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Evidence-Based Complementary and Alternative Medicine Effects of Capybara Oil on Cardiac Remodeling of C57bl/6 Mice

Journal of Biosciences and Medicines 2024年第5期12卷 213-232页

作者： Rafael M. Almeida Wagner D. Giannetti Guilherme R. Silveira Carolina R. Castilho Renata V. Lisboa Bianca T. Ciambarella Rodrigo N. Ferreira Jorge José de carvalho Laboratory of Ultrastructure and Tissue Biology Institute of Biology State University of Rio de Janeiro Rio de Janeiro Brazil Higher Education Center of Valenç a Dom Andr&#233 Arcoverde Educational Foundation Valen&#231a Brazil

Cardiovascular diseases are the main cause of morbidity and mortality in the world, and obesity and the metabolic syndrome are risk factors for its development. One of the therapies to reduce cardiovascular risk is the use of polyunsaturated fatty acids. In Brazil, a source of such acid is the oil extracted from the fat of the capybara. The objective of this work is to study the effects of the capybara oil on lipid and glucose metabolism, as well as its effects on the adipose tissue and cardiac remodeling. We assessed the effects of capybara oil treatment on body mass, lipid and carbohydrate metabolism, systolic blood pressure, adipose tissue and cardiac remodeling, and performed an ultrastructural evaluation of the myocardium in C57Bl/6 mice treated with high-fat diet. Treatment with capybara oil reduced total cholesterol and triglyceride levels, systolic blood pressure, visceral and subcutaneous adipose tissue, and adipocyte diameter. In addition, cardiac remodeling was attenuated, preserving cardiomyocytes, increasing vascularization, reducing cardiomyocyte hypertrophy and the extracellular matrix, and preserving the morphological integrity of mitochondria. Capybara oil has several beneficial effects on the cardiovascular and metabolic system, and further studies are needed to better understand its role in the prevention or treatment of cardiovascular diseases.

关键词： Capybara Oil Cardiac Remodeling Polyunsaturated Fatty Acids Obesity Metabolic Syndrome

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Wear behavior of Ti6Al4V biomedical alloys processed by selective laser melting, hot pressing and conventional casting

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Transactions of Nonferrous Metals Society of China 2017年第4期27卷 829-838页

作者： F.BARTOLOMEU M.BUCIUMEANU E.PINTO N.ALVES F.S.SILVA O.carvalho G.MIRANDA Center for Micro-Electro Mechanical Systems (CMEMS-UMinho) University of Minho Azurem 4800-058 Guimaraes Portugal Cross-Border Faculty of Humanities Economics and Engineering"Dunarea de Jos" University of Galati Domneasca 47 800008 Galati Romania Centre for Rapid and Sustainable Product development Polytechnic institute of Leiria Rua General Norton de Matos Apartado 4133 2411-901 Leiria Portugal

The aim of this work was to study the influence of the processing route on the microstructural constituents,hardness andtribological(wear and friction)behavior of Ti6Al4V biomedical *** this sense,three different processing routes were studied:conventional casting,hot pressing and selective laser melting.A comprehensive metallurgical,mechanical and tribologicalcharacterization was performed by X-ray diffraction analysis,Vickers hardness tests and reciprocating ball-on-plate wear tests ofTi6Al4V/Al2O3sliding *** results showed a great influence of the processing route on the microstructural constituents andconsequent differences on hardness and wear *** highest hardness and wear resistance were obtained for Ti6Al4Valloy produced by selective laser melting,due to a markedly different cooling rate that leads to significantly different microstructurewhen compared to hot pressing and *** study assesses and confirms that selective laser melting is potential to producecustomized Ti6Al4V implants with improved wear performance.

关键词： biomedical alloy Ti6Al4V alloy wear behavior microstructure selective laser melting hot pressing casting

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Hydro-wind Optimal Operation for Joint Bidding in Day-ahead Market: Storage Efficiency and Impact of Wind Forecasting Uncertainty

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Journal of Modern Power Systems and Clean Energy 2020年第1期8卷 142-149页

作者： António Cerejo Sílvio J.P.S.Mariano Pedro M.S.carvalho Maria R.A.Calado Technical-Scientific Unity of Electrical and Industrial Engineering Polytechnic Institute of Castelo BrancoAvenida do Empresário6000-767 Castelo BrancoPortugal department of Electromechanical Engineering University of Beira Interior and Instituto de TelecomunicacoesCalcada Fonte do Lameiro6201-001 CovilhaPortugal department of Electrical and Computer Engineering Instituto Superior Técnicoand INESC-IDUniversity of LisbonAv.Rovisco Pais1049-001 LisbonPortuga

Wind power production is *** imbalance between committed and delivered energy in pool markets leads to the increase of system costs,which must be incurred by defaulting producers,thereby decreasing their *** avoid this situation,wind producers can submit their bids together with hydro *** the mismatches between the predicted and supplied wind power can be used by hydro producers,turbining or pumping such differences when *** study formulates the problem of hydro-wind production optimization in operation contexts of pool *** problem is solved for a simple three-reservoir cascade case to discuss optimization *** results show a depreciation in optimal revenues from hydro power when wind forecasting is *** depreciation is caused by an asymmetry in optimal revenues from positive and negative wind power *** problem of neutralizing the effect of forecasting uncertainty is subsequently formulated and solved for the three-reservoir *** results are discussed to conclude the impacts of uncertainty on joint bidding in pool market contexts.

关键词： Optimization hydro power wind power uncertainty joint bidding pool market

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Prediction of Pulmonary Arterial Pressure Level after Repair of Congenital Cardiac Communications and Discharge from the Hospital: Role of Down Syndrome and Early Postoperative Hemodynamics

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Congenital Heart Disease 2022年第3期17卷 351-363页

作者： Eloisa Sassa carvalho Maria Francilene SSouza Kelly Cristina O.Abud Claudia R.P.Castro Juliano G.Penha Ana Maria Thomaz Vanessa A.Guimaraes Antonio Augusto Lopes Heart institute(InCor) University of Sao Paulo School of MedicineSão PauloBrazil

Background:Postoperative pulmonary hypertension limits the success of surgical treatment in some patients with unrestrictive congenital cardiac *** patients at risk of developing postoperative pulmonary hypertension is important to individualize follow-up ***:We analyzed a prospective cohort of 52 pediatric patients(age 3 to 35 months)looking for perioperative predictors of mildly elevated pulmonary arterial pressure 6 months after surgery,defined as a systolic pressure greater than 30 mmHg by transthoracic *** corresponds to a mean pulmonary arterial pressure of>20 ***,echocardiographic and hemodynamic parameters were *** hemodynamics was assessed by directly measuring pulmonary and systemic arterial pressures using indwelling *** postoperative pulmonary hemodynamics was defined as the mean pulmonary/systemic mean arterial pressure ratio(PAP/SAP)obtained per patient during the first 6 h of postoperative ***:Among the factors that were investigated as possible predictors,perioperative hemodynamics and the presence of Down syndrome were initially selected using univariate analysis(pdependent predictor after adjustments for possible *** early postoperative PAP/SAP of>0.35 was 76%sensitive and 74%specific at predicting a systolic pulmonary arterial pressure of>30 mmHg 6 months after surgery(hazard ratio with 95%CI 8.972[2.428–33.158],p=0.002).Conclusion:The hypertensive early postoperative behavior of the pulmonary circulation was strongly but not exclusively associated with Down syndrome,and it was char

关键词： Pulmonary hypertension congenital heart disease Down syndrome pediatric cardiac surgery

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Studies on Production Planning of Dispersion Type U₃Si₂-Al Fuel in Plate-Type Fuel Elements for Nuclear Research Reactors

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World Journal of Nuclear Science and Technology 2016年第4期6卷 217-231页

作者： Miguel Luiz Miotto Negro Michelangelo Durazzo Marco Aurélio de Mesquita Elita Fontenele Urano de carvalho delvonei Alves de Andrade Instituto de Pesquisas Energéticas e Nucleares (Nuclear and Energy Research institute) S&#227 o Paulo Brazil Escola Politécnica da Universidade de Sã o Paulo (Polytechnic School of Sã o Paulo University) S&#227 o Paulo Brazil

Several fuel plants that supply nuclear research reactors need to increase their production capacity in order to meet the growing demand for this kind of nuclear fuel. After the enlargement of the production capacity of such plants, there will be the need of managing the new production level. That level is usually the industrial one, which poses challenges to the managerial staff. Such challenges come from the fact that several of those plants operate today on a laboratorial basis and do not carry inventory. The change to the industrial production pace asks for new actions regarding planning and control. The production process based on the hydrolysis of UF6 is not a frequent production route for nuclear fuel. Production planning and control of the industrial level of fuel production on that production route is a new field of studies. The approach of the paper consists in the creation of a mathematical linear model for minimization of costs. We also carried out a sensitivity analysis of the model. The results help in minimizing costs in different production schemes and show the need of inventory. The mathematical model is dynamic, so that it issues better results if performed monthly. The management team will therefore have a clearer view of the costs and of the new, necessary production and inventory levels.

关键词： Fabrication of Uranium Silicide Fuel Nuclear Research Reactors Production Planning and Control

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Cecum Dieulafoy＇s Lesion Presenting with Recurrent Lower Gastrointestinal Bleeding： Case Report

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Journal of Pharmacy and Pharmacology 2018年第3期6卷 254-258页

作者： Ludmila Resende Guedes Silas Castro de carvalho Vitor Nunes Arantes Arthur Manoel Braga de Albuquerque Gomes Daniel Antonio de Albuquerque Terra Nathalia da Silva Braga Nicoly Eudes da Silva Dias Endoscopy Unit of Alfa institute of Gastroenterology at Hospital das Clinicas da Universidade Federal de Minas Gerais (UFMG) Belo Horizonte MG 30130100 Brazil

Introduction： Gastrointestinal Dieulafoy＇s lesion is a rare entity, of unknown etiology, and corresponds to an arterial malformation at the submucosal space that can be a source of life-threatening hemorrhage. We report a case of a Cecum Dieulafoy＇s bleeding lesion that was managed endoscopically with a favorable outcome. Case report： Female, 70-year-old, diagnosed with type 2 diabetes, hypothyroidism, and chronic heart failure associated with rheumatic mitral stenosis, submitted to biological valve replacement in 2006 and with permanent atrial fibrillation using vitamin K antagonist anticoagulant for thrombosis prophylaxis. Her background includes a stroke in 2004 without any permanent disability. In 2016, the patient experienced voluptuous and painless lower gastrointestinal bleeding with severe acute anemia, requiring hospital admission, fluid resuscitation and blood transfusion. Urgent colonoscopy revealed a small reddish vascular malformation at the cecum with oozing active bleeding, about 3 mm in size. Initially argon plasma coagulation was performed with satisfactory and immediate hemostasis. One week later, she recurred with hematochezia. The lesion at the cecum was reassessed and it was possible to notice a large caliber vessel surrounded by a normal appearance mucosa, compatible with Dieulafoy＇s lesion and it was treated with an endoscopic clip placement with a good long-term response. Conclusion： Endoscopy is the method of choice for diagnosis of Dieulafuy＇s lesion and may provide efficient treatment with mechanical hemostasis such as endoclip placement with a high success rate.

关键词： Dieulafoy's lesion lower gastrointestinal bleeding endoscopy endoscopic clip

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Cytotoxic T lymphocyte antigen-4 gene polymorphisms and susceptibility to type 1 autoimmune hepatitis in the Tunisian population

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Genes & Diseases 2018年第3期5卷 256-262页

作者： Marwa Chaouali Agostinho carvalho Aymen Tezeghdenti Mouna Ben Azaiez Cristina Cunha Ezzeddine Ghazouani Radhia Kochkar department of Immunology Military Hospital of TunisMontfleury 1008TunisTunisia El Manar University Laboratory of MycologyPathologies and Biomarkers 1092TunisTunisia Life and Health Sciences Research institute(ICVS) School of MedicineUniversity of MinhoCampus de Gualtar 4710-057BragaPortugal ICVS/3B’s-PT Government Associate Laboratory Braga/Guimara˜esPortugal

Genetic factors and gene polymorphisms leading to the onset of autoimmune response in autoimmune hepatitis(AIH)are still not full *** the CTLA-4 molecule is a key modulator of the lymphocytes responses we hypothezied that deficiencies or mutations in the gene encoding CTLA4 protein may be involved in AIH susceptibility and trigger the autoimmune *** investigated 3 distinct polymorphic sites(t49A>G,CT60 G>A and e318C>T)of the CTLA4 gene in 50 AIH patients and 100 healthy controls using the KASP genotyping technology.A significant positive association with AIH susceptibility was found for the GG genotype in t49 position of the CTLA4 gene which was significantly higher in AIH patients compared to controls(28%vs 9%,pZ0.003,ORZ3.93[1.56e9.88]).The CTLA4 A/A genotype in position CT60 was more significantly frequent in controls comparing to AIH patients and could be considered as a protective genotype for the tunisian ***4 genotyping in position318 did not show any statistically significant difference in genotype or allele *** CTLA4 gene polymorphism in position t49 is associated to AIH susceptibility in the Tunisian *** in the CTLA4 gene may lead to a modification of the CTLA4 protein structure that could have functional relevance in AIH pathogenesis and onset.

关键词： Autoimmune hepatitis CTLA4 gene polymorphisms Cytotoxic Tlymphocyte antigen 4

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Mechanical stimulation devices formechanobiology studies:a market,literature,and patents review

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Bio-design and Manufacturing 2023年第3期6卷 340-371页

作者： F.Melo-Fonseca O.carvalho M.Gasik G.Miranda F.S.Silva Center for MicroElectroMechanical Systems University of Minho(CMEMS-UMinho)Campus de Azurém4800-058 GuimarãesPortugal LABBELS–Associate Laboratory BragaGuimarãesPortugal International Iberian Nanotechnology Laboratory(INL) 4715-330 BragaPortugal School of Chemical Engineering Aalto University Foundation00076 EspooFinland Seqvera Ltd. HelsinkiFinland department of Materials and Ceramic Engineering CICECOAveiro Institute of MaterialsUniversity of Aveiro3810-193 AveiroPortugal

Significant advancements in various research and technological fields have contributed to remarkable findings on the physiological dynamics of the human *** closely mimic the complex physiological environment,research has moved from two-dimensional(2D)culture systems to more sophisticated three-dimensional(3D)dynamic *** bioreactors or microfluidic-based culture models,cells are typically seeded on polymeric substrates or incorporated into 3D constructs which are mechanically stimulated to investigate cell response to mechanical stresses,such as tensile or *** review focuses on the working principles of mechanical stimulation devices currently available on the market or custom-built by research groups or protected by patents and highlights the main features still open to *** are the features which could be focused on to perform,in the future,more reliable and accurate mechanobiology studies.

关键词： Biomaterials Polymers Actuators Mechanical stress Mechanotransduction

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Evidence of a J/ψΛstructure and observation of excited■^(-)states in the■b^(-)→J/ψΛK^(-) decay

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Science Bulletin 2021年第13期66卷 1278-1287,M0003页

作者： R.Aaij C.Abellán Beteta T.Ackernley B.Adeva M.Adinolfi H.Afsharnia C.A.Aidala S.Aiola Z.Ajaltouni S.Akar J.Albrecht F.Alessio M.Alexander A.Alfonso Albero Z.Aliouche G.Alkhazov P.Alvarez Cartelle S.Amato Y.Amhis L.An L.Anderlini A.Andreianov M.Andreotti F.Archilli A.Artamonov M.Artuso K.Arzymatov E.Aslanides M.Atzeni B.Audurier S.Bachmann M.Bachmayer J.J.Back S.Baker P.Baladron Rodriguez V.Balagura W.Baldini J.Baptista Leite R.J.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov J.M.Basels G.Bassi B.Batsukh A.Battig A.Bay M.Becker F.Bedeschi I.Bediaga A.Beiter V.Belavin S.Belin V.Bellee K.Belous I.Belov I.Belyaev G.Bencivenni E.Ben-Haim A.Berezhnoy *** D.Berninghoff H.C.Bernstein C.Bertella E.Bertholet A.Bertolin C.Betancourt F.Betti Ia.Bezshyiko S.Bhasin J.Bhom L.Bian M.S.Bieker S.Bifani P.Billoir M.Birch F.C.R.Bishop A.Bizzeti M.Bj┆rn M.P.Blago T.Blake F.Blanc S.Blusk D.Bobulska J.A.Boelhauve O.Boente Garcia T.Boettcher A.Boldyrev A.Bondar N.Bondar S.Borghi M.Borisyak M.Borsato J.T.Borsuk S.A.Bouchiba T.J.V.Bowcock A.Boyer C.Bozzi M.J.Bradley S.Braun A.Brea Rodriguez M.Brodski J.Brodzicka A.Brossa Gonzalo D.Brundu A.Buonaura C.Burr A.Bursche A.Butkevich J.S.Butter J.Buytaert W.Byczynski S.Cadeddu H.Cai R.Calabrese L.Calefice L.Calero Diaz S.Cali R.Calladine M.Calvi M.Calvo Gomez P.Camargo Magalhaes A.Camboni P.Campana A.F.Campoverde Quezada S.Capelli L.Capriotti A.Carbone G.Carboni R.Cardinale A.Cardini I.Carli P.Carniti L.Carus K.carvalho Akiba A.Casais Vidal G.Casse M.Cattaneo G.Cavallero S.Celani J.Cerasoli A.J.Chadwick M.G.Chapman M.Charles Ph.Charpentier G.Chatzikonstantinidis C.A.Chavez Barajas M.Chefdeville C.Chen S.Chen A.Chernov S.-G.Chitic V.Chobanova S.Cholak M.Chrzaszcz A.Chubykin V.Chulikov P.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek P.E.L.Clarke M.Clemencic H.V.Cliff J.Closier J.L.Cobbledick V.Coco J.A.B.Coelho J.Cogan E.Cogneras L.Cojocariu P.Collins T.Colombo L.Congedo A.Contu N.Cooke G.Coombs G.Corti C.M.Costa Sobral B.Couturier D.C.Craik J.Crkovská M.Cruz Torres R.Currie C.L.Da Silva E.Dall’ Centro Brasileiro de Pesquisas Físicas(CBPF) Rio de JaneiroBrazil Universidade Federal do Rio de Janeiro(UFRJ) Rio de JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina School of Physics State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University of Chinese Academy of Sciences BeijingChina institute Of High Energy Physics(IHEP) BeijingChina institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Univ.Grenoble Alpes Univ.Savoie Mont BlancCNRSIN2P3-LAPPAnnecyFrance UniversitéClermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance UniversitéParis-Saclay CNRS/IN2P3IJCLabOrsayFrance Laboratoire Leprince-ringuet(llr) PalaiseauFrance LPNHE Sorbonne UniversitéParis Diderot Sorbonne Paris CitéCNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultät Physik Technische Universität DortmundDortmundGermany Max-Planck-Institut für Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universität HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di Bari BariItaly INFN Sezione di Bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati FrascatiItaly INFN Sezione di Genova GenovaItaly INFN Sezione di Milano-Bicocca MilanoItaly INFN Sezione di Milano MilanoItaly INFN Sezione di Cagliari MonserratoItaly Universita degli Studi di Padova Universita e INFNPadovaPadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma Tor Vergata RomaItaly INFN Sezione di Roma La Sapienza RomaItaly Nikhef National institute for Subatomic Physics AmsterdamNetherlands Nikhef National institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands Henryk Niewodniczanski institute of Nuclear Physics Polish Academy of Sciences KrakówPoland AGH-University of Science and Techno

First evidence of a structure in the J/ψΛinvariant mass distribution is obtained from an amplitude analysis of■b^(-)J/ψΛK^(-)*** observed structure is consistent with being due to a charmonium pentaquark with strangeness with a significance of 3.1r including systematic uncertainties and lookelsewhere *** mass and width are determined to be 4458:8±2:9t4:7-1:1 MeV and 17:3±6:5t8:0-5:7 MeV,respectively,where the quoted uncertainties are statistical and *** structure is also consistent with being due to two *** addition,the narrow excited■^(-)states,N■(1690)and■(1820),are seen for the first time in a■b^(-)decay,and their masses and widths are measured with improved *** analysis is performed using pp collision data corresponding to a total integrated luminosity of 9 fb^(-1),collected with the LHCb experiment at centre-of-mass energies of 7,8 and 13 TeV.

关键词： QCD Exotics Pentaquark Spectroscopy Quarkonium Particle and resonance production

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Personalizing therapies for gastric cancer: Molecular mechanisms and novel targeted therapies

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World Journal of Gastroenterology 2013年第38期19卷 6383-6397页

作者： Michael Luis Ana Tavares Liliana S carvalho Lúcio Lara-Santos António Araújo Ramon Andrade de Mello Gastrointestinal Unit Service of Medical OncologyPortuguese Oncology Institute4200-072 PortoPortugal Gastrointestinal Unit Experimental Pathology and Therapeutics GroupResearch Center-Portuguese Oncology Institute4200-072 PortoPortugal department of Pharmacology and Therapeutics Faculty of MedicineUniversity of Porto4200-319 PortoPortugal institute of Cellular and Molecular Biology 4150-180 PortoPortugal Gastrointestinal Unit Section of Surgical OncologyPortuguese Oncology Institute4200-072 PortoPortugal department of Medicine Faculty of MedicineUniversity of Porto4200-319 PortoPortugal

Globally,gastric cancer is the 4thmost frequently diagnosed cancer and the 2ndleading cause of death from cancer,with an estimated 990000 new cases and738000 deaths registered in *** the advanced setting,standard chemotherapies protocols acquired an important role since last decades in prolong ***,recent advances in molecular therapies provided a new interesting weapon to treat advanced gastric cancer through anti-human epidermal growth factor receptor 2(HER2)***,an anti-HER2 monoclonal antibody,was the first target drug in the metastatic setting that showed benefit in overall survival when in association with platinum-5-fluorouracil based ***,HER2 overexpression analysis acquired a main role in predict response for trastuzumab in this ***,we conducted a review that will discuss the main points concerning trastuzumab and HER2 in gastric cancer,providing a comprehensive overview of molecular mechanisms and novel trials involved.

关键词： Gastric cancer Human epidermal growth factor receptor 2 Biomarkers Target therapies Trastuzumab Lapatinib Pertuzumab Trastuzumab-DM1 Afatinib

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