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Indocyanine green-based nanodrugs: A portfolio strategy for precision medicine

Progress in Natural Science:Materials International 2020年第5期30卷 577-588页

作者： Qixuan Dai En Ren Dazhuang Xu Yun Zeng Chuan Chen Gang Liu Department of Pharmacy Xiamen Medical College State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University amoy hopeful biotechnology co. Ltd.

As the sole cyanine dye approved by the Food and Drug Administration(FDA), indocyanine green(ICG) has been widely applied in solid tumor and metastases surgical navigation as well as malignant tissue destruction. The great performance of ICG benefits from excellent fluorescent properties in the near infrared region(NIR) and reactive oxygen species(ROS) or hyperthermia effects under irradiation. Nevertheless, some intrinsic limitations, such as unstable optical properties, co.centration-dependent aggregation, proneness to photo-bleaching, and poor aqueous stability in vivo, severely restrict its further applications. To overco.e these challenges, ICG-based nanodrugs(nanoICG), as one kind of portfolio strategy, co.ld bridge the efficient cargo-carriers and ICG molecules to artificially improve their existing performance. In this mini-review, we will focus on the developed engineering strategies for nano-ICG formulation synthesis and their desired performance in tumor tracing and eradication. A critical analysis of assembly mechanisms, excellent performance, and further improvement tactics will be examined.

关键词： ICG Nanomedicine Self-assembly Tumor theranostics Tumor synergistic treatment

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Beyond Antibiotics:Photo/Sonodynamic Approaches for Bacterial Theranostics

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Nano-Micro Letters 2020年第10期12卷 313-335页

作者： Xin Pang Dengfeng Li Jing Zhu Jingliang Cheng Gang Liu Henan Key Laboratory of Functional Magnetic Resonance Imaging and Molecular Imaging Department of Magnetic Resonance ImagingThe First Affiliated Hospital of Zhengzhou University450052 ZhengzhouPeople’s Republic of China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine School of Public HealthXiamen University361102 XiamenPeople’s Republic of China amoy hopeful biotechnology co. Ltd361027 XiamenPeople’s Republic of China

Rapid evolution and propagation of multidrug resistance among bacterial pathogens are outpacing the development of new antibiotics,but antimicrobial photodynamic therapy(aPDT)provides an excellent *** treatment depends on the interaction between light and photoactivated sensitizer to generate reactive oxygen species(ROS),which are highly cytotoxic to induce apoptosis in virtually all microorganisms without resistance *** replacing light with low-frequency ultrasonic wave to activate sensitizer,a novel ultrasounddriven treatment emerges as antimicrobial sonodynamic therapy(aSDT).Recent advances in aPDT and aSDT reveal golden opportunities for the management of multidrug resistant bacterial infections,especially in the theranostic application where imaging diagnosis can be acco.plished facilely with the inherent optical characteristics of sensitizers,and the generated ROS by aPDT/SDT cause broad-spectrum oxidative damage for *** this review,we systemically outline the mechanisms,targets,and current progress of aPDT/SDT for bacterial theranostic ***,potential limitations and future perspectives are also highlighted.

关键词： Photodynamic therapy Sonodynamic therapy Theranostics Multidrug resistant Reactive oxygen species

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Radio-granular hydrogels for image-guided tumor brachytherapy

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iLIVER 2023年第3期2卷 177-179页

作者： Shilong Shao Xiao Xu Gan Lin Gang Liu State Key Laboratory of Vaccines for Infectious Diseases Center for Molecular Imaging and Translational MedicineXiang An Biomedicine LaboratoryNational Innovation Platform for Industry-Education Integration in Vaccine ResearchSchool of Public HealthXiamen UniversityXiamen 361005Fujian ProvinceChina State Key Laboratory of Cellular Stress Biology Innovation Center for Cell BiologySchool of Life SciencesXiamen UniversityXiamen 361005Fujian ProvinceChina Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM)&amoy hopeful biotechnology co. Ltd.Xiamen 361028Fujian ProvinceChina

Transarterial radioembolization(TARE),derived from transarterial chemoembolization,embolizes tumor blood vessels and elicits tumor brachytherapy by using radionuclide-loaded microspheres,a promising therapeutic modality for locally advanced hepatocellular carcinoma(HCC)[1,2].However,the implementation of TARE in the clinic has been hampered by the lack of efficient radioembolization agents[3,4].

关键词： Hepatocellular carcinoma TARE co.version therapy Theranostics

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Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in co.on cancer by single-cell transcriptomics

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Acta Pharmaceutica Sinica B 2022年第1期12卷 149-166页

作者： Jian Gao Zhigui Wu Mingxia Zhao Rui Zhang Manru Li Dongdong Sun Haibo Cheng Xianjia Qi Yuxian Shen Qiang Xu Hongqi Chen Dijun Chen Yang Sun State Key Laboratory of Pharmaceutical biotechnology Chemistry and Biomedicine Innovation Center(Chem BIC)School of Life SciencesNanjing UniversityNanjin 210023China Biopharmaceutical Research Institute School of Basic Medical SciencesAnhui Medical UniversityHefei 230032China Department of co.orectal Surgery Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital&InstituteShenyang 110042China The First Clinical co.lege of Nanjing University of Chinese Medicine Nanjing 210023China Shanghai Xu Ran biotechnology co. Ltd.Shanghai 201109China Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical UniversityXuzhou 221004China Department of General Surgery Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China

co.orectal cancer(CRC), a malignant tumor worldwide co.sists of microsatellite instability(MSI) and stable(MSS) phenotypes. Although SHP2 is a hopeful target for cancer therapy, its relationship with innate immunosuppression remains elusive. To address that, single-cell RNA sequencing wasperformed to explore the role of SHP2 in all cell types of tumor microenvironment(TME) from murine MC38 xenografts. Intratumoral cells were found to be functionally heterogeneous and responded significantly to SHP099, a SHP2 allosteric inhibitor. The malignant evolution of tumor cells was remarkably arrested by SHP099. Mechanistically, STING-TBK1-IRF3-mediated type I interferon signaling was highly activated by SHP099 in infiltrated myeloid cells. Notably, CRC patients with MSS phenotype exhibited greater macrophage infiltration and more potent SHP2 phosphorylation in CD68;macrophages than MSI-high phenotypes, suggesting the potential role of macrophagic SHP2 in TME. co.lectively,our data reveals a mechanism of innate immunosuppression mediated by SHP2, suggesting that SHP2 is a promising target for co.on cancer immunotherapy.

关键词： Tumor microenvironment PTPN11 SHP099 STING Type I interferon co.orectal cancer scRNA-seq Macrophage

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