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FUS-mediated HypEVs: Neuroprotective effects against ischemic stroke

Bioactive materials 2023年第11期29卷 196-213页

作者： Yousheng Wu Xiaoxiong Huang Zefeng Tan Jiankun Zang Min Peng Niu He Tao Zhang Hongcheng Mai Anding Xu Dan Lu Department of Neurology and Stroke center The First Affiliated Hospital of Jinan UniversityGuangzhouChina Clinical Neuroscience institute The First Affiliated Hospital of Jinan UniversityGuangzhouChina Key Lab of Guangzhou Basic and Translational Research of Pan-vascular Diseases The First Affiliated Hospital of Jinan UniversityGuangzhouChina Department of Neurology and Stroke center The Central Hospital of ShaoyangHunanChina Department of Neurology The First People’s Hospital of FoshanGuangdongChina Department of Cardiology The First Affiliated Hospital of Jinan UniversityGuangzhouChina Munich Medical Research School(MMRS) Ludwig-Maximilians University MunichMunichGermany Insititute for Tissue Engineering and Regenerative Medicine(iTERM) Helmholtz Zentrum MünchenNeuherbergGermany

Few studies have investigated the properties and protein composition of small extracellular vesicles (sEVs) derived from neurons under hypoxic conditions. Presently, the extent of the involvement of these plentiful sEVs in the onset and progression of ischemic stroke remains an unresolved question. Our study systematically identified the characteristics of sEVs derived from neurons under hypoxic conditions (HypEVs) by physical characterization, sEV absorption, proteomics and transcriptomics analysis. The effects of HypEVs on neurites, cell survival, and neuron structure were assessed in vitro and in vivo by neural complexity tests, magnetic resonance imaging (MRI), Golgi staining, and Western blotting of synaptic plasticity-related proteins and apoptotic proteins. Knockdown of Fused in Sarcoma (FUS) small interfering RNA (siRNA) was used to validate FUS-mediated HypEV neuroprotection and mitochondrial mRNA release. Hypoxia promoted the secretion of sEVs, and HypEVs were more easily taken up and utilized by recipient cells. The MRI results illustrated that the cerebral infarction volume was reduced by 45% with the application of HypEVs, in comparison to the non- HypEV treatment group. Mechanistically, the FUS protein is necessary for the uptake and neuroprotection of HypEVs against ischemic stroke as well as carrying a large amount of mitochondrial mRNA in HypEVs. However, FUS knockdown attenuated the neuroprotective rescue capabilities of HypEVs. Our comprehensive dataset clearly illustrates that FUS-mediated HypEVs deliver exceptional neuroprotective effects against ischemic stroke, primarily through the maintenance of neurite integrity and the reduction of mitochondria-associated apoptosis.

关键词： Hypoxia FUS Neuron-derived small extracellular vesicle Neuroprotection Mitochondrial mRNA

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Recent advance in near-infrared/ultrasound-sensitive 2D-nanomaterials for cancer therapeutics

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Science China materials 2020年第12期63卷 2397-2428页

作者： Wei Yang Qinghua Lyu Jun Zhao Liqi Cao Yi Hao Han Zhang Department of Ultrasound Shenzhen HospitalSouthern Medical UniversityShenzhen 518100China institute of Microscale Optoelectronics Collaborative Innovation Centre for Optoelectronic Science&TechnologyKey Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong ProvinceShenzhen Key Laboratory of Micro-Nano Photonic Information TechnologyGuangdong Laboratory of Artificial Intelligence and Digital Economy(SZ)College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China School of Ophthalmology&Optometry Affiliated to Shenzhen University Shenzhen 518040China Shenzhen Eye institute Shenzhen Eye Hospital Affiliated to Jinan UniversityShenzhen 518040China

In recent years,the emerging two-dimensional(2 D)nanomaterials have shown great potential for a variety of applications such as electronics,catalysis,supercapacitors,and energy *** the biomedical arena,these nanomaterials,especially 2 D-ultrathin nanomaterials,have also been regarded as promising nano-carriers and/or diagnostic agents for cancer diagnosis and treatment,owing to their remarkable mechanical,photothermal,and optical *** this review,we provide the recent development of the nanoplatforms based on near-infrared/ultrasound-sensitive 2 D-materials,representatively such as graphdiyne(GDY),black phosphorus,transition metal dichalcogenides(TMDs),and antimonene,for non-invasive cancer therapeutics including photothermal,photodynamic and sonodynamic *** general properties of these 2 D nanomaterials linking to biomedical interests are first introduced,followed by the fabrication processes of diverse nano-platforms and related outcomes of cancer diagnosis and *** also outline the current challenges and prospects of the 2 D materials for non-invasive approaches to cancer treatments in the future.

关键词： nanomaterial 2D layered materials photothermal therapy photodynamic therapy sonodynamic therapy

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Geology and mineralization of the Dayin’gezhuang supergiant gold deposit(180 t)in the Jiaodong Peninsula,China:A review

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China Geology 2022年第4期5卷 696-721页

作者： Xiang-dong Liu Zheng-jiang Ding Ming-chun Song Ming-ling Zhou Shao-hui Xu Zhen-liangYang Tian-ci Xie Tao Cui Ying-xin Song Xue-kan Gao Rui-xiang Li Liang-liang Zhang Qi-bin Zhang Shan-shan Wang Bin Wang No.6 Geological Team of Shandong Provincial Bureau of Geology and Mineral Resources Weihai 264209China Ministry of Natural Resources technology Innovation center for Deep Gold Resources Exploration and Mining Weihai 264209China State Key Laboratory of Geological Process and Mineral Resources China University of Geosciences(Beijing)Beijing 100083China Hebei Key Laboratory of Strategic Critical Mineral Resources Hebei GEO UniversityShijiazhuang 050031China Shandong institute of Geological Sciences Jinan 250013China Dayin’gezhuang Gold Company Zhaojin Mining Co.Ltd.Zhaoyuan 264000China

The Dayin’gezhuang gold deposit is located in the central part of the Zhaoping Fault metallogenic belt in the Jiaodong gold province-the world’s third-largest gold metallogenic *** is a typical successful case of prospecting at a depth of 500-2000 m in recent years,with cumulative proven gold resources exceeding 180 *** main orebodies(No.1 and No.2 orebody)generally have a pitch direction of NNE and a plunge direction of *** the ore-controlling fault,the Zhaoping Fault is a shovel-shaped stepped fault,with its dip angle presenting stepped high-to-low transitions at the elevation of -2000-0 *** gold mineralization enrichment area is mainly distributed in the step parts where the fault plane changes from steeply to gently,forming a stepped metallogenic pattern from shallow to *** can be concluded from previous studies that the gold mineralization of the Dayin’gezhuang gold deposit occurred at about 120 *** ore-forming fluids were H_(2)O-CO_(2)-NaCl-type hydrothermal solutions with a medium-low temperature and medium-low *** H-O isotopic characteristics indicate that the fluids in the early ore-forming stage were possibly magmatic water or mantle water and that meteoric water gradually entered the ore-forming fluids in the late ore-forming *** S and Pb isotopes indicate that the ore-forming materials mainly originate from the lower crust and contain a small quantity of mantle-derived *** comprehensive analysis shows that the Dayin’gezhuang gold deposit was formed by thermal uplifting-extensional *** strong crust-mantle interactions,large-scale magmatism,and the material exchange arising from the transformation from adakitic granites to arc granites and from the ancient lower crust to the juvenile lower crust during the Early Cretaceous provided abundant fluids and material sources for ***,the detachment faults formed by the rapid magmatic uplift and the extensional tectonism created favorable tem

关键词： Stepped metallogenic model Thermal uplifting-extension mineralization Geological characteristics Supergiant gold deposit Zhaoping metallogenic belt Jiaodong gold province Mineral exploration engineering Dayin’gezhuang Shandong Province China

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Anomalous scaling of flexural phonon damping in nanoresonators with confined fluid

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Microsystems & Nanoengineering 2019年第1期5卷 682-694页

作者： Subhadeep De Narayana R.Aluru Department of Mechanical Science and Engineering University of Illinois at Urbana-ChampaignUrbanaIL 61801USA Beckman institute for Advanced Science and technology University of Illinois at Urbana-ChampaignUrbanaIL 61801USA

Various one and two-dimensional(1D and 2D)nanomaterials and their combinations are emerging as next-generation sensors because of their unique opto-electro-mechanical properties accompanied by large surface-to-volume ratio and high quality *** numerous studies have demonstrated an unparalleled sensitivity of these materials as resonant nanomechanical sensors under vacuum isolation,an assessment of their performance in the presence of an interacting medium like fluid environment is ***,we report the mechanical damping behavior of a 1D singlewalled carbon nanotube(SWCNT)resonator operating in the fundamental flexural mode and interacting with a fluid environment,where the fluid is placed either inside or outside of the SWCNT.A scaling study of dissipation shows an anomalous behavior in case of interior fluid where the dissipation is found to be extremely low and scaling inversely with the fluid *** the sources of dissipation reveals that(i)the phonon dissipation remains unaltered with fluid density and(ii)the anomalous dissipation scaling in the fluid interior case is solely a characteristic of the fluid response under *** linear response theory,we construct a fluid damping kernel which characterizes the hydrodynamic force response due to the resonant *** damping kernel-based analysis shows that the unexpected behavior stems from time dependence of the hydrodynamic response under *** systematic dissipation analysis helps us to infer the origin of the intrinsic *** also emphasize on the difference in dissipative response of the fluid under nanoconfinement when compared to a fluid exterior *** finding highlights a unique feature of confined fluid–structure interaction and evaluates its effect on the performance of high-frequency nanoresonators.

关键词： scaling dissipation flexural

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不同光束移动速度下的激光淬火有限元分析

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材料科学与工艺 2011年第4期19卷 95-102页

作者：汪舟姜传海 Volker Schulze 陈艳华嵇宁上海交通大学材料科学与工程学院 Institut für Werkstoffkunde I Karlsruhe Institute of TechnologyKarlsruhe 76128 LEMHE/ICMMO UMR 8182Université Paris-Sud 11Orsay 91405

为研究不同激光淬火处理条件下激光淬火温度场和物相结构,运用ABAQUS/Standard对激光淬火处理AISI4140钢进行了有限元模拟,并结合实验进行了验证.结果表明:激光淬火材料最高温度并不在光束中心,而是出现在距激光束中心2 mm的位置,且不... 详细信息

为研究不同激光淬火处理条件下激光淬火温度场和物相结构,运用ABAQUS/Standard对激光淬火处理AISI4140钢进行了有限元模拟,并结合实验进行了验证.结果表明:激光淬火材料最高温度并不在光束中心,而是出现在距激光束中心2 mm的位置,且不随着光束移动速度的增大而改变位置;在激光束最高温度恒定为1150℃情况下,不同移动速度对于升温速率影响更加显著,而降温速率则相对稳定;材料本身性质和热边界条件是影响降温速率的主要因素,激光束移动速度为次要因素.另外,可以通过此模型制定合理激光处理工艺得到相应深度马氏体硬化层.

关键词： AISI4140钢激光淬火温度场马氏体层深有限元模拟

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Global trends and hot topics in clinical applications of perovskite materials:a bibliometric analysis

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Biomaterials Translational 2023年第3期4卷 131-141页

作者： Tai-Long Shi Yi-Fan Zhang Meng-Xuan Yao Chao Li Hai-Cheng Wang Chuan Ren Jun-Sheng Bai Xu Cui Wei Chen Department of Orthopaedic Surgery Third Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Key Laboratory of Biomechanics of Hebei Province ShijiazhuangHebei ProvinceChina NHC Key Laboratory of Intelligent Orthopaedic Equipment ShijiazhuangHebei ProvinceChina center for Human Tissues and Organs Degeneration Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina

In recent years,perovskite has received increasing attention in the medical ***,there has been a lack of related bibliometric analysis in this research *** study aims to analyse the research status and hot topics of perovskite in the medical field from a bibliometric perspective and explore the research direction of *** study collected 1852 records of perovskite research in the medical field from 1983 to 2022 in the Web of Science(WOS)*** country,institution,journal,cited references,and keywords were analysed using CiteSpace,VOS viewer,and Bibliometrix *** number of articles related to perovskite research in the medical field has been increasing every *** and USA have published the most papers and are the main forces in this research *** University of London Imperial College of Science,technology,and Medicine is the most active institution and has contributed the most *** Applied materials&Interfaces is the most prolific journal in this field.“Medical electronic devices”,“X-rays”,and“piezoelectric materials”are the most researched directions of perovskite in the medical field.“Performance”,“perovskite”,and“solar cells”are the most frequently used keywords in this *** materials is the most relevant and academically influential journal for perovskite *** perovskites have been a hot topic in this field in recent years and will be a future research trend.X-ray,electronic medical equipment,and medical stents are the main research directions.

关键词： bibliometrics bibliometrix CiteSpace perovskite R package

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Semi-Interpenetrating Novolac-Epoxy Thermoset Polymer Networks Derived from Plant Biomass

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Journal of Renewable materials 2018年第7期6卷 724-736页

作者： Mehul Barde Yusuf Celikbag Brian Via Sushil Adhikari Maria LAuad center for Polymers and Advanced Composites Auburn UniversityAuburn36849ALUnited States of America Department of Chemical Engineering Auburn UniversityAuburn36849ALUnited States of America Forest Products Development center Auburn UniversityAuburn36849ALUnited States of America Department of Biosystems Engineering Auburn UniversityAuburn36849ALUnited States of America

Bio-based phenol-formaldehyde polymer (BioNovolac) was developed by reacting molar excess of bio-oil/phenolwith formaldehyde in acidic medium. Glycidyl 3,5-diglycidoxybenzoate (GDGB), was prepared by directglycidylation of α-resorcylic acid (RA), a naturally occurring phenolic monomer. GDGB was crosslinked in thepresence of BioNovolac by anionic polymerization. Fourier transform infrared spectroscopy (FTIR) confirmedthe formation of semi-interpenetrating polymer networks. The glass transition temperature and moduli of biobasedcrosslinked systems were observed to increase with increasing GDGB content. Active chain density andmass retention measured by dynamic mechanical analysis (DMA) and Soxhlet extraction, respectively, indicated ahigh crosslink density of the cured networks. Scanning electron microscopy (SEM) images depicted thehomogeneity of the bulk phase. The preparation of bio-based epoxy-novolac thermoset network resulted inreduced consumption of petroleum-based chemicals.

关键词： Fast pyrolysis bio-oil BioNovolac semi-interpenetrating polymer networks

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3D-printed NIR-responsive shape memory polyurethane/magnesium scaffolds with tight-contact for robust bone regeneration

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Bioactive materials 2022年第10期7卷 218-231页

作者： Yuanchi Zhang Cairong Li Wei Zhang Junjie Deng Yangyi Nie Xiangfu Du Ling Qin Yuxiao Lai Centre for Translational Medicine Research&Development Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenChina University of Chinese Academy of Sciences ShenzhenChina Key Laboratory of Health Informatics Chinese Academy of SciencesShenzhenChina Musculoskeletal Research Laboratory Department of Orthopaedics&TraumatologyThe Chinese University of Hong KongHong Kong SARChina CAS-HK Joint Lab of Biomaterials ShenzhenChina

Patients with bone defects suffer from a high rate of disability and *** contact of grafts with defective bones and insufficient osteogenic activities lead to increased loose risks and unsatisfied repair *** self-expanding scaffolds were developed to enhance bone integration,the limitations on the high transition temperature and the unsatisfied bioactivity hindered greatly their clinical ***,we report a near-infrared-responsive and tight-contacting scaffold that comprises of shape memory polyurethane(SMPU)as the thermal-responsive matrix and magnesium(Mg)as the photothermal and bioactive component,which fabricated by the low temperature rapid prototyping(LT-RP)3D printing *** designed,due to synergistic effects of the components and the fabrication approach,the composite scaffold possesses a homogeneously porous structure,significantly improved mechanical properties and stable photothermal *** programmed scaffold can be heated to recover under near infrared irradiation in *** 4 wt%Mg,the scaffold has the balanced shape fixity ratio of 93.6%and shape recovery ratio of 95.4%.The compressed composite scaffold could lift a 100 g weight under NIR light,which was more than 1700 times of its own *** results of the push-out tests and the finite element analysis(FEA)confirmed the tight-contacting ability of the SMPU/4 wt%Mg scaffold,which had a signficant enhancement compared to the scaffold without shape memory ***,The osteopromotive function of the scaffold has been demonstrated through a series of in vitro and in vivo *** envision this scaffold can be a clinically effective strategy for robust bone regeneration.

关键词： Shape memory polyurethane Magnesium 3D printing Robust bone regeneration Tight-contact

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Vacancy manipulating of molybdenum carbide MXenes to enhance Faraday reaction for high performance lithium-ion batteries

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Nano Research Energy 2022年第3期1卷 18-26页

作者： Xin Guo Changda Wang Wenjie Wang Quan Zhou Wenjie Xu Pengjun Zhang Shiqiang Wei Yuyang Cao Kefu Zhu Zhanfeng Liu Xiya Yang Yixiu Wang Xiaojun Wu Li Song Shuangming Chen Xiaosong Liu National Synchrotron Radiation Laboratory CAS Center for Excellence in NanoscienceUniversity of Science and Technology of ChinaHefei 230029China School of Chemistry and Material Sciences University of Science and Technology of ChinaHefei 230029China

“Intrinsic”strategies for manipulating the local electronic structure and coordination environment of defect-regulated materials can optimize electrochemical storage ***,the structure–activity relationship between defects and charge storage is ambiguous,which may be revealed by constructing highly ordered vacancy ***,we demonstrate molybdenum carbide MXene nanosheets with customized in-plane chemical ordered vacancies(Mo_(1.33)CT_(x)),by utilizing selective etching ***-based X-ray characterizations reveal that Mo atoms in Mo1.33CTx show increased average valence of+4.44 compared with the control Mo_(2)CT_(x).Benefited from the introduced atomic active sites and high valence of Mo,Mo_(1.33)CT_(x)achieves an outstanding capacity of 603 mAh·g^(−1)at 0.2 A·g^(−1),superior to most original ***+storage kinetics analysis and density functional theory(DFT)simulations show that this optimized performance ensues from the more charge compensation during charge–discharge process,which enhances Faraday reaction compared with pure Mo_(2)CT_(x).This vacancy manipulation provides an efficient way to realize MXene’s potential as promising electrodes.

关键词： ordered vacancies MXenes X-ray absorption fine structure(XAFS) lithium-ion storage mechanism

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Over-expression of nitric oxide and nitric oxide synthase in the rat brain following focal ischemia

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Neural Regeneration Research 2008年第2期3卷 162-166页

作者： Weizhong Yang Chunmei Chen Chunhua Wang Songsheng Shi Junrong Lei Yongliang Zhang Department of Neurosurgery Union Hospital Fujian Medical University Fujian Institute of Neurosurgery Fuzhou 350001 Fujian Province China

BACKGROUND： In cerebral ischemia, over-expression of nitric oxide （NO） exerts neurotoxic effects.OBJECTIVE： This study was designed to measure NO and nitric oxide synthase （NOS） expression in rat brain tissue during cerebral ischemia, and to correlate expression levels of NO and NOS with ischemic time. DESIGN： A complete randomized grouping design, controlled animal experiment. SETTING： Fujian institute of Neurosurgery ＆ Department of Neurosurgery, Union Hospital Affiliated Fujian Medical University. materials： This study was performed at the Fujian institute of Neurosurgery in December 2003. Eighty healthy adult male Sprague Dawley （SD） rats of clean grade were provided by the Zhejiang Laboratory Animal center. The protocol was performed in accordance with ethical guidelines for the use and care of animals. Kits for measuring NO expression by method of nitrate reductase （Boster Company, Wuhan, China） and NOS activity （Jiancheng Bioengineering Co., Ltd., Nanjing, China）, as well as a kit for reverse transcription-PCR （RT-PCR, Promega, USA） were used in the present study. METHODS： Sixty-eight rats underwent cerebral ischemia by occluding the middle cerebral artery by suture method. Forty-eight successfully lesioned rats were included in the study. Six rats were used for each length of ischemic event （30 minutes, 1, 3, 6, 12, 24, and 72 hours, and 5 days of ischemia）. Additionally, a normal control group （n = 6, normally raised） and a sham-operated group （n = 6, corresponding cerebral vessels exposed, without occlusion of middle cerebral artery） were included in the analysis. MAIN OUTCOME MEASURES： Neurological function deficits were scored according to methods of Longa, Bederson, and colleagues. NO levels and NOS activity in the brain tissue were measured via nitrate reductase and chemical colorimetry, respectively. The expression of nitrotyrosine （NT）, an in vivo specific metabolite of NO, was quantitatively measured by flow cytometry. Expression of endoth

关键词： cerebral ischemia NO eNOS, nNOS iNOS

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