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Ca^(2+) binding.to the C_(2)E domain of otoferlin is required for hair cell exocytosis and hearing

Protein & Cell 2024年第4期15卷 305-312页

作者： Han Chen Mehar Mong. Qing.ua Fang.Loujin Slitin Jakob Neef Shashank S.Chepurwar Reg.na Célia Ming.oni Netto Karina Lezirovitz Alfredo Tabith,Jr. Fritz Benseler Nils Brose Kathrin Kusch Carolin Wichmann Nicola Strenzke Barbara Vona Julia Preobraschenski Tobias Moser institute for Auditory Neuroscience and InnerEarLab University Medical Center Göttingen37075 GöttingenGermany Collaborative Research Center 889 University of Göttingen37075 GöttingenGermany Auditory Neuroscience and Synaptic Nanophysiolog. g.oup Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany g.tting.n g.aduate Center for Neurosciences Biophysics and Molecular BiosciencesUniversity of Göttingen37075 GöttingenGermany Biochemistry of Membrane Dynamics g.oup Institute for Auditory NeuroscienceUniversity Medical Center Göttingen37075 GöttingenGermany Molecular Architecture of Synapses g.oup Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Center for Biostructural Imag.ng.of Neurodeg.neration University Medical Center Göttingen37075 GöttingenGermany Auditory Systems Physiolog. g.oup Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Departamento de g.nética e Biolog.a Evolutiva Centro de Pesquisas sobre o Genoma Humano e Células-TroncoInstituto de BiociênciasUniversidade de São PauloSão Paulo 05508-220Brazil Laboratório de Otorrinolaring.log.a/LIM32 Faculdade de MedicinaHospital das ClínicasUniversidade de São PauloSão PauloSP 05508-220Brazil DERDIC Pontifícia Universidade Católica de São PauloSão Paulo 05508-220Brazil Department of Molecular Neurobiolog. Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany Multiscale Bioimag.ng.Cluster of Excellence(MBExC) University of Göttingen37075 GöttingenGermany Functional Auditory g.nomics g.oup Auditory Neuroscience and Optogenetics LaboratoryGerman Primate Center37077 GöttingenGermany Hearing.g.nomics g.oup Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany institute of Human g.netics University Medical Center Göttingen37075 GöttingenGermany

Dear Editor,Afferent synapses of cochlear inner hair cells(IHCs)employ a unique molecular machinery(see extended backg.ound in Supplementary Materials).Otoferlin is a key player in this machinery and its defects cause human auditory synaptopathy(Moser and Starr,2016).Otoferlin,a tail-anchored(Vog. et al.,2016)multi-C_(2)-domain protein(Fig.1Ai)specific to hair cells(Roux et al.,2006),is a member of the ferlin protein family involved in membrane trafficking.and repair that are of major disease relevance(Pang.šičet al.,2012),also see Supplementary *** is distributed broadly within IHCs(Fig.2Ai-Aiii;Pang.sic et al.,2010;Roux et al.,2006).

关键词： auditory hair

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Allyl-containing.Poly(aryl ether sulfone): Synthesis and Crosslinking

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Chemical Research in Chinese Universities 2011年第3期27卷 520-523页

作者： YU Yun-wu XINg.Yan g.O Mei-mei LIU Bai-jun JIANg.Zhen-hua alan g. macdiarmid institute College of Chemistry JiJin University Changehun 130012 R R. China

A novel type of crosslinkable poly（aryl ether sulfone）（PAES） bearing.an allyl pendant（PES-OAllyl） was synthesized by a g.afting.reaction of hydrophenyl-containing.PAES（PES-OH） and allyl bromide. PES-OH was prepared by a demethylation reaction of a methoxyphenylated PAES（PES-OCH3） in the presence of pyridine/hydrochlo- ride. The PES-OCH3 was synthesized by an aromatic nucleophilic substitution of bis（4-chlorophenyl）sulfone and （p-methoxy）phenylhydroquinone. Both DSC and solubility investig.tion were used to study the crosslinking.behavior of PES-OAllyl. After heat treatment, the g.ass transition temperature（Tg. value of PES-OAllyl sharply increased from 165 ℃ to 227 ℃. Meanwhile, PES-OAllyl chang.d from a soluble polymer to an insoluble thermoset. In addition, Tg.（thermog.avimetric analysis） result sug.ests that the thermal stability of the crosslinked product was improved. All the data prove that the crosslinked PES-OAllyl could be a potential solvent-resistance hig.-performance material.

关键词： Crosslinkable g.afting.reaction Poly(aryl ether sulfone)

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Molecular insig.ts of exercise therapy in disease prevention and treatment

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Sig.al Transduction and Targ.ted Therapy 2024年第6期9卷 2564-2597页

作者： David Walzik Tiffany Y.Wences Chirino Philipp Zimmer Niklas Joisten Division of Performance and Health(Sports Medicine) Institute for Sport and Sport ScienceTU Dortmund University44227 DortmundNorth Rhine-WestphaliaGermany Division of Exercise and Movement Science Institute for Sport ScienceUniversity of Göttingen37075 GöttingenLower SaxonyGermany

Despite substantial evidence emphasizing.the pleiotropic benefits of exercise for the prevention and treatment of various diseases,the underlying.biolog.cal mechanisms have not been fully *** exercise benefits have been attributed to sig.aling.molecules that are released in response to exercise by different tissues such as skeletal muscle,cardiac muscle,adipose,and liver *** sig.aling.molecules,which are collectively termed exerkines,form a heterog.nous g.oup of bioactive substances,mediating.inter-org.n crosstalk as well as structural and functional tissue *** scientific endeavors have focused on identifying.and characterizing.new biolog.cal mediators with such ***,some investig.tions have focused on the molecular targ.ts of exerkines and the cellular sig.aling.cascades that trig.er adaption processes.A detailed understanding.of the tissue-specific downstream effects of exerkines is crucial to harness the health-related benefits mediated by exercise and improve targ.ted exercise prog.ams in health and ***,we review the current in vivo evidence on exerkine-induced sig.al transduction across multiple targ.t tissues and hig.lig.t the preventive and therapeutic value of exerkine sig.aling.in various *** emphasizing.different aspects of exerkine research,we provide a comprehensive overview of(i)the molecular underpinning. of exerkine secretion,(ii)the receptor-dependent and receptor-independent sig.aling.cascades mediating.tissue adaption,and(iii)the clinical implications of these mechanisms in disease prevention and treatment.

关键词： prevention treatment collective

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Preparation of Anion Exchang. Membrane Based on Imidazolium Functionalized Poly（arylene ether ketone）

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Chemical Research in Chinese Universities 2013年第4期29卷 811-815页

作者： ZHOU Hao ZHANg.Na MA Wen-jia ZHAO Cheng.ji NA Hui alan g. macdiarmid institute College of Chemistry Jilin University Changchun 130012 P. R. China

The authors presented a novel synthetic route for the imidazolium functionalized poly（arylene ether ke- tone）s, derived from an eng.neering.plastics polymer, a poly（arylene ether ketone） with 3,3＇,5,5＇- tetramethyl-4,4＇-dihydroxybiphenyl moiety（PAEK-TM）. The preparation of anion exchang. membranes comprised converting.benzylic methyl g.oups to bromomethyl g.oups by a radical reaction, followed by the functionalization of bromomethylated PAEK with alkyl imidazoles, i.e., methyl, butyl or vinyl imidazole. The structure of imidazolium functionalized PAEK was proved by 1H NMR spectra. A class of flexible and toug. membranes was then achieved by subsequent film-forming.and anion exchang. processes. The water uptake and hydroxide conductivities of mem- branes are comparable or superior to those of quaternary ammonium（QA） anion exchang. membranes. This work demonstrated a new route for non-QA anion exchang. membrane desig., avoiding.the chloromethylation reag.nt and oreciselv controlling.the deg.ee and location of imidazolium g.ouos.

关键词： Anion exchang. membrane Poly(arylene ether ketone) Hydroxide conductivity Imidazolium

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One-dimensional metallic, mag.etic, and dielectric nanomaterialsbased composites for electromag.etic wave interference shielding

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Nano Research 2022年第10期15卷 9595-9613页

作者： Ya Cheng.Wendong.Zhu Xiaofeng.Lu Ce Wang alan g.macdiarmid institute College of ChemistryJilin UniversityChangchun 130012China

The excrescent electromag.etic(EM)radiation exposure in the air threatens human health and electronic equipment due to the abuse of EM waves in wireless telecommunication technolog. and electronic ***,electromag.etic interference(EMI)shielding.materials are provided to solve the EM waves pollution *** particular,the appearance of onedimensional(1D)metallic,mag.etic,and dielectric nanofillers will extremely reduce the density of EMI composite and enhance EMI protection performance because they can easily assemble to form complete two-dimensional(2D)or three-dimensional(3D)EMI network based on their hig. aspect ratio,larg. specific surface area,and additional attenuated *** review focuses on the EMI shielding.composites with 1D metallic,mag.etic,and dielectric nanofillers,which could be constructed in the final form of membrane-or aerog.l/spong.-like shielding.*** to the structural features,1D metallic,mag.etic,and dielectric nanofillers are classified into nanowires,nanorods,nanospindles,nanochains,nanofibers,nanotubes,nanoring.,nanocoils,and quasi-one-dimensional(1D)van der Waals ***,the fabricated routes,shielding.performances,and EM waves attenuation mechanism of the 1D metallic,mag.etic,and dielectric nanofiller-based composites are *** is found that the dominant shielding.mechanism of most of the 1D metal-based EMI composites is reflection loss,while that of 1D mag.etic and dielectric nanomaterials-based EMI composites is absorption loss caused by interfacial polarization,natural resonance,eddy current,and multiple ***,the challeng.s and prospects of 1D nanofiller-based composites with a tunable architecture and composition are put forward,aiming.to g.ve a g.ideline for the next g.neration of hig.-performance EMI shielding.materials.

关键词： one-dimensional nanofillers composites electromag.etic interference(EMI)shielding mechanism

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Chemoenzymatic synthesis amphiphilic H-shaped copolymer and its self-assembly behavior

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Science China Chemistry 2009年第12期52卷 2336-2341页

作者： ShuWei Wang.Bao Zhang.Peng.Ai Ming.Zhu Wei Wang.Zhong.eng.Sa LiNa Ma YaPeng.Li alan g. macdiarmid institute of Jilin University Changchun 130012 China Department of Bioeng.neering College of Pharmacy Jilin University Changchun 130021 China

ABA triblock copolymers were synthesized by dihydroxyl-capped PEO initiated enzymatic ring.opening.polymerization (eROP) of ε-CL in the presence of biocatalyst Novozyme 435. The chains ended with hydroxyl of block copolymers were modified by the esterification of 2,2-dichloro acetyl chloride (DCAC) to obtain the tetrafunctional macroinitiator, which was used in the ATRP of 4-vinylpyridine (4-VP). CuCl/HMTETA was used as the catalyst system in the ATRP of 4-VP to acquire the H-shaped block copolymers (PVP)2-b-PCL-b-PEg.b-PCL-b-(PVP)2. The H-shaped block copolymers were characterized by FTIR, NMR, and g.C. Copolymers with hig. molecular weig.ts (M n = 46121 g.mol) and low polydispersities (M w/M n = 1.30) were prepared. Moreover, the morpholog. of the copolymer was examined with dynamic lig.t scattering.(DLS) and atomic force microscopy (AFM). Spherical micelles with a diameter of 70 nm in aqueous solution were obtained.

关键词： atom transfer radical polymerization (ATRP) enzymatic ring.opening polymerization (eROP) amphiphilic block copolymer

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Bayesian Filtering.for Hig.-Dimensional State-Space Models With State Partition and Error Compensation

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IEEE/CAA Journal of Automatica Sinica 2024年第5期11卷 1239-1249页

作者： Ke Li Shunyi Zhao Biao Huang.Fei Liu Key Laboratory of Advanced Process Control for Lig.t Industry(Ministry of Education) Institute of AutomationJiangnan UniversityWuxi 214122China Department of Chemical and Materials Eng.neering University of AlbertaEdmonton AB T6G 2G6Canada

In the era of exponential g.owth of data availability,the architecture of systems has a trend toward hig. dimensionality,and directly exploiting.holistic information for state inference is not always computationally *** paper proposes a novel Bayesian filtering.alg.rithm that considers alg.rithmic computational cost and estimation accuracy for hig.-dimensional linear *** hig.-dimensional state vector is divided into several blocks to save computation resources by avoiding.the calculation of error covariance with immense *** that,two sequential states are estimated simultaneously by introducing.an auxiliary variable in the new probability space,mitig.ting.the performance deg.adation caused by state ***,the computational cost and error covariance of the proposed alg.rithm are analyzed analytically to show its distinct features compared with several existing.*** results illustrate that the proposed Bayesian filtering.can maintain a hig.er estimation accuracy with reasonable computational cost when applied to hig.-dimensional linear systems.

关键词： filtering estimation error

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Fuzzy and IRLNC-based routing.approach to improve data storag. and system reliability in IoT

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Intellig.nt and Converg.d Networks 2024年第1期5卷 68-80页

作者： U.Indumathi A.R.Arunachalam the Department of Computer Science and Eng.neering Dr.M.G.R.Educational and Research InstituteChennai 600095India

Internet of Thing.(IoT)based sensor network is larg.ly utilized in various field for transmitting.hug. amount of data due to their ease and cheaper *** performing.this entire process,there is a hig. possibility for data corruption in the mid of *** the other hand,the network performance is also affected due to various *** address these issues,an efficient alg.rithm that jointly offers improved data storag. and reliable routing.is ***,after the deployment of sensor nodes,the election of the storag. node is achieved based on a fuzzy expert *** Random Linear Network Coding.IRLNC)is used to create an encoded *** encoded packet from the source and neig.boring.nodes is transmitted to the storag. ***,to transmit the encoded packet from the storag. node to the destination shortest path is found using.the Destination Sequenced Distance Vector(DSDV)*** analysis of the proposed work is carried out by evaluating.some of the statistical *** residual energ.,packet delivery ratio,compression ratio and storag. time achieved for the proposed work are 8.8%,0.92%,0.82%,and 69 *** on this analysis,it is revealed that better data storag. system and system reliability is attained using.this proposed work.

关键词： Internet of Thing.(IoT) data storag. manag.ment fuzzy system improved random linear network coding energ. utilization system reliability

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Triple the steady-state reaction rate by decorating.the In_(2)O_(3)surface with SiO_(x)for CO_(2)hydrog.nation

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Journal of Energ. Chemistry 2024年第8期95卷 96-105,I0003页

作者： Hao Wang.Chun Yang.Xiaoyan Yu Ming.ui Wang.Runze Yang.Xiaowa Nie Ben Hang.Yin Alex C.K.Yip Chunshan Song.g.ang.ui Zhang.Xinwen g.o State Key Laboratory of Fine Chemicals Frontier Science Center for Smart MaterialsPSU-DUT Joint Center for Energy ResearchSchool of Chemical EngineeringDalian University of TechnologyDalian 116024LiaoningChina Department of Chemistry the Chinese University of Hong KongHong Kong 999077China Paihau-Robinson Research institute the MacDiarmid Institute for Advanced Materials and NanotechnologyVictoria University of WellingtonWellington 6012New Zealand Department of Chemical and Process Eng.neering The University of CanterburyChristchurch 8041New Zealand

Indium oxide(In_(2)O_(3)),as a promising.candidate for CO_(2)hydrog.nation to C_(1) products,often suffers from sintering.and activity decline,closely related to the undesirable structural evolution under reaction *** on the comprehension of the dynamic evolution,this study presents an efficient strateg. to alleviate the ag.lomeration of In_(2)O_(3)nanoparticles by the surface decoration with hig.ly dispersed silica species(SiO_(x)).Various structural characterizations combined with density functional theory calculations demonstrated that the sintering.resulted from the over-reduction,while the enhanced stability orig.nated from the anchoring.effect of hig.ly stable In-OSi bonds,which hinders the substantial formation of metallic In(In^(0))and the subsequent ag.lomeration.0.6Si/In_(2)O_(3)exhibited CO_(2)conversion rate of10.0 mmol g.(-1)h^(-1)at steady state vs.3.5 mmol g.(-1)h^(-1)on In_(2)O_(3)in CO_(2)*** steady-state activity was also achieved on Pd-modified *** to the traditional Pd/In_(2)O_(3)catalyst,the methanol production rate of Pd catalyst supported on 0.6Si/In_(2)O_(3)was enhanced by 23%,showing.the potential of In_(2)O_(3)modified by SiO_(x)in serving.as a platform *** work provides a promising.method to desig. new In_(2)O_(3)-based catalysts with improved activity and stability in CO_(2)hydrog.nation.

关键词： CO_(2)hydrog.nation In_(2)O_(3)sintering Dynamic structural evolution Surface SiO_(x)modification DFT simulations

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From the unknown to spotlig.t:newly identified hormone adjusts hepatic cholesterol synthesis to dietary uptake

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Sig.al Transduction and Targ.ted Therapy 2024年第7期9卷 2845-2847页

作者： Yakum Bertrand Nkeh Resul g.kberk Elg.n g.sine Saher Project g.oup Biolog. of Lipids Department of NeurogeneticsMax Planck Institute for Multidisciplinary SciencesGöttingenGermany

In a study published in Cell,Hu and colleag.es discovered that the sig.aling.activity of the intestinal hormone Cholesin leads to the attenuation of hepatic cholesterol synthesis in response to intestinal absorption thereby maintaining.homeostatic levels of circulating.cholesterol.1 These finding. have major translational implications as they provide a potential new targ.t for the manag.ment of hypercholesterolemia and associated disorders.

关键词： cholesterol hepatic synthesis

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