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Phenanthrene perturbs hematopoietic development and causes hematopoietic defects in zebrafish

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Journal of Environmental Sciences 2025年第5期151卷 573-581页

作者： Lingyu Ren Yue Wang Ying Ren Guangke Li Nan Sang College of Environment and Resource Research Center of Environment and HealthShanxi UniversityTaiyuan 030006China

Phenanthrene(Phe)is one of the common polycyclic aromatic hydrocarbons in the environment,and recent studies show that it can cause cardiac developmental toxicity and ***,it is still unknown whether it can affect the hematopoietic development in aquatic *** address this question,zebrafish(Danio rerio)were chronically exposed to Phe at different *** found that Phe caused structural damage to the renal tubules in the kidney,induced malformed erythrocytes in peripheral blood,and decreased the proportion of myeloid cells in adult zebrafish,suggesting possible negative impacts that Phe posed to hematopoietic ***,using in situ hybridization technology,we found that Phe decreased the expression of primitive hematopoietic marker genes,specifically gata1 and pu.1,accompanied by an obstruction of primitive erythrocyte ***,Phe impaired definitive hematopoiesis,increased aberrations of the transient hematopoietic site(PBI),and reduced the generation of hematopoietic stem cells,ultimately influencing the number of erythrocytes and myeloid *** findings suggested that Phe could induce hematopoietic toxicity in zebrafish embryos and pose unknown ecological risks.

关键词： Phenanthrene Zebrafish Hematopoietic development Hematopoietic defect

Managing virus diseases in citrus:Leveraging high-throughput sequencing for versatile applications

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Horticultural Plant Journal 2025年第1期11卷 57-68页

作者： Hongming Chen Zhiyou Xuan Lu Yang Song Zhang Mengji Cao Integrative Science center of Germplasm Creation in Western China(Chongqing)Science City Citrus Research InstituteSouthwest UniversityChongqing 400712China National Citrus Engineering research center Citrus Research InstituteSouthwest UniversityChongqing 400712China

In this review,the advantages and advances in applying high-throughput sequencing(HTS)in the management of viral diseases in citrus,along with some challenges,are discussed to provide perspectives on future *** the initial implementation of HTS in citrus virology,a substantial number of citrus viruses have been identified,with a notable increase in the last 7 *** acquisition of viral genomes and various HTS-based omics analyses serve as crucial pillars for advancing research in the etiology,epidemiology,pathology,evolution,ecology,and biotechnology of citrus *** has notably contributed to disease diagnosis,such as the diagnoses of concave gum and impietratura,as well as to the surveillance of new virus risks and the preparation of virus-free ***,certain inherent defects in HTS and coupled bioinformatics analysis,such as challenges with sequence assembly and the detection of viral dark matter,require improvement to enhance practical *** addition,the utilization of HTS for the systematic management of citrus viral diseases remains limited,and drawing insights from other virus-plant pathosystems while integrating emerging compatible techniques and ideas may broaden its specific applications.

关键词： Deep sequencing Virus epidemics Functional genomics CRISPR/Cas Virus-host interactions

research landmarks on the 60th anniversary of Epstein-Barr virus

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Science China Life Sciences 2025年第2期68卷 354-380页

作者： Lan-Yi Zhong Chu Xie Le-Le Zhang Yan-Lin Yang Yuan-Tao Liu Ge-Xin Zhao Guo-Long Bu Xian-Shu Tian Zi-Ying Jiang Bo-Yu Yuan Peng-Lin Li Pei-Huang Wu Wei-Hua Jia Christian Münz Benjamin E.Gewurz Qian Zhong Cong Sun Mu-Sheng Zeng State Key Laboratory of Oncology in South China Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer Center viral Immunobiology Institute of Experimental ImmunologyUniversity of Zürich Division of Infectious Diseases Department of MedicineBrigham and Women's Hospital Department of Microbiology Harvard Medical School Harvard Program in Virology Broad Institute of Harvard and MIT

Epstein-Barr virus(EBV), the first human oncovirus discovered in 1964, has become a focal point in virology, immunology, and oncology because of its unique biological characteristics and significant role in human diseases. As we commemorate the 60th anniversary of EBV's discovery, it is an opportune moment to reflect on the major advancements in our understanding of this complex virus. In this review, we highlight key milestones in EBV research, including its virion structure and life cycle, interactions with the host immune system, association with EBV-associated diseases, and targeted intervention strategies.

关键词： Epstein-Barr virus oncovirus immune response epidemiology vaccines antibodies

Synthesis of intermetallic PtCo fuel cell catalysts from bimetallic core@shell structured nanoparticles

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Journal of Energy Chemistry 2025年第2期101卷 1-6页

作者： Le Zhang Lei Tong Shuai Li Chang-Song Ma Kun-Ze Xue Hai-Wei Liang Hefei National research center for Physical Sciences at the Microscale Department of Chemistry University of Science and Technology of China

The high activity and stability of intermetallic PtCo nanocatalysts toward oxygen reduction reaction make them a top candidate as low-Pt cathode catalysts in proton exchange membrane fuel cells（PEMFCs）.However,forming intermetallic structures typically requires high-temperature annealing,posing a challenge for achieving well-size control and highly ordered *** we report the design and synthesis of bimetallic co re@shell structured precursors for affording high-performance intermetallic PtCo *** fabrication of the core@shell precursor involves using a molecular ligand containing both sulfur and oxygen donors to selectively bind with Pt colloidal nanoparticles as the core and chelate Co ions as the *** high-temperature annealing,the ligand transforms into carbon coatings around alloy nanoparticles,preventing particle sintering;meanwhile,Co ions in the shell can easily diffuse into the Pt core,which helps to increase the thermodynamic driving force for forming intermetallic *** benefits enable us to obtain the catalyst with finely dispersed nanoparticles（～3.5 nm）and a high ordering degree of 72%.With 0.1 mgPt/cm2cathode loading,the catalyst delivers superior performance and durability in PEMFCs,showing an initial mass activity of 0.56 A/mgPt,an initial power density of 1.05 W/cm2at 0.67 V（H2-air）,and a voltage loss of 26 mV at 0.8 A/cm2after the accelerated durability test.

关键词： Bimetallic structure Fuel cells Intermetallic PtCo Oxygen reduction reaction

Prediction and optimization of flue pressure in sintering process based on SHAP

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 346-359页

作者： Mingyu Wang Jue Tang Mansheng Chu Quan Shi Zhen Zhang School of Metallurgy Northeastern UniversityShenyang 110819China Liaoning Low-Carbon Steelmaking Technology Engineering research center Northeastern UniversityShenyang 110819China Engineering research center of Frontier Technologies for Low-Carbon Steelmaking(Ministry of Education) Shenyang 110819China

Sinter is the core raw material for blast *** pressure,which is an important state parameter,affects sinter *** this paper,flue pressure prediction and optimization were studied based on the shapley additive explanation(SHAP)to predict the flue pressure and take targeted adjustment ***,the sintering process data were collected and processed.A flue pressure prediction model was then constructed after comparing different feature selection methods and model algorithms using SHAP+extremely random-ized trees(ET).The prediction accuracy of the model within the error range of±0.25 kPa was 92.63%.SHAP analysis was employed to improve the interpretability of the prediction *** effects of various sintering operation parameters on flue pressure,the relation-ship between the numerical range of key operation parameters and flue pressure,the effect of operation parameter combinations on flue pressure,and the prediction process of the flue pressure prediction model on a single sample were analyzed.A flue pressure optimization module was also constructed and analyzed when the prediction satisfied the judgment *** operating parameter combination was then *** flue pressure was increased by 5.87%during the verification process,achieving a good optimization effect.

关键词： sintering process flue pressure shapley additive explanation prediction optimization

Sequencing and characterizing human mitochondrial genomes in the biobank-based genomic research paradigm

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Science China Life Sciences 2025年

作者： Lintao Luo Mengge Wang Yunhui Liu Jianbo Li Fengxiao Bu Huijun Yuan Renkuan Tang Chao Liu Guanglin He Institute of Rare Diseases West China Hospital of Sichuan UniversitySichuan University Department of Forensic Medicine College of Basic MedicineChongqing Medical University center for Archaeological Science Sichuan University anti-Drug Technology center of Guangdong Province

Human mitochondrial DNA (mtDNA) harbors essential mutations linked to aging,neurodegenerative diseases,and complex muscle *** to its uniparental and haploid inheritance,mtDNA captures matrilineal evolutionary trajectories,playing a crucial role in population and medical ***,critical questions about the genomic diversity patterns,inheritance models,and evolutionary and medical functions of mtDNA remain unresolved or underexplored,particularly in the transition from traditional genotyping to largescale genomic *** review summarizes recent advancements in data-driven genomic research and technological innovations that address these questions and clarify the biological impact of nuclear-mitochondrial segments (NUMTs) and mtDNA variants on human health,disease,and *** propose a streamlined pipeline to comprehensively identify mtDNA and NUMT genomic diversity using advanced sequencing and computational ***-resolved mtDNA sequencing and assembly can distinguish authentic mtDNA variants from NUMTs,reduce diagnostic inaccuracies,and provide clearer insights into heteroplasmy patterns and the authenticity of paternal *** review emphasizes the need for integrative multi-omics approaches and emerging long-read sequencing technologies to gain new insights into mutation mechanisms,the influence of heteroplasmy and paternal inheritance on mtDNA diversity and disease susceptibility,and the detailed functions of NUMTs.

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Timing of biomarker changes preceding Alzheimer's disease: for diagnosis, treatment or prevention?

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Science China Life Sciences 2025年第2期68卷 575-577页

作者： Meina Quan Innovation center for Neurological Disorders and Department of Neurology Xuanwu HospitalCapital Medical University National Medical center for Neurological Diseases and National Clinical research center for Geriatric Diseases center of Alzheimer's Disease Beijing Institute of Brain DisordersCollaborative Innovation Center for Brain Disorders

The pathophysiological and behavioural features of Alzheimer's disease(AD) have been extensively investigated in transgenic mouse models, including the temporal sequence of each pathophysiological change and behavioural abnormality, a summary of which was recently presented by our team in this Journal(Li et al.,2023). Nevertheless, studying such features and timings directly in human patients before symptoms occur is challenging.

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Leveraging ROTI map derived from Indonesian GNSS receiver network for advancing study of Equatorial Plasma Bubble in Southeast/East Asia

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Earth and Planetary Physics 2025年第1期9卷 101-116页

作者： Prayitno Abadi Ihsan N.Muafiry Teguh N.Pratama Angga Y.Putra Suraina Gatot H.Pramono Sidik T.Wibowo Febrylian F.Chabibi Umar A.Ahmad Wildan P.Tresna Asnawi research center for Climate and Atmosphere Indonesian National Research and Innovation Agency(BRIN)BandungIndonesia School of Electrical Engineering Telkom UniversityBandungIndonesia Directorate of Laboratory Management Facilities and Science and Technology Park Indonesian National Research and Innovation Agency(BRIN)PontianakIndonesia Geophysics Laboratory Master Program in PhysicsUniversitas Gadjah Mada(UGM)YogyakartaIndonesia research center for Space Indonesian National Research and Innovation Agency(BRIN)BandungIndonesia Indonesian Geospatial Information Agency(BIG) JakartaIndonesia research center for Photonics Indonesian National Research and Innovation Agency(BRIN)Tangerang SelatanIndonesia Department of Earth and Planetary Sciences Hokkaido UniversitySapporoJapan

This paper highlights the crucial role of Indonesia’s GNSS receiver network in advancing Equatorial Plasma Bubble(EPB)studies in Southeast and East Asia,as ionospheric irregularities within EPB can disrupt GNSS signals and degrade positioning *** by the Indonesian Geospatial Information Agency(BIG),the Indonesia Continuously Operating Reference Station(Ina-CORS)network comprises over 300 GNSS receivers spanning equatorial to southern low-latitude ***-CORS is uniquely situated to monitor EPB generation,zonal drift,and dissipation across Southeast *** provide a practical tool for EPB research,by sharing two-dimensional rate of Total Electron Content(TEC)change index(ROTI)derived from this *** generate ROTI maps with a 10-minute resolution,and samples from May 2024 are publicly available for further scientific *** preliminary findings from the ROTI maps of Ina-CORS are ***,the Ina-CORS ROTI maps reveal that the irregularities within a broader EPB structure persist longer,increasing the potential for these irregularities to migrate farther ***,we demonstrate that combined ROTI maps from Ina-CORS and GNSS receivers in East Asia and Australia can be used to monitor the development of ionospheric irregularities in Southeast and East *** have demonstrated the combined ROTI maps to capture the development of ionospheric irregularities in the Southeast/East Asian sector during the G5 Geomagnetic Storm on May 11,*** observed simultaneous ionospheric irregularities in Japan and Australia,respectively propagating northwestward and southwestward,before midnight,whereas Southeast Asia’s equatorial and low-latitude regions exhibited irregularities *** sharing ROTI maps from Indonesia and integrating them with regional GNSS networks,researchers can conduct comprehensive EPB studies,enhancing the understanding of EPB behavior across Southeast and East Asia and contributing significantly to ionosphe

关键词： Equatorial Plasma Bubble(EPB) GNSS receivers’network Indonesia Continuously Operating Reference Station(Ina-CORS) ionospheric map Rate of TEC change index(ROTI)map

Emerging trends in the selective production of value-added aromatics

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Science China Chemistry 2025年第1期68卷 15-20页

作者： Yuchao Wu Houliang Dai Weisheng Yang Yaxing Li Lichen Liu Petrochemical research Institute Company Limited China National Petroleum CorporationBeijing 102206China Engineering research center of Advanced Rare Earth Materials Department of ChemistryTsinghua UniversityBeijing 100084China

1 Introduction Aromatics(mainly benzene,toluene,and xylenes,BTX)are essential intermediates in the chemical *** are employed in the synthesis of a broad spectrum of chemicals and materials,e.g.,various polymers,plastics,resins,solvents,dyes,pharmaceuticals^([1]).The manufacturing pathway of BTX mainly includes petroleum reforming of naphtha,coal-to-aromatics,methanol-to-aromatics^([2]).

关键词： reforming methanol resins