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Relationship Between Climate Change and Marmot Plague of Marmota himalayana Plague Focus—the Altun Mountains of the Qinghai-Xizang Plateau,China,2000–2022

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China CDC weekly 2024年第4期6卷 69-74,I0006页

作者： Qun Duan Xiaojin Zheng Zhiqiang Gan Dongyue Lyu Hanyu Sha Xinmin Lu Xiaoling Zhao Asaiti Bukai Ran Duan Shuai Qin Li Wang Jinxiao Xi Di Wu Peng Zhang Deming Tang Zhaokai He Huaiqi Jing Biao Kan Xin Wang National Institute for Communicable disease control and prevention Chinese Center for Disease Control and PreventionBeijingChina akesai kazak autonomous county center for disease control and prevention Jiuquan CityGansu ProvinceChina Jiuquan center for disease control and prevention Jiuquan CityGansu ProvinceChina Gansu Provincial center for disease control and prevention Lanzhou CityGansu ProvinceChina

Introduction:Plague is a zoonotic disease that occurs naturally in specific geographic *** change can influence the populations of the plague host or vector,leading to variations in the occurrence and epidemiology of plague in ***:In this study,we collected meteorological and plague epidemiological data from the Marmota himalayana plague focus in the Altun Mountains of the Qinghai-Xizang *** data spanned from 2000 to *** describe the climatic factors and plague epidemic conditions and we describe their analysis by Pearson’s ***:During the period from 2000 to 2022,the isolation rates of Yersinia pestis(***)from marmots and fleas were 9.27%(451/4,864)and 7.17%(118/1,646),***,we observed a positive rate of F1 antibody of 11.25%(443/3,937)in marmots and 18.16%(142/782)in *** regards to climate,there was little variation,and a decreasing trend in blowing-sand days was *** temperature in the previous year showed a negative correlation with the *** isolation rate in marmots(r=−0.555,P=0.011)and the positive rate of F1 antibody in marmots(r=−0.552,P=0.012)in the current *** average annual precipitation in the previous two years showed a positive correlation with marmot density(r=0.514,P=0.024),while blowingsand days showed a negative correlation with marmot density(r=−0.701,P=0.001).Furthermore,the average annual precipitation in the previous three years showed a positive correlation with the isolation rate of *** from marmots(r=0.666,P=0.003),and blowing-sand days showed a negative correlation with marmot density(r=−0.597,P=0.009).Conclusions:The findings of this study indicate that there is a hysteresis effect of climate change on the prevalence of ***,monitoring climate conditions can offer significant insights for implementing timely preventive and control measures to combat plague epidemics.

关键词： Plague epidemiology Plateau

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Epidemiology of Leprosy in China,2021:An Update

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International Journal of Dermatology and Venereology 2024年第1期7卷 35-39页

作者： Ying Shi Pei-Wen Sun Le Wang Hong-Sheng Wang Mei-Wen Yu Heng Gu National center for Leprosy control Chinese Center for Disease Control and PreventionHospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China

Objective:Leprosy is an infectious diseases that remains a concerning public health *** infection of Mycobacterium leprae still exists at the county level in hard-to-access areas in southwest *** accurate analysis of the prevalence of leprosy in various regions is necessary for the formulation of prevention and control strategies,so we conducted this study to describe the epidemiological characteristics of leprosy in China in 2021 and provide essential information for future national leprosy control and prevention ***:We collected epidemiological data of leprosy from 31 provinces,autonomous regions,and municipalities of China(except for Hong Kong,Macao,and Taiwan)provided by the Leprosy Management Information *** performed a comparative analysis of the epidemiological features of patients with leprosy including age,sex,geographical distribution,and grade of ***:In total,374 newly detected leprosy cases were reported nationwide in China in 2021,giving an incidence rate of 0.27 per million population,which represented a decrease of 7.9%compared with *** the population with leprosy in 2021 that comprised 238 males(63.6%)and 136 females(36.4%),1.9%(7/374)were children younger than 15 years,92.8%(347/374)had multibacillary leprosy,and 18.2%(68/374)had grade 2 *** than half of the new leprosy cases(54.8%,205/374)were distributed in southwest *** were 33 relapsed leprosy cases reported in *** the end of 2021,there were 1,897 registered leprosy cases reported nationwide,giving a prevalence rate of 1.35 per million ***:The leprosy epidemic in China shows a downward trend in terms of the prevalence and incidence ***,the high prevalence of leprosy in southwest China is still a matter of concern.

关键词： epidemiology leprosy China newly detected leprosy cases multibacillary leprosy paucibacillary leprosy incidence rate prevalence rate

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Identification of Novel Bartonella washoensis Sequence Type 22 in Marmota himalayana-Jiuquan City,Gansu Province,China,2021–2022

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China CDC weekly 2023年第20期5卷 442-445,I0001页

作者： Ran Duan Xiaojin Zheng Qun Duan Asaiti Bukai Peng Zhang Shuai Qin Xinmin Lu Dongyue Lyu Haonan Han Dan Zhang Zhaokai He Junrong Liang Deming Tang Jinxiao Xi Huaiqi Jing Xin Wang State Key Laboratory of Infectious disease prevention and control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina akesai kazak autonomous county center for disease control and prevention JiuquanChina Gansu Provincial center for disease control and prevention LanzhouChina

Summary What is already known about this topic?The prevalence of rodent-adapted Bartonella species has been increasing ***,the specific Bartonella species carried by Marmota himalayana(***),a large rodent species,and the potential risk it poses to human populations remain *** is added by this report?Bartonella washoensis(***),associated with human endocarditis,was initially identified in ***,exhibiting a detection rate of approximately one-third and demonstrating a predilection for the heart and *** discovery of the novel Sequence Type 22 has expanded both the isolation source and genetic lineage of *** are the implications for public health practice?Individuals residing within the *** plague focus are at an elevated risk for *** ***,there is a pressing need for public health warnings and efficient clinical case identification in this population.

关键词： Barton expanded initially

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Efficacy,safety and immunogenicity of hexavalent rotavirus vaccine in Chinese infants

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Virologica Sinica 2022年第5期37卷 724-730页

作者： Zhiwei Wu Qingliang Li Yan Liu Huakun Lv Zhaojun Mo Fangjun Li Qingchuan Yu Fei Jin Wei Chen Yong Zhang Teng Huang Xiaosong Hu Wei Xia Jiamei Gao Haisong Zhou Xuan Bai Yueyue Liu Zhenzhen Liang Zhijun Jiang Yingping Chen Jiuwei Zhang Jialiang Du Biao Yang Bo Xing Yantao Xing Ben Dong Qinghai Yang Chen Shi Tingdong Yan Bo Ruan Haiyun Shi Xingliang Fan Dongyang Feng Weigang Lv Dong Zhang Xiangchu Kong Liuyifan Zhou Dinghong Que Hong Chen Zhongbing Chen Xiang Guo Weiwei Zhou Cong Wu Qingrong Zhou Yuqing Liu Jian Qiao Ying Wang Xinguo Li Kai Duan Yuliang Zhao Gelin Xu Xiaoming Yang Hebei center for disease control and prevention Shijiazhuang050021China National Engineering Technology Research center for Combined Vaccines Wuhan Institute of Biological Product Co.Ltd.Wuhan430207China National Institutes for Food and Drug control Beijing100050China Zhejiang center for disease control and prevention Hangzhou310051China Guangxi Zhuang autonomous Region center for disease control and prevention Nanning530028China Hunan center for disease control and prevention Changsha410005China Zhengding county center for disease control and prevention Shijiazhuang050800China Daming county center for disease control and prevention Handan056900China Liucheng county center for disease control and prevention Liuzhou545200China Xiangtan county center for disease control and prevention Xiangtan411228China Yuhuan county center for disease control and prevention Taizhou317600China Yongnian county center for disease control and prevention Handan056000China Rongshui Miao autonomous county center for disease control and prevention Liuzhou545300China You county center for disease control and prevention Zhuzhou412315China Longyou county center for disease control and prevention Quzhou324400China Laishui county center for disease control and prevention Baoding 074100China Jiangshan county center for disease control and prevention Quzhou324100China China National Biotec Group Company Limited National Engineering Technology Research Center for Combined VaccinesWuhan430207China

A randomized,double-blind,placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a hexavalent live human-bovine reassortant rotavirus vaccine(HRV)against rotavirus gastroenteritis(RVGE).A total of 6400 participants aged 6-12 weeks were enrolled and randomly assigned to either HRV(n?3200)or placebo(n?3200)*** the subjects received three oral doses of vaccine four weeks *** vaccine efficacy(VE)against RVGE caused by rotavirus serotypes contained in HRV was evaluated from 14 days after three doses of administration up until the end of the second rotavirus *** against severe RVGE,VE against RVGE hospitalization caused by serotypes contained in HRV,and VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were also *** adverse events(AEs)were collected for 30 days after each *** AEs(SAEs)and intussusception cases were collected during the entire *** data showed that VE against RVGE caused by serotypes contained in HRV was 69.21%(95%CI:53.31-79.69).VE against severe RVGE and RVGE hospitalization caused by serotypes contained in HRV were 91.36%(95%CI:78.45-96.53)and 89.21%(95%CI:64.51-96.72)*** against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were 62.88%(95%CI:49.11-72.92),85.51%(95%CI:72.74-92.30)and 83.68%(95%CI:61.34-93.11).Incidences of AEs from the first dose to one month post the third dose in HRV and placebo groups were *** was no significant difference in incidences of SAEs in HRV and placebo *** study shows that this hexavalent reassortant rotavirus vaccine is an effective,well-tolerated,and safe vaccine for Chinese infants.

关键词： Rotavirus gastroenteritis(RVGE) Infants Vaccine Efficacy Safety

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Prevalence,Incidence,and Characteristics of Tuberculosis Among Known Diabetes Patients—A Prospective Cohort Study in 10 Sites,2013–2015

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China CDC weekly 2022年第3期4卷 41-46页

作者： Jun Cheng Yanling Yu Qiongjin Ma Zhijian Wang Qingrong Zhou Guolong Zhang Shuangyi Hou Lin Zhou Feiying Liu Lan Xia Lin Xu Canyou Zhang Yinyin Xia Hui Chen Hui Zhang Lixia Wang National center for Tuberculosis control and prevention China CDCBeijingChina Heilongjiang Provincial center for disease control and prevention HarbinHeilongjiangChina Minhang District center for disease control and prevention ShanghaiChina center for disease control and prevention of Danyang county DanyangJiangsuChina center for disease control and prevention of Jiangshan city JiangshanZhejiangChina Henan Provincial center for disease control and prevention ZhengzhouHenanChina Hubei Provincial center for disease control and prevention WuhanHubeiChina center for Tuberculosis control of Guangdong Province GuangzhouGuangdongChina Guangxi center for disease prevention and control NanningGuangxi Zhuang Autonomous RegionChina Sichuan Provincial center for disease control and prevention ChengduSichuanChina Yunnan Provincial center for disease control and prevention KunmingYunnanChina

Summary What is already known about this topic?The association of diabetes mellitus(DM)with both increased risk of tuberculosis(TB)and unfavorable treatment outcomes has been identified by many studies(1).However,epidemic data for TB cases in DM patients is absent in *** is added by this report?This current population-based prospective cohort study,conducted in ten counties located in eastern,central,and western China during 2013–2015,revealed a high prevalence and incidence of TB in known DM *** TB cases were captured by active case-finding and a much higher presence of being asymptomatic among TB/DM patients was *** are the implications for public health practice?Active case-finding should be carried out in DM patients and populations at high risk for developing TB.A TB symptom screening-based case-finding strategy is not enough;chest radiography check should be done once a year for these patients.

关键词： finding Diabetes Patients

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A Knowledge Survey on Health Education of Echinococcosis Among Students — Ganzi Tibetan autonomous Prefecture, Sichuan Province, China, 2020

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China CDC weekly 2022年第8期4卷 137-142页

作者： Xu Wang Meihua Fu Qian Wang Wei Li Zeli Danba Shuai Han Xiaozhou He Jianfeng Ba Chumu Luorong Quzhen Jiangyang Yixi Luorong Dali Chunyang Li Dandan Shi Yayi Guan Weiping Wu Ning Xiao National Institute of Parasitic diseases Chinese Center for Diseases Control and Prevention(Chinese Center for Tropical Diseases Research)NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Centre for Tropical DiseasesNational Center for International Research on Tropical DiseasesShanghaiChina Shanghai Municipal center for disease control and prevention ShanghaiChina Sichuan center for disease control and prevention ChengduSichuanChina Ganzi Tibetan autonomous Prefecture center for disease control and prevention GanziSichuanChina National Institute of Viral diseases control and prevention Chinese Center for Diseases Control and PreventionBeijingChina Shiqu county center for disease control and prevention GanziSichuanChina Daofu county center for disease control and prevention GanziSichuanChina Daocheng county center for disease control and prevention GanziSichuanChina The School of Global Health Chinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghaiChina

Summary What is already known about this topic?Previous surveys have mainly focused on how well residents and primary school students have understood the core knowledge of echinococcosis control and are limited in terms of the comprehensiveness of the knowledge category and *** is added by this report?There were some shortcomings in related knowledge of echinococcosis among students,which showed a tendency to know methods but not the *** differences among regions indicated a lack of a unified system for training educators and allocating comprehensive educational *** are the implications for public health practices?The results of this study provide evidence to potentially help improve health education programs in the new phase of echinococcosis prevention and control in China.

关键词： Tibetan comprehensive prevention

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Folate and Vitamin B_(12)Status and Related Dietary Factors among the Elderly Northern and Southern Rural Chinese Population

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Biomedical and Environmental Sciences 2021年第7期34卷 552-556页

作者： LIU Zhen MAN Qing Qing JIA Shan Shan SONG Peng Kun WANG Jing Zhong WANG Xi Le KANG Bing Xian YANG Li Gui ZHANG Jian National Institute for Nutrition and Health Chinese Center for Disease Control and PreventionBeijing 100050China Wuyuan county center for disease control and prevention Wuyuan CountyBayannaoer 015100Inner Mongoli Autonomous RegionChina Luxi county center for disease control and prevention Luxi CountyHonghe Hani and Yi Autonomous Region 661100YunnanChina

Folate and vitamin B_(12)are involved in the carbon metabolism pathway supplying essential methyl groups for DNA and protein synthesis and play a vital role in individual *** have also been shown to be associated with cardiovascular disease,especially stroke.A recent study showed that stroke was the leading cause of death and disabilityadjusted life years(DALYs)at the national level in ***,the nutritional status of folate and vitamin B_(12)in the Chinese population is a *** elderly are more prone to develop folate and vitamin B_(12)deficiencies due to poor appetite,dental defects,and issues with digestion.

关键词： synthesis vitamin

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Molecular Characterization of HIV-1-circulating Strains among Pre-Treatment Patients in Tibet

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Biomedical and Environmental Sciences 2020年第12期33卷 953-958页

作者： Dorjiwangmo GAN Meng Ze DONG Ao Bo Baimayangjin Tashibazong LIU Lei LIAO Ling Jie RUAN Yu Hua SHAO Yi Ming FENG Yi XING Hui Tibet autonomous Region center for disease control and prevention Lhasa 850000TibetChina State Key Laboratory of Infectious disease prevention and control National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesBeijing 102206China

The Tibet autonomous Region(referred to as‘Tibet’)is located in southwestern China,bordering the Yunnan Province,Sichuan Province,Xinjiang Uygur autonomous Region,and other provinces with high HIV/AIDS prevalence,as well as India,Nepal,and other high-risk border *** 1994,the first patient with HIV-1 infection was detected at Zhangmu port,Namu county,Shigatse,Tibet.

关键词： Tibet southwestern border

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Detection and Initial Response to a Type 2 Vaccine-Derived Poliovirus—Sichuan Province,China,2019

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China CDC weekly 2020年第11期2卷 172-175页

作者： Jiushun Zhou Ning Wen Yong Zhang Qi Qi Chunxiang Fan Dongmei Yan Xiaoping Zhu Lixin Hao Shuangli Zhu Yu Liu Xiaozhen Ma Chao Ma Lei Nan Yong Chen Qianli Ma Cheng Wang Kun Deng Lei Cao Ge Shao Xianxiang Ding Hong Yang Zhijie An Lance ERodewald Aiqiang Xu Huaqing Wang Zijian Feng Zundong Yin Xianping Wu Wenbo Xu Sichuan Provincial center for disease control and prevention ChengduSichuanChina National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina National Institute for Viral disease control and prevention Chinese Center for Disease Control and PreventionBeijingChina Liangshan Yi autonomous Prefectural center for disease control and prevention XichangSichuanChina Leibo county center for disease control and prevention LeiboLiangshanSichuanChina Chinese Field Epidemiology Training Program Chinese center for disease control and prevention BeijingChina Shandong Provincial center for disease control and prevention JinanShandongChina

What is already known about this topic?After the type 2 strain of the live,attenuated poliovirus vaccine was withdrawn globally in 2016,any identification of a type 2 poliovirus is a Public Health Emergency of International Concern.A vaccinederived type 2 poliovirus(VDPV2)was identified in Sichuan,prompting an urgent,comprehensive investigation and *** is added by this report?Type 2 monovalent,live,attenuated oral poliovirus vaccine(mOPV2)is being used to respond to the numerous VDPV2 outbreaks seen around the *** contrast,the response in Sichuan used Sabin strain inactivated poliovirus(sIPV)to stop circulation of the *** the 6 months following the vaccination response,there have been no VDPV2s detected in Sichuan,despite extensive *** are the implications for public health practices?Further search for the VDPV2 must continue in order to determine whether transmission has been *** ongoing investigation and response to the Sichuan VDPV2 is providing evidence to the Global Polio Eradication Initiative on managing VDPV2 outbreaks.

关键词： prompt globally Type

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Human Plague Case Diagnosed in Ningxia Tracked to Animal Reservoirs—Inner Mongolia autonomous Region,China,2021

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China CDC weekly 2021年第52期3卷 1109-1112页

作者： Jianwei Gao Yanhong Hu Cheng Ju Jingyuan Liu Yiting Wang Jiangtao Ma Xiaona Shen Fang Liu Jin Guo Xinxin Yu Wen Zhang Shuyi Wang Kun Li Zhongbing Zhang Biao Kan Wenrui Wang Xianbin Cong Mengguang Fan Wei Li Kuidong Shao Tao Zhang Jianyun Li Yumeng Wang center for disease control and prevention of Ningxia Hui autonomous Region YinchuanNingxia Hui Autonomous RegionChina General center for disease control and prevention of Inner Mongolia autonomous Region HuhhotInner Mongolia Autonomous RegionChina The Base for control and prevention of Plague and Brucellosis Chinese Center for Disease Control and PreventionBaichengJilinChina Beijing Ditan Hospital Capital Medical UniversityBeijingChina National Institute for Communicable disease control and prevention Chinese Center for Disease Control and PreventionBeijingChina State Key Laboratory of Infectious disease prevention and control BeijingChina.

Summary What is already known about this topic?There were a total of 4 and 3 human plague cases that occurred in the Inner Mongolia autonomous Region in 2019 and 2020,respectively,with 1 and 2 deaths in 2019 and 2020 respectively,which indicated that plague still poses a significant threat to human health especially for farmers,shepherds,or residents living in native plague *** is added by this report?On August 14,2021,1 patient from the Otog Qi(county)in the Inner Mongolia sought treatment in Yinchuan City(the capital of Ningxia Hui autonomous Region).

关键词： Ningxia residents farmers

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