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Oil Crop Science 2024年第1期9卷 29-37页

作者： Ali Sahunie department of analytical and Food Chemistry Tishreen UniversityLattakiaSyria

Both rosemary(Rosmarinus officinalis)and marjoram(Origanum majorana)are abundant in phenolic compounds,exhibiting exceptional antioxidant *** study aims to assess the impact of rosemary and marjoram extracts on the stability of sunflower oil during storage and repeated *** oil supplemented with herbal extracts or butylated hydroxytoluene(BHA)at a concentration of 200 ppm was stored for six months under light and dark conditions at room *** value(PV),p-anisidine value(An-V),and total oxidation(TOTOX)value were measured to monitor lipid oxidation progression.A significant difference(P<0.05)was observed between light and dark storage for all studied samples regarding oxidation *** ethanolic extract of rosemary exhibited higher antioxidant activity compared to BHA and other ***,sunflower oil supplemented with the ethanolic extract of rosemary underwent weekly treatment at 100℃for 30 min over four consecutive *** all oxidation indicators increased during repeated heating,the addition of rosemary and marjoram extracts as well as BHA significantly reduced these *** findings demonstrate that both rosemary extracts and marjoram extracts can serve as natural antioxidants in edible oils.

关键词： Phenolic compounds BHA Marjoram extract Rosemary extract Sunflower oil

Geometric and defects engineering collaboration for enhanced cascade enzymatic nanoreactors

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Nano Research 2024年第4期17卷 2451-2461页

作者： Zhichao Yu Ruijin Zeng Hexiang Gong Yuan Gao Shuyun Chen Yunsen Wang Dianping Tang Key Laboratory for analytical Science of Food Safety and Biology(MOE&Fujian Province) Department of ChemistryFuzhou UniversityFuzhou 350108China

Highly evolved multi-enzyme cascade catalytic reactions in organisms facilitate rapid transfer of substrates and efficient conversion of intermediates in the catalytic unit,thus rationalizing their efficient *** this study,pore-ordered mesoporous single-atom(Fe)nitrogen-doped carbon nanoreactors(Mp-Fe-CN)were designed,in which a reasonable pore size was designed as a natural enzyme trap coupled to a simulated enzyme center.A polarity-mediated strategy was developed to obtain atomically dispersed nanoporous substrates,with the finding that polarity-guided engineering of the nitrogen-ligand environment and vacancy cluster defects clearly affects nanoporous activity,accompanied by appreciable mesoporous pore size *** active center and distal N atom coordination of Fe-N_(4) affect the catalytic process of the nanozyme exposed by density functional theory(DFT),determining the contribution of hybridized orbitals to electron transfer and the decisive step.A cascade nanoreactor-based domain-limited sarcosine oxidase developed for non-invasive monitoring of sarcosine levels in urine for evaluation of potential prostate carcinogenesis as a proof of *** on the design of surface mesoporous channels of nanocatalytic units,a bridge was built for the interaction between nanozymes and natural enzymes to achieve cascade nanocatalysis of natural enzymatic products.

关键词： nanozyme single-atom catalyst bioreactor cascade catalysis non-Invasive sensing

Extrusion-base d 3D-printe d“rolle d-up”composite scaffolds with hierarchical pore structure for bone growth and repair

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Journal of Materials Science & Technology 2024年第4期171卷 222-234页

作者： Yufan Li Li Chen Yijing Stehle Mingyue Lin Chenxin Wang Rui Zhang Min Huang Yubao Li Qin Zou Research Center for Nano Biomaterials Analytical&Testing CenterSichuan UniversityChengdu 610064China analytical&Testing Center Sichuan UniversityChengdu 610064China department of mechanical engineering Union College807 Union St.SchenectadyNY 12308USA Sichuan Institute of Atomic Energy Chengdu 610101China

Three-dimensional(3D)bioprinting,specifically direct ink writing(DIW)capable of printing biologically active substances such as growth factors or drugs under low-temperature conditions,is an emerging di-rection in bone tissue ***,limited by the bio-ink mobility and the poor resolution of this printing technology,the lateral pores of current crisscross-stacked scaffolds printed through DIW tend to clog and are inimical to bone ***,it is critical to develop DIW printed biologi-cal scaffold structure with high mechanical strength,porosity,and biocompatibility ***,patterned polylactic acid(PLA)/polycaprolactone(PCL)/nano-hydroxyapatite(n-HA)based scaffold was printed through DIW technological and rolled-up for properties characterization,cytocompatibility test,and bone repair *** result not only shows that the hexagonal patterned scaffolds are me-chanically strong with porosity,but also demonstrated that the hierarchical pore structure formed during rolled-up has the potential to address the clogging problem and stimulates bone growth and repair.

关键词： Direct ink writing(DIW) Bone repair scaffold,Micro-CT Bio composites

Charting the course:India's health expenditure projections for 2035

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Global Health Journal 2024年第2期8卷 58-66页

作者： Pragyan Monalisa Sahoo Himanshu Sekhar Rout department of analytical&Applied Economics Utkal UniversityBhubaneswarOdishaIndia department of analytical and Applied Economics&RUSA Centre of Excellence in Public Policy and Governance Utkal UniversityVani ViharBhubaneswarOdishaIndia

Objectives Understanding past trends and forecasting future changes in health spending is vital for planning and reducing reliance on out-of-pocket(OOP)*** current study analyzed health expenditure patterns in India and forecasted future trends and patterns until *** Data on health expenditure in India from 2000 to 2019 was collected from the Organisation for Economic Co-operation and Development(OECD)iLibrary and National Health Accounts 2019 *** domestic product(GDP)data from the World Bank was also *** statistics analyzed the composition and pattern,while the exponential smoothing model forecasted future health *** The findings revealed that expenditure made by OOP is the primary health financing source,followed by government and pre-paid private *** percentage of GDP allocated to total health expenditure remains stable,while the per capita health expenditure *** in expenditure among states are observed,with Karnataka relying heavily on pre-paid private *** projections suggest a decline in per capita and total health expenditure as a share of GDP,with a slight increase in the government’s ***-paid private expenditure per capita and OOP health expenditure as a share of the total is projected to remain relatively constant but still high in absolute *** The study highlights variations in health spending in India,characterized by high OOP spending,limited public coverage,and a need for investments,and reforms to improve healthcare access and equity.

关键词： Health expenditure Health spending Health financing Forecasting Exponential smoothing India

Impact of inorganic and organic pollutants from a Belgian wastewater treatment plant on adjacent surface and groundwaters

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Frontiers of Environmental Science & Engineering 2024年第4期18卷 75-90页

作者： Mingyue Luo Yiqi Su Delphine Jenny Vandeputte Yuwei Jia Guanlei Li Willy Baeyens Marijke Huysmans Marc Elskens Yue Gao analytical Environmental and Geo-Chemistry Department(AMGC)Vrije Universiteit Brussel(VUB)Pleinlaan 21050 BrusselsBelgium Hydrology and Hydraulic Engineering(HYDR) Vrije Universiteit Brussel(VUB)Pleinlaan 21050 BrusselsBelgium

Under the pressure of global droughts and water shortage,it is essential to evolve toward a sustainable and robust water *** possible avenue is the maximum reuse of treated wastewater,but the quality of which determines its ***,inorganic(Cd,Pb,Cr,Ni,Cu,and As)and organic(xenoestrogens and polycyclic aromatic contaminants,PACs)contaminants were monthly monitored in an effluent of the wastewater treatment plant(WWTP),the surrounding surface waters and the local groundwater in *** and particulate concentrations of inorganic contaminants in these water bodies were *** addition,Diffusive Gradients in Thin-films(DGT)was used in situ to obtain bioavailable metal *** the WWTP effluent and surface waters,only Ni exceeds the Annual Average-Environmental Quality Standard(AA-EQS),while in the groundwater,dissolved As was the predominant ***,in the surface and effluent waters the highest lability degrees were observed for Cd and *** concentrations of these metal species in the effluent water were lower than in the other water ***-organic pollutants,xenoestrogens and PACs were analyzed by dual Estrogen and Aryl hydrocarbon Receptor-Chemical Activated LUciferase gene eXpression(ER&AhR-CALUX)*** the annual averaged(AA)bioequivalent concentration of E2(0.18 ng/L)is below the AA-EQS standard(0.4 ng/L),and the bioequivalent concentration of benzo[a]pyrene never exceeded the maximum admissible concentration(MAC),the reclamation and reuse of treated wastewater for groundwater replenishment and agricultural irrigation should pose no environmental problems,at least in a short-term.

关键词： Metal contaminants DGT Labile metal fractions ERE/AhR-CALUX BEQ Xenoestrogens and polycyclic aromatic contaminants

Thiol-mediated transportation pathway:an approach for improving tumor penetration of nanomedicines in vivo

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Science China Chemistry 2024年第1期67卷 383-389页

作者： Junjie Zhang Weican Sun Xing Wang Senyan Chen Jingying Li Huanghao Yang New Cornerstone Science Laboratory Key Laboratory for Analytical Science of Food Safety and Biology(Ministry of Education)College of ChemistryFuzhou UniversityFuzhou 350116China department of Chemistry and College of Biological Science and Engineering Fuzhou UniversityFuzhou 350116China

Abnormal tumor microenvironment imposes barriers to tumor penetration of nanomedicine,which remains a major challenge for effective ***,we present disulfide-based nanoparticles that actively penetrate deep tumors in vivo through a thiol-mediated transportation *** achieve active tumor accumulation in vivo,disulfide-based nanoparticles are modified with folic acid units(FA-DBNPs).It is gratifying that FA-DBNPs still enter cells via the thiol-mediated pathway,which facilitates transcellular transportation and tumor penetration both in vitro and in ***,FA-DBNPs exhibit GSH concentration-dependent depolymerization characterization,indicating that the GSH level in tumor tissues regulates the penetration depth of *** from these advantages,FA-DBNPs showed potent anti-tumor activity in mouse models,leading to the significant regression of *** current study lays a foundation that thiol-mediated transportation is a promising approach in nanomedicine design for solid tumor therapy.

关键词： deep penetration thiol-mediated pathway transcellular transportation solid tumor

Postmortem ^(7)Li NMR analysis for assessing the reversibility of lithium metal electrodes in lithium metal batteries

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Journal of Energy Chemistry 2024年第7期94卷 430-440页

作者： Jaewon Baek Sunha Kim Hee-Tak Kim Oc Hee Han department of Chemical&Biomolecular Engineering KAISTDaejeon 34141Republic of Korea Metropolitan Seoul Center Korea Basic Science InstituteSeoul 03759Republic of Korea Graduate School of analytical Science&Technology Chungnam National UniversityDaejeon 34134Republic of Korea

Despite the proficiency of lithium(Li)-7 NMR spectroscopy in delineating the physical and chemical states of Li metal electrodes,challenges in specimen preparation and interpretation impede its *** this study,we conducted a comprehensive postmortem analysis utilizing ^(7)Li NMR,employing a stan-dard magic angle spinning probe to examine protective-layer coated Li metal electrodes and LiAg alloy electrodes against bare Li metal electrodes within Li metal batteries(LMBs).Our investigation explores the effects of sample burrs,alignment with the magnetic field,the existence of liquid electrolytes,and precycling on the ^(7)Li NMR *** contrasting NMR spectra before and after cycling,we identi-fied alterations in Li^(0) and Li^(+) signals attributable to the degradation of the Li metal *** NMR analyses decisively demonstrate the efficacy of the protective layer in mitigating dendrite and solid elec-trolyte interphase ***,we noted that Li*ions near the Li metal surface exhibit magnetic susceptibility anisotropy,revealing a novel approach to studying diamagnetic species on Li metal elec-trodes in *** study provides valuable insights and practical guidelines for characterizing distinct lithium states within LMBs.

关键词： NMR spectroscopy Lithium-7 Lithium metal battery Electrolyte Electrode-protective layer Solid electrolyte interface Magnetic susceptibility anisotropy Lithium-metal NMR signal Diamagnetic^(7)Li NMR signal

Elasto-inertial microfluidic separation of microspheres with submicron resolution at high-throughput

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Microsystems & Nanoengineering 2024年第1期10卷 203-216页

作者： Hyunwoo Jeon Song Ha Lee Jongho Shin Kicheol Song Nari Ahn Jinsoo Park department of Mechanical Engineering Chonnam National University77 Yongbong-ro Buk-guGwangju 61186Republic of Korea analytical Engineering Team Samsung Display Co.Ltd.181 Samsung-roTangjeong-myeonAsan-siChungcheongnam-do 31454Republic of Korea

Elasto-inertial microfluidic separation offers many advantages including high throughput and separation *** though the separation efficiency highly depends on precise control of the flow conditions,no concrete guidelines have been reported yet in elasto-inertial ***,we propose a dimensionless analysis for precise estimation of the microsphere behaviors across the interface of Newtonian and viscoelastic *** number,modified Weissenberg number,and modified elastic number are used to investigate the balance between inertial and elastic lift *** on the findings,we introduce a new dimensionless number defined as the width of the Newtonian fluid stream divided by microsphere *** proposed dimensionless analysis allows us to predict whether the microspheres migrate across the co-flow *** theoretical estimation is found to be in good agreement with the experimental results using 2.1-and 3.2-μm-diameter polystyrene microspheres in a co-flow of water and polyethylene oxide *** on the theoretical estimation,we also realize submicron separation of the microspheres with 2.1 and 2.5μm in diameter at high throughput,high purity(>95%),and high recovery rate(>97%).The applicability of the proposed method was validated by separation of platelets from similar-sized Escherichia coli(***).

关键词： solution. separation estimation

Reversed-Phase-HPLC Assay Method for Simultaneous Estimation of Sorbitol, Sodium Lactate, and Sodium Chlorides in Pharmaceutical Formulations and Drug Solution for Infusion

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American Journal of analytical Chemistry 2024年第2期15卷 57-71页

作者： Sreenivas Pippalla Venugopal Komreddy Srinivasulu Kasa Vaishnavi Chintala Poluri Venkata Reddy department of Chemistry Sikkim Professional University Gangtok India analytical Research & Development Hikma Pharmaceuticals USA Inc. Bedford USA department of Chemistry Osmania University Hyderabad India analytical Research & Development Cambrex High Point High Point USA department of analytical Chemistry Annamalai University Annamalai Nagar India

A rapid, straightforward, sensitive, efficient, and cost-effective reverse-phase high-performance liquid chromatographic method was employed for the simultaneous determination of Sorbitol, Sodium Lactate, and Chlorides in a drug solution for infusion. Sorbitol, Sodium lactate, and Chloride are all officially recognized in the USP monograph. Assay methods are provided through various techniques, with titrations being ineffective for trace-level quantification. Alternatively, IC, AAS, and ICP-MS, though highly accurate, are costly and often unavailable to most testing facilities. When considering methods, it’s important to prioritize both quality control requirements and user-friendly techniques. A simple HPLC simultaneous method was developed for the quantification of Chlorides, Sorbitol, and Sodium Lactate with a shorter run time. The separation utilized a Shimpack SCR-102(H) ion exclusion analytical column (7.9 mm × 300 mm, 7 μm), with a flow rate of 0.6 mL per min. The column compartment temperature was maintained at 40°C, and the injection volume was set at 10 μL, with detection at 200 nm. All measurements were conducted in a 0.1% solution of phosphoric acid. The analytical curves demonstrated linearity (r > 0.9999) in the concentration range of 0.79 to 3.8 mg per mL for Sodium Lactate (SL), 0.16 to 0.79 mg per mL for Sodium Chloride (SC), and 1.5 to 7.2 mg per mL for Sorbitol. Validation of the developed method followed the guidelines of the International Conference on Harmonization (ICH Q2B) and USP. The method exhibited precision, robustness, accuracy, and selectivity. In accelerated stability testing over 6 months, no significant variations were observed in organoleptic analysis and pH. Consequently, the developed method is deemed suitable for routine quality control analyses, enabling the simultaneous determination of Sodium Lactate, Sodium Chloride, and Sorbitol in pharmaceutical formulations and infusions.

关键词： Sorbitol Sodium Lactate and Chloride Assay analytical Validation HPLC

HDPairFinder:A data processing platform for hydrogen/deuterium isotopic labeling-based nontargeted analysis of trace-level amino-containing chemicals in environmental water

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Journal of Environmental Sciences 2024年第2期136卷 583-593页

作者： Tingting Zhao Kristin Carroll Caley B.Craven Nicholas J.P.Wawryk Shipei Xing Jian Guo Xing-Fang Li Tao Huan department of Chemistry Faculty of ScienceUniversity of British ColumbiaVancouver Campus2036 Main MallVancouverBritish ColumbiaV6T 1Z1Canada Division of analytical and Environmental Toxicology Department of Laboratory Medicine and PathologyFaculty of Medicine and DentistryUniversity of AlbertaEdmontonAlberta T6G 2G3Canada

The combination of hydrogen/deuterium(H/D)formaldehyde-based isotopic methyl labeling with solid-phase extraction and high-performance liquid chromatography–high resolution mass spectrometry(HPLC-HRMS)is a powerful analytical solution for nontargeted analysis of trace-level amino-containing chemicals in water *** the huge amount of chemical information generated in HPLC-HRMS analysis,identifying all possible H/Dlabeled amino chemicals presents a significant challenge in data *** address this,we designed a streamlined data processing pipeline that can automatically extract H/D-labeled amino chemicals from the raw HPLC-HRMS data with high accuracy and ***,we developed a cross-correlation algorithm to correct the retention time shift resulting from deuterium isotopic effects,which enables reliable pairing of H-and D-labeled ***,we implemented several bioinformatic solutions to remove false chemical features generated by in-source fragmentation,salt adduction,and natural13C ***,we used a data mining strategy to construct the AMINES library that consists of over 38,000 structure-disjointed primary and secondary amines to facilitate putative compound ***,we integrated these modules into a freely available R program,*** rationale of each module was justified and its performance tested using experimental H/D-labeled chemical standards and authentic water *** further demonstrated the application of HDPairFinder to effectively extract N-containing contaminants,thus enabling the monitoring of changes of primary and secondary N-compounds in authentic water *** is a reliable bioinformatic tool for rapid processing of H/D isotopic methyl labeling-based nontargeted analysis of water samples,and will facilitate a better understanding of N-containing chemical compounds in water.

关键词： Isotope labeling Nontargeted analysis Reactive N-compounds HPLC-HRMS Source water