检索结果-南通市图书馆

Remote-controlled dexamethasone-duration on eye-surface with a micelle-magnetic nanoparticulate co-delivery system for dry eye disease

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第8期14卷 3730-3745页

作者： Qinxiang Zheng Chaoxiang Ge Kexin Li Longxin Wang Xiaoyu Xia Xiao Liu Rashid Mehmood Jianliang Shen Kaihui Nan Wei Chen Sen Lin National Engineering Research Center of Ophthalmology and Optometry Eye HospitalWenzhou Medical UniversityWenzhou 325027China National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027China Zhejiang Engineering Research Center for Tissue Repair Materials Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325000China School of Chemical Engineering UNSW SydneyHigh StreetBuilding E10KensingtonNSW 2052Australia Adult Cancer Program Lowy Cancer Research CentreUNSW SydneyCorner Botany&High StreetsKensingtonNSW 2052Australia

Dexamethasone(DEX)is used to treat ocular surface ***,regulating DEX duration in tears while preventing its absorption into the anterior chamber is critical for balancing its therapy effects and the side *** this study,a novel magnetic nanoparticle(MNP)-micelle(MC)codelivery system(MMDS)was *** MC moiety in the MMDS served as the carrier for DEX and the MNP part endowed the MMDS with magnetic-responsive *** extend its residency,the MMDS was magnetically attracted by an external magnet after instilling,which acted as a precorneal drug-depot enabling a sustainable release of DEX in *** combination of magnet treatment,the topical instillation of MMDS@DEX significantly prolonged the DEX-retention in tears and increased the DEX-concentration in the cornea and conjunctiva,as well as concurrently reduced the DEX-level in the aqueous humor,when compared with the commercial DEX eye drop *** combination of MMDS@DEX and magnet treatment exerted significantly better therapeutic effects against DED with smaller side effects than conventional treatments including DEX suspension,commercial DEX eye drops,as well as the MMDS@DEX treatment *** present work provided a new method for the effective delivery of DEX to ocular surface tissues while reducing its side effects,which will be beneficial to the treatments of a wide range of ocular surface diseases.

关键词： Magnetic nanoparticle Micelle Dexamethasone eye drop Bioavailability Dry eye disease Cornea Conjunctiva

Fabrication of a 3D bioprinting model for posterior capsule opacification using GelMA and PLMA hydrogel-coated resin

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Regenerative Biomaterials 2024年第4期3卷 52-65页

作者： Xin Liu Jiale Li Shuyu Liu Yan Long Ching Kang Chen Zhao Ling Wei Shaoqi Huang Yi Luo Bo Dai Xiangjia Zhu Cataract and Lens Refractive Surgery Group Department of OphthalmologyEye&ENT Hospital of Fudan UniversityShanghai 200031People’s Republic of China NHC Key Laboratory of Myopia Key Laboratory of MyopiaChinese Academy of Medical SciencesFudan UniversityShanghai 200031People’s Republic of China Shanghai Key Laboratory of Visual Impairment and Restoration Shanghai 200031People’s Republic of China Engineering Research Center of Optical Instrument and system the Ministry of EducationShanghai Key Laboratory of Modern Optical SystemUniversity of Shanghai for Science and TechnologyShanghai 200093China

Posterior capsule opacification(PCO)remains the predominant complication following cataract surgery,significantly impairing visual function *** this study,we developed a PCO model that closely mimics the anatomical structure of the crystalline lens capsule *** model incorporated a threaded structure for accurate positioning and observation,allowing for opening and *** 3D printing technology,a stable external support system was created using resin material consisting of a rigid,hollow base and *** replicate the lens capsule structure,a thin hydrogel coating was applied to the resin *** biocompatibility and impact on cellular functionality of various hydrogel compositions were assessed through an array of staining techniques,including calcein-AM/PI staining,rhodamine staining,BODIPY-C11 staining and EdU staining in conjunction with transwell ***,the PCO model was utilized to investigate the effects of eight drugs with anti-inflammatory and anti-proliferative properties,including 5-aminoimidazole-4-carboxamide ribonucleotide(AICAR),THZ1,sorbinil,4-octyl itaconate(4-OI),xanthohumol,zebularine,rapamycin and caffeic acid phenethyl ester,on human lens epithelial cells(HLECs).Confocal microscopy facilitated comprehensive imaging of the PCO *** results demonstrated that the GelMA 605%þPLMA 2%composite hydrogel exhibited superior biocompatibility and minimal lipid peroxidation levels among the tested ***,compared to using hydrogel as the material for 3D printing the entire model,applying surface hydrogel spin coating with parameters of 2000 rpm�2 on the resin-based 3D printed base yielded a more uniform cell distribution and reduced ***,rapamycin,4-OI and AICAR demonstrated potent antiproliferative effects in the drug intervention *** microscopy imaging revealed a uniform distribution of HLECs along the anatomical structure of the crystalline lens capsule with

关键词： posterior capsule opacification(PCO) human lens epithelial cells(HLECs) 3D bioprinting hydrogel resin

Bibliometric analysis of hotspots and trends of global myopia research

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2024年第5期17卷 940-950页

作者： Xing-Yang Wu Hui-Hui Fang Yan-Wu Xu Yan-Ling Zhang Shao-Chong Zhang Wei-Hua Yang Shenzhen eye Institute Shenzhen Eye HospitalJinan UniversityShenzhen 518040Guangdong ProvinceChina School of Future Technology South China University of TechnologyGuangzhou 510641Guangdong ProvinceChina

AIM:To gain insights into the global research hotspots and trends of ***:Articles were downloaded from January 1,2013 to December 31,2022 from the Science Core Database website and were mainly statistically analyzed by bibliometrics ***:A total of 444 institutions in 87 countries published 4124 *** 2013 and 2022,China had the highest number of publications(n=1865)and the highest H-index(61).Sun Yat-sen University had the highest number of publications(n=229)and the highest H-index(33).Ophthalmology is the main category in related *** from 2020 to 2022 highlight keywords of options and reference,child health(pediatrics),myopic traction mechanism,public health,and machine learning,which represent research ***:Myopia has become a hot research *** and Chinese institutions have the strongest academic influence in the field from 2013 to *** main driver of myopic research is still medical or *** study highlights the importance of public health in addressing the global rise in myopia,especially its impact on children’s *** present,a unified theoretical system is still *** surgical and therapeutic solutions must be proposed for people with different characteristics to manage and intervene refractive *** addition,the benefits of artificial intelligence(AI)models are also reflected in disease monitoring and prediction.

关键词： bibliometric analysis myopia global trends

Multi-class classification of pathological myopia based on fundus photography

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Innovative Optical Health Sciences 2024年第6期17卷 125-136页

作者： Jiaqing Zhao Guogang Cao Jiangnan He Cuixia Dai Shanghai Institute of Technology No.100 Haiquan RoadFengxian DistrictShanghaiP.R.China Shanghai eye Diseases Prevention&Treatment Center Shanghai Eye HospitalSchool of MedicineTongji UniversityShanghai 200331P.R.China

Pathological myopia(PM)is a severe ocular disease leading to *** a traditional noninvasive diagnostic method,fundus color photography(FCP)is widely used in detecting PM due to its highfidelity and ***,manual examination of fundus photographs for PM is time-consuming and prone to high error *** automated detection technologies have yet to study the detailed classification in diagnosing different stages of PM *** this paper,we proposed an intelligent system which utilized Resnet101 technology to multi-categorically diagnose PM by classifying FCPs with different stages of *** system subdivided different stages of PM into eight subcategories,aiming to enhance the precision and e±ciency of the diagnostic *** achieved an average accuracy rate of 98.86%in detection of PM,with an area under the curve(AUC)of 98.96%.For the eight subcategories of PM,the detection accuracy reached 99.63%,with an AUC of 99.98%.Compared with other widely used multi-class models such as VGG16,Vision Transformer(VIT),E±cientNet,this system demonstrates higher accuracy and *** artificial intelligence system is designed to be easily integrated into existing clinical diagnostic tools,providing an e±cient solution for large-scale PM screening.

关键词： Fundus color photography pathological myopia deep learning Resnet101.

Utility of real-time 3D visualization system in the early stage of phacoemulsification training

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2024年第3期17卷 577-582页

作者： Zhe Xu Dan Chen Jing-Wei Xu Yi-Xuan Feng Ce Shi Li Zhang Wen Xu eye Center the Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009Zhejiang ProvinceChina Zhejiang Provincial Key Laboratory of Ophthalmology Hangzhou 310009Zhejiang ProvinceChina Zhejiang Provincial Clinical Research Center for eye Diseases Hangzhou 310009Zhejiang ProvinceChina Zhejiang Provincial Engineering Institute on eye Diseases Hangzhou 310009Zhejiang ProvinceChina

●AIM:To determine the teaching effects of a real-time three dimensional(3D)visualization system in the operating room for early-stage phacoemulsification training.●METHODS:A total of 10 ophthalmology residents of the first-year postgraduate were *** the residents were novices to cataract ***-time cataract surgical observations were performed using a custom-built 3D visualization *** training lasted 4wk(32h)in all.A modified International Council of Ophthalmology’s Ophthalmology Surgical Competency Assessment Rubric(ICO-OSCAR)containing 4 specific steps of cataract surgery was *** self-assessment(self)and expert-assessment(expert)were performed through the microsurgical attempts in the wet lab for each participant.●RESULTS:Compared with pre-training assessments(self 3.2±0.8,expert 2.5±0.6),the overall mean scores of posttraining(self 5.2±0.4,expert 4.7±0.6)were significantly improved after real-time observation training of 3D visualization system(P<0.05).Scores of 4 surgical items were significantly improved both self and expert assessment after training(P<0.05).●CONCLUSION:The 3D observation training provides novice ophthalmic residents with a better understanding of intraocular microsurgical *** is a useful tool to improve teaching efficiency of surgical education.

关键词： 3D visualization system phacoemulsification training wet lab

Repeatability and reproducibility of corneal higher-order aberrations measurements after small incision lenticule extraction using the Scheimpfug-Placido topographer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

eye and Vision 2024年第1期10卷 1-9页

作者： Rui Ning Rongrong Gao David PPiñero Jun Zhang Qingyi Gao Yili Jin Yiran Wang Chenxiao Wang Jinhai Huang eye Hospital and School of Ophthalmology and Optometry Wenzhou Medical UniversityWenzhouZhejiangChina eye Institute and Department of Ophthalmology Eye and ENT HospitalFudan UniversityShanghaiChina Group of Optics and Visual Perception Department of OpticsPharmacology and AnatomyUniversity of AlicanteAlicanteSpain NHC Key Laboratory of Myopia(Fudan University) Key Laboratory of MyopiaChinese Academy of Medical SciencesShanghaiChina Shanghai Research Center of Ophthalmology and Optometry ShanghaiChina

Background:To evaluate the precision of corneal higher-order aberrations measurements after small incision lenticule extraction(SMILE)using the Sirius Scheimpfug-Placido topographer(CSO,Italy).Methods:Seventy-fve eyes from 75 postoperative subjects were included in this prospective *** consecutive corneal aberrometric measurements were obtained with the Scheimpfug-Placido topographer by two experienced operators to assess intra-and inter-observer *** within-subject standard deviation(Sw),test-retest repeatability(TRT)and the intraclass correlation coefcient(ICC)were ***:For intraobserver repeatability of anterior and total corneal aberrations,all ICCs were more than 0.922,except for trefoil(0.722 to 0.768).The ICCs of total root mean square(RMS),coma Z(3,±1),and spherical aberration Z(4,0)were over 0.810 while higher-order RMS,trefoil Z(3,±3),and astigmatism II Z(4,±2)were below 0.634 for posterior corneal surface *** Sw values for all types of aberrations were equal to or below 0.07μ*** interobserver reproducibility,all TRT values were no more than 0.12μm,0.05μm,and 0.11μm for anterior,posterior,and total corneal aberrations,*** ICC values ranged from 0.875 to 0.989,from 0.686 to 0.976 and over 0.834 for anterior,posterior,and total corneal aberrations,***:The repeatability of measurements of anterior and total corneal aberrations with the Sirius system in corneas after SMILE surgery was high,except for *** was some variability in posterior corneal aberrometric *** reproducibility of corneal aberrometric measurements was observed between measurements of both examiners,except for trefoil,with poor to moderate reproducibility.

关键词： Sirius Higher-order aberrations Repeatability Reproducibility Small incision lenticule extraction

Recent advances in ocular lubrication

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Friction 2024年第9期12卷 1929-1954页

作者： Jianhua ZHANG Yunjuan SU Jian WU Hongdong WANG School of Mechatronic Engineering and Automation and Key Laboratory of Advanced Display and system Application Ministry of EducationShanghai UniversityShanghai 200444China

The ocular lubrication,where the eyelid constantly slides on the curved corneal surface,is considered as one of primary lubrication systems in *** reliable lubrication conditions,sensitive ocular tissues remain intact from fatigue damage during spontaneous blink *** tear film,evenly filled between cornea and conjunctiva,is a biological fluid with dynamic adjustment ability,which provides superior lubrication with the friction coefficient of below ***,the lubrication failure may result in a variety of uncomfortable symptoms such as inflammatory reactions,tissue damage and neurological ***,it is essential to clarify the fundamental mechanism of ocular lubrication,which helps to alleviate and even recover from various ocular *** review firstly demonstrates that the ocular components,containing lipids and mucins,contribute to maintaining the lubrication stability of tear ***,the ocular lubrication state in various physiological environments and the physical effect on tear film dynamics are further *** typical applications,the therapeutic agents of dry eye syndrome and contact lens with superior lubrication effects are introduced and their lubrication mechanisms are ***,this review summarizes a series of the latest research inspired by ocular ***,this work will provide a valuable guidance on the theoretical research and extensive applications in the field of biological lubrication.

关键词： bio-tribology ocular lubrication tear film dry eye syndrome tear film dynamics

Targeting Nrf2 signaling in dry eye

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2024年第10期17卷 1911-1920页

作者： Yu-Nuo Zhang Wei-Jie Ouyang Jiao-Yue Hu Zu-Guo Liu Xiamen University Affiliated Xiamen eye Center Fujian Provincial Key Laboratory of Ophthalmology and Visual ScienceFujian Engineering and Research Center of Eye Regenerative MedicineEye Institute of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361005Fujian ProvinceChina Department of Ophthalmology the First Affiliated Hospital of University of South ChinaHengyang 421001Hunan ProvinceChina Department of Ophthalmology Xiang’an Hospital of Xiamen UniversityXiamen 361005Fujian ProvinceChina

Dry eye,the most common ocular surface disease,can cause ocular surface tissue damage and discomfort symptoms and seriously affect people’s quality of *** etiology of dry eye is diverse,and its pathogenesis is *** oxidative stress reaction is considered to be among the important factors in the pathogenesis of dry ***,activating the antioxidant system has a potential therapeutic effect on dry *** factor erythroid 2-related factor 2(Nrf2)signaling pathway is considered the most important antioxidant pathway in the *** activation of the Nrf2 signaling pathway and its interaction with other pathways are important mechanisms to prevent the occurrence and development of dry *** review describes the structure and function of Nrf2,summarizes the changes in the oxidative stress response in dry eye,focuses on the potential mechanism of the Nrf2 signaling pathway in the treatment of dry eye,and,finally,summarizes the drugs that activate the Nrf2 signaling pathway in the treatment of dry eye.

关键词： nuclear factor erythroid 2-related factor 2 Keap1 dry eye oxidative stress

Effect of low-degree astigmatism on the objective visual quality

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2024年第6期17卷 1086-1093页

作者： Ling-Ying Ye Shu-Feng Li Jing-Jing Zuo Jin Li Hui-Xiang Ma National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To evaluate the effect of low-degree astigmatism on objective visual quality through the Optical Quality Analysis system(OQAS).METHODS:This study enrolled 46 participants(aged 23 to 30y,90 eyes)with normal or corrected-to-normal *** cylindrical lenses(0,0.5,0.75,1.0,and 1.25 D)were placed at the axial direction(180°,45°,90°,and 135°)in front of the eyes with the best correction to form 16 types of regular low-degree *** was used to detect the objective visual quality,recorded as the objective scattering index(OSI),OQAS values at contrasts of 100%,20%,and 9%predictive visual acuity(OV100%,OV20%,and OV9%),modulation transfer function cut-off(MTFcut-off)and Strehl ratio(SR).The mixed effect linear model was used to compare objective visual quality differences between groups and examine associations between astigmatic magnitude and objective visual quality ***:Apparent negative relationships between the magnitude of low astigmatism and objective visual quality were *** increase of OSI per degree of astigmatism at 180°,45°,90°,and 135°axis were 0.38(95%CI:0.35,0.42),0.50(95%CI:0.46,0.53),0.49(95%CI:0.45,0.54)and 0.37(95%CI:0.34,0.41),*** decrease of MTFcut-off per degree of astigmatism at 180°,45°,90°,and 135°axis were-10.30(95%CI:-11.43,-9.16),-12.73(95%CI:-13.62,-11.86),-12.75(95%CI:-13.79,-11.70),and-9.97(95%CI:-10.92,-9.03),*** the same astigmatism degree,OSI at 45°and 90°axis were higher than that at 0°and 135°axis,while MTFcut-off were ***:Low astigmatism of only 0.50 D can significantly reduce the objective visual quality.

关键词： low-degree astigmatism objective visual quality Optical Quality Analysis system