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Biochemical mechanisms implemented by human acute myeloid leukemia cells to suppress host immune surveillance

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Cellular & Molecular Immunology 2018年第11期15卷 989-991页

作者： Inna M.Yasinska Isabel Gonçalves Silva Svetlana Sakhnevych Bernhard F.Gibbs Ulrike Raap Elizaveta Fasler-Kan Vadim V.Sumbayev Medway school of pharmacy Universities of Kent and GreenwichChatham MaritimeUK Department of Dermatology and Allergy University of OldenburgOldenburgGermany Department of Pediatric Surgery and Department of Biomedical Research Children’s HospitalInselspitalUniversity of BernBernSwitzerland Department of Biomedicine University Hospital Basel and University of Basel BaselSwitzerland

Acute myeloid leukaemia(AML)is a blood/bone marrow cancer originating from myeloid cell precusors capable of *** cells implement biochemical mechanisms which allow them not only to survive,but also to successfully escape immune *** this work,we discuss crucial molecular mechanisms used by human AML cells in order to evade immune attack.

关键词： Acute myeloid leukaemia Immune surveillance Tim-3 galectin-9

Prediction of Chemical-Protein Interactions via Weighted and Unweighted Network-Based Inference Methods

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Prediction of Chemical-Protein Interactions via Weighted and...

中国化学会第28届学术年会

作者：程飞雄李卫华唐赟 Shanghai Key Laboratory of New Drug Design School of PharmacyEast China University of Science and Technology

＜正＞Chemical-protein interaction （CPI） is the basis of drug discovery.1 In this study, we developed weighted and unweighted network-based inference （NBI） methods for CPI prediction.

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PCDH17 increases the sensitivity of colorectal cancer to 5-fluorouracil treatment by inducing apoptosis and autophagic cell death

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Signal Transduction and Targeted Therapy 2019年第1期4卷 176-185页

作者： Shuiping Liu Haoming Lin Da Wang Qiang Li Hong Luo Guoxiong Li Xiaohui Chen Yongqiang Li Peng Chen Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Mingming Zhang Xuemeng Han Qiujie Li Liuxi Chen Ying Liu Xiaying Chen Guohua Li Yu Xiang Ting Duan Jiao Feng Jianshu Lou Xingxing Huang Qin Zhang Ting Pan Lili Yan Ting Jin Wenzheng Zhang Lvjia Zhuo Yitian Sun Tian Xie Xinbing Sui Holistic Integrative pharmacy Institutes and Comprehensive Cancer Diagnosis and Treatment Center the Affiliated Hospital of Hangzhou Normal UniversityCollege of MedicineHangzhou Normal UniversityHangzhouZhejiangChina Key Laboratory of Elemene Class Anti-cancer Chinese Medicine of Zhejiang Province and Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province Hangzhou Normal UniversityHangzhouZhejiangChina Department of Hepatobiliary Pancreatic Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouChina Department of Colorectal Surgery The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouChina Department of Ultrasound Medicine The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina Department of Medical Oncology Sir Run Run Shaw HospitalZhejiang UniversityHangzhouChina Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica School of PharmacyNanjing University of Chinese MedicineNanjingChina

5-Fluorouracil(5-FU)is known as a first-line chemotherapeutic agent against colorectal cancer(CRC),but drug resistance occurs frequently and significantly limits its clinical *** previous study showed that the protocadherin 17(PCDH17)gene was frequently methylated and functioned as a tumor suppressor in ***,the relationship between PCDH17 and 5-FU resistance in CRC remains ***,we revealed that PCDH17 was more highly expressed in 5-FU-sensitive CRC tissues than in 5-FU-resistant CRC tissues,and high expression of PCDH17 was correlated with high BECN1 ***,this expression profile contributed to superior prognosis and increased survival in CRC *** PCDH17 expression augmented the 5-FU sensitivity of CRC in vitro and in vivo by promoting apoptosis and autophagic cell ***,autophagy played a dominant role in PCDH17-induced cell death,as an autophagy inhibitor blocked cell death to a greater extent than the pancaspase inhibitor ***17 inhibition by siRNA decreased the autophagy response and 5-FU ***,we showed that c-Jun NH2-terminal kinase(JNK)activation was a key determinant in PCDH17-induced *** compound SP600125,an inhibitor of JNK,suppressed autophagy and 5-FU-induced cell death in PCDH17-reexpressing CRC *** together,our findings suggest for the first time that PCDH17 increases the sensitivity of CRC to 5-FU treatment by inducing apoptosis and JNK-dependent autophagic cell ***17 may be a potential prognostic marker for predicting 5-FU sensitivity in CRC patients.

关键词： death treatment apoptosis

Novel ginsenoside Rh2 based multifunctional liposome for high efficacy drug delivery and cancer therapy

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Novel ginsenoside Rh2 based multifunctional liposome for hig...

2018年第十二届中国药物制剂大会

作者：洪超 Jianxin Wang Department of Pharmaceutics School of Pharmacy Fudan University ＆ Key Laboratory of Smart Drug Delivery Ministry of Education

＜正＞Of the many nanoparticle types used in drug delivery,liposomes have been particularly successful,and many formulations have passed into clinical *** has become an indispensable component in liposome preparation at ***,the clinical application of cholesterol liposomes has been limited due to various *** have found that cholesterol can regulate serum lipoprotein level to induce"complementmediated pseudoallergic reaction"after intravenous injection of liposomes,resulting in

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Crisaborole and Apremilast: PDE4 Inhibitors with Similar Mechanism of Action, Different Indications for Management of Inflammatory Skin Conditions

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Pharmacology & pharmacy 2018年第9期9卷 357-381页

作者： Jan M. Kitzen Joseph V. Pergolizzi Jr. Robert Taylor Jr. Robert B. Raffa Kitzen Pharmaceutical Consulting Collegeville PA USA Temple University school of Medicine Philadelphia PA USA NEMA Research Inc. Naples FL USA Neumentum Inc. Palo Alto CA USA University of Arizona College of pharmacy Tucson AZ USA Temple University school of pharmacy Philadelphia PA USA

Two selective phosphodiesterase-4 (PDE4) inhibitors—viz., crisaborole (Eucrisa®, Pfizer) and apremilast (Otezla®, Celgene)—have recently received approval by the United States Food and Drug Administration for the treatment of related but different dermatologic skin conditions (viz., atopic dermatitis and plaque psoriasis, respectively). The purpose of this review is to summarize the underlying biochemistry and pathophysiology associated with these dermatologic conditions, review the chemistry, pharmacology and safety of each of these products, and present preclinical and clinical evidence that may help explain why these two PDE4 inhibitors offer new treatment options for these skin conditions.

关键词： Crisaborole Apremilast Phosphodiesterase PDE4 Inflammation Cytokines Interleukins cAMP

Development of Novel Assay for the Determination of Lipoxygenases Activity

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Development of Novel Assay for the Determination of Lipoxyge...

第八届全国化学生物学学术会议

作者： Weiqiang Lu Xue Zhao Jin Huang Shanghai Key Laboratory of New Drug Design School of PharmacyEast China University of Science and Technology

＜正＞Lipoxygenases（LOXs） are important targets for inflammation-related *** the development of the anti-flammatory drug by targeting LOXs is slowed down because of the limit of existing assay *** the present study,we developed two new methods for the determintion of LOXs enzyme activity by taking advantage of the oxidation capacity of LOXs

关键词： Lipoxygenase assay methods anti-inflammation durg

Identification of small molecules for accelerating the differentiation of GABA interneurons from human pluripotent stem cells

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Journal of Molecular Cell Biology 2020年第3期12卷 245-248页

作者： Luping Shen Fang Yuan Yuan Hong Min Xu Yao Hu Yan Liu Institute for Stem Cell and Neural Regeneration Key Laboratory of Targeted Intervention of Cardiovascular DiseaseSchool of PharmacyNanjing Medical UniversityNanjing 211166China State Key Laboratory of Reproductive Medicine Nanjing Medical UniversityNanjing 211166China Co-innovation Center of Neuroregeneration Nantong UniversityNantong 226019China

Dear Editor,Here,we present a method to accelerate the differentiation of γ-aminobutyric acid(GABA)interneurons(GINs)from human pluripotent stem cells(hPSCs).Normal brain function requires balanced levels of excitation and inhibition of *** are the main inhibitory neurons in the central nervous system,and they are thought to play a critical role in sculpting inhibitory network dynamics in the cerebral cortex(Rossignol,2011).Thus,dysfunction of GINs induces many neurological diseases,such as epilepsy,major depression,anxiety,and *** it is difficult to recover from the dysfunction/loss of GINs in the neural network,exogenous GIN transplantation has been considered a potential therapeutic strategy for the treatment of GIN-associated neurological diseases.

关键词： epilepsy cortex cerebral

The application of azaspirocycles in the discovery of Bcr-Abl kinase inhibitors

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The application of azaspirocycles in the discovery of Bcr-Ab...

2013医学前沿论坛暨第十三届全国肿瘤药理与化疗学术会议

作者： Yichao Zhao Weixing Zhang Xiuhong Lu Min Jiang Xiaochun Dong Weili Zhao school of pharmacy Fudan University Key Laboratory for Special Functional Materials of the Ministry of Education Henan University

Heteroatom-substituted spiro[3.3]heptanes have been reported as viable and promising surrogates for piperazines,piperidines,morpholines,and *** novel framework has been mounted onto scaffolds of druglike structures,such as fluoroquinolones,to afford active compounds with similar or even improved metabolic stability.

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Effect on platelet aggregation activity: extracts from 31 Traditional Chinese Medicines with the property of activating blood and resolving stasis

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Journal of Traditional Chinese Medicine 2017年第1期37卷 64-75页

作者： Chen Cen Wang Fengqin Xiao Wen Xia Zhining Hu Guang Wan Jianbo Yang Fengqing school of Chemistry and Chemical Engineering Chongqing University Chongqing 400030 China school of pharmacy and Bioengineering Chongqing University of Technology Chongqing 400054 China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Macao Macao China

OBJECTIVE: To evaluate the anti-platelet aggregation effects of extracts from 31 Traditional Chinese Medicines(TCM) with the property of activating blood and resolving stasis in terms of TCM ***: The 31 TCMs extracts were prepared using water, 90% ethanol and ethyl acetate., and the effects on anti-platelet aggregation were tested on a platelet aggregation analyzer in vitro with adenosine 5'-diphosphate, bovine thrombin and arachi-donic acid(AA) as aggregation inducers, respectively. Aspirin was the positive ***: Lots of the tested TCMs had inhibitory effects with concentration-dependent manner on platelet aggregations induced by various ***, some of the TCMs such as Chuanxiong(Rhizoma Chuanxiong), Yanhusuo(Rhizoma Corydalis Yanhusuo) and Danshen(Radix Salviae Miltiorrhizae) showed good anti-platelet aggregation effect similar or higher than that in positive control ***: The study provided scientific references that several TCMs such as Chuanxiong(Rhizoma Chuanxiong), Yanhusuo(Rhizoma Corydalis Yanhusuo) and Danshen(Radix Salviae Miltiorrhizae),possess the property of anti-platelet aggregation.

关键词： Platelet aggregation inhibitors Adenosine diphosphate Thrombin Arachidonic acid Blood activating stasis removing Medicine Chinese traditional