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CSRWA:Covert and Severe Attacks Resistant Watermarking algorithm

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Computers, Materials & Continua 2025年第1期82卷 1027-1047页

作者： Balsam Dhyia Majeed Amir Hossein Taherinia Hadi Sadoghi Yazdi Ahad Harati faculty of Engineering Ferdowsi University of MashhadMashhad***Iran Department of Computer Techniques Engineering Imam Al-Kadhum CollegeBaghdad10087Iraq

Watermarking is embedding visible or invisible data within media to verify its authenticity or protect *** watermark is embedded in significant spatial or frequency features of the media to make it more resistant to intentional or unintentional *** of these features are important perceptual features according to the human visual system(HVS),which means that the embedded watermark should be imperceptible in these ***,both the designers of watermarking algorithms and potential attackers must consider these perceptual features when carrying out their *** two roles will be considered in this paper when designing a robust watermarking algorithm against the most harmful attacks,like volumetric scaling,histogram equalization,and non-conventional watermarking attacks like the Denoising Convolution Neural Network(DnCNN),which must be considered in watermarking algorithm design due to its rising role in the state-of-the-art *** DnCNN is initialized and trained using watermarked image samples created by our proposed Covert and Severe Attacks Resistant Watermarking algorithm(CSRWA)to prove its *** this algorithm to satisfy the robustness and imperceptibility tradeoff,implementing the Dither Modulation(DM)algorithm is boosted by utilizing the Just Noticeable Distortion(JND)principle to get an improved performance in this ***,luminance,inter and intra-block contrast are used to adjust the JND values.

关键词： Covert attack digital watermarking DnCNN JND perceptual model robustness

Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad al Kabbani Christoph Köhler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-KO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

The impact of alpha-fetoprotein(AFP),child-turcotte-pugh(CTP)score and disease staging on the survival of hepatocellular carcinoma(HCC)patients:a retrospective cohort from single oncology center

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Oncology Research 2025年第1期33卷 149-160页

作者： NASSER MULLA YOUSEF KATIB ASIM M.alMUGHAMSI DUAA S.alKHAYAT MOHAMED MOSAAD SAMIR T.alFOTIH RAWAN alAOFI Department of Internal medicine Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Department of Radiology Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Department of Surgery Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Department of Endemic and Infectious Diseases Suez Canal UniversityIsmailia41522Egypt King Salman bin Abdulaziz Medical City Madinah42311Saudi Arabia Prince Mohammed Bin Abdulaziz Hospital Madinah41511Saudi Arabia

Background:Hepatocellular carcinoma(HCC)is the most common cause of cancer-related death in Saudi *** study aimed to investigate the patterns of HCC and the effect of TNM staging,alfa-fetoprotein(AFP),and Child-Turcotte Pugh(CTP)on patients’overall survival(OS).Methods:A retrospective analysis was conducted on 43 HCC patients at a single oncology center in Saudi Arabia from 2015 to *** patients had to fulfill one of the following criteria:(a)a liver lesion reported as definitive HCC on dynamic imaging and/or(b)a biopsy-confirmed ***:The mean patient age of all HCC cases was 66.8 with a male-to-female ratio of 3.3:*** patients were stratified into two groups:viral HCC(n=22,51%)and non-viral HCC(n=21,49%).Among viral-HCC patients,55%were due to HBV and 45%due to *** was diagnosed in 79%of *** and sex did not significantly statistically differ in OS among viral and non-viral HCC patients(p-value>0.05).About 65%of patients had tumor size>5 cm during the diagnosis,with a significant statistical difference in OS(p-value=0.027).AFP was>400 ng/ml in 45%of the *** was a statistically significant difference in the OS in terms of AFP levels(p-value=0.021).A statistically significant difference was also observed between the CTP score and OS(p-value=0.02).CTP class B had the longest *** was the most common treatment provided to HCC patients followed by sorafenib *** was a significant statistical difference in OS among viral and non-viral HCC patients(p-value=0.008).Conclusions:The most common predictors for OS were the underlying cause of HCC,AFP,and tumor *** having non-viral etiology,a tumor size>5 cm,an AFP>400 ng/mL,and a CTP score class C were all negatively associated with OS.

关键词： Hepatocellular carcinoma Pattern alpha-fetoprotein(AFP) Child-turcotte-pugh Progression free survival

Studying and Estimating Visual Pollution in Irbid City (Centre of Irbid City-Case Study)

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Journal of Environmental Science and Engineering(A) 2025年第1期14卷 14-30页

作者： Mohmd Addad Shehadeh A-Taani Architecture Department Faculty of EngineeringAl al-Bayt UniversityMafraq 25113Jordan

Despite the global attention towards pollution,it remains a significant global threat and challenge for both developed and developing *** and economic development influence different types of *** pollution is considered a new phenomenon referring to the impact of existing and growing mainstream pollution which impairs an individual’s ability to enjoy visits or ***,Jordanian cities have expanded in response to urbanization and ongoing *** City has the second largest population in Jordan after the capital Amman City highest population density in *** the modern era,Irbid City dramatically increased in population and *** growth of the demographic population has been significant and has led to overpopulation,rapid urbanization,and unresolved problems associated with spatial planning and infrastructures leading to different types of pollution including visual *** study area focuses on the city center with the most crowded population through field visits and actual *** study technique is descriptive and analytical,with a focus on meticulous monitoring and a follow-up-based questionnaire which is a tool for the study,involving data collection,classification,presentation,analysis,interpretation,and exploration to identify new facts and generalizations that can help solve current issues of visual *** study provides recommendations for Irbid Municipal to eliminate visual pollution,in parallel with stricter supervision from the municipality during the building process to ensure proper implementation of the new rules,adopting an integrated policy for the city with the rest of the social,political,sensory,cultural,economic,and functional aspects,so that this policy is in the short and long term.

关键词： Visual pollution Irbid city spatial planning overpopulation questionnaire visual distortion urban planning.

A Review on Integration of IoT as an Approach for Energy Saving in Smart Sustainable Cities

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Journal of Environmental Science and Engineering(A) 2025年第1期14卷 60-71页

作者： Mohd Addad Shehadeh al-Taani Architecture Department Faculty of EngineeringAl al-Bayt UniversityMafraq 25113Jordan

Rapid urbanization has been happening around the world,leading to many challenges and difficulties in infrastructure,communication network,transportation,environmental and organizational *** and responsible management of urban resources plays a significant role in sustainable *** sustainable cities use ICTs(Information and Communication Technologies)to improve quality of life,efficiency of urban operation and *** latest advancement in communication,technology,data management,and IoT(Internet of Things)provide a tremendous role for practical implementations and adoption of devices and *** sustainable cities can be intellectualized as an innovative approach of controlling urban resources and valuable components based on the latest advancement in *** study focuses on reviewing and discussing the literature that states the vital components of IoT associated with smart sustainable cities in general and specifically with green energy.

关键词： IOT devices and sensors smart sustainable cities and green energy.

Enhancing Solar Photovoltaic Efficiency:A Computational Fluid Dynamics Analysis

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Energy Engineering 2025年第1期122卷 153-166页

作者： Rahool Rai Fareed HussainMangi Kashif Ahmed Sudhakar Kumaramsay faculty of Mechanical and Automotive Engineering Universiti Malaysia Pahang Al-Sultan AbdullahPekan26600PahangMalaysia faculty of Engineering Science&Technology Hamdard UniversityKarachi74600Pakistan Electrical Engineering Department SUKKUR IBA UniversitySukkur65200Pakistan Berlin School of Business and Innovation BSBI Faculty of Computer Science and InformaticsBerlin12043Germany Automotive Engineering Centre University Malaysia Pahang Al Sultan AbdullahPekan26600PahangMalaysia Centre for Research in Advanced Fluid&Processes(Fluid Centre) Universiti Malaysia Pahang Al-Sultan Abdullah(UMPSA)Paya BesarKuantan26300PahangMalaysia

The growing need for sustainable energy solutions,driven by rising energy shortages,environmental concerns,and the depletion of conventional energy sources,has led to a significant focus on renewable *** energy,among the various renewable sources,is particularly appealing due to its abundant ***,the efficiency of commercial solar photovoltaic(PV)modules is hindered by several factors,notably their conversion efficiency,which averages around 19%.This efficiency can further decline to 10%–16%due to temperature increases during peak sunlight *** study investigates the cooling of PV modules by applying water to their front surface through Computational fluid dynamics(CFD).The study aimed to determine the optimal conditions for cooling the PV module by analyzing the interplay between water film thickness,Reynolds number,and their effects on temperature reduction and heat *** CFD analysis revealed that the most effective cooling condition occurred with a 5 mm thick water film and a Reynolds number of *** specific parameters were found to maximize the heat transfer and temperature reduction *** finding is crucial for the development of practical and efficient cooling systems for PV modules,potentially leading to improved performance and longevity of solar *** cooling fluids or advanced cooling techniques that might offer even better efficiency or practical benefits.

关键词： PV module efficiency water film thickness reynolds number CFD analysis PV/T renewable energy

Unlocking hypoglycemia–associated brain microvascular dysfunction:critical insights from proteomic analysis

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Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： Siva S.V.P.Sakamuri Anil Sakamuri Department of Chemistry Auburn University at MontgomeryMontgomeryALUSA Vascular Biology Center and Department of medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological *** hypoglycemia,classified as level 1 hypoglycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hypoglycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left *** with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms.

关键词： impaired intake critical

Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru C.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada faculty of medicine–The University of British Columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science Core Collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P GC-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

Genistein:a possible solution for the treatment of alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2903-2905页

作者： Karolina Pierzynowska Bartosz Karaszewski Grzegorz Węgrzyn Department of Molecular Biology University of GdanskGdanskPoland Gdansk Polandand Department of Adult NeurologyFaculty of MedicineMedical University of GdanskGdanskPoland

Neurodegenerative diseases are defined as disorders resulting from the slow and progressive loss of function and eventual death of neural cells that result from the primary pathology of nervous *** can lead to severe nervous system dysfunction,eventually affecting multiple organs and *** hundred neurodegenerative diseases have been described,and owing to their prevalence,severity.

关键词： organs alzheimer death