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Asian Pacific Journal of Tropical Biomedicine 2024年第1期14卷 40-46页

作者： Jyotsana Bakshi Somnath Singh KP Mishra DRDO Defence institute of physiology and allied sciences DelhiIndia

Objective:To investigate the underlying mechanism of anti-inflammatory action of coumarin and eugenol in lipopolysaccharide(LPS)-stimulated RAW 264.7 ***:RAW 264.7 cells were treated with 2.5μg/mL of LPS,50μM of coumarin,and 50μM eugenol for 24 *** viability of the cells was assessed using MTT *** production of nitric oxide was determined using Griess reagent and DCFH-DA was used to measure the production of reactive oxygen *** protein expression of NLRP3,IL-1β,NF-κB,and cyclooxygenase 2 was assessed using Western blot ***:Coumarin and eugenol showed anti-inflammatory effects against LPS-induced inflammatory response by ameliorating the expression of NLRP3 inflammasome and NF-κB,which further led to a subsequent reduction in IL-1β,nitric oxide,and reactive oxygen ***:Coumarin and eugenol exert their anti-inflammatory activities by modulating the NLRP3 inflammasome pathway and NF-κ*** compounds may have promising therapeutic applications for the treatment of various inflammatory diseases.

关键词： Inflammation Cytokines Coumarin Eugenol NLRP3 LPS

On some new fuzzy entropy measure of Pythagorean fuzzy sets for decision-making based on an extended TOPSIS approach

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Journal of Management Analytics 2024年第1期11卷 87-109页

作者： H.D.Arora Anjali Naithani Department of Mathematics Amity Institute of Applied SciencesAmity University Uttar PradeshNoidaIndia

Fuzzy entropy measures are valuable tools in decision-making when dealing with uncertain or imprecise *** exist many entropy measures for Pythagorean Fuzzy Sets(PFS)in the literature that fail to deal with the problem of providing reasonable or consistent results to the *** deal with the shortcomings of the existing measures,this paper proposes a robust fuzzy entropy measure for PFS to facilitate decision-making under *** usefulness of the measure is illustrated through an illustration of decision-making in a supplier selection problem and compared with existing fuzzy entropy *** Technique for Order Performance by Similarity to Ideal Solution(TOPSIS)approach is also explored to solve the decision-making *** results demonstrate that the proposed measure can effectively capture the degree of uncertainty in the decision-making process,leading to more accurate decision outcomes by providing a reliable and robust ranking of alternatives.

关键词： Pythagorean fuzzy sets entropy measures multi criteria decision analysis TOPSIS method supplier selection

Phytochemical analysis of Tinospora cordifolia and Withania somnifera and their therapeutic activities with special reference to COVID-19

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World Journal of Experimental Medicine 2024年第3期14卷 39-47页

作者： Prateek Rai Tanya Garain Deepshikha Gupta Chemistry Amity Institute of Applied SciencesAmity UniversityNoida 201301Uttar PradeshIndia

Various important medicines make use of secondary metabolites that are produced by *** plants,such as Withania somnifera and Tinospora cordifolia,are rich sources of chemically active compounds and are reported to have numerous therapeutic *** therapeutic use of medicinal plants is widely mentioned in Ayurveda and has folkloric importance in different parts of the *** aim of this review is to summarize the phytochemical profiles,folkloric importance,and primary pharmacological activity of *** and *** with emphasis on their action against the novel coronavirus.

关键词： Phytochemical analysis Tinospora cordifolia Withania somnifera COVID-19 Immunomodulators Giloy Ashwagandha

Perception,use of social media,and its impact on the mental health of Indian adolescents:A qualitative study

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World Journal of Clinical Pediatrics 2024年第3期13卷 61-68页

作者： Vishnu V Taddi Ravshish K Kohli Pooja Puri amity institute of Forensic sciences Amity UniversityNoida 201313India

BACKGROUND Mental illness is a health challenge faced by adolescents that has grown worse after the Coronavirus disease 2019 *** on social media and young people’s mental health has recently increased,and numerous studies have examined whether frequent use of social media is linked to issues such as anxiety,stress,depression,eating disorders,insomnia,frustration,feeling alone,and externalizing problems among *** influence of social media on adolescents’lives is clear,with many platforms like Facebook,Instagram,and YouTube playing an important role in daily interactions and *** though social media offers numerous benefits,such as connectivity and information sharing,excessive usage can have detrimental effects on mental health,particularly among *** To study the impact of social media on the mental wellbeing of adolescents,and the associated potential dangers in *** A total of 204 adolescents aged 14 years to 23 years were included in the *** study explored the intricate relationship between social media usage and adolescent mental health in *** study employs a cross-sectional survey design to capture a snapshot of adolescent mental health and social media usage *** collection involved administering structured questionnaires and the analysis utilized quantitative methods,including descriptive *** Excessive use of social media is correlated with increased stress,anxiety,and *** engage in compulsive behaviors such as scrolling in the middle of the night,which negatively impacts their mental and physical health,and leads to significant sleep *** from the study aim to provide insights into the current state of adolescent mental health and inform strategies to promote positive wellbeing in the Indian *** The study underscores the need for further research to better understand the complex interplay between social media

关键词： Adolescents Anxiety Cyberbullying Depression Mental health Social media

Numerical evaluations on the fluid production in the in-situ conversion of continental shale oil reservoirs

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Petroleum Science 2024年第4期21卷 2485-2501页

作者： Zhao-Bin Zhang Maryelin Josefina Brice?o Montilla Shou-Ding Li Xiao Li Jian-Peng Xing Yan-Zhi Hu Key Laboratory of Shale Gas and Geoengineering Institute of Geology and Geophysics Chinese Academy of Sciences institute of Earth sciences Chinese Academy of Sciences College of Earth and Planetary sciences University of Chinese Academy of Sciences institute of Energy Peking University

In-situ conversion presents a promising technique for exploiting continental oil shale formations,characterized by highly fractured organic-rich rock. A 3D in-situ conversion model, which incorporates a discrete fracture network, is developed using a self-developed thermal-flow-chemical(TFC) *** of the model elucidates the in-situ conversion process in three stages and defines the transformation of fluids into three distinct outcomes according to their end stages. The findings indicate that kerogen decomposition increases fluid pressure, activating fractures and subsequently enhancing permeability. A comprehensive analysis of activated fracture permeability and heating power reveals four distinct production modes, highlighting that increasing heating power correlates with higher cumulative fluid production. Activated fractures, with heightened permeability, facilitate the mobility of heavy oil toward production wells but hinder its cracking, thereby limiting light hydrocarbon ***, energy efficiency research demonstrates the feasibility of the in-situ conversion in terms of energy utilization, especially when considering the surplus energy from high-fluctuation energy sources such as wind and solar power to provide heating.

关键词： In-situ conversion Continental shale oil Natural fracture network TFC model

Serum tumor markers:Can they clinically implicate in type 2 diabetes mellitus?

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World Journal of Diabetes 2024年第7期15卷 1648-1650页

作者： Kotha Sugunakar Reddy Ilakkiya Priya Pandiaraj Archana Gaur Sakthivadivel Varatharajan Department of General Medicine All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of physiology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia

“Serum tumor markers expression(CA19-9,CA242,and CEA)and its clinical implications in type 2 diabetes mellitus”authored by Meng and Shi presents an observational case-control study investigating the correlation between tumor markers and type 2 diabetes mellitus(T2DM).The study explores the diagnostic accuracy of tumor markers,particularly cancer antigen 19-9(CA19-9),CA242,and carcinoembryonic antigen,in poorly controlled T2DM patients with hemoglobin A1c levels exceeding 9%,employing receiver operating characteristic curve *** study offers valuable insights into the potential utility of tumor markers in clinical practice,caution is advised regarding routine tumor marker testing due to challenges such as limited availability and ***,the study overlooks potential confounding factors like smoking and alcohol *** in CA19-9 and CA242 expression underscore the complex interplay between tumor markers and systemic diseases,warranting further investigation into their diagnostic and prognostic *** Meng and Shi represent a significant contribution to the field,more extensive research is needed to fully elucidate the role of tumor markers in diabetes management and beyond.

关键词： Cancer antigen 19-9 Cancer antigen 242 Carcinoembryonic antigen Tumor markers Type 2 diabetes mellitus

Plasticity of photorespiratory carbon concentration mechanism in Sedobassia sedoides(Pall.)Freitag&*** under elevated CO_(2)concentration and salinity

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Journal of Arid Land 2024年第7期16卷 963-982页

作者： Zulfira RAKHMANKULOVA Elena SHUYSKAYA Maria PROKOFIEVA Kristina TODERICH Pavel VORONIN Timiryazev institute of Plant physiology Russian Academy of SciencesMoscow 127276Russia Graduate School of Bioresources Mie University1577 KurimamachiyaTsu 514-8507Japan

Rising atmospheric CO_(2)(carbon dioxide)concentrations and salinization are manifestations of climate change that affect plant growth and *** with an intermediate C_(3)-C_(4)type of photosynthesis live in a wide range of precipitation,temperature,and soil quality,but are more often found in warm and dry *** of the intermediate C_(3)-C_(4)photosynthetic type is C_(2)photosynthesis with a carbon concentration mechanism(CCM)that reassimilates CO_(2)released via ***,the ecological significance under which C_(2)photosynthesis has advantages over C_(3)and C_(4)plants remains largely *** tolerance and functioning of CCM were studied in plants from two populations(P1 and P2)of Sedobassia sedoides(Pall.)Freitag&*** *** with C_(2)photosynthesis exposed to 4 d and 10 d salinity(200 mM NaCl)at ambient(785.7 mg/m^(3),aCO_(2)and elevated(1571.4 mg/m^(3),eCO_(2))CO_(2).On the fourth day of salinity,an increase in Na+content,activity catalase,and superoxide dismutase was observed in both populations.P2 plants showed an increase in proline content and a decrease in photosynthetic enzyme content:rubisco,phosphoenolpyruvate carboxylase(PEPC),and glycine decarboxylase(GDC),which indicated a weakening of C_(2)and C_(4)characteristics under *** under 10 d salinity led to an increased Na^(+)content and activity of cyclic electron flow around photosystem I(PSI CEF),a decreased content of K^(+)and GDC in both populations.P1 plants showed greater salt tolerance,which was assessed by the degree of reduction in photosynthetic enzyme content,PSI CEF activity,and changes in relative growth rate(RGR).Differences between populations were evident under the combination of eCO_(2)and *** long-term salinity and eCO_(2),more salt-tolerant P1 plants had a higher dry biomass(DW),which was positively correlated with PSI CEF *** less salt-tolerant P2 plants,DW correlated with transpiration and dark

关键词： photosystemsⅠandⅡ carbon-concentrating mechanism glycine decarboxylase rubisco phosphoenolpyruvate carboxylase(PEPC) cyclic electron flow salinity stress drylands

Molecular characterization of an outbreak-involved Bacillus anthracis strain confirms the spillover of anthrax from West Africa

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Infectious Diseases of Poverty 2024年第1期13卷 93-94页

作者： Shuchao Wang Roland Suluku Mohamed B.Jalloh Ahmed F.Samba Baogui Jiang Yubiao Xie Doris Harding Mengyao Zhang Foday Sahr Mahmud E.Sesay James S.Squire Mohamed A.Vandi Moinina N.Kallon Shoufeng Zhang Rongliang Hu Yuee Zhao Zhiqiang Mi Changchun Veterinary Research institute Chinese Academy of Agricultural Sciences Changchun China Department of Animal sciences School of Agriculture and Food Sciences Njala University Njala Sierra Leone Department of Microbiology College of Medicine and Allied Health Sciences University of Sierra Leone Freetown Sierra Leone Ministry of Agriculture and Food sciences Freetown Sierra Leone Beijing institute of Microbiology and Epidemiology Beijing China Ministry of Health and Sanitation Freetown Sierra Leone Beijing institute of Biotechnology Beijing China

Background Anthrax,a zoonotic disease caused by the spore-forming bacterium Bacillus anthracis,remains a major global public health concern,especially in countries with limited *** Leone,a West African country historically plagued by anthrax,has almost been out of report on this disease in recent *** this study,we described a large-scale anthrax outbreak affecting both animals and humans and attempted to characterize the *** The causative agent of the animal outbreak in Port Loko District,Sierra Leone,between March and May 2022 was identified using the nanopore sequencing technique.A nationwide active surveillance was implemented from May 2022 to June 2023 to monitor the occurrence of anthrax-specific symptoms in *** cases were subsequently verified using quantitative polymerase chain ***-genome sequencing was accomplished by combining long-read and short-read sequencing *** phylogenetic analysis was performed based on the full-chromosome single nucleotide *** The outbreak in Port Loko District,Sierra Leone,led to the death of 233 animals between March 26th and May 16th,*** ruled out the initial suspicion of Anaplasma species and successfully identified *** as the causative agent of the *** a result of the government's prompt response,out of the 49 suspected human cases identifed during the one-year active surveillance,only 6 human cases tested positive,all within the frst month after the official declaration of the *** phylogenetic analysis indicated that the BaSL2022 isolate responsible for the outbreak was positioned in the ***.153 clade within the TransEuroAsian group of *** We successfully identifed a large-scale anthrax outbreak in Sierra *** causative isolate of ***,BaSL2022,phylogenetically bridged other lineages in ***.153 clade and neighboring genetic groups,***.144 and ***.148,

关键词： Molecular identification Anthrax Bacillus anthracis Sierra Leone Phylogeny Single nucleotide polymorphism

Accuracy and precision of dried urine spot method for the detection of Schistosoma mansoni circulating cathodic antigens in resource-limited settings

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Infectious Diseases of Poverty 2024年第1期13卷 103-104页

作者： Abdallah Zacharia Clemence Kinabo Twilumba Makene Huda Omary George Ogweno Faraja Lyamuya Billy Ngasala Muhimbili University of Health and allied sciences Dar es Salaam Tanzania National institute for Medical Research Mwanza Tanzania Neglected Tropical Diseases Control Program Ministry of Health Dodoma Tanzania

Background The World Health Organization recommends the use of Schisto point-of-care circulating cathodic anti-gens(Schisto POC-CCA)for screening of Schistosoma mansoni as it offers better sensitivity than ***,there are limitation facing the use of this method including timely availability of the test *** aim of this study was to determine the reliability of dried urine spot(DUS)method for collection of urine and detection of *** using Schisto POC-CCA cassettes in a resource-limited *** A cross-sectional study was conducted between October and November 2022 among 250 primary school children in Sengerema District,northwestern *** CCA was detected in filter paper-based DUSs,liquid urine using DUS Schisto POC-CCA(index),and direct urine Schisto POC-CCA(comparator)methods *** eggs in stool were detected using duplicate Kato-Katz(KK)*** measures of accuracy were com-puted and compared between the index and comparator *** strength of agreement between inter-raters precisions was tested using Cohen's kappa(k).Results This study revealed *** prevalence rates of 28.8%,54.0%and 50.8%by duplicate KK,direct urine Schisto POC-CCA and DUS Schisto POC-CCA methods *** mean intensity of infection among infected participants Was 86.3 eggs per gram of stool(EPG)ranging from 12.0 EPG to 824.0 *** sensitivity of DUS Schisto POC-CCA and direct urine Schisto POC-CCA Was 94.44%(95%CI:89.15-99.74%)and 97.22%(95%CI:93.43-100.00%)*** DUS Schisto POC-CCA method had slightly higher specificity(66.85%)than direct urine Schisto POC-CCA method(63.48%).The accuracy of the DUS Schisto POC-CCA Was found to be slightly high(74.80%,95%CI:68.94-79.06%)compared to that of direct urine Schisto POC-CCA(73.20%,95%CI:67.25-78.59%).There was good agreement between two laboratory technologists who performed the DUS Schisto POC-CCA method on similar samples(k=0.80,95%CI:0.59-0.95).Con

关键词： Accuracy Point-of-care circulating cathodic antigen Dried urine spot Schistosoma mansoni Sensiti Specificity

Fusion of a rice endogenous N-methylpurine DNA glycosylase to a plant adenine base transition editor ABE8e enables A-toK base editing in rice plants

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aBIOTECH 2024年第2期5卷 127-139页

作者： Yucai Li Shaoya Li Chenfei Li Chen Zhang Lei Yan Jingying Li Yubing He Yan Guo Lanqin Xia institute of Crop sciences(ICS) Chinese Academy of Agricultural Sciences(CAAS)Beijing 100081China State Key Laboratory of Plant physiology and Biochemistry College of Biological SciencesChina Agricultural UniversityBeijing 100193China Hainan Yazhou Bay Seed Laboratory/National Nanfan Research institute(Sanya) CAASSanya 572024China

Engineering of a new type of plant base editor for simultaneous adenine transition and transversion within the editing window will greatly expand the scope and potential of base editing in directed evolution and crop ***,we isolated a rice endogenous hypoxanthine excision protein,N-methylpurine DNA glycosylase(OsMPG),and engineered two plant A-to-K(K=G or T)base editors,rAKBE01 and rAKBE02,for simultaneous adenine transition and transversion base editing in rice by fusing OsMPG or its mutant mOsMPG to a plant adenine transition base editor,*** further coupled either OsMPG or mOsMPG with a transactivation factor VP64 to generate rAKBE03 and rAKBE04,*** these four rAKBEs,at five endogenous loci in rice protoplasts,indicated that rAKBE03 and rAKBE04 enabled higher levels of A-to-G base transitions when compared to ABE8e and ***,whereas rAKBE01 only enabled A-to-C/T editing at one endogenous locus,in comparison with rAKBE02 and rAKBE03,rAKBE04 could significantly improve the A-to-C/T base transversion efficiencies by up to 6.57-and 1.75-fold in the rice protoplasts,***,although no stable lines with A-to-C transversion were induced by rAKBE01 and rAKBE04,rAKBE04 could enable simultaneous A-to-G and A-to-T transition and transversion base editing,at all the five target loci,with the efficiencies of A-to-G transition and A-to-T transversion editing ranging from 70.97 to 92.31%and 1.67 to 4.84%in rice stable lines,***,these rAKBEs enable different portfolios of editing products and,thus,now expands the potential of base editing in diverse application scenario for crop improvement.

关键词： Rice(Oryza sativa L) Rice N-methylpurine DNA glycosylase(OsMPG) A-to-K base editor(AKBE) Transactivation module VP64