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Epidural oscillating field stimulation increases axonal regenerative capacity and myelination after spinal cord trauma

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Neural Regeneration research 2022年第12期17卷 2730-2736页

作者： Maria Bacova Katarina Bimbova Alexandra Kisucka Nadezda Lukacova Jan Galik Institute of Neurobiology of biomedical research center Slovak Academy of SciencesSoltesovejKosiceSlovak Republic

Oscillating field stimulation(OFS)with regular alterations in the polarity of electric current is a unique,experimental approach to stimulate,support,and potentially guide the outgrowth of both sensory and motor nerve fibers after spinal cord injury(SCI).In previous experiments,we demonstrated the beneficial effects of OFS in a 4-week survival period after SCI.In this study,we observed the major behavioral,morphological,and protein changes in rats after 15 minutes of T9 spinal compression with a 40 g force,followed by long-lasting OFS(50μA),over a 8-week survival period.Three groups of rats were analyzed:rats after T9 spinal compression(SCI group);SCI rats subjected to implantation of active oscillating field stimulator(OFS+SCI group);and SCI rats subjected to nonfunctional OFS(nOFS+SCI group).Histopathological analysis of spinal tissue indicated a strong impact of epidural OFS on the reduction of tissue and myelin loss after SCI in the segments adjacent to the lesion site.Quantitative fluorescent analysis of the most affected areas of spinal cord tissue revealed a higher number of spared axons and oligodendrocytes of rats in the OFS+SCI group,compared with rats in the SCI and nOFS+SCI groups.The protein levels of neurofilaments(NF-l),growth-associated protein-43(marker for newly sprouted axons),and myelin basic protein in rats were signifiantly increased in the OFS+SCI group than in the nOFS+SCI and SCI groups.This suggests a supporting role of the OFS in axonal and myelin regeneration after SCI.Moreover,rats in the OFS+SCI group showed great improvements in sensory and motor functions than did rats in the nOFS+SCI and SCI groups.All these findings suggest that long-lasting OFS applied immediately after SCI can provide a good microenviroment for recovery of damaged spinal tissue by triggering regenreative processes in the acute phase of injury.

关键词： axonal regenerative capacity behavioral assessment epidural stimulation motor recovery myelin regeneration oscillating field stimulation spinal cord injury

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Structure for energy cycle: a unique status of the second law of thermodynamics for living systems

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Science China(Life Sciences) 2018年第10期61卷 1266-1273页

作者： Shunong Bai Hao Ge Hong Qian State Key Laboratory of Protein and Plant Gene research College of Life Sciences Center for Quantitative Biology Peking University Beijing International center for Mathematical research (BICMR) and biomedical Pioneering Innovation center (BIOPIC) Peking University Department of applied Mathematics University of Washington

Distinguishing things from beings, or matters from lives, is a fundamental question. Extending E. Schr?dinger's neg-entropy and I. Prigogine's dissipative structure, we propose a chemical kinetic view that the earliest "live" process is embedded essentially in a special interaction between a pair of specific components under a particular, corresponding environmental conditions. The interaction exists as an inter-molecular-force-bond complex(IMFBC) that couples two separate chemical processes: one is the spontaneous formation of the IMFBC driven by a decrease of Gibbs free energy as a dissipative process; while the other is the disassembly of the IMFBC driven thermodynamically by free energy input from the environment. The two chemical processes coupled by the IMFBC originated independently and were considered non-living on Earth, but the IMFBC coupling of the two can be considered as the earliest form of metabolism: the first landmark on the path from things to a being. The dynamic formation and disassembly of the IMFBC, as a composite individual, follows a principle designated as "… structure for energy for structure for energy…", the cycle continues; and for short it will be referred to as "structure for energy cycle". With additional features derived from this starting point, the IMFBC-centered "live" process spontaneously evolved into more complex living organisms with the characteristics currently known.

关键词：热力学精力结构生活周期法律系统化学过程

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Evaluation of co-metabolic removal of trichloroethylene in a biotrickling filter under acidic conditions

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Journal of Environmental Sciences 2017年第7期29卷 54-61页

作者： Dhawal Chheda George A.Sorial Department of biomedical Chemicaland Environmental EngineeringCollege of Engineering and Applied ScienceUniversity of Cincinnati701 Engineering Research Center2901 Woodside DriveCincinnatiOH 45221-0012USA

This study investigated the removal of hydrophobic trichloroethylene（TCE） in the presence of methanol（co-metabolite） in a biotrickling filter,which was seeded with fungi at pH 4.Starvation was chosen as the biomass control strategy.Two systems,Biofilter I（methanol：TCE 70：30） and Biofilter II（methanol：TCE 80：20） were run in parallel,each with varying composition ratios.The TCE loading rates for both biofilters ranged from 3.22 to 12.88 g/m^3/hr.Depending on the ratio,methanol concentrations varied from 4.08 to 27.95 g/m^3/hr.The performance of the systems was evaluated and compared by calculating removal kinetics,carbon mass balance,efficiencies and elimination capacities.Methanol was observed to enhance TCE removal during the initial loading rate.However,methanol later inhibited TCE degradation above 6.44 g TCE/m^3/hr（Biofilter I） and 3.22 g TCE/m^3/hr（Biofilter II）.Conversely,TCE did not impede methanol removal because over 95% methanol elimination was consistently achieved.Overall,Biofilter I was able to outperform Biofilter II due to its greater resistance towards methanol competition.

关键词： Biofiltration Biotrickling Filter Fungi Methanol Trichloroethylene

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A review: Systematic research approach on toxicity model of liver and kidney in laboratory animals

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Animal Models and Experimental Medicine 2022年第5期5卷 436-444页

作者： Abbasali Abbasnezhad Fatemeh Salami Reza Mohebbati Department of Physiology Faculty of MedicineGonabad University of Medical SciencesGonabadIran Department of Physiology Faculty of MedicineMashhad University of Medical SciencesMashhadIran Applied Biomedical Research Center Mashhad University of Medical SciencesMashhadIran

Therapeutic experiments are commonly performed on laboratory animals to inves-tigate the possible mechanism(s)of action of toxic agents as well as drugs or sub-stances under consideration.The use of toxins in laboratory animal models,including rats,is intended to cause toxicity.This study aimed to investigate different models of hepatotoxicity and nephrotoxicity in laboratory animals to help researchers advance their research goals.The current narrative review used databases such as Medline,Web of Science,Scopus,and Embase and appropriate keywords until June 2021.Nephrotoxicity and hepatotoxicity models derived from some toxic agents such as cisplatin,acetaminophen,doxorubicin,some anticancer drugs,and other materials through various signaling pathways are investigated.To understand the models of renal or hepatotoxicity in laboratory animals,we have provided a list of toxic agents and their toxicity procedures in this review.

关键词： animal drug toxicity drug-induced abnormality liver dysfunction renal injury

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Versatile Ti_(3)C_(2)T_(x)MXene for free-radical scavenging

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Nano research 2022年第3期15卷 2558-2566页

作者： Jiang Liu Wei Lu Xifeng Lu Lu Zhang Haifeng Dong Yingchun Li Flexible Printed Electronics Technology center and School of Science Harbin Institute of Technology(Shenzhen)Shenzhen 518055China Department of Physiology Health Science CenterShenzhen UniversityShenzhen 518055China Marshall Laboratory of biomedical Engineering Research Center for Biosensor and NanotheranosticSchool of Biomedical EngineeringShenzhen UniversityShenzhen 518055China

MXene,as an emerging two-dimensional(2D)material with ultrathin structure and fascinating physiochemical properties,has been widely explored in broad applications.Versatile functions of MXenes are continuously explored.This work presents distinctive feature of MXene-Ti_(3)C_(2)T_(x)nanosheets for free-radical(FRs)scavenging that never reported before.We demonstrated the mechanism and equation in regard to the reaction between Ti_(3)C_(2)T_(x)and H_(2)O_(2),which was applied to design colorimetric H_(2)O_(2)strip assay with good performance.The good FRs scavenging capability of Ti_(3)C_(2)T_(x),including a series of reactive oxygen species(ROS)and reactive nitrogen species(RNS),was systemically confirmed.The antioxidation capability of Ti_(3)C_(2)T_(x)for protecting cells from oxidative damage was demonstrated using the oxidative damage model of alpha mouse liver 12(AML-12)cells.This original work provides huge opportunities for MXenes in FR-related biomedical applications.

关键词： MXene hydrogen peroxide colorimetric sensor reactive oxygen species anti-oxidative damage

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biomedical Polymers--Escort for Human Health

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Chinese Journal of Polymer Science 2022年第9期40卷 1004-1005页

作者： Xue-Si Chen Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of Sciences School of applied Chemistry and Engineering University of Science and Technology of China Jilin biomedical Polymers Engineering Laboratory National and Local Joint Engineering research center for the Development and Application of Environmentally Friendly Polymer Materials

biomedical polymers are a kind of engineered materials used for disease diagnosis and treatment, tissue fixation,tissue or organ repair, or organ replacement to restore or enhance the related functions in humans.[1]biomedical polymers are the earliest developed and most widely used materials in biomedicine and continue to evolve as an essential frontier field of polymer science in the 21century.With the development of molecular biology, cell biology.

关键词： frontier aggregation evolve

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Prophylactic managements of hepatitis B viral infection inliver transplantation

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World Journal of Gastroenterology 2016年第1期22卷 165-175页

作者： Takashi Onoe Hiroyuki Tahara Yuka Tanaka Hideki Ohdan Division of applied Immunobiology Institute for Clinical ResearchNational Hospital OrganizationKure Medical Center/Chugoku Cancer CenterHiroshima 737-0023Japan Gastroenterological and Transplant Surgery Applied Life SciencesInstitute of Biomedical and Health SciencesHiroshima UniversityHiroshima 734-8551Japan

Liver transplantation(LT)is a considerably effective treatment for patients with end-stage hepatitis B virus(HBV)-related liver disease.However,HBV infection often recurs after LT without prophylaxis.Since the1990s,the treatment for preventing HBV reinfection after LT has greatly progressed with the introduction of hepatitis B immunoglobulin(HBIG)and nucleos(t)ide analogues(NAs),resulting in improved patient survival.The combination therapy consisting of high-dose HBIG and lamivudine is highly efficacious for preventing the recurrence of HBV infection after LT and became the standard prophylaxis for HBV recurrence.However,mainly due to the high cost of HBIG treatment,an alternative protocol for reducing the dose and duration of HBIG has been evaluated.Currently,combination therapy using low-dose HBIG and NAs is considered as the most efficacious and cost-effective prophylaxis for post-LT HBV reinfection.Recently,NA monotherapy and withdrawal of HBIG from combination therapy,along with the development of new,potent high genetic barrier NAs,have provided promising efficacy,especially for low-risk recipients.This review summarizes the prophylactic protocol and their efficacy including prophylaxis of de novo HBV infection from anti-HBc antibody-positive donors.In addition,challenging approaches such as discontinuation of all prophylaxis and active immunity through hepatitis B vaccination are discussed.

关键词： Liver transplantation Hepatitis B infection prophylaxis nucleos(t)ide analogue anti-hepatitis Bimmunoglobulin

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Emerging single-atom nanozymes for catalytic biomedical uses

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Nano research 2023年第12期16卷 13056-13076页

作者： Shuangfei Cai Wei Zhang Rong Yang CAS Key Laboratory for biomedical Effects of Nanomaterials and Nanosafety Center of Materials Science and Optoelectronics EngineeringCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyUniversity of Chinese Academy of SciencesBeijing 100190China Sino-Danish College Sino-Danish Center for Education and ResearchUniversity of Chinese Academy of SciencesBeijing 100049China Institute of applied Physics and Computational Mathematics Beijing 100088China

The past four years have witnessed booming progress in single-atom nanozymes(SANs),one of the newest generations of nanozymes with atomically dispersed metal sites for catalytic biomedical uses.They show distinct advantages over their nanoparticle-based counterparts,such as well-defined electronic/geometric structures and complete atomic utilization efficiency,thus offering opportunities to develop advanced nanozymes for practical uses.The atomically dispersed active centers in SANs could also facilitate the precise regulation of catalytic performance,while probing structure–activity relationship for in-depth understanding of mechanism.In this review,we first introduce the synthetic approaches,surface engineering,and characterization techniques of SANs.Subsequently,we discuss the enzyme-like properties of SANs,including some strategies for boosting their catalytic activities.Furthermore,we present their biomedical applications,ranging from biosensors,antibacterial uses,antioxidants,to therapeutics.Finally,the challenges and opportunities of SANs are prospected.

关键词： single atom metal nanozyme enzyme-like catalysis biomedical

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Development and accuracy of artificial intelligence-generated prediction of facial changes in orthodontic treatment:a scoping review

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第11期24卷 974-984页

作者： Jiajun ZHU Yuxin YANG Hai Ming WONG Stomatology Hospital School of StomatologyZhejiang University School of MedicineZhejiang Provincial Clinical Research Center for Oral DiseasesKey Laboratory of Oral Biomedical Research of Zhejiang ProvinceCancer Center of Zhejiang UniversityEngineering Research Center of Oral Biomaterials and Devices of Zhejiang ProvinceHangzhou310000China Faculty of Dentistry The University of Hong KongHong KongChina

Artificial intelligence(AI)has been utilized in soft-tissue analysis and prediction in orthodontic treatment planning,although its reliability has not been systematically assessed.This scoping review was conducted to outline the development of AI in terms of predicting soft-tissue changes after orthodontic treatment,as well as to comprehensively evaluate its prediction accuracy.Six electronic databases(PubMed,EBSCOhost,Web of Science,Embase,Cochrane Library,and Scopus)were searched up to March 14,2023.Clinical studies investigating the performance of AI-based systems in predicting post-orthodontic soft-tissue alterations were included.The Quality Assessment of Diagnostic Accuracy Studies-2(QUADAS-2)and Joanna Briggs Institute(JBI)appraisal checklist for diagnostic test accuracy studies were applied to assess risk of bias,while the Grading of Recommendation,Assessment,Development,and Evaluation(GRADE)assessment was conducted to evaluate the certainty of outcomes.After screening 2500 studies,four non-randomized clinical trials were finally included for full-text evaluation.We found a low level of evidence indicating an estimated high overall accuracy of AI-generated prediction,whereas the lower lip and chin seemed to be the least predictable regions.Furthermore,the facial morphology simulated by AI via the fusion of multimodality images was considered to be reasonably true.Since all of the included studies that were not randomized clinical trials(non-RCTs)showed a moderate to high risk of bias,more well-designed clinical trials with sufficient sample size are needed in future work.

关键词： Facial morphology Soft-tissue changes Artificial intelligence(AI) Orthodontic treatment

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Gum resin extract of Boswellia serrata attenuates lipopolysaccharide-induced inflammation and oxidative damage in hepatic and renal tissues of rats

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Asian Pacific Journal of Tropical Biomedicine 2022年第1期12卷 20-25页

作者： Narges Marefati Farimah Beheshti Poorya Etemadizadeh Mahmoud Hosseini Akbar Anaeigoudari Applied Biomedical Research Center Mashhad University of Medical SciencesMashhadIran Neuroscience research center Torbat Heydariyeh University of Medical SciencesTorbat HeydariyehIran Department of Physiology School of Paramedical SciencesTorbat Heydariyeh University of Medical SciencesTorbat HeydariyehIran Division of Neurocognitive Sciences Psychiatry and Behavioral Sciences Research CenterMashhad University of Medical SciencesMashhadIran Department of Physiology School of MedicineJiroft University of Medical SciencesJiroftIran

Objective:To explore the effect of ethyl acetate gum resin extract of Boswellia serrata on lipopolysaccharide(LPS)induced inflammation and oxidative damage in hepatic and renal tissues of rats.Methods:The rats were divided into four groups:control,LPS,LPS+Boswellia serrata extracts(100 mg/kg and 200 mg/kg).LPS(1 mg/kg)and the extract(100 and 200 mg/kg,30 min before LPS)were administered intraperitoneally for 3 weeks.The levels of liver enzymes,albumin,total protein,creatinine,blood urea nitrogen(BUN),interleukin(IL)-6,malondialdehyde(MDA),and total thiol groups and superoxide dismutase(SOD)and catalase(CAT)activities were measured.Results:The levels of liver enzymes,creatinine,and BUN,IL-6,MDA in the LPS group were markedly increased(P<0.001)while albumin,total protein,and total thiol concentration,as well as SOD and CAT activities,were decreased compared with the control group(P<0.05 or 0.01).Boswellia serrata extracts diminished the levels of liver enzymes,creatinine,BUN,IL-6,and MDA(P<0.01 and P<0.001),and elevated the concentration of total protein and total thiol and SOD and CAT activities(P<0.05 or 0.01).Conclusions:The ethyl acetate gum resin extract of Boswellia serrata reduces LPS-induced inflammatory reactions and oxidative damage,thus ameliorating hepatic and renal function.

关键词： Boswellia serrata Lipopolysaccharide Inflammation Oxidative stress Renal function Hepatic function

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