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Implementation and validation of a bonded particle model to predict rheological properties of viscoelastic materials

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Particuology 2024年第6期89卷 198-210页

作者： Michael Mascara Arno Mayrhofer Stefan Radl Christoph Kloss Institute of Process and Particle Engineering Graz University of TechnologyInffeldgasse 13Graz8010Austria DCS Computing GmbH Industriezeile 35Linz4020Austria

This work focuses on implementing a particle-based method able to characterize viscoelastic materials whose rheological properties,such as storage modulus G′and loss modulus G″,are *** is based on the bonded particle model,with the elastic constitutive relation here substituted with a viscoelastic one to capture time-scale *** Burgers model,vastly used in literature to model viscoelastic systems,is discretized and *** test case used for calibration comprises of a cubic lattice,sheared with a periodic motion,to mimic the effect of a shear *** appropriate filtering of the stress response,the rheological properties are obtained,highlighting the effect of the lattice geometry,as well as the particle size,on the accuracy of the ***,the Burgers parameters are calibrated by analytically fitting the experimental dataset,showing the limitation of the Burgers *** micro-contact parameters are obtained from the macro parameters through appropriate *** completing a frequency sweep,the simulated G′and G″show a relatively large error,around 25%for G’for *** this reason,a more robust model,namely the generalized Maxwell model,has been *** calibration procedure is performed in the same fashion as for the Burgers ***,the tangential micro-contact parameters are scaled *** normal *** scaling parameter,calledα,is calibrated by minimizing the root mean square error between simulation and experimental data,giving errors below 10%in both G′and G″for a large ***,a full ring plate-plate rheometer setup is simulated,and the simulation is compared with the given experimental dataset,again finding a good agreement.

关键词： DEM Rheology Numerical modeling Viscoelasticity

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Influence of BPPV and Meniere's Disease on Cognitive Abilities: A Questionnaire-Based Study

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Journal of Otology 2024年第1期19卷 10-18页

作者： Rohit Bhattacharyya Animesh Barman Freddy Antony all India Institute of Speech and Hearing MysoreMysuruIndia

The vestibular system connects the inner ear to the midbrain and subcortical structures and can affect cognition. Patients with vertigo often experience cognitive symptoms such as attention deficits, memory problems, and spatial perception difficulties. This study aimed to explore the cognitive impairments associated with Benign paroxysmal positional vertigo(BPPV) and Meniere's Disease(MD). A non-experimental group comparison design was used with 107 participants divided into three groups: Group I(clinically normal), Group II(BPPV), and Group III(MD). Participants completed a questionnaire with 10 cognition-related questions, and their responses were scored. The data were found to be non-normally distributed. The analysis revealed a significant difference in scores between Group I and both Group II and Group III. Chi-square tests showed that the responses to cognition-related questions varied among the groups, with Group II exhibiting more cognitive problems. Associated conditions like hypertension, diabetes, and hearing loss did not significantly influence the responses within each group. This study suggests a significant relationship between cognitive problems and patients with BPPV and MD. However, there was no association found between the cognitive problems experienced in BPPV and MD patients. These findings align with previous research indicating that vestibular disorders can lead to deficits in spatial memory, attention, and other cognitive functions. By understanding the link between cognition and vestibular disorders, we can improve diagnosis and rehabilitation services to enhance the quality of life for these patients.

关键词： BPPV Meniere's disease Cognition Questionnaire

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Chiglitazar and Thiazolidinedione in patients with type 2 diabetes:Which is better?

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World Journal of Diabetes 2024年第3期15卷 565-567页

作者： Kotha Sugunakar Reddy Archana Gaur Sakthivadivel Varatharajan Arvind Kumar Morya Department of General Medicine All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Physiology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Medicine All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Ophthalmology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia

This published Meta-Analysis by Lin et al is an indirect comparison between two drugs Chiglitazar and Thiazolidinedione which are commonly used for glycemic control in type-Ⅱ diabetes *** terms of safety and efficacy... 详细信息

关键词： Type-Ⅱdiabetes mellitus Glucose intolerance Hyperglycemia Research methodology

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Simple and robust 3D MINFLUX excitation with a variable phase plate

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Light(Science & Applications) 2024年第7期13卷 1354-1363页

作者： Takahiro Deguchi Jonas Ries European Molecular Biology Laboratory Cell Biology and BiophysicsHeidelbergGermany. Max Perutz Labs Vienna Biocenter Campus(VBC)ViennaAustria. University of Vienna Center for Molecular BiologyDepartment of Structural and Computational BiologyViennaAustria. University of Vienna Faculty of PhysicsViennaAustria

MINFLUX has achieved extraordinary resolution in superresolution imaging and single fluorophore *** is based on localizing single fluorophores by rapid probing with a patterned beam that features a local intensity *** implementations,however,are complex and expensive and are limited in speed and ***,we show that a combination of an electro-optical modulator with a segmented birefringent element such as a spatial light modulator produces a variable phase plate for which the phase can be scanned on the MHz *** or top-hat phase patterns generate high-contrast compact excitation point-spread functions for MINFLUX localization in the x,y,and z-direction,respectively,which can be scanned across a fluorophore within a microsecond,switched within 60 microseconds and alternated among different excitation *** discuss how to compensate for non-optimal performance of the components and present a robust 3D and multi-color MINFLUX excitation module,which we envision as an integral component of a high-performance and cost-effective open-source MINFLUX.

关键词： excitation phase switched

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CO_(2)capture costs of chemical looping combustion of biomass:A comparison of natural and synthetic oxygen carrier

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Journal of Energy Chemistry 2024年第5期92卷 296-310页

作者： Benjamin Fleiß Juraj Priscak Martin Hammerschmid Josef Fuchs Stefan Müller Hermann Hofbauer Institute of Chemical Environmental and Bioscience EngineeringTU WienVienna1060 ViennaAustria BEST–Bioenergy and Sustainable Technologies GmbH Graz8010 StyriaAustria

Chemical looping combustion has the potential to be an efficient and low-cost technology capable of contributing to the reduction of the atmospheric concentration of CO_(2) in order to reach the 1.5/2°C goal and mitigate climate *** this process,a metal oxide is used as oxygen carrier in a dual fluidized bed to generate clean CO_(2) via combustion of *** commonly,natural ores or synthetic materials are used as oxygen carrier whereas both must meet special requirements for the conversion of solid *** oxygen carriers are characterized by higher reactivity at the expense of higher costs versus the lower-cost natural *** determine the viability of both possibilities,a techno-economic comparison of a synthetic material based on manganese,iron,and copper to the natural ore ilmenite was *** synthetic oxygen carrier was characterized and tested in a pilot plant,where high combustion efficiencies up to 98.4%and carbon capture rates up to 98.5%were *** techno-economic assessment resulted in CO_(2) capture costs of 75 and 40€/tCO_(2) for the synthetic and natural ore route respectively,whereas a sensitivity analysis showed the high impact of production costs and attrition rates of the synthetic *** synthetic oxygen carrier could break even with the natural ore in case of lower production costs and attrition rates,which could be reached by adapting the production process and recycling *** comparison to state-of-the-art technologies,it is demonstrated that both routes are viable and the capture cost of CO_(2) could be reduced by implementing the chemical looping combustion technology.

关键词： Chemical looping combustion BECCS Techno-economic assessment CO_(2)capture costs Oxygen carrier development Synthetic materials Ilmenite

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Amebic liver abscess: An update

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World Journal of Hepatology 2024年第3期16卷 316-330页

作者： Ramesh Kumar Rishabh Patel Rajeev Nayan Priyadarshi Ruchika Narayan Tanmoy Maji Utpal Anand Jinit R Soni Department of Gastroenterology All India Institute of Medical SciencesPatna 801507India Department of Radiodiagnosis All India Institute of Medical SciencesPatna 801507India Department of Surgical Gastroenterology All India Institute of Medical SciencesPatna 801507India

Amebic liver abscess(ALA)is still a common problem in the tropical world,where it affects over three-quarters of patients with liver *** is caused by an anaerobic protozoan Entamoeba hystolytica,which primarily colonises the *** is a non-suppurative infection of the liver consisting primarily of dead hepatocytes and cellular *** of the male gender,during their reproductive years,are most prone to ALA,and this appears to be due to a poorly mounted immune response linked to serum testosterone *** is more common in the right lobe of the liver,is strongly associated with alcohol consumption,and can heal without the need for *** majority of ALA patients have an uncomplicated course,a number of complications have been described,including rupture into abdomino-thoracic structures,biliary fistula,vascular thrombosis,bilio-vascular compression,and secondary bacterial *** on clinico-radiological findings,a classification system for ALA has emerged recently,which can assist clinicians in making treatment *** research has revealed the role of venous thrombosis-related ischemia in the severity of *** years have seen the development and refinement of newer molecular diagnostic techniques that can greatly aid in overcoming the diagnostic challenge in endemic area where serology-based tests have limited *** has been the drug of choice for ALA patients for many ***,concerns over the resistance and adverse effects necessitate the creation of new,safe,and potent antiamebic *** the indication of the drainage of uncomplicated ALA has become more clear,high-quality randomised trials are still necessary for robust *** drainage appears to be a viable option for patients with ruptured ALA and diffuse peritonitis,for whom surgery represents a significant risk of *** regard to all of the aforementioned issues,this article intends to present an u

关键词： Amebic liver abscess Amebiasis Ruptured liver abscess Percutaneous drainage Metronidazole

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Analysis of the urethral stricture score and patient-related factors as predictors of outcomes following oral mucosal graft urethroplasty

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Asian Journal of Urology 2024年第3期11卷 473-479页

作者： Nikita Shrivastava Rahul Jena Deepak Prakash Bhirud Mahendra Singh Gautam Ram Choudhary Arjun Singh Sandhu Department of Urology All India Institute of Medical SciencesJodhpurRajasthanIndia

Objective:The complexity of urethral strictures can predict outcomes following *** previously described urethral stricture score(U score)considered only stricture-related factors to grade the complexity of urethral strictures and to predict recurrence post urethroplasty,but not considered patient-related factors for the *** aimed to study the correlation of both of these factors to the outcomes of oral mucosal graft ***:We retrospectively reviewed data of 101 patients who underwent oral mucosal graft urethroplasty in our institute with a minimum follow-up of 6 *** patient characteristics and stricture-related parameters were *** U score was calculated for all patients which consisted of the length,location,number,and etiology of *** and multivariate Cox proportional hazard regression models were used to determine significant risk factors of ***:The mean follow-up of patients was 15 *** was seen in 28 patients and the mean time for detection of recurrence was 8 months of *** Charlson Comorbidity Index,history of previous intervention,length of strictures,location of strictures,number of strictures,history of smoking,and etiology were independent predictors of recurrence following *** on these parameters,we formulated the modified U score(MU score).The scores ranged from 0 to 6 and a score of>2 was found to be predictive of *** comparing receiver operating characteristic curves for both scores by the DeLong test,the MU score had larger area under the curve than the U ***:The MU scoring system is the first of its kind attempt taking into consideration both patient-and stricture-related factors to predict recurrence following oral mucosal graft urethroplasty.

关键词： Urethral stricture Urethral stricture score Recurrence Urethroplasty

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Typhoid fever presenting as neuropsychiatric oddities:A case report

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Asian Pacific Journal of Tropical Medicine 2024年第6期17卷 281-284页

作者： Prashant Badole Jivtesh Singh Preetam N Wasnik Rohini Rokkam Department of General Medicine All India Institute of Medical SciencesRaipur 492099India

Rationale:Salmonella is a common etiological agent behind the tropical fever syndrome in the Indian *** prevalence in India remains high due to a lack of proper sanitation services in large parts of the *** neuropsychiatric manifestations is rare and the understanding on their pathophysiology is still *** concerns:A 19-year-old male,presented with a 10-day history of altered mental status,high-grade fever and violent behaviour.2 Days prior to admission,he developed decreased responsiveness and a muttering delirium with ***:Coma vigil secondary to ***:Intravenous ceftriaxone and ***:The resolution of the coma vigil and the associated Salmonella infection were observed;however,the patient developed residual ***:The atypical presentation of a globally obtunded state followed by mutism in typhoid coma in this case should be brought to the attention of clinicians ***,the enduring speech limitations and potential psychiatric consequences may be linked to the prolonged duration of the infection.

关键词： Salmonella Salmonellosis Coma vigil Typhoid fever

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Single carbon metabolism–A new paradigm for microbial bioprocesses?

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Synthetic and Systems Biotechnology 2024年第2期9卷 322-329页

作者： Michael Baumschabl Özge Ata Diethard Mattanovich austrian Centre of Industrial Biotechnology(ACIB) Vienna1190Austria University of Natural Resources and Life Sciences Department of BiotechnologyInstitute of Microbiology and Microbial BiotechnologyViennaAustria

Increasing atmospheric carbon dioxide levels,a reduction of arable land area and the dependence of first and second generation biotechnology feedstocks on agricultural products,call for alternative,sustainable feedstock sources for industrial *** direct use of CO_(2)or conversion of CO_(2)into other single carbon(C1)sources have great potential as they might help to reduce carbon emissions and do not compete with agricultural land *** we discuss the microbial use of C1 carbon sources,their potential applications in biotechnology,and challenges towards sustainable C1-based industrial biotechnology *** focus on methanol,formic acid,methane,syngas,and CO_(2)as feedstocks for bioprocesses,their assimilation pathways,current and emerging applications,and limitations of their *** mini-review is intended as a first introduction for researchers who are new to the field of C1 biotechnology.

关键词： Sustainability BioeconomyCarbon dioxide Methanol Formate Methane

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Post-urethroplasty complications in hypospadias repair: a systematic review and meta-analysis comparing, polydioxanone and polyglactin sutures

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World Journal of Pediatric Surgery 2024年第1期7卷 1-9页

作者： Nitinkumar Borkar Charu Tiwari Debajyoti Mohanty Tridip Dutta Baruah Manoj Mohanty C K Sinha Pediatric Surgery All India Instituteof Medical Sciences-RaipurRaipurChhattisgardhIndia General Surgery All India Institute of Medical Sciences-RaipurRaipurChhattisgardhIndia Pediatric Surgery All India Institute of Medical Sciences-BhubaneswarBhubaneswarOrissaIndia St George's University of London LondonUK

Background Polyglactin(PG)and polydioxanone(PDS)sutures are extensively used based on the surgeon's *** development of post-reconstruction urethrocutaneous fistula(UCF)is variably attributed to the choice of suture material for *** meta-an alysiscompares complications of hypospadia srepair using PGand PDS *** The systematic review and meta-analysis were performed as per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses *** authors conducted thorough searches in databases including MEDLINE,EMBASE,CENTRAL,Scopus,Google Scholar,and clinical trial *** measures included UCF,meatal stenosis,wound infection,urethral stricture,glans dehiscence,and overall *** analysis was used with fixed or random-effect models to find the pooled risk ratio and I2 *** The criteria for inclusion were met by five comparative studies with the inclusion of 1244 children *** analysis failed to show a statistically significant difference in the incidence of meatal stenosis,urethral stricture,wound infection,and total complications using PG and PDS ***,it showed a reduction in the incidence of UCF with PDS suture hypospadias repairs(risk ratio=0.66,95%Cl 0.48 to 0.92).Conclusions PDS sutures are associated with decreased incidence of UCF than PG after hypospadias *** incidence of meatal stenosis,urethral stricture,wound infection,and total complications was not affected by the type of suture material used for *** implications This meta-analysis suggests decreased incidence of UCF when PDS sutures are used for hypospadias repair which may impact the choice of suturematerialforrepair.

关键词： complications wound suture

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