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Journal of Computer and Communications 2020年第11期8卷 130-144页

作者： Krunoslav Ris Zeljko Stankovic Zoran Avramovic Information Systems in Communication and Logistic Pan-European University APEIRON Banja Luka Republic of Srpska Bosnia and Herzegovina Pan-European University apeiron Banja Luka Republic of Srpska Bosnia and Herzegovina

Banks daily interact with a vast number of customers and are still depending on a legacy system. With today’s advances in technology, regarding lifting almost all processes to automation, from start of production to finish, there is a need for revolution in archaic monetary management institutes. By not being in tune with the contemporary trends and times, banks are losing on an opportunity to transform some of their business models and relieve humans of repetitive work, prevent frauds, make better decisions and consequently gain losses. Banks can engage in implementation of new Virtual Assistants and Artificial Intelligence (A.I.) machine learning technologies, just as the other industries have engaged in modernizing i.e. medical checks, medical reports and evaluations, and this research paper will elaborate and emphasize the impact of artificial intelligence implementation on the banking sector processes. This research is based on both quantitative and model-based proofs of system performance by using several analytical tools, such as SPSS. The automation process helps institutions to enhance profitability, performance and to reduce human dependency. In a nutshell, Virtual Assistants powered with Artificial Intelligence improve the business process performance in every sector of business, especially the banking sector making it fast, reliable and not human dependent.

关键词： Artificial Intelligence Machine Learning Automation Banking Systems Virtual Assistants Chatbots

Induction of Human Anti-Human Antibody Responses (Ab2) after Application of a Humanized Lewis Y Carbohydrate Specific Antibody (Ab1): Connection of Prolonged Disease Stabilization with Ab3 Induction?

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Journal of Cancer Therapy 2012年第4期3卷 269-277页

作者： Andreas Nechansky Stefan Stranner Oliver Scheiber Nicole Halanek Ralf Kircheis apeiron Biologics AG Igeneon GmbH Vienna Austria Virologik GmbH Erlangen Germany

Purpose: Detailed analysis of a patient with epithelial Lewis Y (LeY) positive cancer who received twice 50 mg of the humanized Lewis Y carbohydrate specific mAb IGN311 and developed a clinically significant human anti-human antibody (HAHA) response (Ab2). Results: Clinical stabilization of the disease was assigned to in this patient. The HAHA response consisted mainly of IgG1 and was found to be directed against the IGN311 binding site. Consistent with the induction of the HAHA response, CDC activity against Lewis Y positive target cells was completely abolished at day 8 and could not be restored by the second 50 mg infusion indicating complete neutralization of applied IGN311. The ADCC reactivity was also significantly reduced and anti-anti idiotype-specific antibodies (Ab3) were detectable at day 65. Conclusions: Induction of Ab3 antibodies should be considered as an additional factor influencing the efficacy of humanized antibodies. In this context, the potential threat of induced HAHA responses against therapeutic mAbs might have to be reconsidered because they might actually have also beneficial immunological long-term effects leading to an active immunization component induced by therapeutic antibodies.

关键词： Lewis Y Carbohydrate Immunotherapy Immunogenicity Anti-Idiotype HAHA (Human Anti-Human Antibodies)

The Problem of Athletes Violence in Sports Competitions and Its Prevention

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Journal of Sports Science 2018年第1期6卷 60-64页

作者： Mirko Tufegdzija Ernest Sabic Management in sport Panevropean University of Apeiron Banja Luka 78 000 Bosnia and Herzegovina

In today"s modern world, a will to succeed is inextricably linked with the acquisition of profit, while sports competition turns into an aggressive fight for the result and prestige. The athletes in professional sports, where victory is imperative, often treated as just another object and an obstacle to be overcome. Violence in sports performed primarily athletes themselves. In sports games can be applied aggressive tactics, but the use of violence is considered to be beyond the scope of what is considered to be the good behavior of an athlete. Athletes decide on violence sometimes with a clear goal of hurting the opposing player, and sometimes only for intimidation, in order to win. Extreme exercise, accompanied by great hardships and frequent injuries, are not always sufficient to achieve the required and expected results, and more and more athletes turning to the use of prohibited doping substances, thus trying to improve their own capabilities.

关键词： Sport violence aggressiveness of sportsmen professional sport sports competition

Phase I Dose Escalation Study with the Lewis Y Carbohydrate Specific Humanized Antibody IGN311

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Journal of Cancer Therapy 2011年第5期2卷 760-771页

作者： Daniel Oruzio Gunter Waxenecker Christoph Aulmann Bruno Markl Theodor Wagner Geert Mudde Manfred Schuster Norbert Eller Andrea Mayer Stefan Stranner Gottfried Himmler Hans Loibner Günter Schlimok Ralf Kircheis Andreas Nechansky Zentralklinikum AugsburgGermany Igeneon ViennaAustria AGES Pharmed ViennaAustria S-TARget ViennaAustria apeiron ViennaAustria CDMS ViennaAustria Immatics TubingenGermany f-Star ViennaAustria ViroLogik ErlangenGermany Meridian Biopharmaceuticals ViennaAustria.

Purpose: Investigation of safety, tolerability, pharmacokinetics, and anti-tumor activity of the Lewis Y-specific, fully humanized monoclonal antibody (mAb) IGN311 in patients with Lewis Y positive tumors in a Phase I clinical trial. Experimental Design: Twelve patients (pts) were enrolled in an open-label, uncontrolled, dose escalating Phase I study. Three pts received 50 mg, three pts 100 mg and six pts 200 mg IGN311 by i.v. infusion on days 1 and 15. Blood samples were taken immediately before infusion, and 0.5, 4, 8, 24 hours post infusion, as well as on days 3, 5 and 8 after the first and second infusion, respectively, and day 29. A final visit was scheduled for day 43. Results: No drug related adverse events were observed in the 50 mg and 100 mg dose groups. Three out of six patients in the 200 mg dose group showed drug related adverse reactions with nausea, vomiting and hypotension in one patient (NCI CTC grade 3) being the dose limiting toxicities. t1/2 of IGN311 was ~20 days after second infusion of IGN311. Sera of patients receiving IGN311 were capable of lysing Lewis Y positive tumor cells in vitro by both, complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC). Circulating tumor cells found in the peripheral blood in two out of twelve pts prior to treatment were reduced after treatment to below the quantification limit of the detection method. None of the patients showed an increase in the number of disseminated tumor cells during treatment period. Conclusions: The good safety and PK profile, the biological activity regarding CDC and ADCC mediated tumor cell lysis, and the elimination of circulating tumor cells warrant further clinical investigation of IGN311.

关键词： Passive Immunotherapy Therapeutic Monoclonal Antibody Disseminated Tumor Cells Phase I Study Lewis Y Carbohydrate HAHA (Human Anti-Human Antibodies)

Protection of Environment in Serbia:Responsibility for Ecological Economy Offences

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Management Studies 2018年第3期6卷 212-224页

作者： Miodrag N.Simovic Dragan Jovasevic Vladimir M.Simovic Constitutional Court of Bosnia and Herzegovina SarajevoBosnia and Herzegovina University of Banja Luka Banja LukaBosnia and Herzegovina Academy of Sciences and Arts of Bosnia and Herzegovina SarajevoBosnia and Herzegovina Russian Academy of Natural Sciences MoscowRussia European Academy of Sciences and Arts SalzburgAustria University of Nis NisRepublic of Serbia Prosecutor’s Office SarajevoBosnia and Herzegovina Independent University Banja LukaBosnia and Herzegovina “apeiron”University Banja LukaBosnia and Herzegovina

A new system of protection,regulation,and improvement of environment has been introduced in Serbia since 2004,on the basis of numerous fatified universal and regional international *** measures having the aim to prevent the possibility of jeopardizing,endangering,or pollution of the environment as a whole or some of its segments like air,water,soil,flora,and fauna have a special importance in the system of ecological protection of ***,in case when such preventive measures are not sufficient or efficient,ecological values are protected from different forms of violation and jeopardizing by prescribing ecological delicts like:criminal offences,economic felonies and *** delicts having wide range of measures,sanctions,and actions lead by competent courts(general,economic,or misdemeanor)for natural and legal persons,***,should provide efficient,quality,and legal ecological security,that is its protection from economic offences and that is what this paper is about.

关键词： environment regulation protection economic offence sanction

The metabolite BH4 controls T cell proliferation in autoimmunity and cancer

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四川生理科学杂志 2023年第10期45卷 1825-1825页

作者： Shane J F Cronin IMBA Institute of Molecular Biotechnology of the Austrian Academy of Sciences Vienna Austria. Department of Neurobiology Harvard Medical School Boston MA USA. FM Kirby Neurobiology Center Boston Children's Hospital Boston MA USA. Ludwig Boltzmann Institute for Experimental and Clinical Traumatology AUVA Research Center Vienna Austria. Département de Pharmacologie et Physiologie Université de Montréal Montréal Québec Canada. Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-University Mainz Mainz Germany. Department of Internal Medicine II (Infectious Diseases Immunology Rheumatology and Pneumology) Medical University of Innsbruck Innsbruck Austria. Institute of Chemical Sciences and Engineering Institute of Bioengineering National Centre of Competence in Research (NCCR) in Chemical Biology École Polytechnique Fédérale de Lausanne (EPFL) Lausanne Switzerland. Division of Cardiovascular Medicine British Heart Foundation Centre for Research Excellence John Radcliffe Hospital University of Oxford Oxford UK. Wellcome Trust Centre for Human Genetics Roosevelt Drive University of Oxford Oxford UK. Division of Gastroenterology and Liver Center Department of Medicine Beth Israel Deaconess Medical Center (BIDMC) and Harvard Medical School (HMS) Harvard University Boston MA USA. LABOX Departamento de Bioquímica Universidade Federal de Santa Catarina Florianópolis Brazil. Research Institute of Molecular Pathology Vienna Biocenter Campus-Vienna-Biocenter 1 Vienna Austria. Karolinska Institute Department of Medicine Solna Center for Molecular Medicine Karolinska University Hospital Solna Stockholm Sweden. Department of Neuronal Control of Metabolism Max Planck Institute for Metabolism Research Cologne Germany. Department of Neurosciences Centre de Recherche de CHU de Québec-Université Laval Québec Québec Canada. Department of Molecular Medicine Faculty of Medicine Université Laval Québec Quebec Canada. Neurosurgery Departm

Genetic regulators and environmental stimuli modulate T cell activation in autoimmunity and *** enzyme co-factor tetrahydrobiopterin(BH4)is involved in the production of monoamine neurotransmitters,the generation of n... 详细信息

关键词： BH4 cancer. autoimmunity