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Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin Li Ting Zhang Yanlin Fu Peiyan Long Xiao Gao Zhengwei Wang Zhizhong Guan Xiaolan Qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou center for disease control and prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation center for prevention and control of Endemic and Ethnic Regional diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

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Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation

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Neural Regeneration Research 2025年第2期20卷 326-342页

作者： Yi Ji Chaoyi Yang Xuerui Pang Yibing Yan Yue Wu Zhi Geng Wenjie Hu Panpan Hu Xingqi Wu Kai Wang Department of Neurology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders HefeiAnhui ProvinceChina Collaborative Innovation center of Neuropsychiatric Disorders and Mental Health HefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina Department of Psychology and Sleep Medicine The Second Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina

Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and *** Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neurodegeneration and ultimately disrupting the operational abilities in daily life,leaving patients *** transcranial magnetic stimulation is a cost-effective,neuro-modulatory technique used for multiple neurological *** the past two decades,it has been widely used to predict cognitive decline;identify pathophysiological markers;promote neuroplasticity;and assess brain excitability,plasticity,and *** has also been applied to patients with dementia,because it can yield facilitatory effects on cognition and promote brain recovery after a neurological ***,its therapeutic effectiveness at the molecular and synaptic levels has not been elucidated because of a limited number of *** study aimed to characterize the neurobiological changes following repetitive transcranial magnetic stimulation treatment,evaluate its effects on synaptic plasticity,and identify the associated *** review essentially focuses on changes in the pathology,amyloidogenesis,and clearance pathways,given that amyloid deposition is a major hypothesis in the pathogenesis of Alzheimer’s *** mechanisms associated with repetitive transcranial magnetic stimulation procedures and different pathways mediating gene transcription,which are closely related to the neural regeneration process,are also ***,we discuss the outcomes of animal studies in which neuroplasticity is modulated and assessed at the structural and functional levels by using repetitive transcranial magnetic stimulation,with the aim to highlight future directions for better clinical translations.

关键词： Alzheimer’s disease amyloid deposition apoptotic mechanisms biomarker neural regeneration neurodegeneration repetitive transcranial magnetic stimulation synaptic plasticity

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Approach from the laboratory to the field: New strategies in the control of mosquito-borne infectious diseases

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Science China Life Sciences 2025年第01期 303-305页

作者： Ziqian Xu Lianpan Dai Jun Liu National Key Laboratory of Intelligent Tracking and Forecasting for Infectious diseases (NITFID) National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences

Vector-borne viruses, transmitted among humans and animal hosts through bites of vectors such as mosquitoes and ticks,pose a great and ongoing threat to public health and biosafety(Yang et al., 2022).Among them, dengue virus-induced epidemics, have dramatically increased worldwide in recent decades. The report released by the World Health Organization(WHO) at the end of 2023 showed that dengue epidemic globally surged in2023, with the number of reported cases nearing a historical peak.

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Anaplasma bovis Infection in Fever and Thrombocytopenia Patients——anhui Province,China,2021

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China CDC weekly 2022年第12期4卷 249-253,I0005,I0006页

作者： Miao Lu Qingqing Chen Xincheng Qin Yong Lyu Zhongqiu Teng Kun Li Liang Yu Xiaojing Jin Hongwei Chang Wen Wang Dayin Hong Yong Sun Biao Kan Lei Gong Tian Qin State Key Laboratory of Infectious disease prevention and control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina anhui Provincial center for disease control and prevention Hefei CityAnhui ProvinceChina Lu’an Municipal center for disease control and prevention Lu’an CityAnhui ProvinceChina Jinzhai County center for disease control and prevention Lu’an CityAnhui ProvinceChina Jinzhai County People’s Hospital Lu’an CityAnhui ProvinceChina

Summary What is already known about this topic?The genus Anaplasma contains seven recognized bacterial species,mainly transmitted by tick *** two species,*** and ***,are known commonly to cause diseases in *** is added by this report?Anaplasma bovis was initially thought to be only an animal agent until the first patient case was reported in *** study investigated another two patients who became sick within one month in the same township and were infected with *** in anhui Province.

关键词： anhui Province. initially

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Coverage of 13-Valent Pneumococcal Conjugate Vaccine Among Children 0–15 Months of Age—9 Provinces,China,2019–2021

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China CDC weekly 2023年第17期5卷 379-384页

作者： Lijun Liu Zhaonan Zhang Xixi Zhang Changsha Xu Yifan Song Li Li Jiakai Ye Zhiguo Wang Hui Liang Weiyan Zhang Ling Lin Ning Li Shujun Zhang Qianli Ma Wen Du Yongzhuo Jiao Lingsheng Cao Qi Qi Lei Cao Wenzhou Yu Sichuan center for disease control and prevention Chengdu CitySichuan ProvinceChina National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina Suqian center for disease control and prevention Suqian CityJiangsu ProvinceChina Jiangsu center for disease control and prevention Nanjing CityJiangsu ProvinceChina Zhejiang center for disease control and prevention Hangzhou CityZhejiang ProvinceChina Shandong center for disease control and prevention Jinan CityShandong ProvinceChina anhui center for disease control and prevention Hefei CityAnhui ProvinceChina Hubei center for disease control and prevention Wuhan CityHubei ProvinceChina Hunan center for disease control and prevention Changsha CityHunan ProvinceChina Guizhou center for disease control and prevention Guiyang CityGuizhou ProvinceChina Gansu center for disease control and prevention Lanzhou CityGansu ProvinceChina

Summary What is already known on this topic?Limited data exist regarding the coverage of the 13-valent pneumococcal conjugate vaccine(PCV13)in China.A lack of official statistics,coupled with an insufficient body of published literature,hinders the accurate depiction of the current *** is added by this report?This study investigated the utilization of PCV13 and estimated its coverage in nine provinces across eastern,central,and western China between 2019 and *** an annual increase in PCV13 usage during this period,the overall coverage remained suboptimal.

关键词： spite coverage hinder

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Pollution of HCHs,DDTs and PCBs in tidal flat of Hangzhou Bay 2009–2013

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Chinese Journal of Oceanology and Limnology 2016年第3期34卷 539-548页

作者：赵鹏龚文杰毛国华李继革徐奋奋施家威 Jiangbei center for disease control and prevention Ningbo Cixi center for disease control and prevention Ningbo Ningbo Municipal center for disease control and prevention Ningbo

The concentration and distribution of three persistent organic pollutants （hexachlorocyclohexanes （HCHs）, dichlorodiphenyltrichloroethanes （DDTs） and polyehlorinated biphenyls （PCBs）） was assessed in tidal fiat sediments collected from the south bank of Hangzhou Bay, China from 2009 to 2013. Gas chromatography coupled to triple quadrupole mass spectrometry （GC-MS/MS） was used for analysis, based on United States Environmental Protection Agency methods EPAS080A, EPA8081B, and EPA3550B. The results showed that the levels of HCHs, DDTs and PCBs decreased in the order of DDTs 〉 HCHs 〉 PCBs, and their mass fractions ranged from 0.29-32.91, 0.09-13.19 and 0.16-4.10 ktg/kg （dry mass）, respectively. The levels of HCHs, DDTs and PCBs decreased slowly from 2009 to 2013, with considerably greater concentrations in winter than in spring and summer. In this study area, the concentrations of DDTs and HCHs decreased gradually towards the mouth of Hangzhou Bay, while the concentrations of PCBs were related to changes in the local economy. In addition, the sources of HCHs and DDTs were identified as atmospheric precipitation and historical residues, Finally, we predicted that PCBs pollution primarily originated from Aroclor 1254（Lot A4）, which might root in the illegal demolition and stacking of abandoned paint, transformer or electronic equipment in the south bank of Hangzhou Bay.

关键词： South Bank of Hangzhou Bay sediment hexachlorocyclohexanes (HCHs) dichlorodiphenyltrichloroethanes (DDTs) polychlorinated biphenyls (PCBs)

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Coverage of the Combined DTaP-IPV/Hib Vaccine Among Children Aged 2-18 Months—9 PLADs,China,2019-2021

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China CDC weekly 2024年第19期6卷 418-423,I0001页

作者： Li Li Hui Liang Yifan Song Zhaonan Zhang Jing An Ning Li Huifeng Sun Ying Bao Leijin Mao Lin Ding Jie Yan Zhiguo Wang Lei Cao Jiakai Ye Wenzhou Yu National Key Laboratory of Intelligent Tracking and Forecasting for Infectious diseases BeijingChina National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina Zhejiang center for disease control and prevention Hangzhou CityZhejiang ProvinceChina Gansu center for disease control and prevention Lanzhou CityGansu ProvinceChina Hubei center for disease control and prevention Wuhan CityHubei ProvinceChina Shandong center for disease control and prevention Jinan CityShandong ProvinceChina Sichuan center for disease control and prevention Chengdu CitySichuan ProvinceChina anhui center for disease control and prevention Hefei CityAnhui ProvinceChina Guizhou center for disease control and prevention Guiyang CityGuizhou ProvinceChina Hunan center for disease control and prevention Changsha CityHunan ProvinceChina Jiangsu center for disease control and prevention Nanjing CityJiangsu ProvinceChina

Summary What is already known on this topic?In China,there is limited data available on the use and coverage of the non-program,combined diphtheria,tetanus toxoid,acellular pertussis adsorbed,inactivated poliovirus and haemophilus influenzae type b(DTaPIPV/Hib)pentavalent vaccine,and its role as a substitute for the separately administered standalone program vaccines.

关键词： vaccine Hib DTaP

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Epidemiological Features of Foodborne disease Outbreaks in Catering Service Facilities—China,2010–2020

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China CDC weekly 2023年第22期5卷 479-484页

作者： Donglei Lu Jikai Liu Hong Liu Yunchang Guo Yue Dai Junhua Liang Lili Chen Lizi Xu Ping Fu Ning Li Shanghai Municipal center for disease control and prevention ShanghaiChina China National center for Food Safety Risk Assessment BeijingChina Jiangsu Provincial center for disease control and prevention Nanjing CityJiangsu ProvinceChina Guangdong Provincial center for disease control and prevention Guangzhou CityGuangdong ProvinceChina Zhejiang Provincial center for disease control and prevention Hangzhou CityZhejiang ProvinceChina anhui Provincial center for disease control and prevention Hefei CityAnhui ProvinceChina

Introduction:In terms of food preparation settings,catering service facilities have been identified as locations with the highest incidence of foodborne disease outbreaks in *** 2010,the China National center for Food Safety Risk Assessment has established the Foodborne disease Outbreak Surveillance System(FDOSS)to monitor foodborne disease ***,data from the FDOSS has provided a more accurate depiction of the epidemic characteristics of outbreaks within these ***:From 2010 to 2020,the FDOSS gathered data related to the prevalence of outbreaks,cases,hospitalizations,and deaths linked to foodborne disease outbreaks in catering service *** study examined the temporal and geographical distribution,pathogenic factors,and contributing variables of these outbreaks over the course of the ***:From 2010 to 2020,China’s catering service facilities reported 18,331 outbreaks,which resulted in 206,718 illnesses,68,561 hospitalizations,and 201 *** second and third quarters of the year accounted for 76.12%of the outbreaks and 72.93%of the *** primary pathogenic factors were pathogenic organisms,which caused 4,883(26.64%)outbreaks,94,047(45.50%)cases,32,170(46.92%)hospitalizations,and 21(10.45%)*** were 5,607(30.59%)outbreaks in restaurants,2,876(15.69%)outbreaks from street vendors,and 2,560(13.97%)outbreaks in employee canteens in ***:The implementation of relevant control methods,including health education and promotion,is critical for addressing foodborne diseases in catering service *** food safety training sessions for restaurant personnel and managers are essential to ensuring the effective management of these health risks.

关键词： Service restaurant facilities

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Survival and proliferation of the lysogenic bacteriophage CTXΦ in Vibrio cholerae

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Virologica Sinica 2015年第1期30卷 19-25页

作者： Fenxia Fan Biao Kan State Key Laboratory for Infectious disease prevention and control National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention

The lysogenic phage CTXΦ of Vibrio cholerae can transfer the cholera toxin gene both horizontally(inter-strain) and vertically(cell proliferation). Due to its diversity in form and species, the complexity of regulatory mechanisms, and the important role of the infection mechanism in the production of new virulent strains of ***, the study of the lysogenic phage CTXΦ has attracted much attention. Based on the progress of current research, the genomic features and their arrangement, the host-dependent regulatory mechanisms of CTXΦ phage survival, proliferation and propagation were reviewed to further understand the phage's role in the evolutionary and epidemiological mechanisms of V. cholerae.

关键词： Vibrio cholerae lysogenic bacteriophage CTXΦ regulation evolution

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Emergency Response for a Laboratory Biosafety Incident

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Biomedical and Environmental Sciences 2019年第3期32卷 231-233页

作者： ZHANG En Min WANG Jia Qi GAO Li Dong ZHAN Zhi Fei ZHANG Heng HU Yan Hong WEI Jian Chun LIANG Xu Dong WAN Kang Lin WEI Qiang National Institute for Communicable disease control and prevention Chinese Center for Disease Control and Prevention/State Key Laboratory for Infectious Disease Prevention and Control Chinese center for disease control and prevention Hunan Provincial center for disease control and prevention Changsha center for disease control and prevention Yuelu District center for disease control and prevention

On December 14, 2017, a faculty member of a university in Hunan Province reported that an anthrax vaccine strain might have recovered virulence during an undergraduate experiment and potential exposure could not be ruled out for the students involved. Upon receiving the case report, the CDC, health bureaus, and local governments at the county, prefectural, and provincial levels promptly organized experts in different fields (including epidemiologists, biosafety experts, and laboratory testing experts) for case investigation, evaluation, and response. As the investigation results showed, no virulence recovery was identified in the involved anthrax vaccine strain;and no contamination of Bacillus anthracis was detected at the involved areas. Thus, the university returned to normal functioning.

关键词： Emergency Response Laboratory Biosafety Incident

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