factors along with mandibular repositioning appliances has induced 1) 1.70-fold expression of Col-2Agene (p value < 0.0005) and 2) 1.47-fold expression of Col-10Agene (p value < 0.0005). In contrast, administration of only mandibular repositioning appliances induced 1) 1.28-fold expression of Col-2Agene (p value < 0.0005) and 2) merely 0.62-fold expression of Col-10Agene (p value < 0.0005), while administration of growth factors only induced 1) mere 0.56-fold expression of Col-2Agene (p value 10A gene (p value growth factors along with mandibular repositioning appliances causes an increase in genetic expressions which have been corroborated by histomorphometry and validated by statistical analysis, during an accelerated growth of mandibular condylar cartilage. Administration of growth factors in the TMJ could provide a synergistic role along with mandibular repositioning appliances for treatment of mandibular retrognathism as well as disorders on the MCC.

关键词： Transforming Growth Factor-β (TGF-β) Insulin-Like Growth Factor (IGF-1) Condylar Cartilage Growth Mandibular Repositioning Appliances Col-2A Col-10A