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Oral anti-coagulants use in Chinese hospitalized patients with atrial fibrillation

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Chinese Medical Journal 2024年第2期137卷 172-180页

作者： Jing Lin Deyong Long Chenxi Jiang Caihua Sang Ribo Tang Songnan Li Wei Wang Xueyuan Guo Man Ning Zhaoqing Sun Na Yang Yongchen Hao Jun Liu Jing Liu Xin Du Louise Morgan Gregg C.Fonarow Sidney C.Smith Jr Gregory Y.H.Lip Dong Zhao Jianzeng Dong Changsheng Ma On behalf of CCC-AF investigators Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China National Clinical Research Center for Cardiovascular Diseases Beijing 100029 China Department of Epidemiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of HeartLung and Blood Vessel DiseasesBeijing 100029China International Quality Improvement Department American Heart AssociationDallasTX 07076USA Division of Cardiology Geffen School of Medicine at University of CaliforniaLos Angeles CA 90024USA Division of Cardiology University of North CarolinaChapel HillNC 27599USA Department of Cardiology Liverpool Centre for Cardiovascular ScienceUniversity of Liverpool and Liverpool Heart&Chest HospitalLiverpool L143PEUK Department of Clinical Medicine Aalborg UniversityAalborg 9000Denmark 不详

Background:Oral anti-coagulants(OAC)are the intervention for the prevention of stroke,which consistently improve clinical outcomes and survival among patients with atrial fibrillation(AF).The main purpose of this study is to identify problems in OAC utilization among hospitalized patients with AF in ***:Using data from the Improving Care for Cardiovascular Disease in China-Atrial Fibrillation(CCC-AF)registry,guideline-recommended OAC use in eligible patients was ***:A total of 52,530 patients with non-valvular AF were enrolled from February 2015 to December 2019,of whom 38,203 were at a high risk of stroke,9717 were at a moderate risk,and 4610 were at a low *** admission,only 20.0%(6075/30,420)of patients with a diagnosed AF and a high risk of stroke were taking *** use of pre-hospital OAC on admission was associated with a lower risk of new-onset ischemic stroke/transient ischemic attack among the diagnosed AF population(adjusted odds ratio:0.54,95%confidence interval:0.43-0.68;P70%of AF patients were at a high risk of *** poor performance on guideline-recommended OAC use was found in this study,over time the CCC-AF project has made progress in stroke prevention in the Chinese AF ***

关键词： Atrial fibrillation Oral anti-coagulants OAC Stroke prevention Contraindication

Detection of ARV-Resistant Mutants in HIV-1-Infected Individuals in a Context of Systematic Switching to an association Based on Dolutegravir in Abidjan, Côte d’Ivoire

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american Journal of Molecular Biology 2024年第3期14卷 138-151页

作者： Odegue Kpadraux Danielle Kakou-Ngazoa Solange Dechi Jean-Jacques Renaud Diallo Zelica Sina Kouamé Mireille Sylla Aboubacar Tossea Koui Stéphane Kouakou Venance Adagba Marius Apia N’Chouo Kouamé Basile Touré Offianan André Dosso Mireille Molecular Biology Platform Institut Pasteur Abidjan Cte dIvoire Laboratory of the Regional blood Transfusion Center Yamoussoukro Cte dIvoire Department of Infectious and Tropical Diseases University Hospital Treichville Abidjan Cte dIvoire Laboratory of the Regional blood Transfusion Center San-Pdro Cte dIvoire Department of Epidemic Virus Institut Pasteur Abidjan Cte dIvoire Department of Parasitology Mycology Institut Pasteur Abidjan Cte dIvoire Department of Bacteriology-Virology Institut Pasteur Abidjan Cte dIvoire

The emergence of antiretroviral resistance mutations represents a major threat to the achievement of national and global goals for the elimination of HIV-1 infection. The global strategy in 2019 in Cte d'Ivoire is a new national policy for the management of people living with HIV with the administration of dolutegravir (DTG)-based fixed-dose combination. The aim of our study was to evaluate HIV-1 resistance to antiretrovirals (ARVs) in infected adult subjects in Cte d’Ivoire in the context of a systematic switch to a DTG-based combination. Between February 2022 and October 2023, a cross-sectional survey with random sampling was conducted in 06 services caring for people living with HIV. A total of 139 participants were included in the study. Adults with a viral load ≥ 1000 copies/mL were tested for HIV-1 ARV resistance mutations. Molecular analyses were performed using protocol of ANRS-MIE (National Agency for Research on AIDS and emerging infectious diseases). The interpretation is performed by HIVGRAD (https://***/cms/grade/). The frequencies of HIV-1 resistance to non-nucleotide reverse transcriptase inhibitors (NNRTIs), nucleotide reverse transcriptase inhibitors (NRTIs), integrase inhibitors (IINTs) and protease inhibitors (PIs) were 82%, 73%, 19% and 11% respectively. The main mutations observed in the different classes were K103N (45%), M184V (64%), E157Q (19%) and L10V/M46I/A71V/I54V (6%) respectively. This study reveals the emergence of resistance to DTG-based fixed-dose combinations, favored by high rates of resistance to NRTIs and NNRTIs. This finding underlines the need for enhanced viral load monitoring and HIV-1 genotyping tests to guide the choice of NRTIs for combination therapy. In addition, monitoring for mutations to second-generation NRTIs is essential, given the scale-up of DTG-based regimens currently underway in Cte d’Ivoire.

关键词： Resistant Mutants Dolutegravir HIV-1 Antiretrovirals Côte d’Ivoire

MANAGEMENT OF HIV DISEASE IN CHINA

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中华医学杂志(英文版) 1991年第1期104卷 87-88页

作者： Li De-lai Chinese Medical association Beijing 100710

The Sino-american Symposium onManagement of HIV Disease was held inBeijing from November 8 to 9, 1990. Morethan 600 participants from the United Statesand China attended the meeting. At thistwo-day symposium, the american andChinese experts had broad and profound exchanges on HIV disease related issues indiagnosis, treatment, research, prevention,psychology, sociology, ethics, education andlaw. More than 40 experts presented papers.

关键词： Acquired Immunodeficiency Syndrome--prevention and control Asia China Conferences And Congresses Delivery Of Health Care Developing Countries Diseases Eastern Asia Examinations And Diagnoses Health Health Services Hematologic Tests Hiv Infections--prevention and control International Cooperation Laboratory Examinations And Diagnoses Laboratory Procedures Medicine Medicine, Traditional Treatment Viral Diseases

The role of peptidase neurolysin in neuroprotection and neural repair after stroke

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Neural Regeneration Research 2021年第1期16卷 21-25页

作者： Vardan T.Karamyan Department of Pharmaceutical Sciences and Center for blood Brain Barrier Research School of PharmacyTTUHSCAmarilloTXUSA

Current experimental stroke research has evolved to focus on detailed understanding of the brain’s self-protective and restorative mechanisms,and harness this knowledge for development of new *** this context,the role of peptidases and neuropeptides is of growing *** this focused review,peptidase neurolysin(Nln)and its extracellular peptide substrates are briefly discussed in relation to pathophysiology of ischemic *** of Nln following stroke is viewed as a compensatory cerebroprotective mechanism in the acute phase of stroke,because the main neuropeptides inactivated by Nln are neuro/cerebrotoxic(bradykinin,substance P,neurotensin,angiotensin II,hemopressin),whereas the peptides generated by Nln are neuro/cerebroprotective(angiotensin-(1–7),Leu-/Met-enkephalins).This notion is confirmed by experimental studies documenting aggravation of stroke outcomes in mice after inhibition of Nln following stroke,and dramatic improvement of stroke outcomes in mice overexpressing Nln in the *** role of Nln in the(sub)chronic phase of stroke is less clear and it is likely,that this peptidase does not have a major role in neural repair *** is because,the substrates of Nln are less uniform in modulating neurorestorative mechanisms in one direction,some appearing to have neural repair enhancing/stimulating potential,whereas others doing the *** studies focusing on the role of Nln in pathophysiology of stroke should determine its potential as a cerebroprotective target for stroke therapy,because its unique ability to modulate multiple neuropeptide systems critically involved in brain injury mechanisms is likely advantageous over modulation of one pathogenic pathway for stroke pharmacotherapy.

关键词： compensatory cerebroprotection drug target endogenous neuroprotective mechanism neuropeptide neurorestoration peptidase

比较Framingham冠心病危险评估法与中国各省队列研究预测中国人发病危险的价值

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美国医学会杂志（中文版） 2006年第2期25卷 67-74页

作者： Jing Liu Yuling Hong Ralph B. D＇ Agostino Zhaosu Wu Wei Wang Jiayi Sun Peter W. F. Wilson William B. Kannel Dong Zhao 倪靖炜（译）沈卫峰（校） Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing China american Heart association Dallas Tex Boston University Boston Mass 不详

背景：Framingham心脏研究（Framingham Heart Study）有助于建立冠心病（coronary heast disease，CHD）危险的评价方法，但由于该研究人群比较单一，因而不能将其简单地用于其他人群。对Framingham评估方法进行重新校正可使其适用于... 详细信息

背景：Framingham心脏研究（Framingham Heart Study）有助于建立冠心病（coronary heast disease，CHD）危险的评价方法，但由于该研究人群比较单一，因而不能将其简单地用于其他人群。对Framingham评估方法进行重新校正可使其适用于世界各地区人群。

关键词：发病危险冠心病 Framingham心脏研究队列研究评估法中国 disease 价值预测研究人群

Pre-hospital delay in patients with acute myocardial infarction in China:findings from the Improving Care for Cardiovascular Disease in China-Acute Coronary Syndrome(CCC-ACS)project

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Journal of Geriatric Cardiology 2022年第4期19卷 276-283页

作者： Dan-Qing HU Yong-Chen HAO Jun LIU Na YANG Yi-Qian YANG Zhao-Qing SUN Dong ZHAO Jing LIU Department of Epidemiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of HeartLung and Blood Vessel DiseasesBeijingChina

OBJECTIVE To describe the duration of the pre-hospital delay time and identify factors associated with prolonged pre-hospital delay in patients with acute myocardial infarction(AMI)in *** Data were collected from November 2014 to December 2019 as part of the Improving Care for Cardiovascular Dis-ease in China-Acute Coronary Syndrome(CCC-ACS)project.A total of 33,386 patients with AMI admitted to the index hospitals were included in this ***-level logistic regression was conducted to explore the factors associated with the pre-hospital delay and the associations between different pre-hospital delay and in-hospital *** Of the 33,386 patients with AMI,70.7%of patients arrived at hospital≥2 h after symptom *** age,female,ru-ral medical insurance,symptom onset at early dawn,and non-use of an ambulance predicted a prolonged pre-hospital delay(all P<0.05).Hypertension and heart failure at admission were only significant in predicting a longer delay in patients with ST-seg-ment elevation myocardial infarction(STEMI)(all P<0.05).A pre-hospital delay of≥2 h was associated with an increased risk of mortality[odds ratio(OR)=1.36,95%CI:1.09-1.69,P=0.006]and major adverse cardiovascular events(OR=1.22,95%CI:1.02-1.47,P=0.033)in patients with STEMI compared with a pre-hospital delay of<2 *** Prolonged pre-hospital delay is associated with adverse in-hospital outcomes in patients with STEMI in *** study identifies that patient characteristics,symptom onset time,and type of transportation are associated with pre-hospital delay time,and provides focuses for quality improvement.

关键词： patients infarction admitted

HDAC inhibitors improve CRISPR-mediated HDR editing efficiency in iPSCs

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Science China(Life Sciences) 2021年第9期64卷 1449-1462页

作者： Jian-Ping Zhang Zhi-Xue Yang Feng Zhang Ya-Wen Fu Xin-Yue Dai Wei Wen Beldon Zhang Hannah Choi Wanqiu Chen Meredith Brown David Baylink Lei Zhang Hongyu Qiu Charles Wang Tao Cheng Xiao-Bing Zhang State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesInstitute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China School of Medicine Loma Linda UniversityLoma LindaCA 92354USA Center for Genomics School of MedicineLoma Linda UniversityLoma LindaCA 92350USA CAMS Key Laboratory of Gene Therapy for blood Diseases Tianjin 300020China Center for Stem Cell Medicine Chinese Academy of Medical SciencesTianjin 300020China Department of Stem Cell&Regenerative Medicine Peking Union Medical CollegeTianjin 300020China Tianjin Key Laboratory of Gene Therapy for blood Diseases Tianjin 300020China Center of Molecular and Translational Medicine Institution of Biomedical ScienceGeorgia State UniversityAtlantaGA 30303USA

Genome-edited human induced pluripotent stem cells(iPSCs)hold great promise for therapeutic ***,low editing efficiency has hampered the applications of CRISPR-Cas9 technology in creating knockout and homology-directed repair(HDR)-edited iPSC lines,particularly for silent *** is partially due to chromatin compaction,inevitably limiting Cas9 access to the target *** the six HDAC inhibitors we examined,vorinostat,or suberoylanilide hydroxamic acid(SAHA),led to the highest HDR efficiency at both open and closed loci,with acceptable *** inhibitors equally increased non-homologous end joining(NHEJ)editing efficiencies(~50%)at both open and closed loci,due to the considerable HDAC inhibitor-mediated increase in Cas9 and sgRNA ***,we observed more substantial HDR efficiency improvement at closed loci relative to open chromatin(2.8 vs.1.7-fold change).These studies provide a new strategy for HDRediting of silent genes in iPSCs.

关键词： HDAC inhibitors CRISPR-Cas9 genome editing iPSC

Intimate hygiene practices and reproductive tract infections: A systematic review

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Gynecology and Obstetrics Clinical Medicine 2022年第3期2卷 129-135页

作者： Alaa Daher Obey Albaini Lauren Siff Stephanie Farah Karl Jallad Department of Obstetrics and Gynecology American University of Beirut Medical CenterBeirutLebanon Department of Clinical Research Lebanese American University Medical CenterGilbert and Rose-Marie Chagoury School of MedicineBeirutLebanon Virginia Commonwealth University School of Medicine VirginiaUSA Lebanese american University Medical Center Gilbert and Rose-Marie Chagoury School of MedicineBeirutLebanon

Introduction:Worldwide,women perform a variety of vaginal practices to enhance their intimate hygiene and sexual ***:To conduct a systematic review to assess the different kinds of intimate hygiene practices and their association with reproductive tract infections and ***:PubMed,Medline and The Cochrane Library were *** observational and interventional studies targeting the urogenital infections and their association with hygiene practices were *** criteria included studies that assessed the knowledge and attitudes towards intimate hygiene practices rather than their relation to *** design of this systematic review complied with the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis(PRISMA).Results:Fifteen articles were *** practices were found to be associated with reproductive tract *** absorbent material used during menstruation increased the risk of Candida infection with an adjusted proportional reported ratio(aPRR)of 1.54(95%CI 1.2–2.0),but no association with bacterial vaginosis or trichomonas vaginalis infection was *** or vaginal washing during menstruation with water only showed a higher association with symptoms of urogenital infections when compared with washing with both soap and water during *** reusable pads inside the house and storing them inside the toilet was found to be associated with a higher candida infection ***,bathing in sitting position during menstruation,not drying the genital area or using cloth for drying it,and not paying attention to hand washing,were all associated with a higher risk of genital ***,postpartum use of native homemade vaginal preparations might be a risk factor for ascending vaginal infections,and the use of inappropriate material for menstrual blood absorption was associated with secondary ***:Several hygiene pract

关键词： Intimate hygiene practice Reproductive tract infection Sexually transmitted infection Vaginal douching

The association of cardiovascular mortality with a first-degree family member history of different cardiovascular diseases

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Journal of Geriatric Cardiology 2021年第10期18卷 816-824页

作者： Charbel Gharios Mireille Leblebjian Samia Mora Roger S.Blumenthal Miran A.Jaffa Marwan M.Refaat Department of Internal Medicine Division of CardiologyAmerican University of Beirut Medical CenterBeirutLebanon Cardiovascular Imaging Research Center Massachusetts General Hospital and Harvard Medical SchoolBostonMAUSA Epidemiology and Population Health Department Faculty of Health SciencesAmerican University of BeirutBeirutLebanon Center for Lipid Metabolomics Divisions of Preventive and Cardiovascular MedicineBrigham and Women’s Hospital and Harvard Medical SchoolBostonMAUSA The Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease BaltimoreMDUSA Department of Biochemistry and Molecular Genetics American University of Beirut Faculty of MedicineBeirutLebanon

OBJECTIVE To investigate which history of cardiovascular disease[coronary heart disease(CHD),stroke,or peripheral arterial disease]in a first-degree family member predicts cardiovascular *** We studied a prospective cohort(the Lipid Research Clinics Prevalence Study)from ten primary care centers across North *** primary outcome was cardiovascular mortality,assessed using Cox survival *** There were 8,646 participants(mean age:47.4±12.1 years,46%women,52%of participants with hyperlipidemia)who were followed up for a mean duration of 19.4±4.9 *** were 1,851 deaths(21%),including 852 cardiovascular deaths.A paternal,maternal or sibling history of premature CHD(before 60 years)was present in 26%of participants,of stroke in 27%of participants,and of peripheral arterial disease in 24%of *** adjusting for risk factors(age,sex,systolic blood pressure,diastolic blood pressure,body mass index,smoking,fasting glucose,low-density lipoprotein cholesterol and triglycerides),only a paternal history of premature or any CHD,a maternal history of diabetes mellitus or premature or any CHD,and a sibling history of premature CHD,hypertension,or hyperlipidemia were individually predictive of cardiovascular *** adjusting for risk factors and the mentioned familial factors,only paternal and maternal histories of CHD,espe-cially before 60 years,remained predictive of cardiovascular mortality,with a somewhat higher association for a maternal history[adjusted hazard ratio(aHR)=1.99,95%CI:1.36−2.92,P<0.001 for maternal history of premature CHD;aHR=1.52,95%CI:1.10−2.10,P=0.011 for paternal history of premature CHD].Family history of stroke or peripheral arterial disease did not predict cardiovascular *** history of premature CHD predicted cardiovascular mortality independently of baseline age(<60 years and≥60 years),hypertension,or hyperlipidemia and carried more important prognostic value in men rather than wo-m

关键词： cardiovascular Lipid mentioned