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Gut peptide changes in patients with obstructive jaundice undergoing biliary drainage:A prospective case control study

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World Journal of Clinical Cases 2022年第17期10卷 5551-5565页

作者： Tajana Pavic Stipe Pelajic Nina Blazevic Dominik Kralj Milan Milosevic Ivana Mikolasevic Ivan Lerotic Davor Hrabar Department of Gastroenterology and Hepatology University Hospital Center Sestre MilosrdniceZagreb 10000Croatia andrija stampar school of public health who collaborative centre for occupational health University of ZagrebSchool of MedicineZagreb 10000Croatia Department of Gastroenterology University Hospital Center RijekaRijeka 51000Croatia

BACKGROUND Biliary obstruction is a relatively common condition that affects approximately 5 in 1000 people *** is very common in patients with biliary obstruction and since it is associated with significant morbidity and mortality,it is important to identify factors and mechanisms involved in its *** To determine the influence of obstructive jaundice on the hormones controlling appetite and nutritive *** This was a prospective case control study performed in a tertiary center in Zagreb,*** with biliary obstruction undergoing internal biliary drainage from September 2012 until August 2013 were *** excluding patients who developed procedure related complications or were lost in the follow-up,out of initial 73 patients,55 patients were included in the analysis,including 34 with benign and 21 with malignant ***,40 non-jaundiced controls were also ***,nutritional status,and serum ghrelin,cholecystokinin(CCK),interleukin 6(IL-6),and tumor necrosis factorα(TNF-α)were determined at admission,48 h and 28 d after internal biliary *** square test was used for categorical *** variables were analysed for normality by Kolmogorov-Smirnov test and relevant non-parametric(Mann-Whitney,Kruskal-Wallis,and Friedman)or parametric(t-test and analysis of variance)tests were *** Patients with obstructive jaundice were significantly malnourished compared to controls,regardless of disease *** ghrelin and CCK levels were significantly higher in patients with obstructive *** bilirubin concentrations were negatively correlated with ghrelin levels and positively correlated with TNF-α,but had no correlation with CCK *** internal biliary drainage,a significant improvement of nutritional status was observed although serum concentrations of ghrelin,IL-6,and TNF-α remained significantly elevated even 28 d after the *** level

关键词： Ghrelin Cholecystokinin Biliary obstruction Malnutrition

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Effect of clonidine on the cutaneous silent period during spinal anesthesia

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World Journal of Clinical Cases 2018年第16期6卷 1136-1145页

作者： Sandra Graf Zupcic Miroslav Zupcic Viktor Duzel Tatjana imurina Milan Miloevi Silvio Basic Vladimira Vuletic Leonardo Kapural Clinic of Neurology Clinical Hospital Centre Rijeka Faculty of Medicine J.J.Strossmayer University Clinic of Anesthesiology and Intensive Care Medicine Clinical Hospital Centre Rijeka Faculty of Medicine University of Rijeka Department of Anaesthesia Barking Havering and Redbridge University Hospitals NHS Trust Department of health Studies University of Zadar Department of Anesthesiology and Intensive Care Medicine General Hospital Zadar University of Zagreb School of Medicine Andrija Stampar School of Public Health WHO Collaborative Centre for Occupational Health Department of Neurology Clinical Hospital Dubrava Center for Clinical Research Winston Salem

AIM To investigate the effect of clonidine on the cutaneous silent period(CSP) during spinal anesthesia. METHODS A total of 67 adult patients were included in this randomized, prospective, single-center, double-blind trial. They did not have neurological disorders and were scheduled for inguinal hernia repair surgery. This trial was registered on ***(NTC03121261). The patients were randomized into two groups with regards to the intrathecally administered solution:(1) 15 mg of 0.5% levobupivacaine with 50 μg of 0.015% clonidine, or(2) 15 mg of 0.5% levobupivacaine alone. There were 34 patients in the levobupivacaine-clonidine(LC) group and 33 patients in the levobupivacaine(L) group. CSP and its latency were measured four times: prior to the subarachnoid block(SAB), after motor block regression to the 0 level of the Bromage scale, with ongoing sensory blockade, and both 6 and 24 h after *** Only data from 30 patients in each group were analyzed. There were no significant differences between the groups investigated preoperatively and after 24 h. The CSP of the L group at the time point when the Bromage scale was 0 was 44.8 ± 8.1 ms, while in the LC group it measured 40.2 ± 3.8 ms(P = 0.007). The latency in the L group at the time point when the Bromage scale was 0 was 130.3 ± 10.2 ms, and in the LC group it was 144.7 ± 8.3 ms(P < 0.001). The CSP of the L group after 6 h was 59.6 ± 9.8 ms, while in the LC group it was 44.5 ± 5.0 ms(P < 0.001). The latency in the L group after 6 h was 110.4 ± 10.6 ms, while in LC group it was 132.3 ± 9.7 ms(P < 0.001).CONCLUSION Intrathecal addition of clonidine to levobupivacaine for SAB in comparison with levobupivacaine alone resultsin a diminished inhibitory tonus and shortened CSP.

关键词： Clonidine Local anesthetics Nerve fibers Spinal anesthesia Reflex

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MethylGenotyper:Accurate Estimation of SNP Genotypes and Genetic Relatedness from DNA Methylation Data

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Genomics, Proteomics & Bioinformatics 2024年第3期22卷 43-54页

作者： Yi Jiang Minghan Qu Minghui Jiang Xuan Jiang Shane Fernandez Tenielle Porter Simon M.Laws Colin L.Masters Huan Guo Shanshan Cheng Chaolong Wang Ministry of Education Key Laboratory of Environment and health School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Epidemiology and Biostatistics School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China centre for Precision health Edith Cowan UniversityPerthWA 6027Australia collaborative Genomics and Translation Group School of Medical and Health SciencesEdith Cowan UniversityPerthWA 6027Australia Curtin Medical school BentleyWA 6102Australia The Florey Institute of Neuroscience and Mental health University of MelbourneMelbourneVIC 3052Australia Department of occupational and Environmental health School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Epigenome-wide association studies(EWAS)are susceptible to widespread confounding caused by population structure and genetic ***,kinship estimation is challenging in EWAS without genotyping ***,we proposed MethylGenotyper,a method that for the first time enables accurate genotyping at thousands of single nucleotide polymorphisms(SNPs)directly from commercial DNA methylation *** modeled the intensities of methylation probes near SNPs with a mixture of three beta distributions corresponding to different genotypes and estimated parameters with an expectation-maximization *** conducted extensive simulations to demonstrate the performance of the *** applying MethylGenotyper to the Infinium EPIC array data of 4662 Chinese samples,we obtained genotypes at 4319 SNPs with a concordance rate of 98.26%,enabling the identification of 255 pairs of close ***,we showed that MethylGenotyper allows for the estimation of both population structure and cryptic relatedness among 702 Australians of diverse *** also implemented MethylGenotyper in a publicly available R package(https://***/Yi-Jiang/MethylGenotyper)to facilitate future large-scale EWAS.

关键词： DNA methylation Genotype calling Genetic relatedness Population structure Epigenome-wide association study

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Edible mushrooms as a potent therapeutics of subclinical thyroid dysfunction among adults,especially in obese individuals:a prospective cohort study

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Food Science and Human Wellness 2023年第1期12卷 295-302页

作者： Juanjuan Zhang Sabina Rayamajhi Amrish Thapa Ge Meng Qing Zhang Li Liu Hongmei Wu Yeqing Gu Shunming Zhang Tingjing Zhang Xuena Wang Zhixia Cao Jun Dong Xiaoxi Zheng Xu Zhang Xinrong Dong Xing Wang Shaomei Sun Ming Zhou Qiyu Jia Kun Song Kaijun Niu Nutritional Epidemiology Institute and school of public health Tianjin Medical UniversityTianjin 300070China Department of Toxicology and Sanitary Chemistry School of Public HealthTianjin Medical UniversityTianjin 300070China health Management centre Tianjin Medical University General HospitalTianjin 300070China Nutrition and Radiation Epidemiology Research Center Institute of Radiation MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300192China Tianjin Key Laboratory of Environment Nutrition and Public HealthTianjin 300070China Center for International collaborative Research on Environment Nutrition and Public HealthTianjin 300070China

Background:Mushrooms are a good source of many nutrients which are potentially beneficial for chronic *** speculated that due to its abundant nutrients edible mushrooms might have a beneficial effect on the prevention of subclinical thyroid dysfunction(SCTD).Therefore,we designed a large-scale cohort study to examine whether mushrooms consumption is a protective factor for SCTD in ***:This prospective cohort study investigated 6631 participants(mean age:(45.0±10.2)years;55.1%men).Edible mushrooms consumption was measured at baseline using a validated food frequency *** was defined as abnormal serum thyroid-stimulating hormone levels and normal free *** proportional hazards regression models were used to examine the association of edible mushrooms consumption with incident ***:During follow-up period,a total of 262 new cases of SCTD were identified,the incidence rate of subclinical hypothyroidism was 8.9/1000 person-years and subclinical hyperthyroidism was 7.2/1000 *** adjusting potential confounding factors,the multivariable hazard ratios(95%confidence intervals)for subclinical hypothyroidism were 1.00(reference)for almost never,0.53(0.29,0.97)for 1-3 times/week and 0.30(0.10,0.87)for≥4 times/week(P for trend=0.02).It also showed edible mushrooms consumption was inversely associated with subclinical hypothyroidism in obese individuals but not non-obese individuals,the final hazard ratios(95%confidence intervals)were 0.14(0.03,0.73)(P for trend<0.01).Conclusions:This population-based prospective cohort study has firstly demonstrated that higher edible mushrooms consumption was significantly associated with lower incidence of subclinical hypothyroidism among general adult population,especially in obese individuals.

关键词： Edible mushrooms Subclinical thyroid dysfunction Obese individuals Cohort study

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Constitutive STAT3 phosphorylation and IL-6/IL-10 co-expression are associated with impaired T-cell function in tuberculosis patients

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Cellular & Molecular Immunology 2019年第3期16卷 275-287页

作者： Kirstin Harling Ernest Adankwah Alptekin Güler Anthony Afum-Adjei Awuah Louis Adu-Amoah Ertan Mayatepek Ellis Owusu-Dabo Norman Nausch Marc Jacobsen Department of General Pediatrics Neonatologyand Pediatric CardiologyUniversity Children’s HospitalDuesseldorf 40225Germany Kumasi centre for collaborative Research in Tropical Medicine(KCCR) KumasiGhana school of public health College of Health SciencesKwame Nkrumah University of Science and Technology(KNUST)KumasiGhana

T-cells critically contribute to protection against Mycobacterium tuberculosis infection,and impaired T-cell responses can lead to disease ***-inflammatory and immunosuppressive cytokines affect T-cells,and fine-tuned regulation of cytokine signaling via the Jak/STAT signaling pathways is crucial for appropriate T-cell *** STAT3 phosphorylation as a consequence of aberrant cytokine signaling has been described to occur in pathognomonic T-cell responses in inflammatory and autoimmune *** characterized blood samples from tuberculosis patients(n=28)and healthy contacts(n=28)from Ghana for ***-specific T-cell responses,constitutive cytokine production,and SOCS3 and pSTAT3 *** modulation of primary CD4+T-cells was performed to determine the effects of SOCS3 on T-cell functions.T-cells from tuberculosis patients expressed higher levels of IL-10 and IL-6 and lower levels of T helper type(TH)17 cytokines after ***-specific stimulation compared to healthy *** addition,tuberculosis patients had higher IL-10 and IL-6 levels in the supernatants of non-stimulated immune cells and plasma samples compared to healthy ***,aberrant cytokine expression was accompanied by high constitutive pSTAT3 levels and SOCS3 expression in *** analysis identified an IL-6/IL-10 co-expression-based principal component in tuberculosis patients that correlated with high pSTAT3 ***3 contributed to a regulatory component,and tuberculosis patients with high SOCS3 expression showed decreased TH1 cytokine expression and impaired IL-2-induced STAT5 ***3 over-expression in primary CD4+T-cells confirmed the SOCS3 inhibitory function on IL-2-induced STAT5 *** conclude that constitutive pSTAT3 and high SOCS3 expression are influential factors that indicate impaired T-cell functions in tuberculosis patients.

关键词： tuberculosis Interleukin-6 Interleukin-10 STAT3 SOCS3

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Time to tackle clonorchiasis in China

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Infectious Diseases of Poverty 2013年第1期2卷 23-26,22页

作者： Men-Bao Qian Ying-Dan Chen Fei Yan National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionWHO Collaborative Center for MalariaSchistosomiasis and FilariasisKey Laboratory of Parasite and Vector BiologyMinistry of HealthShanghaiPeople’s Republic of China school of public health Fudan UniversityShanghaiPeople’s Republic of China

Recent publication of the global epidemiology of clonorchiasis and its relationship with cholangiocarcinoma in the journal of Infectious Diseases of Poverty has stressed the importance of Clonorchis sinensis *** further demonstrate its threat on public health,especially in China,comparisons between clonorchiasis and hepatitis B are made in terms of epidemiology,clinical symptoms and carcinogenicity,disability,as well as changing ***,major problems and prioritized researches are argued,from basic biology to *** between the majority of infected population and the minority of researches in China urges for more work from Chinese scientists and international cooperation.

关键词： Clonorchis sinensis Clonorchiasis Hepatitis B virus Liver cancer Research

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The global epidemiology of clonorchiasis and its relation with cholangiocarcinoma

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Infectious Diseases of Poverty 2012年第1期1卷 20-30,19页

作者： Men-Bao Qian Ying-Dan Chen Song Liang Guo-Jing Yang Xiao-Nong Zhou National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionWHO Collaborative Center for MalariaSchistosomiasis and FilariasisKey Laboratory of Parasite and Vector BiologyMinistry of HealthShanghaiPeople’s Republic of China Department of Environmental and Global health College of Public Health and Health Professionsand Emerging Pathogens InstituteUniversity of FloridaGainesvilleUSA Jiangsu Institute of Parasitic Diseases WuxiPeople’s Republic of China school of public health Chinese University of Hong KongHong KongPeople’s Republic of China

This paper reviews the epidemiological status and characteristics of clonorchiasis at global level and the etiological relationship between Clonorchis sinensis infection and cholangiocarcinoma(CCA).A conservative estimation was made that 15 million people were infected in the world in 2004,of which over 85%distributed in *** epidemiology of clonorchiasis is characterized by rising trend in its prevalence,variability among sexes and age,as well as endemicity in different *** data indicate that *** infection is carcinogenic to human,and it is predicted that nearly 5000 CCA cases attributed to *** infection may occur annually in the world decades later,with its overall odds ratio of *** is becoming one major public health problem in east Asia,and it is worthwhile to carry out further epidemiological studies.

关键词： Clonorchiasis Clonorchis sinensis Epidemiology Cholangiocarcinoma Odds ratio

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Predicting the Risk of Arterial Stiffness in Coal Miners Based on Different Machine Learning Models

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Biomedical and Environmental Sciences 2024年第1期37卷 108-111页

作者： CHEN Qian Wei HUANG Xue Zan DING Yu ZHU Feng Ren WANG Jia ZOU Yuan Jie DU Yuan Zhen ZHANG Ya Jun HUI Zi Wen ZHU Feng Lin MU Min The Project was supported by Open Research Grant of Joint National-Local Engineering Research centre for Safe and Precise Coal Mining Anhui University of Science and TechnologyHefei 232001AnhuiChina school of public health Anhui University of Science and TechnologyHefei 232001AnhuiChina Key Laboratory of Industrial Dust Prevention and Control Occupational Safety and HealthMinistry of EducationAnhui University of Science and TechnologyHefei 232001AnhuiChina Anhui Institute of occupational Safety and health Anhui University of Science and TechnologyHefei 232001AnhuiChina Joint Research Center of occupational Medicine and health Institute of Grand HealthHefei Comprehensive National Science CenterAnhui University of Science and TechnologyHefei 232001AnhuiChina Department of occupational&Environmental health School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030HubeiChina Key Laboratory of Environment and health Ministry of Education&Ministry of Environmental Protectionand State Key Laboratory of Environmental Health(Incubating)School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030HubeiChina

Coal is one of the world’s main energy resources,accounting for approximately 68%of China’s current total power ***,several studies have demonstrated that dust,exhaust fumes,and other harmful factors in coal mines increase the risk of cardiovascular disease(CVD)among miners^([1]).Arterial stiffness(AS)is an independent risk factor of CVD,and epidemiological studies have shown that AS plays a vital role in assessing the risk of CVD^([2]).

关键词： Arterial cardiovascular assessing

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Developing a Research Network of Early Warning Systems for Infectious Diseases Transmission Between China and Australia

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China CDC weekly 2024年第30期6卷 740-753页

作者： Cynthia Lu Liping Wang Ian Barr Stephen Lambert Kerrie Mengersen Weizhong Yang Zhongjie Li Xiaohan Si Hannah McClymont Shovanur Haque Ting Gan Sotiris Vardoulakis Hilary Bambrick Wenbiao Hu Ecosystem Change and Population health Research Group School of Public Health and Social WorkQueensland University of TechnologyBrisbaneAustralia Division of Infectious Disease National Key Laboratory of Intelligent Tracking and Forcasting for Infectious DiseasesChinese Centre for Disease Control and PreventionBeijingChina who Collaborating centre for Reference and Research on Influenza VIDRLDoherty InstituteMelbourneAustralia Department of Microbiology and Immunology University of MelbourneVictoriaAustralia Communicable Disease Branch Queensland HealthBrisbaneQueenslandAustralia National centre for Immunisation Research and Surveillance Sydney Children’s Hospitals NetworkWestmeadNSWAustralia school of Mathematical Sciences Faculty of ScienceQueensland University of TechnologyBrisbaneQueenslandAustralia school of Population Medicine&public health Chinese Academy of Medical Science/Peking Union Medical CollegeBeijingChina HEAL Global Research centre Health Research InstituteUniversity of CanberraAustralian Capital TerritoryAustralia National centre for Epidemiology and Population health College of Health and MedicineThe Australian National UniversityCanberraAustralian Capital TerritoryAustralia.

This article offers a thorough review of current early warning systems(EWS)and advocates for establishing a unified research network for EWS in infectious diseases between China and *** propose that future research should focus on improving infectious disease surveillance by integrating data from both countries to enhance predictive models and intervention *** article highlights the need for standardized data formats and terminologies,improved surveillance capabilities,and the development of robust spatiotemporal predictive *** concludes by examining the potential benefits and challenges of this collaborative approach and its implications for global infectious disease *** is particularly relevant to the ongoing project,early warning systems for Infectious Diseases between China and Australia(NetEWAC),which aims to use seasonal influenza as a case study to analyze influenza trends,peak activities,and potential interhemispheric transmission *** project seeks to integrate data from both hemispheres to improve outbreak predictions and develop a spatiotemporal predictive modeling system for seasonal influenza transmission based on socio-environmental factors.

关键词： Australia integrating establishing

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Association between Long-Term Exposure to PM_(2.5) Inorganic Chemical Compositions and Cardiopulmonary Mortality: A 22-Year Cohort Study in Northern China

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Environment & health 2024年第8期2卷 530-540页

作者： Hongyue Sun Xi Chen Wenzhong Huang Jing Wei Xueli Yang Anqi Shan Liwen Zhang Honglu Zhang Jiayu He Chengjie Pan Jingjing Li Jing Wu Tong Wang Jie Chen Yuming Guo Shilu Tong Guanghui Dong Nai-Jun Tang Department of occupational and Environmental health School of Public HealthTianjin Medical UniversityTianjin 300070China Tianjin Key Laboratory of Environment Nutrition and public health Tianjin Medical UniversityTianjin 300070China Center for International collaborative Research on Environment Nutrition and public health Tianjin 300070China Key Laboratory of Prevention and Control of Major Diseases in the Population Ministry of EducationTianjin Medical UniversityTianjin 300070China Climate Air Quality Research UnitSchool of Public Health and Preventive MedicineMonash UniversityMelbourne 3004Australia Department of Atmospheric and Oceanic Science Earth System Science Interdisciplinary CenterUniversity of MarylandCollege ParkMaryland 20740United States Shandong Provincial Hospital Affiliated to Shandong First Medical University Ji nan 250021ShandongChina National Center for Chronic and Noncommunicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 100050China Department of Epidemiology and Biostatistics School of Public HealthTianjin Medical UniversityTianjin 300070China school of public health Shanxi Medical UniversityTaiyuan 030001China school of public health and Social Work Queensland University of TechnologyBrisbane 4072QLD Australia National Institute of Environmental health Chinese Centre for Disease Control and PreventionBeijing 100021China Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and health Risk Assessment Department of Occupational and Environmental HealthSchool of Public HealthSun Yat-sen UniversityGuangzhou 510080China

Particulate matter with diameters≤2.5μm(PM_(2.5))has been identified as a significant air pollutant contributing to premature ***,the specific compositions within PM_(2.5) that play the most crucial role remain unclear,especially in areas with high pollution *** study aims to investigate the individual and joint mortality risks associated with PM_(2.5) inorganic chemical compositions and identify primary *** 1998,we conducted a prospective cohort study in four northern Chinese cities(Tianjin,Shenyang,Taiyuan,and Rizhao).Satellite-based machine learning models calculated PM_(2.5) inorganic chemical compositions,including sulfate(SO_(4)^(2–)),nitrate(NO_(3)^(–)),ammonium(NH_(4)^(+)),and chloride(Cl^(-)).A time-varying Cox proportional hazards model was applied to analyze associations between these compositions and cardiorespiratory mortality,encompassing nonaccidental causes,cardiovascular diseases(CVDs),nonmalignant respiratory diseases(RDs),and lung *** quantile-based g-computation model evaluated joint exposure effects and relative contributions of the *** analysis was used to identify vulnerable *** 785,807 person-years of follow-up,5812(15.5%)deaths occurred from nonaccidental causes,including 2932(7.8%)from all CVDs,479(1.3%)from nonmalignant RDs,and 552(1.4%)from lung *** interquartile range(IQR)increase in SO_(4)^(2–)was associated with mortality from nonaccidental causes(hazard ratio:1.860;95%confidence interval:1.809,1.911),CVDs(1.909;1.836,1.985),nonmalignant RDs(2.178;1.975,2.403),and lung cancer(1.773;1.624,1.937).In the joint exposure model,a simultaneous rise of one IQR in all four compositions increased the risk of cardiorespiratory mortality by at least 36.3%,with long-term exposure to SO_(4)^(2–)contributing the most to nonaccidental and cardiopulmonary *** with higher incomes and lower education levels were found to be more vulnerable.

关键词： PM_(2.5)inorganic chemical compositions mortality cohort study cardiorespiratory disease joint association

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