检索结果-南通市图书馆

Sequential dual-locking strategy using photoactivated Pt(Ⅳ)-based metallo-nano prodrug for enhanced chemotherapy and photodynamic efficacy by triggering ferroptosis and macrophage polarization

引用

Acta Pharmaceutica Sinica B 2024年第7期14卷 3251-3265页

作者： Jun Li Qiang Zhang Hao Yang Wenli Lu Yulong Fu Yingcai Xiong Xuan Wang Tianming Lu Yanlin Xin Zejuan Xie Weichao Chen Guoqiang Wang Yuanyuan Guo Ruogu Qi School of Medicine Nanjing University of Chinese MedicineNanjing 210023China Key Laboratory of Mesoscopic Chemistry of Ministry of Education Institute of Theoretical and Computational ChemistrySchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China Laboratory for Manufacturing Low Carbon and Functionalized Textiles College of Textiles&ClothingQingdao UniversityQingdao 266071China

Selective activation of Pt(Ⅳ)prodrugs within tumors has emerged as a promising strategy in tumor *** progress has been made with photo-and ultrasound-activated Pt(Ⅳ)prodrugs,concerns remain over the non-specific activation of photosensitizers(PS)and the potential for phototoxicity and chemical *** this study,a sequential dual-locked Pt(Ⅳ)nano-prodrug that can be activated by both the acidic tumor microenvironment and light was *** Pt(Ⅳ)prodrug was prepared by conjugating PS-locked Pt(Ⅳ)to a polymeric core,which was then chelated with metallo iron to lock its photoactivity and form a metallo-nano *** acidic tumor microenvironment conditions,the metallo-nano prodrug undergoes dissociation of iron,triggering a reduction process in oxaliplatin under light irradiation,resulting in the activation of both chemotherapy and photodynamic therapy(PDT).Additionally,the prodrug could induce metallo-triggered ferroptosis and polarization of tumorassociated macrophages(TAM),thereby enhancing tumor *** dual-lock strategy employed in a nanoparticle delivery system represents an expansion in the application of platinum-based anticancer drugs,making it a promising new direction in cancer treatment.

关键词： Dual-locking Pt(Ⅳ)reduction Chemotherapy Photodynamic therapy Ferroptosis Macrophage polarization Medicinal inorganic chemistry Metals in medicine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Naphthalene diimide-based cathode interlayer material enables 20.2% efficiency in organic photovoltaic cells

引用

Science China Chemistry 2024年

作者： Yue Yu Jianqiu Wang Zhihao Chen Yang Xiao Zhen Fu Tao Zhang Haoyu Yuan Xiao-Tao Hao Long Ye Yong Cui Jianhui Hou State Key Laboratory of Polymer Physics and Chemistry Beijing National Laboratory for Molecular Sciences Institute of Chemistry Chinese Academy of Sciences University of Chinese Academy of Sciences School of Physics State Key Laboratory of Crystal Materials Shandong University Beijing Advanced Innovation Center for Soft Matter Science and engineering College of Materials Science and Engineering Beijing University of Chemical Technology School of Materials Science and engineering Tianjin University

Cathode interlayer(CIL) materials play an important role in improving the power conversion efficiency(PCE) of organic photovoltaic(OPV) cells. However, the current understanding of the structure-property relationship in CIL materials is limited, and systematic studies in this regard are scarce. Here, two new CIL materials, NDI-PhC 4 and NDI-PhC 6 were synthesized by varying the alkylamine chain length on the NDI-Ph core. Our investigation reveals a systematic variation in the physical and chemical properties of these materials with increasing alkylamine chain length. Specifically, we observe a sequential decrease in melting point and self-doping effect, accompanied by an enhancement in crystallinity. Among these CIL materials, NDI-PhC 4 has a notable balance across various performance metrics. It also exhibits excellent surface modification capabilities, leading to a low surface roughness. Consequently, OPV cells based on NDI-PhC 4 achieve a PCE of 20.2%, which is one of the highest reported efficiencies for OPV cells. In addition, the appropriate melting point of NDI-PhC 4 contributes to the excellent stability of OPV cells.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

LncRNA HCP5-encoded protein contributes to adriamycin resistance through ERK/mTOR pathway-mediated autophagy in breast cancer cells

引用

Genes & Diseases 2024年第4期11卷 69-72页

作者： Jia-Ni Xing Yi-Ni Shang Zheng-Ling Yu Shun-Heng Zhou Wang-Yang Chen Li-Hong Wang Department of Pathophysiology Medical College of Southeast UniversityNanjingJiangsu 210009China Department of Biomedical engineering Nanjing University of Aeronautics and AstronauticsNanjingJiangsu 211106China School of Medicine Taizhou UniversityTaizhouZhejiang 318000China Jiangsu Provincial Key Laboratory of Critical Care Medicine NanjingJiangsu 210009China

Adriamycin(ADR),also known as doxorubicin,is an anthracycline anticancer drug and a chemotherapeutic drug commonly used in breast cancer treatments.1 However,breast cancer patients can gradually become tolerant to ***,improving the curative effect of ADR remains an urgent problem to be *** is a complex catabolic process;normal living cells break down damaged organelles or aggregated molecules and absorb energy to maintain homeostasis through autophagy.

关键词： breast cancer homeostasis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Compressive performance of innovative reinforced pillars in closed/abandoned mines

引用

Journal of Central South University 2024年第8期31卷 2780-2793页

作者： LI Jian BAI Jin-wen FENG Guo-rui WANG Shan-yong ZHAO Hong-chao MI Jia-chen PAN Rui-kai SHI Xu-dong MA Jun-biao college of Mining engineering Taiyuan University of TechnologyTaiyuan 030024China Key Laboratory of Shanxi Province for Mine Rock Strata Control and Disaster Prevention Taiyuan University of TechnologyTaiyuan 030024China Shanxi-Zheda Institute of Advanced Materials and Chemical engineering Taiyuan 030024China Department of Mining engineering Shanxi Institute of EnergyJinzhong 030600China Priority Research Centre for Geotechnical Science and engineering School of Engineeringthe University of NewcastleCallaghanNSW 2308Australia School of Geology and Mining engineering Xinjiang UniversityUrumqi 830000China

Pillar is closely related to the stability and reliability of underground spaces in closed/abandoned *** present research introduced a new technique to strengthen square cement mortar columns via fiber-reinforced polymer(FRP)strips to verify the strengthening effect of FRP on *** to a fully wrapped FRP jacket,the advantages of FRP strip are cost-effective and easy-to-construct.A series of compression tests as well as theoretical analysis were carried out to explore the mechanical behavior of square cement mortar specimens partially strengthened with FRP *** results verified the effectiveness of FRP strips in enhancing the stress and strain of cement *** from unconfined cement mortar specimens,these FRP-strengthened cement mortar specimens are featured with the double-peaked behaviors,mainly attributed to the stress state transformation from a one-dimensional to a three-dimensional stress *** also indicated that the enhancement of stress increased with the FRP strip ***,the brittle-ductile transition ductile failure characteristics were also observed in FRP-confined cement mortar *** ultimate ductility of the cement mortar specimen decreases gradually with the growth of the FRP strip *** main contribution of this research is to enrich the strengthening techniques for residual pillars.

关键词： fiber-reinforced polymer uniaxial compression partially strengthening double-peaked behaviors brittle-ductile transition

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bifunctional ZrO@ZIF-90 nanozyme with high phosphohydrolase activity for sensitive electrochemical detection of methyl parathion

引用

Food Science and Human Wellness 2024年

作者： Xiaomin Pang Geoffrey I.N.Waterhouse Ruiqiang Wang Xuguang Qiao Yufeng Sun Zhixiang Xu Key Laboratory of Food Nutrition and Healthy in Universities of Shandong， college of Food Science and engineering， Shandong Agricultural University School of Chemical Sciences， the University of Auckland Shandong Cayon Testing Co.， Ltd.

In this work， a novel bifunctional zirconium dioxide @ zeolitic imidazolate framework-90 (ZrO2@ZIF-90) nanozyme was successfully developed for the catalytic degradation and electrochemical detection of methyl parathion (MP). The ZrO2@ZIF-90 nanozyme with phosphatase hydrolysis activity can convert MP into p-nitrophenol (p-NP). The addition of ZrO2riched in Lewis acid Zr(IV) sites significantly enhanced the phosphatase hydrolysis activity of ZIF-90. ZrO2@ZIF-90 also displayed satisfactory electrocatalytic performance on account of the high surface area， high porosity and powerful enrichment ability of the ZIF-90 and the excellent ion transfer capacity of ZrO2. A ZrO2@ZIF-90 nanozyme modified glassy carbon electrode (ZrO2@ZIF-90/GCE) was then fabricated to analyze p-NP formed through MP degradation. Under the optimized conditions， the developed sensor displayed satisfactory analytical performance with a low limit of detection of 0.53 μmol L-1and two wide linear ranges (3-10 μmol L-1and 10-200 μmol L-1). ZrO2@ZIF-90 nanozyme accomplished to the degradation and electrochemical detection of MP in river water and spiked fruits. This study identifies a promising new strategy for the design of bifunctional nanozymes for the detection of environmental hazards.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Peaches pulp(Prunus persica L.) mitigate type 2 diabetic mice by modulating of glucose metabolism and gut microbiota

引用

Food Science and Human Wellness 2024年

作者： Leyi Zhou Jianfen Ye Yingying Wei Mouayche Salma Shu Jiang Yi Chen Xingfeng Shao State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products， Zhejiang-Malaysia Joint Research Laboratory for Agricultural Product Processing and Nutrition， college of Food Science and engineering， Ningbo University

Peach are a fruit with high nutritional and economic value， but their safety and suitability for diabetic patients have been questioned. This study investigated the effects and potential mechanisms of peach pulp (PP) on type 2 diabetes mellitus (T2DM) in mice induced by a high-fat diet (HFD) combined with streptozotocin (STZ). The results showed that PP alleviated hyperglycemia， hyperlipidemia， hyperuricemia， and tissue dysfunction in T2DM mice through the synergistic effect of nutrients and non-nutrient compounds. Analysis of mRNA expression levels revealed that PP improved glucose metabolism in T2DM mice by promoting glycogen synthesis and inhibiting gluconeogenesis. Furthermore， elevated levels of PP resulted in an increase in acetic acid content following a 4 weeks intervention period. Additionally， it led to the restoration of gut microbiota balance by decreasing the Firmicutes/Bacteroidota (F/B) ratio and enhancing the presence of Romboutsia， Allobaculum， Alloprevotella， and Bacteroides after an 8 weeks intervention. Ultimately， our results suggest that PP may offer advantages for individuals with diabetes.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

The impact of supply chain resilience on customer satisfaction and financial performance:A combination of contingency and configuration approaches

引用

Journal of Management Science and engineering 2024年第1期9卷 38-52页

作者： Baofeng Huo Dan Li Minhao Gu college of Management and Economics Tianjin UniversityTianjin300072China

Supply chain resilience(SCR)refers to a supply chain's(SC's)ability to recover from disruptions timely and *** study uses a combination of contingency and configuration approaches to examine the direct and contingent relationships between SCR dimensions(i.e.,internal,supplier,and customer resilience)and *** analyzes survey data collected from 206 Chinese *** results show that the three SCR dimensions are positively related to customer satisfaction,whereas customer resilience has no direct contribution to financial *** resilience moderates the relationship between supplier resilience and performance(negative for customer satisfaction and positive for financial performance).A taxonomy for SCR was developed based on internal,supplier,and customer resilience,providing a holistic perspective for examining the performance discrepancies among four different SCR patterns:high externalleaning,high uniform,medium uniform,and low *** findings offer insights for managers in building SCR from the crisis-management process.

关键词： Supply chain resilience Risk management Taxonomy Performance China

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

HWD-YOLO:A New Vision-Based Helmet Wearing Detection Method

引用

Computers, Materials & Continua 2024年第9期80卷 4543-4560页

作者： Licheng Sun Heping Li Liang Wang college of Information Science and Technology Beijing University of TechnologyBeijing100124China Chinese Institute of Coal Science Beijing100013China State Key Laboratory for Intelligent Coal Mining and Strata Control Beijing100013China engineering Research Center of Digital Community of Ministry of Education Beijing100124China

It is crucial to ensure workers wear safety helmets when working at a workplace with a high risk of safety accidents,such as construction sites and mine *** existing methods can achieve helmet detection in images,their accuracy and speed still need improvements since complex,cluttered,and large-scale scenes of real workplaces cause server occlusion,illumination change,scale variation,and perspective ***,a new safety helmet-wearing detection method based on deep learning is ***,a new multi-scale contextual aggregation module is proposed to aggregate multi-scale feature information globally and highlight the details of concerned objects in the backbone part of the deep neural ***,a new detection block combining the dilate convolution and attention mechanism is proposed and introduced into the prediction *** block can effectively extract deep featureswhile retaining information on fine-grained details,such as edges and small ***,some newly emerged modules are incorporated into the proposed network to improve safety helmetwearing detection performance *** experiments on open dataset validate the proposed *** reaches better performance on helmet-wearing detection and even outperforms the state-of-the-art *** be more specific,the mAP increases by 3.4%,and the speed increases from17 to 33 fps in comparison with the baseline,You Only Look Once(YOLO)version 5X,and themean average precision increases by 1.0%and the speed increases by 7 fps in comparison with the YOLO version *** generalization ability and portability experiment results show that the proposed improvements could serve as a springboard for deep neural network design to improve object detection performance in complex scenarios.

关键词： Object detection deep learning safety helmet wearing detection feature extraction attention mechanism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Blockchain-Enabled Federated Learning for Privacy-Preserving Non-IID Data Sharing in Industrial Internet

引用

Computers, Materials & Continua 2024年第8期80卷 1967-1983页

作者： Qiuyan Wang Haibing Dong Yongfei Huang Zenglei Liu Yundong Gou School of Electrical and Information engineering Hunan Institute of TechnologyHengyang421002China

Sharing data while protecting privacy in the industrial Internet is a significant *** machine learning methods require a combination of all data for training;however,this approach can be limited by data availability and privacy *** learning(FL)has gained considerable attention because it allows for decentralized training on multiple local ***,the training data collected by data providers are often non-independent and identically distributed(non-IID),resulting in poor FL *** paper proposes a privacy-preserving approach for sharing non-IID data in the industrial Internet using an FL approach based on blockchain *** overcome the problem of non-IID data leading to poor training accuracy,we propose dynamically updating the local model based on the divergence of the global and local *** approach can significantly improve the accuracy of FL training when there is relatively large *** addition,we design a dynamic gradient clipping algorithm to alleviate the influence of noise on the model accuracy to reduce potential privacy leakage caused by sharing model ***,we evaluate the performance of the proposed scheme using commonly used open-source image *** simulation results demonstrate that our method can significantly enhance the accuracy while protecting privacy and maintaining efficiency,thereby providing a new solution to data-sharing and privacy-protection challenges in the industrial Internet.

关键词： Federated learning data sharing non-IID data differential privacy blockchain

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Solving traffic data occlusion problems in computer vision algorithms using DeepSORT and quantum computing

引用

Journal of Traffic and Transportation engineering(English Edition) 2024年第1期11卷 1-15页

作者： Frank Ngeni Judith Mwakalonge Saidi Siuhi Department of engineering South Carolina State UniversityOrangeburgSC 29117USA

Inaccuracies of traffic sensors during traffic counting and vehicle classification have persisted as transportation agencies have been prompted to calibrate sensors *** of multiple objects,heavy occlusions,and similar appearances in congested places are some causes of computer vision model *** paper used the YOLOv5 model for detection and the DeepSORT model for tracking *** to the nature of the reported problem caused by many misses and mismatches,the power of quantum computing with the alternating direction method of multipliers(ADMM)optimizer was leveraged.A basic Kalman filter and the Hungarian algorithm features were used in combination with a quantum optimizer to present robust multiple object tracking(MOT)*** hybrid combination of the classical and quantum model has fastened learning the occludes during frame matching of tracks and detections by generating minimum quantum cost function *** with the existing models indicated a significant increase in the primary MOT metric multiple object tracking accuracy(MOTA)by 16%more than the regular YOLOv5-DeepSORT model when using a quantum ***,a 6%multiple object tracking precision(MOTP)increases and a 6%identification metrics(F_(1))score increase were observed using the quantum optimizer with identity switching reduced from 6 to *** model is expected to assist transportation officials in improving the accuracy of traffic counts and vehicle classification and reduce the need for regular computer vision software calibration.

关键词： Traffic classification Traffic counting DeepSORT YOLOv5 Quantum computing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：