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Star power: harnessing the reactive astrocyte response to promote remyelination in multiple sclerosis

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Neural Regeneration Research 2024年第3期19卷 578-582页

作者： Markley Silva Oliveira Junior Laura Reiche Emerson Daniele Ines Kortebi Maryam Faiz Patrick Küry Department of Neurology Neuroregeneration laboratoryMedical FacultyHeinrich-Heine-UniversityDüsseldorfGermany Institute of Medical science University of TorontoTorontoCanada division of Anatomy Department of SurgeryUniversity of TorontoTorontoCanada

Astrocytes are indispensable for central nervous system development and *** response to injury and disease,astrocytes are integral to the immunological-and the,albeit limited,repair *** this review,we will examine some of the functions reactive astrocytes play in the context of multiple sclerosis and related animal *** will consider the heterogeneity or plasticity of astrocytes and the mechanisms by which they promote or mitigate ***,we will discuss a set of biomedical strategies that can stimulate astrocytes in their promyelinating response.

关键词： astrocytes demyelination drug-based therapies myelin repair oligodendrocyte precursor cells reactive astrogliosis

Global Research Progress on Municipal Waste and Future Prospect Based on the Cross-national Comparisons

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Chinese Geographical science 2024年第2期34卷 250-264页

作者： ZHANG Yuxin LIU Xiaoqian YAN Xiaoxia MA Sike MAO Weiyun College of Applied arts and science of Beijing Union university Beijing 100191China

Due to the acceleration of urbanization,the municipal waste(MW)problem has transformed into a global challenge for urb-an *** elucidate historical trends,current focal points,and future directions in MW research,we conducted a bibliometric analysis and employed knowledge graph visualization to scrutinize a total of 34212 articles,which were published between 1991 and 2021 in the Web of science(WoS)core *** results indicated that current major research themes encompass waste classifica-tion and recycling,waste management and public behavior,waste disposal methods and technologies,as well as environmental impact and *** has been a shift in the research focus from the environmental impacts of waste incineration to sustainable manage-ment related issues.A comparison of research from six typical countries revealed the differences in research priorities and techniques *** from the USA and Britain initiated MW research earlier than other countries and investigated management issues in depth,such as public behavior and willingness to ***,Japanese,German,and Swedish scholars conducted extensive studies on advanced waste treatment technologies,such as disposal and recycling,risk assessment,and waste-to-energy *** scholars placed particular emphasis on end-of-pipe treatments and their associated environmental *** and poten-tial future frontiers were identified by burst detection *** with high value of burst index(BI)worldwide are food waste and circular *** scholars have put great efforts on waste environmental impact and its recycling technologies,while we’re expecting to further investigating vulnerable ***,this study contributes to bridging the regional gap of scientific research among different countries and fostering international collaboration.

关键词： bibliometrics municipal waste(MW) CiteSpace hotspot prediction burst index(BI) sustainability cross-national comparison Web of science(WoS)

Advancements in the modification of magnesium-based hydrogen storage materials

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Progress in Natural science:Materials International 2024年第3期34卷 540-554页

作者： Lin Yang Wen Zeng Yanqiong Li College of Materials science and Engineering Chongqing University School of Electronic Information & Electrical Engineering Chongqing University of Arts and Sciences

Magnesium-based hydrogen storage materials represent a hydrogen storage technology with broad application prospects. As the global energy crisis and environmental pollution issues become increasingly severe, hydrogen,as a clean and efficient energy source, has garnered growing attention. Magnesium-based hydrogen storage,serving as a crucial means for storing and transporting hydrogen, is gaining prominence due to its abundant resources, low cost, low density, and high hydrogen storage density. However, challenges in terms of absorption/desorption rates, temperature, activation energy, and enthalpy during hydrogen application impede its development. To address these challenges, this paper systematically reviews current research on magnesium-based hydrogen storage materials, encompasses their types, characteristics, and hydrogen absorption ***, it delves into the impacts of nanoscale dimensions, alloying, doping, and catalysis on the performance of magnesium-based materials. The aim is to provide valuable insights for research in related fields.

关键词： For hydrogen storage Magnesium-based materials Research on modifying

Dark Localized Waves in Shallow Waters:Analysis within an Extended Boussinesq System

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Chinese Physics Letters 2024年第4期41卷 32-37页

作者： Zhengping Yang Wei-Ping Zhong Milivoj Belic Department of Medical science Shunde PolytechnicShunde 528300China Department of Electronic Engineering Shunde PolytechnicShunde 528300China division of arts and sciences Texas A&M University at Qatar23874 DohaQatar

We study dark localized waves within a nonlinear system based on the Boussinesq approximation,describing the dynamics of shallow water *** symbolic calculus,we apply the Hirota bilinear method to transform an extended Boussinesq system into a bilinear form,and then use the multiple rogue wave method to obtain its dark rational *** the first-and second-order dark solutions,we examine the conditions under which these localized solutions exist and their spatiotemporal *** the selection of various parameters and by utilizing different visualization techniques(intensity distributions and contour plots),we explore the dynamical properties of dark solutions found:in particular,the first-and second-order dark rogue *** also explore the methods of their *** findings presented here not only deepen the understanding of physical phenomena described by the(1+1)-dimensional Boussinesq equation,but also expand avenues for further *** method can be extended to other nonlinear systems,to conceivably obtain higher-order dark rogue waves.

关键词： Boussinesq bilinear nonlinear

Core-shell design of UiO66-Fe_(3)O_(4) configured with EDTA-assisted washing for rapid adsorption and simple recovery of heavy metal pollutants from soil

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Journal of Environmental sciences 2024年第5期139卷 556-568页

作者： Xi Wang Asif Hussain Qingqing Li Mingyu Ma Juan Wu Mingqiang Deng Jie Yang Dengxin Li Department of Environmental science and Engineering Donghua UniversityShanghai 201620China Department of Environmental science Federal Urdu University of ArtsScience and Technology75300 KarachiPakistan Shanghai Academy of Environmental sciences Shanghai 200233China

The coupling of washing with adsorption process can be adopted for the treatment of soils contaminated with heavy metals ***,the complex environment of soil and the competitive behavior of leaching chemicals considerably restrain adsorption capacity of adsorbent material during washing process,which demands a higher resistance of the adsorbents to *** this study,we synthesized strongly magnetic,high specific surface area(573.49 m^(2)/g)UiO66 composites(i.e.,UiO66-Fe_(3)O_(4))using hydrothermal *** UiO66-Fe_(3)O_(4) was applied as an adsorbent during the ethylene diamine tetraacetic acid(EDTA)-assisted washing process of contaminated *** incorporation of UiO66-Fe_(3)O_(4)results in rapid heavy metal removal and recovery from the soil under low concentrations of washing agent(0.001 mol/L)with reduced residual heavy metal mobility of soil after ***,UiO66-Fe_(3)O_(4)can quickly recollect by an external magnet,which offers a simple and inexpensive recovery method for heavy metals from contaminated ***,UiO66-Fe_(3)O_(4)configuration with EDTA-assisted washing process showed opportunities for heavy metals contaminated sites.

关键词： UiO66 composites Metal-EDTA complexes EDTA-assisted washing Heavy metals recovery Soil

Optimal Asymmetric Quantum Codes from the Euclidean Sums of Linear Codes

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Wuhan university Journal of Natural sciences 2024年第1期29卷 45-50页

作者： XU Peng LIU Xiusheng School of science and Technology College of Arts and Science of Hubei Normal UniversityHuangshi 435109HubeiChina

In this paper,we first give the definition of the Euclidean sums of linear codes,and prove that the Euclidean sums of linear codes are Euclidean *** we construct two new classes of optimal asymmetric quantum error-correcting codes based on Euclidean sums of the Reed-Solomon codes,and two new classes of optimal asymmetric quantum error-correcting codes based on Euclidean sums of linear codes generated by Vandermonde matrices over finite ***,these optimal asymmetric quantum errorcorrecting codes constructed in this paper are different from the ones in the literature.

关键词： Euclidean sums of linear codes optimal asymmetric quantum errorcorrecting codes vandermonde matrices Reed-Solomon codes

Mapping the metabolic responses to oxaliplatin-based chemotherapy with in vivo spatiotemporal metabolomics

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Journal of Pharmaceutical Analysis 2024年第2期14卷 196-210页

作者： Mariola Olkowicz Khaled Ramadan Hernando Rosales-Solano Miao Yu Aizhou Wang Marcelo Cypel Janusz Pawliszyn Department of Chemistry University of WaterlooWaterlooONCanada Jagiellonian Centre for Experimental Therapeutics(JCET) Jagiellonian UniversityKrakowPoland Latner Thoracic Surgery Research Laboratories Toronto General Hospital Research InstituteUniversity Health NetworkTorontoONCanada The Jackson Laboratory JAX Genomic MedicineFarmingtonCTUSA division of Thoracic Surgery Department of SurgeryUniversity Health NetworkUniversity of TorontoToronto Lung Transplant ProgramTorontoONCanada

Adjuvant chemotherapy improves the survival outlook for patients undergoing operations for lung metastases caused by colorectal cancer (CRC). However, a multidisciplinary approach that evaluates several factors related to patient and tumor characteristics is necessary for managing chemotherapy treatment in metastatic CRC patients with lung disease, as such factors dictate the timing and drug regimen, which may affect treatment response and prognosis. In this study, we explore the potential of spatial metabolomics for evaluating metabolic phenotypes and therapy outcomes during the local delivery of the anticancer drug, oxaliplatin, to the lung. 12 male Yorkshire pigs underwent a 3 h left lung in vivo lung perfusion (IVLP) with various doses of oxaliplatin (7.5, 10, 20, 40, and 80 mg/L), which were administered to the perfusion circuit reservoir as a bolus. Biocompatible solid-phase microextraction (SPME) microprobes were combined with global metabolite profiling to obtain spatiotemporal information about the activity of the drug, determine toxic doses that exceed therapeutic efficacy, and conduct a mechanistic exploration of associated lung injury. Mild and subclinical lung injury was observed at 40 mg/L of oxaliplatin, and significant compromise of the hemodynamic lung function was found at 80 mg/L. This result was associated with massive alterations in metabolic patterns of lung tissue and perfusate, resulting in a total of 139 discriminant compounds. Uncontrolled inflammatory response, abnormalities in energy metabolism, and mitochondrial dysfunction next to accelerated kynurenine and aldosterone production were recognized as distinct features of dysregulated metabolipidome. Spatial pharmacometabolomics may be a promising tool for identifying pathological responses to chemotherapy.

关键词： Pulmonary metastases Colorectal cancer Adjuvant chemotherapy In vivo lung chemo-perfusion Solid-phase microextraction(SPME)microprobes Spatial metabolomics

Super-Resolution Fluorescence Microscopy for Cilia Investigation and Ciliopathy Diagnosis(Invited)

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激光与光电子学进展 2024年第6期61卷 260-271页

作者： Liu Zhen Wu Yang division of Life science The Hong Kong University of Science and TechnologyHong KongChina

The last two decades have witnessed the invention and development of super-resolution microscopy(SRM)that breaks the diffraction limit of light and pushes the fluorescence microscopy resolution to several *** SRM is widely used in biological studies,such as resolving subdiffraction structures,molecular mapping,tracking single molecules,probing protein-protein interactions,and observing organelle dynamics,its direct application in translational medicine,such as disease diagnosis,is still *** their small size,cilia play a crucial role as organelles in cell signaling and motility,with defects in cilia leading to *** to other miniature organelles and macromolecular complexes,cilia are ideal for super-resolution *** this review,we will 1)introduce cilia and ciliopathy,2)show how SRM extends our knowledge of cilia,and 3)focus on how SRM improves the diagnosis of motile ciliopathies.

关键词： diagnosis limit spite

Combined Insights from Leachate Structure and Microstructure Characteristics for Eating Quality of Convenience Rice Processed by Super-Heated and Pressurized Steam Technologies

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Rice science 2024年第4期31卷 475-488,I0035,I0036页

作者： Mingyo HA Hyo-Young JEONG Ju Hun LEE Hyun-Jung CHUNG division of Food and Nutrition Chonnam National UniversityGwangju 61186South Korea Department of Biotechnology College of Life Sciences and BiotechnologyKorea UniversitySeoul 02841South Korea division of Food science&Culinary arts Shinhan UniversityGyeonggi 11644South Korea

Convenience rice has become widely popular due to its easy availability for cooking. This study investigated the starch structure and composition of leachate and the microstructure of reheated convenience rice using novel processing technologies: super-heated steaming(SHS), auto-electric cooking(AEC), and pressurized-steam cooking(PSC). Additionally, the effect of two different target water contents(58% and 63%) was also evaluated. The PSC_63% sample had the highest total solids and amylopectin amount in the leachate. The amylopectin amount in the leachate differed significantly based on the targeted water content. Morphological characterization revealed that the swelling of starch and the coated layer on the surface of rice grains were most pronounced in the PSC_63% sample due to the pressure processing. The textural hardness of the AEC_58% sample was much higher than that of the other samples. The PSC_63% sample had the highest textural adhesiveness value, which can be attributed to the highest amylopectin amount in the leachate. Sensory characterization showed that the PSC_63% sample had the highest glossiness, whiteness, moistness, and overall acceptability. The principal component analysis score plots presented substantial differences in the leachate and textural and sensory characteristics of reheated convenience rice among the different processing technologies.

关键词： reheated convenience rice starch structure leachate multi-scale structure eating quality processing technology