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Acute Thoracic syndrome in children: Epidemiological, Diagnostic and Evolutionary Aspects at the albert royer National children’s hospital in dakar senegal

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Open Journal of Pediatrics 2023年第6期13卷 763-773页

作者： Guillaye Diagne Papa souleye sow Khadim Bop Maimouna sow Idrissa Demba Ba albert royer National children’s hospital Dakar Senegal

Acute chest syndrome (ACs) is a serious pulmonary complication of sickle cell disease. It is estimated to be responsible for a quarter of deaths in the pediatric sickle cell population. In senegal, there are not enough pediatric studies in this area. The objective of our study was to determine the epidemiological, diagnostic and evolutionary characteristics of ATs at the albert royer National children’s hospital (CHNEAR) in dakar. This was a retrospective study in patients hospitalized at CHNEAR for ATs from January 1, 2021 to March 31, 2022. We included patients hospitalized and diagnosed with ATs. We had collected 102 patients, i.e. a hospital incidence of 2.96%. The average age of the children was 9 years old;the sex ratio was 1.04. The main symptoms on admission were hypoxemia (97.06%), chest pain (77.45%), dyspnea (77.45%) and fever (65.69%). 52.94% of patients had an associated vaso-occlusive crisis (VOC). The chest x-ray was abnormal in 92 patients, a rate of 90.20% and showed images of pneumonia (71%);bronchitis (17.65%) and pleurisy (0.98%). None of the children benefited from a pulmonary ultrasound. The treatment associated with analgesics (100%), broad-spectrum antibiotics (100%), oxygen therapy (100%), hydration (95.09%), transfusion (73.53%), non-ventilation invasive (6.86%), intubation (2.94%) and beta 2 mimetics (12.75%). No patient benefited from incentive spirometry. Almost all of the patients 95.10% (n = 97) had a favorable clinical evolution. However, five children (4.90%) had an unfavorable outcome including one case of complication such as stroke (0.98%) and four (4) cases of death. The average hospital stay was 8 days. ATs is common in children with sickle cell disease in senegal and its etiologies seem to be dominated by infectious causes in our context.

关键词： Acute Chest syndrome sickle Cell Disease children senegal

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Pneumothorax in children: Epidemiological Diagnostic and Evolutionary Aspects at the albert royer National children’s hospital in dakar

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Open Journal of Pediatrics 2023年第5期13卷 663-668页

作者： Guillaye Diagne Khadim Bop Papa souleye sow Mohamed Mbodj serigne Tawa Ndiaye Idrissa Demba Ba Department of Pediatric Pulmonology Albert Royer National Children’s Hospital of Dakar Dakar Senegal

Pneumothorax is defined by the presence of air between the parietal pleura and the visceral pleura. Most of the child’s pneumothorax is traumatic. The spontaneous pneumothorax (Ps) of the child is rare, and often associated with a favoring factor. When it is large, it can affect the life expectancy. The objective of our study was to determine the epidemiological, diagnostic and evolutionary aspects of pneumothorax in children aged 0 to 15 years, hospitalized at the albert royer National children’s hospital in dakar. This is a retrospective descriptive study of patient records followed at the albert royer National children’s hospital (CHNEAR) for the management of a pneumothorax during the period from 2020 to 2022. During our study, 15 patients were hospitalized for pneumothorax, with an average annual incidence of 7.5 cases per year. The sex ratio (H/F) was 2.03. The average age was 3.7 years. Chest pain was present in 27% of patients, dyspnea was found in 93%, and cough in 87% of patients. All patients underwent chest radiography and the location of the pneumothorax was predominant on the right in 60% of cases. Thoracic drainage was performed in 93.3% of patients associated with etiological treatment. The average length of hospitalization was 27.8 days with a cure rate of 86.7% and a recurrence rate of 13.3%.

关键词： Pneumothorax Drainage children dakar

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Epidemiological, Diagnostic and Therapeutic Aspects of Cardiogenic shock in children at the albert royer children’s hospital in dakar

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Open Journal of Pediatrics 2021年第4期11卷 669-675页

作者： Mohameth Mbodj Amadou Lamine Fall Aliou Thiongane Ibrahima Diagne Amadou sow serigne T. Ndiaye Khadim Bop Papa s. sow Ousmane Ndiaye albert royer National children hospital Dakar Senegal Cheikh Anta Diop University Dakar Senegal Gaston Berger University Saint Louis Senegal saint Louis Regional hospital Saint Louis Senegal Abass Ndao hospital Center Dakar Senegal

Introduction: The objective of this study was to evaluate the epidemiological, diagnostic and therapeutic aspects of cardiogenic shock in children at the albert royer children’s hospital in dakar. Methods: This was a... 详细信息

strong>Introduction: strong>The objective of this study was to evaluate the epidemiological, diagnostic and therapeutic aspects of cardiogenic shock in children at the Albert Royer Children’s Hospital in Dakar. Methods: This was a retrospective, descriptive and analytical study from January 2020 to February 2021, including all children aged 2 months to 16 years hospitalised for cardiogenic shock diagnosed on the basis of clinical and ultrasound criteria. Results: During the study, 38 patients were hospitalised for cardiogenic shock. The hospital prevalence was 4.2%. The mean age of onset of shock was 64 months, and there was a predominance of females with a sex ratio of 1.92. Consanguinity was found in 42% of the patients. Consanguinity was found in 42% of patients. Infection was identified as a trigger for cardiogenic shock in 18 (52.9%) of our patients. The most common type of heart disease was rheumatic heart disease in 12 (32%) of the patients. The mortality rate was 65.8%. Conclusion: Cardiogenic shock is a diagnostic and therapeutic emergency. Its prevalence and mortality are still high in developing countries.span>

关键词： Heart Disease Consanguinity CMDH shortening Fraction senegal

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Infantile spinal Muscular Atrophy at the albert royer National children’s hospital Center in dakar

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Open Journal of Pediatrics 2024年第3期14卷 514-521页

作者： Guillaye Diagne Khadim Bop sofiatou Dieye Arame Faye Fatou Ly Amadou Lamine Fall Pediatrics Ward of Pikine hospital Pikine Senegal Pé diatrics Ward of Albert Royer National Hospital Dakar Senegal

Introduction: Infantile spinal muscular atrophy (IsA) is an autosomal recessive disease caused by primary degeneration of cells in the anterior horn of the spinal cord, leading to muscle weakness and hypotonia. Its incidence is estimated at 1 in 6000 births worldwide. In Africa, particularly in senegal, there are few studies interested on this pathology. We therefore deemed this study necessary, which set itself the objective of describing the diagnostic, therapeutic and progressive aspects of infantile spinal muscular atrophy at the albert royer National children’s hospital Center in dakar (CHNEAR). Methodology: We conducted a retrospective descriptive study over a period of two (2) years from December 2020 to December 2022. Included were all hospitalized patients in whom the diagnosis of spinal muscular atrophy was made with or without genetic confirmation. The data were collected on a pre-established form then entered and analyzed with the following software: Excel 2013 and R version 4.1.3. Results: During our study period, 2100 children were hospitalized, the annual incidence was 0.76%. The average age of our patients was 9 ± 9 months with a range of 3 months to 32 months and the median was 6.5 months. The sex ratio was 7. The notion of family consanguinity was found in 62.5% of cases and the notion of IsA in the family in 25% of cases. Hypotonia and respiratory distress were found at the forefront in equal proportions (50% of cases). Electromyogram (EMG) was performed in 3 patients (37.5%). symptomatic medical treatment was administered in 100% of patients, 04 patients had benefited from respiratory physiotherapy, i.e. 50% of cases, and genetic counseling was carried out in one patient (12.5%). The evolution was immediately favorable in 2 patients or 25% of cases, unfavorable in 75% of cases with a death rate of 50% and the average age of death was 5.5 months ± 1 with extremes ranging from 3 to 7 months. Conclusion: The number of Infantile spinal muscular atrop

关键词： spinal Muscular Atrophy Child Hypotonia dakar

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Morbidity and Mortality in the Emergency Department of the albert royer National children’s hospital Center dakar: Prospective study from January 1 to April 30, 2020

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Journal of Biosciences and Medicines 2024年第11期12卷 137-159页

作者： Hilaire Lisimo Abwa Halladin Mansoj Alioune Thiogane Mf Faye Feza Muhemerie Yvette Kpakpo Nyange Patient Kapambu Joel Djunguluka Erick albert Kombo Uele University Clinics Department of Pediatrics Faculty of Medicine University of Uele Isiro Democratic Republic of the Congo royer National childrens hospital Center Dakar Senegal hospital General of Watsa Watsa Democratic Republic of the Congo

Introduction: Infant and child morbidity and mortality constitute a public health problem in Africa, particularly in senegal. The objective of this work was to help identify the determinants this morbidity and mortality. Materials and Methods: A prospective study, over a 4-month period (January to April 2020). All patients aged 0 to 15 years, hospitalized for emergency reasons in the albert royer emergency department, were included. Mortality was analyzed according to sociodemographic data, the patient’s itinerary, transfer procedures, availability of emergency medications, diagnosis made during hospitalization and causes of death. The data were collected based on a protocol in an established file and analyzed by sPss (statistical Package for science social) software. Version 18. Results: 225 children in emergency situations were included. The age of our patients is between 0 and 15 years (minimum 0.23 months, maximum 191 months, average 47 months and standard deviation 54). Thus, emergencies represented 57.98% of the 388 hospitalizations. seventy percent of patients were less than 60 months old with a male predominance (sex ratio 1.16), 2.22% were newborns and 27.11% were aged between 60 and 191 months). A total of 79 (35.1%) were transferred and only 57.4% received care before transfer. A total of 12 deaths were reported, representing a lethality of 5.3%. Only young age (less than 59 months, a mortality rate of 91.7%), cardiac decompensations, severe sepsis, and neonatal conditions were more associated with mortality. The majority of our deceased patients came from families with a low socio-economic level (83.3%). Conclusion: Pediatric emergencies are frequent and responsible for lethality and require the necessary efforts, particularly through parent education, the creation of emergency outpatient care units and, above all, the strengthening of the technical platform and therapeutic means.

关键词： Morbidity Mortality Emergencies Infant and Juvenile

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Bacteriological Profile of Acute Respiratory Infections in children: About a Prospective study at the albert royer hospital in dakar

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Open Journal of Pediatrics 2021年第1期11卷 71-77页

作者： Guillaye Diagne A. Kane A. Mbaye A. M. Coundoul s. sow K. Bop A. sow I. D. Ba O. Ndiaye albert royer children’s hospital of dakar Dakar Senegal Pediatrics Department of the Abass NDAO hospital Center Dakar Senegal

Introduction: Acute Respiratory Infections (ARI) is a global public health priority. It is the leading cause of childhood morbidity and mortality, especially in developing countries. The main objective of this work wa... 详细信息

strong>Introduction: strong>Acute Respiratory Infections (ARI) is a global public health priority. It is the leading cause of childhood morbidity and mortality, especially in developing countries. The main objective of this work was to look mainly at the bacteriological aspects of ARI in children in Senegalese hospitals. Methodology: We have been conducted a prospective descriptive mono-centric study over a period of one year (from July 1, 2017 to June 30, 2018) at the Albert Royer National child hospital in Dakar. A multiplex PCR (protein chain reaction) has been performed on nasopharyngeal swabs taken from all patients. This technique (viral RNA transcribed into DNA, then the DNA of the different pathogens is simultaneously amplified in the same tube by PCR Fast-tract®, multiplex). span>Results: During the study period, 109 patients were included. The hospital prevalence of acute respiratory infections was 3.7%. The mean age was 23.7 months with extremes between 1 month and 144 months. Peaks of consultations were found in the months of August, March and April with 22%, 15.6% and 12.8% respectively. Fever, respiratory distress and pulmonary condensation syndrome were the main signs found in our patients. Bacteriology was positive in 82.6% of samples and the most frequently found bacteria were Streptococcus pneumoniae in 38.5%, Haemophilus influenza b in 32.1% and span style="font-family:Verdana;"

关键词： Acute Respiratory Infection Child Bacteria dakar

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Pulmonary Arterial Hypertension in Congenital Heart Disease with Left-to-Right shunt: According to a Retrospective study at albert royer’s National children’s hospital Center

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Open Journal of Pediatrics 2023年第5期13卷 649-656页

作者： Aliou Mar Coundoul Khadim Bop Abdou Aziz Faye Amadou Lamine Fall Idrissa Demba Ba Papa Mactar Faye Department of Cardiology Albert Royer’s National Children’s Hospital Dakar Senegal Pediatric Ward Abass Ndao Hospital Center Dakar Senegal

Pulmonary arterial hypertension PAH is a progressive disease characterized by an increase in pulmonary arterial pressure and resistance. It often complicates congenital heart disease with a left-to-right shunt. The objective of this study is to evaluate the evolutionary profile of the pulmonary pressures of children with congenital heart disease with left-to-right shunt and to identify the factors favoring an evolution towards PAH. This is a retrospective, descriptive and analytical study over a period of four years and six months (from January 1, 2016 to June 30, 2020) at the Center National d’Enfant albert royer in dakar on a series of 87 cases. The hospital frequency was 3.98 per thousand, and the incidence of PAH was 9.44%. The sex ratio of 0.74. The average age was 44.76 months. The average time between the onset of symptoms and the diagnosis of heart disease is 78.81 days. Dyspnea was found in 70.11% of cases, the burst of pulmonary B2 was found in 55%. Global heart failure was noted in 39.08% of cases. Cardiomegaly was found in 89.66% and pulmonary hypervascularization was found in 57.72% of cases. CIV was present in 54.02% of cases, followed by PCA in 21.14% and CAVc in 18.39% of cases. furosemide was used in 97.70% of cases and Captopril in 74.71% of cases. sildenafil was used in 10.34% of patients, and 12.64% of patients benefited from surgical management. Eisenmenger syndrome was found in 12.64% of patients. PAH in these heart diseases is a formidable and frequent complication, due to an increase in precapillary flow. The major improvement in mortality and morbidity is early surgical management, in the first months of life, to prevent pulmonary vascular disease.

关键词： PAH Left-to-Right shunt Einsenmenger syndrome

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Evolutionary Profile of Graves’ Disease in children at albert royer National children hospital in dakar

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Open Journal of Pediatrics 2019年第2期9卷 119-125页

作者： Babacar Niang Lamine Thiam Fatou Ly Indou Dème Ly Djibril Boiro Amadou sow Aliou Thiongane Aliou Abdoulaye Ndongo Aminata Mbaye Younoussa Keita Abou Ba Idrissa Demba Ba Yaay Joor Dieng Dienaba Fafa Cissé Papa Matar Faye Amadou Lamine Fall Ousmane Ndiaye albert royer National children hospital Center Dakar Senegal La Paix hospital Ziguinchor Senegal Pediatric Ward University Hospital Center of Pikine Dakar Senegal Pediatric Ward University Hospital Center of Abass Ndao Dakar Senegal Pediatric Ward University Hospital Center of Aristide Le Dantec Dakar Senegal

Graves’ disease is the most common cause of hyperthyroidism. Adequate management is an area of controversy, especially when it comes to children. The objective of our study was to assess the outcome of Graves’ disease treatment in albert royer children hospital of dakar. This was a retrospective study conducted from 2001 to 2015, and which involved all children between 0 to 15 years of age who were being monitored in the albert royer National children hospital. The evolutionary modalities were: stability, remission, failure, relapse, lost to follow-up and death. The data were analyzed with sPss software version 20.0. For the comparisons, the KHI 2 or Fisher test was used with a significance threshold (p study period, 88 children were enrolled. The average age was 8.6 years [ranging from 8 months to 15 years]. The consultation delay was 11.36 months. In our study, 61.4% of the patients were regular in the follow-up, the observance was good in 40.9% of the cases and 19 patients (21.6%) were lost to follow-up. Clinical courses of 69 children after treatment with Carbimazole for 37 months were promising in 21 cases (30.43%), with 17 cases of remission (24.63%) and 4 cases of stability (5.8%). Age older than 10, the initial ATD dose greater than 1 mg/kg/day and the initial free T4 lower than 50 pmol/l were significantly associated with remission with a p value of 0.01;0.024 and 0.004.

关键词： Graves’ Disease Child Antithyroid Drug Remission senegal

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Neonatal Bilirubin Encephalopathy: study of 30 Cases at albert royer National children hospital of dakar

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Open Journal of Pediatrics 2020年第1期10卷 116-124页

作者： P. M. Faye Y. J. Dieng I. Deme D. F. Cissé M. Kane s. R. Tcheuffa Wekang A. Thiongane I. D. Ba A. Ba M. Gueye B. Niang P. s. sow Amadou sow Djibril Boiro N. R. Diagne-Gueye A. L. Fall O. Ndiaye Centre hospitalier National d’Enfants albert royer Dakar Senegal Centre hospitalier Abass Ndao Dakar Senegal Hopital pour Enfants de Diamniadio Dakar Senegal

Introduction: Unconjugated bilirubin jaundice is a common symptom in neonatal period. In some babies, excessive serum bilirubin concentrations can place them at risk of acute bilirubin encephalopathy (BE) when the unconjugated pigment crosses the blood-brain barrier. Our study aimed to describe epidemiology, diagnosis and prognosis of BE at the Neonatology Department of albert royer children’s hospital of dakar. Materials and Methods: It was a retrospective, descriptive study of cases of BE from January 1, 2015 to June 30, 2019. Obstetric and perinatal data as well as postnatal jaundice data (onset time, associated signs, signs of encephalopathy, treatment and evolution) were collected and analyzed by sPss software version 2.0. Almost all newborns (27 cases;90%) were exclusively breastfed. At admission, all children exhibited blunt jaundice and signs of encephalopathy dominated by the abolition of archaic reflexes (76.7%), low suction (22 cases;73.3%), central apnea (12 cases, 40%). The mean serum bilirubinemia was 322 mg/litre. Neonatal infection (10 cases;33.3%) and fetal-maternal incompatibility (16 cases;53.3%) were the main causes. All children received intensive phototherapy and exsanguino transfusion was performed for 7 newborns (23.3%). Nine children died (30% mortality rate). Conclusion: Only better organisation of perinatal care with enhanced postnatal follow-up can reduce the incidence of EB.

关键词： Neonatal Hyperbilirubinemia Encephalopathy Perinatal Care

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Congenital Cyanogenic Heart Disease in children: About 420 Cases in Africa

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World Journal of Cardiovascular surgery 2020年第6期10卷 83-90页

作者： Amadou Lamine Fall Amadou sow Idrissa Basse Aliou Mar Coundoul Fondjo P. s. Monoue Aliou Thiongane Djibril Boiro Indou Deme Ly Babacar Niang Idrissa Demba Ba Guilaye Diagne Papa Moctar Faye Ousmane Ndiaye albert royer National children’s hospital Dakar Senegal Abass Ndao hospital Center Dakar Senegal Diamniadio children’s hospital Dakar Senegal

Congenital cyanogenic heart disease (CCHD) is a malformation of the heart and large vessels characterized by an oxygen desaturation in the arterial blood, responsible for cyanosis. The general objective was to study the profile of CCHD in Senegalese hospitals. This is a retrospective study carried out over a period of 8 years (January 1, 2010 - December 31, 2017) and including all children aged 0 to 16 years followed for a CCHD. The hospital prevalence was 0.87% for 420 cases collected. The sex ratio was 1.44 and the average age at diagnosis was 16 months. First degree parental consanguinity was noted in 36 cases (30.78%). The main reasons for consultation were breathing difficultyspan> in 242 cases (57.62%) and fever in 136 patients (32.36%). Apart from cyanosis, the clinical signs were dominated by the heart murmur in 313 cases (74.7%), tachycardia in 283 cases (67.38%) and digital hippocratism in 162 cases (38.57%). Cardiomegaly was found in 239 patients (83.36%). The main types of CCHD were tetralogy of Fallot and transposition of the large vessels. In biology, 206 patients (49.05%) presented polyglobulia. A complete surgical cure was carried out in 22 patients (5.24%). Complications were anoxic crisis (52 cases) and hemorrhagic syndrome (17 cases). There were 97 deaths (28.28%) during hospitalization. The diagnosis of CCHD is late in our country and surgical management is poor explaining the high mortality.span>

关键词： Heart Disease Cyanosis Tetralogy Fallot surgery senegal

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