检索结果-南通市图书馆

Toward a nomenclature consensus for diverse intelligent systems:Call for collaboration

在线全文

学校读者我要写书评

暂无评论

The Innovation 2024年第5期5卷 32-34页

作者： Brett J.Kagan Michael Mahlis Anjali Bhat Josh Bongard Victor MCole Phillip Corlett Christopher Gyngell Thomas Hartung Bianca Jupp Michael Levin Tamra Lysaght Nicholas Opie Adeel Razi Lena Smirnova Ian Tennant Peter Thestrup Wade Ge Wang Cortical Labs BrunswickVIC 3056Australia Wellcome centre for Human Neuroimaging University College LondonLondon WC1N 3ARUK university of Vermont BurlingtonVT 05405USA centre for Professional Communication Singapore Institute of TechnologySingapore 138683Singapore Department of Psychiatry Yale UniversityNew HavenCT 06511USA Murdoch Children’s Research Institute ParkvilleVIC 3052Australia centre for Alternatives to Animal Testing(CAAT) Bloomberg School of Public Health and Whiting School of EngineeringJohns Hopkins UniversityDoerenkamp-Zbinden Chair for Evidence-based ToxicologyBaltimoreMD 21205USA CAAT-Europe University of Kostanz78464 KostanzGermany Department of Neuroscience Central Clinical SchoolMonash UniversityPrahranVIC 3004Australia allen discovery centre at tufts university MedfordMA 02155USA Yong Loo Lin School of Medicine National University of SingaporeSingapore 117597Singapore Faculty of Medicine and Health Sydney School of Public Health The University of SydneyCamperdownNSW 2050Australia Department of Medicine University of MelbourneParkvilleVIC 3010Australia Turner Institute for Brain and Mental Health Monash UniversityClaytonVIC 3168Australia Center for Alternatives to Animal Testing(CAAT) Bloomberg School of Public Health and Whiting School of EngineeringJohns Hopkins UniversityBaltimoreMD 21205USA Faculty of Engineering AgriTech and EnvironmentAnglia Ruskin UniversityPeterborough PE15BWUK Interacting Minds centre Aarhus University8000 Aarhus CDenmark Department of Biomedical Engineering School of EngineeringBiomedical Imaging CenterCenter for Biotechnology and Interdisciplinary StudiesRensselaer Polytechnic InstituteTroyNY 12180USA Department of Biochemistry and Pharmacology University of MelbourneParkvilleVIC 3010Australia

Disagreements about language use are common both between and within *** interests require multidisciplinary collaboration or the field of research has the potential to impact society at large,it becomes critical to minimize these disagreements where *** development of diverse intelligent systems,regardless of the substrate(e.g.,silicon ***),is a case where both conditions are *** advancements have occurred in the development of technology progressing toward these diverse intelligence *** progress is silicon based,such as the use of large language models,or through synthetic biology methods,such as the development of organoids,a clear need for a community-based approach to seeking consensus on nomenclature is now ***,we welcome collaboration from the wider scientific community,proposing a pathway forward to achieving this intention,highlighting key terms and fields of relevance,and suggesting potential consensus-making methods to be applied.

关键词： seeking collaboration diverse

Boosting proteolytic pathways as a treatment against glycation-derived damage in the brain?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第2期17卷 320-322页

作者： allen Taylor Eloy Bejarano Laboratory for Nutrition and Vision Research USDA Human Nutrition Research Center on AgingTufts UniversityBostonMAUSA Departments of Chemical and Molecular Biology and Ophthalmology Tufts University School of MedicineBostonMAUSA Friedman School of Nutrition and Science Policy Tufts UniversityBostonMAUSA School of Health Sciences and Veterinary School Universidad Cardenal Herrera-CEUCEU UniversitiesMoncadaValenciaSpain

The worldwide adaptation of a Western lifestyle is associated with the increased consumption of high glycemia diets and an increased prevalence of obesity, metabolic syndrome, and diabetes.

关键词： damage obesity prevalence

Thermal conductivity of glasses: first-principles theory and applications

在线全文

学校读者我要写书评

暂无评论

npj Computational Materials 2023年第1期9卷 1253-1274页

作者： Michele Simoncelli Francesco Mauri Nicola Marzari Theory of Condensed Matter Group of the Cavendish Laboratory University of CambridgeCambridgeUK Dipartimento di Fisica Universitàdi Roma La SapienzaRomaItaly Theory and Simulation of Materials(THEOS)and National centre for Computational Design and discovery of Novel Materials(MARVEL) École Polytechnique Fédérale de LausanneLausanneSwitzerland

Predicting the thermal conductivity of glasses from first principles has hitherto been a very complex *** established allen-Feldman and Green-Kubo approaches employ approximations with limited validity—the former neglects anharmonicity,the latter misses the quantum Bose-Einstein statistics of vibrations—and require atomistic models that are very challenging for first-principles ***,we present a protocol to determine from first principles the thermal conductivityκ(T)of glasses above the plateau(i.e.,above the temperature-independent region appearing almost without exceptions in theκ(T)of all glasses at cryogenic temperatures).The protocol combines the Wigner formulation of thermal transport with convergence-acceleration techniques,and accounts comprehensively for the effects of structural disorder,anharmonicity,and Bose-Einstein *** validate this approach in vitreous silica,showing that models containing less than 200 atoms can already reproduceκ(T)in the macroscopic *** discuss the effects of anharmonicity and the mechanisms determining the trend ofκ(T)at high temperature,reproducing experiments at temperatures where radiative effects remain negligible.

关键词： glasses conductivity harmonic

Nasal cytology with emphasis on mast cells can improve the diagnosis and treatment of chronic rhinosinusitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2019年第18期132卷 2237-2241页

作者： Hua-Li Ren Jian-Dong Li Feng-Shu Yue Jin-Lu Sun Elie E.Rebeiz Theoharis C.Theoharides Department of Allergy Beijing Electric Power Hospital Beijing 100073 China Department of Otolaryngology Beijing Electric Power Hospital Beijing 100073 China Department of Allergy Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100730 China Department of Otolaryngology Tufts Medical Center Boston MA 02111 USA Molecular Immunopharmacology and Drug discovery Laboratory Department of Integrative Physiology and Pathobiology Tufts University School of Medicine Boston MA 02111 USA Sackler School of Graduate Biomedical Sciences Program in Pharmacology and Experimental Therapeutics Tufts University Boston MA 02153 USA Department of Internal Medicine Tufts University School of Medicine and Tufts Medical Center Boston MA 02111 USA

Objective:Chronic rhinosinusitis (CRS) involves inflammation of the nasal and para-nasal *** to its heterogeneous nature,unknown pathogenesis,and high recurrence rate,effective treatment is *** cytology is presently not a part of the routine diagnosis or treatment decision for *** sources:A literature search was performed for published papers in English between January 1990 and June 2019 using *** sdection:Terms used were chronic rhinosinusids,eosinophils,etiology,immunopathology,inflammation,mast cells,nasal cytology,polyps,and *** reviews and original articles were collected and ***:There is no standard nasal fluid,mucus sampling,or staining techniques for identifying inflammatory cell *** were divergent from different ***,the main focus of these papers on the cells in nasal washings was eosinophils,with infrequent mentioning of other cell types that may imply different etiology and *** heterogeneous cell profile of CRS and the role of mast cells have been unappreciated due to the lack of specific immunohistochemical technique or study of its unique ***:Nasal cytology could help distinguish the type and the activation state of inflammatory *** it can help in providing a clearer picture of CRS pathogenesis,identifying different patient groups,and developing effective treatments.

关键词： Rhinitis Sinusitis Nasal polyps Nasal mucosa Cytology Inflammation Eosinophils Mast cells

Long-term phenotypic characterization of human bone marrow and adipose tissue derived mesenchymal stromal cells

在线全文

学校读者我要写书评

暂无评论

Stem Cell discovery 2013年第2期3卷 99-116页

作者： Dean L. Glettig David L. Kaplan Department of Biomedical Engineering Tufts University Medford USA

We present methods to characterize mesenchymal stromal cells (MSC) over long time periods in vitro. The methods entail passaging cells multiple times and performing differentiation studies with the cells at each passage. Using an array of surface markers and flow cytometric quantification, the data can be correlated to traditional measures of differentiation such as PCR and staining. Using these methods to quantify the amount of differentiation, we concluded that many common MSC markers do not specifically define MSCs with true stem cell properties. Additionally, adipose-derived as opposed to bone marrow-derived MSCs show long-term CD34+ labeling. The methods described can be used to help identify stem cell markers and to characterize the state of stem cells in vitro. Compiling these data from multiple laboratories would be helpful to determine source, extraction and culture methods needed to obtain high yields of useful stem cells.

关键词： Stem Cells Adipose Stem Cells Mesenchymal Stem Cells Flow Cytometry Surface Markers Human Cells Long-Term Cell Culture

DIETARY FOOD PATTERNS AND RISK OF AMD AND CATARACT RELATIONSHIPS BETWEEN DIETARY CARBOHYDRATE,INCREASED RISK FOR AMD AND CATARACT,AND PROTEOMETABOLISM

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

DIETARY FOOD PATTERNS AND RISK OF AMD AND CATARACT RELATIONS...

Driving efficiency in a high-throughput metabolic stability assay through a generic high-resolution accurate mass method and automated data mining

第十八届国际眼科研究大会

作者： allen.Taylor Chiu.Chung-Jung Ram.Nagaraj Edward.Dudek Hugh.Taylor Roy.Milton Gary.Gensler tufts university/USDA Human Nutrition Research Center

＜正＞Work in four different cohorts indicates that dietary glycemia,measured either as above the median for glycemic index or total carbohydrate is associated with increased risk for cataract or AMD and progress of *** with cataracts and AMD-related deposits are accumulation of damaged proteins,often including markers of glycation and

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Protein & Cell 2011年第8期2卷 680-688页

作者： Wenqing Shui Song Lin allen Zhang Yan Chen Yingying Huang Mark Sanders College of Life Sciences Nankai UniversityTianjin 300071China High-Throughput Molecular Drug discovery Center Tianjin Joint Academy of Biotechnology and MedicineTianjin 300074China Metabolism&Pharmacokinetics NovartisEmeryvilleCA 94608USA Thermo Fisher Scientific San JoseCA 95134USA

Improving analytical throughput is the focus of many quantitative workflows being developed for early drug *** drug candidate screening,it is common practice to use ultra-high performance liquid chromatography(U-HPLC)coupled with triple quadrupole mass *** approach certainly results in short analytical run time;however,in assessing the true throughput,all aspects of the workflow needs to be considered,including instrument optimization and the necessity to re-run samples when information is *** we describe a high-throughput metabolic stability assay with a simplified instrument set-up which significantly improves the overall assay *** addition,as the data is acquired in a non-biased manner,high information content of both the parent compound and metabolites is gathered at the same time to facilitate the decision of which compounds to proceed through the drug discovery pipeline.

关键词： metabolic stability high-resolution mass spectrometry accurate mass ultra-high performance liquid chromatography

A human cell atlas of fetal chromatin accessibility

在线全文

学校读者我要写书评

暂无评论

四川生理科学杂志 2020年第4期42卷 443-443页

作者： Silvia Domcke Department of Genome Sciences University of Washington School of Medicine Seattle WA USA. Department of Pediatrics University of Washington School of Medicine Seattle WA USA. Brotman Baty Institute for Precision Medicine Seattle WA USA. Center for Integrative Brain Research Seattle Children’s Research Institute Seattle WA USA. Illumina San Diego CA USA. Center for Data Visualization Fred Hutchinson Cancer Research Center Seattle WA USA. allen discovery Center for Cell Lineage Tracing Seattle WA USA. Department of Cellular and Molecular Medicine University of Arizona Tucson AZ USA. Asthma and Airway Disease Research Center University of Arizona Tucson AZ USA. Howard Hughes Medical Institute Seattle WA USA.

The chromatin landscape underlying the specification of human cell types is of fundamental *** generated human cell atlases of chromatin accessibility and gene expression in fetal *** chromatin accessibility,we devised a three-level combinatorial indexing assay and applied it to 53 samples representing 15 organs,profiling^800,000 single *** leveraged cell types defined by gene expression to annotate these data and cataloged hundreds of thousands of candidate regulatory elements that exhibit cell type-specific chromatin *** investigated the properties of lineage-specific transcription factors(such as POU2F1 in neurons),organ-specific specializations of broadly distributed cell types(such as blood and endothelial),and cell type-specific enrichments of complex trait *** data represent a rich resource for the exploration of in vivo human gene regulation in diverse tissues and cell types.

关键词： fetal organs hundreds

The amazing potential of fungi:50 ways we can exploit fungi industrially

在线全文

学校读者我要写书评

暂无评论

Fungal Diversity 2019年第4期97卷 1-136页

作者： Kevin D.Hyde Jianchu Xu Sylvie Rapior Rajesh Jeewon Saisamorn Lumyong allen Grace T.Niego Pranami D.Abeywickrama Janith V.S.Aluthmuhandiram Rashika S.Brahamanage Siraprapa Brooks Amornrat Chaiyasen K.W.Thilini Chethana Putarak Chomnunti Clara Chepkirui Boontiya Chuankid Nimali I.de Silva Mingkwan Doilom Craig Faulds Eleni Gentekaki Venkat Gopalan Pattana Kakumyan Dulanjalee Harishchandra Hridya Hemachandran Sinang Hongsanan Anuruddha Karunarathna Samantha C.Karunarathna Sehroon Khan Jaturong Kumla Ruvishika S.Jayawardena Jian-Kui Liu Ningguo Liu Thatsanee Luangharn Allan Patrick G.Macabeo Diana S.Marasinghe Dan Meeks Peter E.Mortimer Peter Mueller Sadia Nadir Karaba N.Nataraja Sureeporn Nontachaiyapoom Meghan O’Brien Watsana Penkhrue Chayanard Phukhamsakda Uma Shaanker Ramanan Achala R.Rathnayaka Resurreccion B.Sadaba Birthe Sandargo Binu C.Samarakoon Danushka S.Tennakoon Ramamoorthy Siva Wasan Sriprom T.S.Suryanarayanan Kanaporn Sujarit Nakarin Suwannarach Thitipone Suwunwong Benjarong Thongbai Naritsada Thongklang Deping Wei S.Nuwanthika Wijesinghe Jake Winiski Jiye Yan Erandi Yasanthika Marc Stadler Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand World Agroforestry centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China Mushroom Research Foundation 128 M.3 Ban Pa Deng T.PaPaeA.Mae TaengChiang Mai 50150Thailand Aix Marseille Université INRAUMR1163 BBF13288 Marseille Cedex 09France Beijing Key Laboratory of Environment Friendly Management on Fruit Diseases and Pests in North China Center of Plant and Environment ProtectionBeijing Academy of Agriculture and Forestry SciencesBeijing 100097People’s Republic of China Center of Chemical Innovation for Sustainability Mae Fah Luang UniversityTasudMuangChiang Rai 57100Thailand Center of Excellence in Microbial Diversity and Sustainable Utilization Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Center for Mountain Ecosystem Studies Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanPeople’s Republic of China Institute of Fungal Research School of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China Department Microbial Drugs Helmholtz Centre for Infection Researchand German Centre for Infection Research(DZIF)partner site Hannover-BraunschweigInhoffenstrasse 738124 BrunswickGermany Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Department of Chemistry and Biochemistry The Ohio State UniversityColumbusOH 43210USA Department of Chemistry University of Science and TechnologyBannuKhyber PakhtunkhwaPakistan Department of Crop Physiology University of Agricultural SciencesGKVKBengaluruKarnataka 560065India Department of Entomology and Plant Pathology Faculty of AgricultureChiang Mai Univers

Fungi are an understudied,biotechnologically valuable group of *** to the immense range of habitats that fungi inhabit,and the consequent need to compete against a diverse array of other fungi,bacteria,and animals,fungi have developed numerous survival *** unique attributes of fungi thus herald great promise for their application in biotechnology and ***,fungi can be grown with relative ease,making production at scale *** search for fungal biodiversity,and the construction of a living fungi collection,both have incredible economic potential in locating organisms with novel industrial uses that will lead to novel *** manuscript reviews fifty ways in which fungi can potentially be utilized as *** provide notes and examples for each potential exploitation and give examples from our own work and the work of other notable *** also provide a flow chart that can be used to convince funding bodies of the importance of fungi for biotechnological research and as potential *** have provided the world with penicillin,lovastatin,and other globally significant medicines,and they remain an untapped resource with enormous industrial potential.

关键词： Biocontrol Biodiversity Biotechnology Food Fungi Mushrooms