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Decreased LDHB expression in breast tumor cells causes NK cell activation and promotes tumor progression

Cancer Biology & Medicine 2024年第6期21卷 513-540页

作者： Zhihong Luo Xiaohua Huang Xinyi Xu Kefeng Wei Yi Zheng Ke Gong Wenhua Li Hubei Key Laboratory of Cell Homeostasis College of Life SciencesWuhan UniversityWuhan 430072China Wuhan University Shenzhen research Institute Shenzhen 518057China Central Laboratory University of Chinese Academy of Sciences-Shenzhen HospitalShenzhen 518107China Hubei Province Key Laboratory of allergy and immunology and Department of immunology School of Basic Medical SciencesWuhan UniversityWuhan 430071China

Objective: Abnormal metabolism is the underlying reason for breast cancer progression. Decreased lactate dehydrogenase B(LDHB) has been detected in breast cancer but the function of LDHB remains ***: Western blot was used to analyze LDHB expression in breast cancer cells. The impact of LDHB on tumor cell migration and invasion was determined using Transwell assays, wound healing assays, and a mouse lung metastasis model. Subcutaneous tumor formation, a natural killer(NK) cell cytotoxicity assay, and flow cytometry evaluated NK cell activation. Immunofluorescence and quantitative real-time PCR detected NK cell activation markers. Kaplan-Meier analysis evaluated the effect of immune cell infiltration on prognosis. Single-sample gene set enrichment analysis determined NK cell activation scores. A support vector machine predicted the role of LDHB in NK cell ***: In this study we showed that LDHB inhibits the breast cancer cell metastasis and orchestrates metabolic reprogramming within tumor cells. Our results revealed that LDHB-mediated lactic acid clearance in breast cancer cells triggers NK cell activation within the tumor microenvironment. Our findings, which were confirmed in a murine model, demonstrated that LDHB in tumor cells promotes NK cell activation and ultimately results in the eradication of malignant cells. Clinically, our study further validated that LDHB affects immune cell infiltration and function. Specifically, its expression has been linked to enhanced NK cell-mediated cytotoxicity and improved patient survival. Furthermore, we identified LDHB expression in tumors as an important predictor of NK cell activation, with strong predictive ability in some ***: Our results suggest that LDHB is a promising target for activating the tumor immune microenvironment in breast cancer, where LDHB-associated lactic acid clearance leads to increased NK cell activity. This study highlights the critical role of LDHB in regula

关键词： Breast cancer lactate dehydrogenase B lactic acid NK cells tumor immunity

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Nano polystyrene microplastics could accumulate in Nile tilapia(Oreochromis niloticus):Negatively impacts on the intestinal and liver health through water exposure

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Journal of Environmental Sciences 2024年第3期137卷 604-614页

作者： Di Wu Xing Lu Li-Xue Dong Juan Tian Jin Deng Lei Wei Hua Wen Shan Zhong Ming Jiang School of Basic Medical Sciences Wuhan UniversityWuhan 430071China Key Laboratory of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural AffairsYangtze River Fisheries Research InstituteChinese Academy of Fishery SciencesWuhan 430223China Hubei Province Key Laboratory of allergy and immunology Wuhan 430071China

Microplastics(MPs)have become a significant concern for their potential ***,the correlation between the size of plastic particles and their toxicity remains ***,we investigate the toxic effects of different sizes(80 nm,800 nm,8μm and 80μm)polystyrene MPs(PS-MPs)on the model organism Nile tilapia(Oreochromis niloticus).The results of bioluminescent imaging indicate that the 80 nm PS-MPs are more likely to invade the body.H&E staining shows severe damage on the intestinal villi and distinct hepatic steatosis in the 80 nm *** U labeling shows that the proliferation activity of intestinal and liver cells reduces significantly in the 80 nm *** gut microbiome analysis shows a severe imbalance of gut microbiota homeostasis in the 80 nm *** analysis of liver transcriptomics and metabolomics shows that the liver lipid metabolism is disordered in the 80 nm *** conclusion,this study confirms that the 80 nm PS-MPs are more likely to induce intestinal and liver *** the above lay the foundation for further study on the pathological damage of MPs to other organisms.

关键词： Microplastics(MPs) Intestinal toxicity Liver toxicity Gut microbiome Lipid metabolism

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COVID-19 and cardiac complications:Myocarditis and multisystem inflammatory syndrome in children

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World Journal of Cardiology 2024年第5期16卷 260-268页

作者： Muhammed Gunes Oner Ozdemir Department of Pediatric Cardiology Research and Training Hospital of SakaryaAdapazarı54100SakaryaTürkiye Department of Pediatric allergy and immunology Research and Training Hospital of SakaryaSakarya University Medical FacultyAdapazarı54100SakaryaTürkiye

Coronavirus is an important pathogen causing disease in humans and *** the end of 2019,an investigation into an increase in pneumonia cases in Wuhan,Hubei Province,China,found that the cause was a new *** disease,which spread rapidly across China and caused an outbreak worldwide,resulted in a *** this virus has previously been referred to as 2019-nCoV,which causes coronavirus disease 2019(COVID-19),later it was named severe acute respiratory syndrome coronavirus *** were usually asymptomatic and rarely severely *** April 2020,reports from the United Kingdom indicated that children may have Kawasaki disease or a clinical condition similar to toxic shock *** clinical picture was later defined as multisystem inflammatory syndrome in *** then,similarly affected children as well as cases with other cardiac complications have been reported in other parts of the *** this review,we aimed to evaluate COVID-19 in terms of cardiac involvement by reviewing the literature.

关键词： COVID-19 Cardiac complication Myocarditis Multisystem inflammatory syndrome in children SARS-CoV-2

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Ancient dormant virus remnant ERVW-1 drives ferroptosis via degradation of GPX4 and SLC3A2 in schizophrenia

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Virologica Sinica 2024年第1期39卷 31-43页

作者： Dongyan Zhang Xiulin Wu Xing Xue Wenshi Li Ping Zhou Zhao Lv Kexin Zhao Fan Zhu State Key Laboratory of Virology and Department of Medical Microbiology School of Basic Medical SciencesWuhan UniversityWuhan430071China Hubei Province Key Laboratory of allergy&immunology Wuhan UniversityWuhan430071China

Human endogenous retroviruses(HERVs)are remnants of retroviral infections in human germline cells from millions of years *** these,ERVW-1(also known as HERV-W-ENV,ERVWE1,or ENVW)encodes the envelope protein of the HERV-W family,which contributes to the pathophysiology of ***,neuropathological studies have revealed cell death and disruption of iron homeostasis in the brains of individuals with ***,our bioinformatics analysis showed that differentially expressed genes in the human prefrontal cortex RNA microarray dataset(GSE53987)were mainly related to ferroptosis and its associated *** data demonstrated significantly lower expression levels of ferroptosis-related genes,particularly Glutathione peroxidase 4(GPX4)and solute carrier family 3 member 2(SLC3A2),in schizophrenia patients compared to normal *** in-depth analyses revealed a significant negative correlation between ERVW-1 expression and the levels of GPX4/SLC3A2 in *** indicated that ERVW-1 increased iron levels,malondialdehyde(MDA),and transferrin receptor protein 1(TFR1)expression while decreasing glutathione(GSH)levels and triggering the loss of mitochondrial membrane potential,suggesting that ERVW-1 can induce *** research has shown that ERVW-1 reduced the expression of GPX4 and SLC3A2 by inhibiting their promoter ***,Ferrostatin-1(Fer-1),the ferroptosis inhibitor,reversed the iron accumulation and mitochondrial membrane potential loss,as well as restored the expressions of ferroptosis markers GSH,MDA,and TFR1 induced by *** conclusion,ERVW-1 could promote ferroptosis by downregulating the expression of GPX4 and SLC3A2,revealing a novel mechanism by which ERVW-1 contributes to neuronal cell death in schizophrenia.

关键词： ERVW-1 Glutathione peroxidase 4(GPX4) Solute carrier family 3 member 2(SLC3A2) Ferroptosis Schizophrenia

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Immunomodulation of Proton-activated G Protein-coupled Receptors in Inflammation

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Current Medical Science 2024年第3期44卷 475-484页

作者： Min-shan LI Xiang-hong WANG Heng WANG Department of Otolaryngology-Head and Neck Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Institute of allergy and Clinical immunology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Hubei Clinical research Center for Nasal Inflammatory Diseases Wuhan430030China

Proton-activated G protein-coupled receptors(GPCRs),initially discovered by Ludwig in 2003,are widely distributed in various *** receptors have been found to modulate the immune system in several inflammatory diseases,including inflammatory bowel disease,atopic dermatitis,and ***-activated GPCRs belong to the G protein-coupled receptor family and can detect alternations in extracellular *** detection triggers downstream signaling pathways within the cells,ultimately influencing the function of immune *** this review,we specifically focused on investigating the immune response of proton-activated GPCRs under inflammatory conditions.

关键词： proton-activated G protein-coupled receptors inflammation immunomodulation disease

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Climate change induced heat stress impact on workplace productivity in a net zero-carbon timber building towards the end of the century

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Building Simulation 2024年第6期17卷 893-906页

作者： Deepak Amaripadath Mattheos Santamouris Shady Attia School of Geographical Sciences and Urban Planning Arizona State UniversityTempeAZUSA Urban Climate research Center Arizona State UniversityTempeAZUSA School of Built Environment University of New South Wales2052SydneyAustralia Sustainable Building Design Lab Department of UEEFaculty of Applied SciencesUniversity of Liege4000LiegeBelgium

Changing climate intensifies heat stress,resulting in a greater risk of workplace productivity decline in timber office buildings with low internal thermal *** impact of climate change induced heat exposure on indoor workplace productivity in timber office buildings has not been extensively ***,further investigation to reduce the work capacity decline towards the end of the century is ***,heat exposure in a net zero-carbon timber building near Brussels,Belgium,was evaluated using a reproducible comparative approach with different internal thermal mass *** analysis indicated that strategies with increased thermal mass were more effective in limiting the effects of heat exposure on workplace *** medium and high thermal mass strategies reduced workplace productivity loss to 0.1%in the current,0.3%and 0.2%in the midfuture,and 4.9%and 3.9%for future *** comparison,baseline with low thermal mass yielded a decline of 2.3%,3.3%,and 8.2%.The variation in maximum and minimum wet-bulb globe temperatures were also lower for medium and high thermal mass strategies than for low thermal mass *** study findings lead to the formulation of design guidelines,identification of research gaps,and recommendations for future work.

关键词： heat exposure office buildings work capacity thermal mass climate change

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Participatory Risk Governance for Seoul, South Korea's Flood Risk Management

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International Journal of Disaster Risk Science 2024年第3期15卷 317-331页

作者： Bokjin Ro Gregg Garfin School of Geography Development and Environment The University of Arizona Interdisciplinary Program for Disaster Crisis and Risk Management Sungkyunkwan University School of Natural Resources and the Environment The University of Arizona

Risk governance is a widely used framework in natural and societal risk management research. Risks from natural hazards in urban areas call for the establishment of rigorous and participatory urban risk governance. In this study, we examined participatory risk governance(PRG) of flood risk management(FRM) in Seoul, South Korea. We conducted key informant interviews and implemented a survey with citizens, to explore perceptions of flood risks and risk management, and to examine prospects for improving PRG in Seoul. We found a gap between the perceptions of key informants and *** informants believed that citizens' low awareness of flood risks hinders PRG. Yet our research found that citizens' risk awareness was not low, and risk awareness may not be the main barrier to participation in PRG. Instead, we found that citizens lacked knowledge of FRM actions, and they assigned government bodies a high level of responsibility for FRM,compared to the level of responsibility that citizens assigned to themselves. Moreover, the actors involved in FRM tended not to trust each other, which implies a lack of mutual understanding. To increase the eff ectiveness of PRG, we suggest a polycentric governance structure anchored by a leading actor group, and active promotion of the participation of actors at multiple levels of governance. Communication between government and citizen participants, designed to foster improved understanding and recognition of one another's roles and contributions to FRM, will enhance trust and improve the implementation of PRG in Seoul.

关键词： Citizen participation Flood risk management Participatory risk governance Risk awareness South Korea Urban flood risk

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Semi-automated detection of rangeland runoff and erosion control berms using high-resolution topography data

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International Soil and Water Conservation research 2024年第1期12卷 217-226页

作者： Li Li Changjiang River Scientific research Institute of Changjiang Water Resources Commission Wuhan430010China research Center on Mountain Torrent&Geologic Disaster Prevention Ministry of Water ResourcesWuhan430010China University of arizona School of Natural Resources and the EnvironmentTucsonAZ85719USA

An inventory of topographic modifications is essential to addressing their impacts on hydrological and morphological processes in human-altered ***,such inventories are generally *** study presents two workflows for semi-automatic detection of linear earthen runoff and erosion control berms in rangelands using high-resolution topographic *** workflows consist of initial object identification by applying either morphological grayscale reconstruction(MGR)or the Geomorphon(GEO)method,followed by identification refinements through filters based on objects’horizontal and vertical *** sites were selected within the Altar Valley,arizona,in the southwestern United *** site was used for developing workflows and optimizing filter thresholds,and the other two sites were used to validate *** results showed that:1)The MGR-based workflow methodology could produce final precision and detection rates of up to 92%and 75%,respectively,and take less than 5 s for a 10.1 km^(2) site;2)The workflow based on the MGR method yielded greater identification accuracy than did the GEO workflow;3)Object length,orientation,and eccentricity were important characteristics for identifying earthen berms,and are sensitive to general channel flow direction and berm shape;4)Manual interrogation of topographic data and imagery can significantly improve identification precision *** proposed workflows will be useful for developing inventories of runoff and erosion control structures in support of sustainable rangeland management.

关键词： Earthen berm Rangeland Grayscale morphological reconstruction Geomorphon LiDAR

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Efficacy and safety of single microneedle radiofrequency *** therapy on moderate-to-severe acne vulgaris:A prospective,randomized,controlled study

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Chinese Medical Journal 2024年第8期137卷 1006-1008页

作者： Chuchu Huang Mengping Mao Yiran Peng Ben Wang Yuxuan Deng Hongfu Xie Dan Jian Department of Dermatology Xiangya HospitalCentral South UniversityChangshaHunan 410008China National Clinical research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan 410008China Hunan Key Laboratory of Aging Biology Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Dermatology and allergy and Christine Kühne-Center for Allergy Research and EducationUniversity Hospital of BonnD-53127BonnGermany

To the Editor:Acne vulgaris is a prevalent skin disorder affecting both physical and psychosocial health.[1]Although photodynamic therapy(PDT)exists for moderate-to-severe acne,due to its adverse reactions,we are still looking forward to a novel therapeutic option with fewer side ***,radiofrequency has been used to treat moderate acne.[2]In this study,we aimed to evaluate the efcacy and safety of moderate-to-severe acne treatment based on a single microneedle with radiofrequency(MRF)*** during three consecutive sessions through a prospective,randomized,and controlled trial study.

关键词： needle prospective randomized

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Use of infrared thermography to detect reactions to stressful events:does animal personality matter?

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Integrative Zoology 2024年第2期19卷 224-239页

作者： Maria Vittoria MAZZAMUTO Marina MORANDINI William LAMPMAN Lucas Armand WAUTERS Damiano PREATONI John Lad KOPROWSKI Adriano MARTINOLI School of Natural Resources and Environment College of Agriculture and Life ScienceUniversity of ArizonaArizonaUSA Unitàdi Analisi e Gestione delle Risorse Ambientali Dipartimento di Scienze Teoriche e ApplicateGuido Tosi Research GroupUniversitàdegli Studi dell’InsubriaVareseItaly Haub School of Environment and Natural Resources University of WyomingWyomingUSA

The study of the relationship between animal stress and personality for free-ranging animals is limited and provides contrasting *** perception of stressors by an individual may vary due to its personality,and certain personality traits may help individuals to better cope with *** non-invasive infrared thermography(IRT),we investigated the link between physiological and behavioral components expressed during an acute stress event by free-ranging Fremont’s squirrels(Tamiasciurus fremonti).We expected that,during the acute stress event of being approached by the researcher,individuals that showed a fast pace-of-life syndrome(bolder,more active,and less social/more aggressive)based on an arena test would exhibit stronger sympathetic-adrenal-medullary system reactivity showing a more intense stress-induced hyperthermia(high core body temperature and low peripheral temperature)than individuals with a slow pace of life(shy,less active,and more social).We successfully employed IRT technology to images of Fremont’s squirrels with identification of the individuals’body parts(eye,nose,ear,hind foot).However,we found no support for our ***’body surface temperatures told us more about a squirrel’s external environment and less about the thermal state of the body in that environment following a stressful *** studies need to assess how to make IRT effective and efficient in the field and improve its performance in studying the relationships between physiology and personality in wildlife.

关键词： non-invasive method open field test physiology stress-induced hyperthermia Tamiasciurus fremonti

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