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Application of Computer Integration Technology for Fire Safety Analysis

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Tsinghua Science and Technology 2008年第S1期13卷 387-392页

作者：史健勇李引擎陈虎传 Department of Civil Engineering Shanghai Jiao Tong University institute of building Fire research China Academy of Building Research

With the development of information technology, the fire safety assessment of whole structure or region based on the computer simulation has become a hot topic. However, traditionally, the concerned studies are performed separately for different objectives and difficult to perform an overall evaluation. A new multi-dimensional integration model and methodology for fire safety assessment were presented and two newly developed integrated systems were introduced to demonstrate the function of integration simulation technology in this paper. The first one is the analysis on the fire-resistant behaviors of whole structure under real fire loads. The second one is the study on fire evaluation and emergency rescue of campus based on geography information technology (GIS). Some practical examples are presented to illuminate the advantages of computer integration technology on fire safety assessment and emphasize some problems in the simulation. The results show that the multi-dimensional integration model offers a new way and platform for the integrating fire safety assessment of whole structure or region, and the integrated software developed is the useful engineering tools for cost-saving and safe design.

关键词： fire simulation large space building fire safety steel structure integrated system

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Intricacies during pregnancy with gestational diabetes mellitus

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World Journal of Clinical Cases 2025年第1期13卷 62-64页

作者： Richa Rattan Rimesh Pal Parul Chawla Gupta Arvind Kumar Morya Ripunjay Prasad Department of Endocrinology Post Graduate Institute of Medical Education and ResearchChandigarh 160012India Department of Ophthalmology Post Graduate Institute of Medical Education and ResearchChandigarh 160012PunjabIndia Department of Ophthalmology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Ophthalmology RP Eye InstituteDelhi 110001India

The study by Cao et al aimed to identify early second-trimester biomarkers that could predict gestational diabetes mellitus(GDM)development using advanced proteomic techniques,such as Isobaric tags for relative and absolute quantitation isobaric tags for relative and absolute quantitation and liquid chromatography-mass spectrometry liquid chromatography-mass *** analysis revealed 47 differentially expressed proteins in the GDM group,with retinol-binding protein 4 and angiopoietin-like 8 showing significantly elevated serum levels compared to *** these findings are promising,the study is limited by its small sample size(n=4 per group)and lacks essential details on the reproducibility and reliability of the protein quantification methods ***,the absence of experimental validation weakens the interpretation of the protein-protein interaction network identified through bioinformatics *** study's focus on second-trimester biomarkers raises concerns about whether this is a sufficiently early period to implement preventive interventions for *** GDM risk during the first trimester or pre-conceptional period may offer more clinical *** its limitations,the study presents valuable insights into potential GDM biomarkers,but larger,well-validated studies are needed to establish their predictive utility and generalizability.

关键词： Gestational diabetes mellitus Biomarkers Differentially expressed proteins Retinol-binding protein 4 Angiopoietin-like 8 Proteomics Lifestyle interventions Early prediction

Energy consumption pattern and indoor thermal environment of residential building in rural China

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Energy and Built Environment 2020年第3期1卷 327-336页

作者： Baiyi Li Liyao You Min Zheng Yao Wang Ziguang Wang Faculty of architecture Southwest Jiaotong UniversitySichuanChina Chengdu Shude High School SichuanChina Sichuan institute of building research SichuanChina

With the continuous deepening of China’s rural construction and development,people’s living conditions are improved day by day,while accompanied by energy and environment crisis *** paper mainly analyzes the energy consumption pattern and the indoor environment of rural households in China and discusses the energy-saving optimization strategies for improving the thermal environment of *** surveys and field surveys were conducted in three villages in Guanghan,*** measurement results show that the annual indoor temperature range of the region in the summer is 15-31℃and the relative humidity range is 34%-96%.The average indoor temperatures in summer and winter are 28℃and 16℃*** indoor thermal environment of rural buildings is usually poor and cannot meet the requirements of Chinese *** the same time,the architectural design and energy consumption pattern of rural households are different from those in urban areas as countryside has unique ***,we put forward certain energy-saving improvement measures at the end of the article.

关键词： Rural residential building Energy Indoor thermal environment Hot summer and cold winter zone China

Restless head syndrome:A retrospective study

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World Journal of Methodology 2025年第1期15卷 51-59页

作者： Sanjay Prakash Varoon Vadodaria Niraj Chawda Chetsi S Shah Anurag Prakash Department of Neurology Smt.B.K.Shah Medical Institute and Research CentreSumandeep VidyapeethVadodara 391760GujarātIndia Department of Medicine Smt.B.K.Shah Medical Institute and Research CentreSumandeep VidyapeethVadodara 391760GujarātIndia Department of Medicine Parul Institute of Medical Sciences and Research CentreParul University WaghodiaVadodara 391760India

BACKGROUND Restless legs syndrome(RLS)is characterized by an urge to move with an unpleasant sensation in the lower *** typically affects the ***,it can also affect several other body regions,such as the arms,abdomen,face,neck,head,and genital *** are only a few reports of the RLS variant affecting the *** To assess the epidemiological,clinical,and other aspects of the RLS variant affecting the *** We conducted a retrospective study of 17 adult patients(>18 years)who met the RLS criteria and simultaneously experienced RLS-like symptoms in the *** The median age at which symptoms appeared was 41.6 *** and females were equally affected(1.1:1).All 17 patients had uncomfortable sensations in the lower *** or disturbed sleep was the most common comorbidity(n=16,88.2%).However,headache was the most common presenting or primary symptom(n=10,70.5%).Dizziness or an abnormal sensation in the head was the second most common presenting symptom(5 patients,29.4%).Other presenting features were leg pain,backache,and generalized body *** patients responded favorably to dopaminergic *** If RLS-related unpleasant sensations and pain are felt in the head,they may be misinterpreted as headache,dizziness,or psychosomatic *** and headaches in a subset of patients may be two phenotypic manifestations of the same disorder.

关键词： Restless legs syndrome Restless head syndrome Dopamine Headache Migraine Tension-type headache

Efficient photocatalytic reduction of CO2 to formate by a molecular noble metal-free system

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Science China Chemistry 2025年第1期 152-156页

作者： Lihua Zhang Lingjing Chen Huatian Shi Yue Wei Gui Chen Tai-Chu Lau School of Environment and Civil Engineering Research Center for Eco-environmental Engineering Dongguan University of Technology Department of Chemistry and institute of Molecular Functional Materials City University of Hong Kong

Reducing CO2to carbon-neutral solar fuels can not only alleviate the energy demand but also mitigate the greenhouse *** present,developing an efficient non-noble metal photo/electrocatalytic system for converting CO2to a specific product beyond CO is still a big ***,we report a new cobalt complex bearing 2,2′-bi-1,10-phenanthroline ligand that can photocatalytically reduce CO2to formate （HCOO-）.Turnover number （TON） for HCOO-up to 677 with 99%selectivity can be achieved using organic dyes purpurin as photosensitizer and 1,3-dimethyl-2-phenyl-2,3-dihydro-1H-benzo[d]imidazole （BIH） as sacrificial reductant in a CO2-saturated NMP/TEA （v/v,3:1） solution under visible light *** potential electrolysis at-1.41 V （***/Ag Cl） in the presence of 12 m M Et3NHBF4also produced HCOO-with Faradaic efficiency of 39%.Spectroscopic and electrochemical studies suggest that a[CoI-H]species is the key intermediate for CO2reduction.

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Peficitinib suppresses diffuse-type tenosynovial giant cell tumor by targeting TYK2 and JAK/STAT signaling

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Science China Life Sciences 2025年

作者： Shan Lu Chenxi Cao Wenjia Zhang Jiayi Li Jingli Yang Zisheng Huang Zhijun Wu Baitao Liu Hongjie Huang Haijun Wang Yongjian Wang Dingge Liu Zhihua Zhang Kaiping Liu Gang Yang Xi Gong Hui Dai Yingjia Li Erdan Dong Xin Zhang Yan Zhang Haihe Laboratory of Cell Ecosystem institute of Cardiovascular Diseases The First Affiliated Hospital of Dalian Medical University institute of Cardiovascular Sciences School of Basic Medical Sciences Peking University Health Science Center Department of Cardiology and Institute of Vascular Medicine Peking University Third HospitalState Key Laboratory of Vascular Homeostasis and Remodeling Peking University Department of Sports Medicine Peking University Third Hospital Institute of Sports Medicine of Peking University Beijing Key Laboratory of Sports Injuries Engineering research Center of Sports Trauma Treatment Technology and Devices Ministry of Education State Key Laboratory of Membrane Biology Institute of Molecular Medicine College of Future Technology Peking University Peking University Health Science Centre Peking University Department of Immunology School of Basic Medical Sciences NHC Key Laboratory of Medical Immunology Peking University research Center for Cardiopulmonary Rehabilitation University of Health and Rehabilitation Sciences Qingdao Hospital (Qingdao Municipal Hospital) School of Health and Life Sciences University of Health and Rehabilitation Sciences research Unit of Medical Science research Management/Basic and Clinical research of Metabolic Cardiovascular Diseases Chinese Academy of Medical Sciences

Diffuse-type tenosynovial giant cell tumor(dTGCT) is a destructive but rare benign proliferative synovial neoplasm. Although surgery is currently the main treatment modality for dTGCT, the recurrence risk is up to 50%. Therefore, there is a great need for effective drugs against dTGCT with minor side effects. The Janus kinase(JAK)/signal transducer and activator of transcription(STAT) signaling plays a central role in rheumatoid arthritis(RA), a disease with similar characteristics as dTGCT, but its function in dTGCT remains *** fibroblast-like synoviocytes(FLS) and macrophages were isolated from 10 synovial tissue samples from dTGCT patients for the screening and validation of the five clinically approved JAK inhibitors to treat RA against dTGCT. Cell viability, cell death, inflammation and the activity of the JAK family members of cultured dTGCT FLS(both 2-D and 3-D) and macrophages were investigated for the efficacy of the JAK inhibitors. Here, we found that similar to RA, JAK/STAT signaling was markedly activated in the dTGCT synovium. Of the 5 JAK inhibitors, peficitinib was shown to have the most potency in addressing some of the pathological responses of dTGCT FLS and *** potency of peficitinib was much higher than pexidartinib, which is the only FDA-approved drug for dTGCT. Mechanistically, peficitinib inhibited tyrosine kinase 2(TYK2), a JAK family member necessary for the pathological progression of dTGCT FLS and macrophages. In summary, we not only revealed JAK/STAT(especially TYK2) signaling as the major mechanism underlying dTGCT, but also identified peficitinib as a promising drug against dTGCT.

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Quantitative crack evaluation in slender reinforced concrete walls with rectangular section

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Resilient Cities and Structures 2024年第4期3卷 1-20页

作者： Priyana Rajbhandari Chanipa Netrattana Taku Obara Kono Susumu Department of architecture and building Engineering Tokyo Institute of TechnologyJapan National institute for Land and Infrastructure Management Ministry of LandInfrastructureTransportand TourismJapan institute of Innovative research Tokyo Institute of TechnologyJapan

Past earthquakes have shown that cracking affects post-earthquake functionality and accounted for huge repair costs for reinforced concrete(RC)wall buildings,even though the code-compliant seismic design prevents *** should know the maximum residual flexural crack width and volume of repair material needed for the flexural cracks to determine the damage degree and the repair *** paper presents the experimental campaign on four RC slender walls that investigated the effect of confining reinforcement and thickness of the wall on flexural crack parameters under quasi-static reversed cyclic *** width of all flexural cracks was measured when reaching each cycle peak drift and when unloading to zero lateral *** widths at peak and residual states increased with increasing peak *** on the experimental observations,it was found that the maximum residual crack width is obtained as a simple function of the extreme tension fiber elongation of the wall tensile fiber within±30%*** addition,this paper outlines methods to calculate the volume of repair material for flexural cracks from the extreme tension fiber elongation of the *** the funda-mental rules found from the experiment in this paper,it will become possible to obtain the maximum crack width and the volume of repair material from simple numerical analysis tools such as a multi-spring line element model.

关键词： Flexural crack Residual crack RC wall Damage evaluation Crack width Crack length

The Pathways toward Carbon Peak and Carbon Neutrality in China's building Sector

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Chinese Journal of Urban and Environmental Studies 2022年第2期10卷 57-69页

作者： GUO Siyue JIANG Yi HU Shan institute of Energy Environment and Economy Tsinghua University building Energy research Center School of Architecture Tsinghua University

Achieving carbon peaking and carbon neutrality in the building sector is an important component of China’s "dual carbon" *** recent years,the country’s direct carbon emissions in the building sector have hit a plateau while the total emissions still grow ***,the building materials for construction and refrigerants leaked during buildings’ operation also result in greenhouse gas *** achieve the targets set for future low-carbon development,the building sector should feature sufficient demand,decarbonized structure and flexible load." According to the analysis of the emission reduction approaches adopted by different sectors,China’s building sector should make a ceaseless effort to promote building energy conservation,improve electrification,and load flexibility,reform the energy system in rural areas,optimize the heating structure in northern China’s urban areas,as well as reduce the emissions during construction and the non-CO2gas *** the 14th Five-Year period,it is suggested to clarify the total energy consumption and carbon emission targets,adjust the energy structure more vigorously,and draw up more measures to reduce the emissions related to construction and refrigerant leakage.

关键词： Carbon peaking carbon neutrality the building sector

Identifying the dynamic behaviors in complete reconstruction of Co-based complex precatalysts during electrocatalytic oxygen evolution

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Journal of Energy Chemistry 2025年第1期100卷 226-233页

作者： Jingfang Zhang Danyang Wu Linke Cai Youluan Lu Fanpeng Cheng Lijuan Shi Qun Yi Yao Liu Yi Huang Key Laboratory of Green Chemical Engineering Process of Ministry of Education Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education Hubei Key Laboratory of Novel Reactor and Green Chemical Technology School of Chemical Engineering & Pharmacy Wuhan Institute of Technology Key Laboratory of Pesticide & Chemical Biology of Ministry of Education Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction of Ministry of Education College of Chemistry Central China Normal University College of Materials Science and Engineering Fuzhou University

Transition metal-based nanomaterials have emerged as promising electrocatalysts for oxygen evolution reaction（OER）. Considerable research efforts have shown that self-reconstruction occurs on these nanomaterials under operating conditions of OER process. However, most of them undergo incomplete reconstruction with limited thickness of reconstruction layer, leading to low component utilization and arduous exploration of real catalytic mechanism. Herein, we identify the dynamic behaviors in complete reconstruction of Co-based complexes during OER. The hollow phytic acid（PA） cross-linked CoFe-based complex nanoboxes with porous nanowalls are designed because of their good electrolyte penetration and mass transport ability, in favor of the fast and complete reconstruction. A series of experiment characterizations demonstrate that the reconstruction process includes the fast substitution of PA by OH-to form Co（Fe）(OH)xand subsequent potential-driven oxidation to Co（Fe）OOH. The obtained CoFeOOH delivers a low overpotential of 290 mV at a current density of 10 mA cm-2and a long-term *** experiment results together with theory calculations reveal that the Fe incorporation can result in the electron rearrangement of reconstructed CoFeOOH and optimization of their electronic structure,accounting for the enhanced OER activity. The work provides new insights into complete reconstruction of metal-based complexes during OER and offers guidelines for rational design of high-performance electrocatalysts.

关键词： Oxygen evolution reaction