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LncRNA pol-lnc78 as a ceRNA regulates antibacterial responses via suppression of pol-miR-n199-3p-mediated SARM down-regulation in Paralichthys olivaceus

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Zoological Research 2024年第1期45卷 25-35页

作者： Xian-Hui Ning Bing Han Ye Peng Shao-Wu Yin College of marine science and Engineering Nanjing Normal UniversityNanjingJiangsu 210023China CAS Key laboratory of Experimental marine Biology Center for Ocean Mega-ScienceInstitute of OceanologyChinese Academy of SciencesQingdaoShandong 266071China Co-Innovation Center for marine Bio-Industry Technology of Jiangsu Province LianyungangJiangsu 222005China

Long non-coding RNAs(lncRNAs)function as key modulators in mammalian immunity,particularly due to their involvement in lncRNA-mediated competitive endogenous RNA(ceRNA)*** their recognized significance in mammals,research on lncRNAs in lower vertebrates remains *** the present study,we characterized the first immune-related lncRNA(pol-lnc78)in the teleost Japanese flounder(Paralichthys olivaceus).Results indicated that pol-lnc78 acted as a ceRNA for pol-miR-n199-3p to target the sterile alpha and armadillo motif-containing protein(SARM),the fifth discovered member of the Toll/interleukin 1(IL-1)receptor(TIR)adaptor *** ceRNA network regulated the antibacterial responses of flounder via the Toll-like receptor(TLR)signaling ***,SARM acted as a negative regulator and exacerbated bacterial infection by inhibiting the expression of inflammatory cytokines IL-1βand tumor necrosis factor-α(TNF-α).Pol-miR-n199-3p reduced SARM expression by specifically interacting with the 3’untranslated region(UTR),thereby promoting SARM-dependent inflammatory cytokine expression and protecting the host against bacterial ***,pol-lnc78 sponged pol-miR-n199-3p to ameliorate the inhibition of SARM *** infection,the negative regulators pol-lnc78 and SARM were significantly down-regulated,while pol-miR-n199-3p was significantly up-regulated,thus favoring host antibacterial *** findings provide novel insights into the mechanisms underlying fish immunity and open new horizons to better understand ceRNA crosstalk in lower vertebrates.

关键词： LncRNA SARM miRNA ceRNA Antibacterial response

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Accurate simulations of pure-viscoacoustic wave propagation in tilted transversely isotropic media

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Petroleum science 2024年第2期21卷 866-884页

作者： Qiang Mao Jian-Ping Huang Xin-Ru Mu Ji-Dong Yang Yu-Jian Zhang Geosciences Department China University of Petroleum(East China)Qingdao266580ShandongChina Pilot National laboratory for marine science and Technology(Qingdao) Qingdao266207ShandongChina

Forward modeling of seismic wave propagation is crucial for the realization of reverse time migration(RTM) and full waveform inversion(FWI) in attenuating transversely isotropic media. To describe the attenuation and anisotropy properties of subsurface media, the pure-viscoacoustic anisotropic wave equations are established for wavefield simulations, because they can provide clear and stable wavefields. However, due to the use of several approximations in deriving the wave equation and the introduction of a fractional Laplacian approximation in solving the derived equation, the wavefields simulated by the previous pure-viscoacoustic tilted transversely isotropic(TTI) wave equations has low accuracy. To accurately simulate wavefields in media with velocity anisotropy and attenuation anisotropy, we first derive a new pure-viscoacoustic TTI wave equation from the exact complex-valued dispersion formula in viscoelastic vertical transversely isotropic(VTI) media. Then, we present the hybrid finite-difference and low-rank decomposition(HFDLRD) method to accurately solve our proposed pure-viscoacoustic TTI wave equation. Theoretical analysis and numerical examples suggest that our pure-viscoacoustic TTI wave equation has higher accuracy than previous pure-viscoacoustic TTI wave equations in describing q P-wave kinematic and attenuation characteristics. Additionally, the numerical experiment in a simple two-layer model shows that the HFDLRD technique outperforms the hybrid finite-difference and pseudo-spectral(HFDPS) method in terms of accuracy of wavefield modeling.

关键词： Pure-viscoacoustic TTI wave equation Attenuation anisotropy Seismic modeling Low-rank decomposition method

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Evaluation of Nonbreaking Wave-Induced Mixing Parameterization Schemes Based on a One-Dimensional Ocean Model

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Journal of Ocean University of China 2024年第3期23卷 567-576页

作者： TANG Ran HUANG Chuanjiang DAI Dejun WANG Gang The First Institute of Oceanography Ministry of Natural ResourcesQingdao 266061China laboratory for Regional Oceanography and Numerical Modeling Laoshan LaboratoryQingdao 266237China Shandong Key laboratory of marine science and Numerical Modeling Qingdao 266061China

Surface waves have a considerable effect on vertical mixing in the upper *** the past two decades,the vertical mixing induced through nonbreaking surface waves has been used in ocean and climate models to improve the simulation of the upper *** far,several nonbreaking wave-induced mixing parameterization schemes have been proposed;however,no quantitative comparison has been performed among *** this paper,a one-dimensional ocean model was used to compare the performances of five schemes,including those of Qiao et al.(Q),Hu and Wang(HW),Huang and Qiao(HQ),Pleskachevsky et al.(P),and Ghantous and Babanin(GB).Similar to previous studies,all of these schemes can decrease the simulated sea surface temperature(SST),increase the subsurface temperature,and deepen the mixed layer,thereby alleviating the common thermal deviation problem of the ocean model for upper ocean *** these schemes,the HQ scheme exhibited the weakest wave-induced mixing effect,and the HW scheme exhibited the strongest effect;the other three schemes exhibited roughly the same *** particular,the Q and P schemes exhibited nearly the same *** the simulation based on observations from the Ocean Weather Station Papa,the HQ scheme exhibited the best performance,followed by the Q *** the experiment with the HQ scheme,the root-mean-square deviation of the simulated SST from the observations was 0.43℃,and the mixed layer depth(MLD)was 2.0 *** a contrast,the deviations of the SST and MLD reached 1.25℃ and 8.4 m,respectively,in the experiment without wave-induced mixing.

关键词： wave-induced mixing surface waves sea surface temperature mixed layer depth General Ocean Turbulence Model

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Heteroatom tuning in agarose derived carbon aerogel for enhanced potassium ion multiple energy storage

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Carbon Energy 2024年第3期6卷 239-254页

作者： Kaijun Xie Xin Liu Haolin Li Long Fang Kai Xia Dongjiang Yang Yihui Zou Xiaodong Zhang State Key laboratory of Bio-fibers and Eco-textiles Shandong Collaborative Innovation Center of Marine Biobased Fibers and Ecological TextilesInstitute of Marine Biobased MaterialsCollege of Chemistry and Chemical EngineeringCollege of Environmental Science and EngineeringQingdao UniversityQingdaoChina

The incorporation of heteroatoms into carbon aerogels(CAs)can lead to structural distortions and changes in active sites due to their smaller size and electronegativity compared to pure ***,the evolution of the electronic structure from single-atom doping to heteroatom codoping in CAs has not yet been thoroughly investigated,and the impact of codoping on potassium ion(K+)storage and diffusion pathways as electrode material remains *** this study,experimental and theoretical simulations were conducted to demonstrate that heteroatom codoping,composed of multiple heteroatoms(O/N/B)with different properties,has the potential to improve the electrical properties and stability of CAs compared to single-atom *** states near the Fermi level have revealed that doping with O/N/B generates a greater number of active centers on adjacent carbon atoms than doping with O and O/N *** a result of synergy with enhanced wetting ability(contact angle of 9.26°)derived from amino groups and hierarchical porous structure,ON-CA has the most optimized adsorption capacity(−1.62 eV)and diffusion barrier(0.12 eV)of K^(+).The optimal pathway of K^(+)in ON-CA is along the carbon ring with N or O *** K^(+)storage material for supercapacitors and ion batteries,it shows an outstanding specific capacity and capacitance,electrochemical stability,and rate ***,the assembled symmetrical K^(+)supercapacitor demonstrates an energy density of 51.8 Wh kg^(−1),an ultrahigh power density of 443Wkg^(−1),and outstanding cycling stability(maintaining 83.3%after 10,000 cycles in 1M KPF6 organic electrolyte).This research provides valuable insights into the design of highperformance potassium ion storage materials.

关键词： agarose carbon aerogels O/N/B codoping potassium-ion battery potassium-ion supercapacitor

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Three-dimensional thermohaline structure estimation derived from HY-2 satellite data over the Maritime Silk Road and its applications

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Acta Oceanologica Sinica 2024年第5期43卷 41-53页

作者： Zhiqiang Chen Xidong Wang Xiangyu Wu Yuan Cao Zikang He Dakui Wang Jian Chen Key laboratory of marine Hazards Forecasting Ministry of Natural ResourcesHohai UniversityNanjing 210024China laboratory for Regional Oceanography and Numercial Modeling Qingdao Marine Science and Technology CenterQingdao 266061China National marine Environmental Forecasting Center Ministry of Natural ResourcesBeijing 100081China Beijing Institute of Applied Meteorology Beijing 100029China

Estimated ocean subsurface fields derived from satellite observations provide potential data sources for operational marine environmental monitoring and prediction *** study employs a statistic regression reconstruction method,in combination with domestic autonomous sea surface height and sea surface temperature observations from the Haiyang-2(HY-2)satellite fusion data,to establish an operational quasi-realtime three-dimensional(3D)temperature and salinity products over the Maritime Silk *** products feature a daily temporal resolution and a spatial resolution of 0.25°×0.25°and exhibit stability and *** have demonstrated the accuracy of the reconstructed thermohaline fields in capturing the 3D thermohaline variations through comprehensive statistical evaluations,after comparing them against Argo observations and ocean analysis data from *** results illustrate that the reconstructed fields effectively represent seasonal variations in oceanic subsurface structures,along with structural changes resulting from mesoscale processes,and the upper ocean’s responses to tropical ***,the incorporation of HY-2 satellite observations notably enhances the accuracy of temperature and salinity reconstructions in the Northwest Pacific Ocean and marginally improves salinity reconstruction accuracy in the North Indian Ocean when compared to the World Ocean Atlas 2018 monthly climatology thermohaline *** a result,the reconstructed product holds promise for providing quasi-real-time 3D temperature and salinity field information to facilitate fast decisionmaking during emergencies,and also offers foundational thermohaline fields for operational ocean reanalysis and forecasting *** contributions enhance the safety and stability of ocean subsurface activities and navigation.

关键词： HY-2 satellite observations subsurface structures reconstruction Maritime Silk Road operational thermohaline product

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Docosahexaenoic acid-acylated astaxanthin monoester enhances microglial autophagy for ameliorating amyloid-β load and cognitive deficits in models of Alzheimer’s disease

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Food science and Human Wellness 2024年

作者： Xiaoxu Wang Bo Dong Yu Song Zhigao Wang Yuming Wang Jie Xu Changhu Xue State Key laboratory of marine Food Processing & Safety Control， College of Food science and Engineering， Ocean University of China College of marine Life sciences， Ocean University of China Qingdao National laboratory for marine science and Technology

Autophagy directly regulates the amyloid-peptides （Aβ） clearance， and its dysfunction occurs in the early pathogenesis of Alzheimer’s disease （AD）. We previously reported that docosahexaenoic acid-acylated astaxanthin monoester （AST-DHA） showed neuroprotection against AD pathology. However， its in-depth mechanism and autophagic responses in AD brains are poorly understood. Herein， SH-SY5Y cells overexpressing the APP gene were established to preliminarily evaluate the actions of AST-DHA on reducing Aβ1-42levels and regulating autophagy. In microglial BV2 cells， AST-DHA and free astaxanthin （F-AST） recovered p62 and LC3II/I levels， and restored autophagy flux by rescuing the late phase of microglial autophagy. Notably， autophagic inhibitor bafilomycin A1 blunted the abilities of AST-DHA to reduce Aβ1-42and fibral Aβ， suggesting that AST-DHA probably promoted Aβ clearance in a microglial autophagy-dependent manner. Further studies in APP/PS1 mice verified that dietary AST-DHA and F-AST promoted Aβ phagocytosis via microglial autophagy. Significant decreases of Iba1 and p62 levels were observed around Aβ plaque in the hippocampus and cortex using triple fluorescence staining. Furthermore， AST-DHA exhibited superior performance over F-AST in restoring autophagic dysfunction， ameliorating Aβ burden and cognitive deficit. Our findings suggest a possible mechanism of AST-DHA in improving AD by which it restores microglial autophagy to facilitate cerebral Aβ clearance. It supports the future application of AST-DHA as an autophagic regulator in maintaining brain function.

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A chitosan-based antibacterial hydrogel with injectable and self-healing capabilities

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marine Life science & Technology 2024年第1期6卷 115-125页

作者： Rui Chen Yanan Hao Secundo Francesco Xiangzhao Mao Wen-Can Huang State Key laboratory of marine Food Processing and Safety Control College of Food Science and EngineeringOcean University of ChinaQingdao 266404China laboratory for marine Drugs and Bioproducts of Qingdao National laboratory for marine science and Technology Qingdao 266237China Qingdao Key laboratory of Food Biotechnology Qingdao 266404China Key laboratory of Biological Processing of Aquatic Products China National Light IndustryQingdao 266404China Istituto di Scienze e Tecnologie Chimiche“Giulio Natta” Consiglio Nazionale delle Ricerche via Mario Bianco 920131 MilanItaly

The presence of bacteria directly affects wound ***-based hydrogel biomaterials are a solution as they offer advantages for wound-healing applications due to their strong antimicrobial ***,a double-cross-linking chitosanbased hydrogel with antibacterial,self-healing,and injectable properties is *** chitosan was successfully prepared,and the thiolated chitosan molecules were cross-linked by Ag-S coordination to form a supramolecular ***,the amine groups in the thiolated chitosan covalently cross-linked with genipin to further promote hydrogel *** vitro experimental results indicate that hydrogel can release Ag^(+)over an extended time,achieving an antibacterial rate of over 99% against Escherichia coli and Staphylococcus *** to the reversible and dynamic feature of Ag-S coordination,an antibacterial hydrogel exhibited injectable and self-healing ***,the hydrogel showed excellent biocompatibility and biodegradability.

关键词： Hydrogel Chitosan Silver ion Cross-linking Antibacterial

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Effects of Ocean Acidification on Nitrogen Metabolism of Skeletonema costatum

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Journal of Ocean University of China 2024年第5期23卷 1359-1370页

作者： WANG Shuxing MI Tiezhu ZHEN Yu ZHU Jianbin Key laboratory of marine Environment and Ecology Ministry of Education College of Environmental Science and Engineering Ocean University of China laboratory for marine Ecology and Environmental science Qingdao Marine Science and Technology Center Frontiers science Center for Deep Ocean Multispheres and Earth System Ocean University of China

Ocean acidification（OA）, caused by the rising concentration of atmospheric CO2, leads to changes in the marine carbonate system. This, in turn, affects the physiological processes of phytoplankton. In response to increased p CO2levels, marine microalgae modulate their physiological responses to meet their energy and metabolic requirements. Nitrogen metabolism is a critical metabolic pathway, directly affecting the growth and reproductive capacity of marine microorganisms. Understanding the molecular mechanisms that regulate nitrogen metabolism in microalgae under OA conditions is therefore crucial. This study aimed to investigate how OA affects the expression profiles of key genes in the nitrogen metabolic pathway of the marine diatom Skeletonema costatum. Our findings indicate that OA upregulates key genes involved in the nitrogen metabolic pathway, specifically those related to nitrate assimilation and glutamate metabolism. Moreover, p CO2has been identified as the predominant factor affecting the expression of these genes, with a more significant impact than pH variations in S. costatum. This research not only advances our understanding of the adaptive mechanisms of S. costatum in response to OA but also provides essential data for predicting the ecological consequences of OA on marine diatoms.

关键词： gene expression nitrogen metabolism ocean acidification Skeletonema costatum transcriptome

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Friction reactions induced by selective hydrogenation of textured surface under lubricant conditions

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Friction 2024年第1期12卷 174-184页

作者： Naizhou DU Xubing WEI Xiaowei LI Zan CHEN Shiqi LU Jiaqing DING Cunao FENG Kai CHEN Jianghao QIAO Dekun ZHANG Kwang-Ryeol LEE Tiancai ZHANG School of Materials science and Physics China University of Mining and TechnologyXuzhou 221116China Key laboratory of marine Materials and Related Technologies Zhejiang Key Laboratory of Marine Materials and Protective TechnologiesNingbo Institute of Materials Technology&EngineeringChinese Academy of SciencesNingbo 315201China Computational science Center Korea Institute of Science and TechnologySeoul 136-791Republic of Korea Technology Development Department Shipbuilding Technology Research InstituteShanghai 200032China

The passivation of hydrogen atoms and the conformation of textured surfaces under oil-lubricated conditions are effective strategies to obtain amorphous carbon(a-C)films with extremely low *** is critical to understanding the influence mechanism of selective surface hydrogenation on the tribological behaviors of textured a-C film under oil-lubricated *** particular,the interactions of hydrogen atoms and lubricants are confusing,which is enslaved to the in situ characterization *** reactive molecular dynamics(RMD)simulations were conducted to analyze the friction response of textured a-C films with selective hydrogenation surfaces under oil-lubricated *** results indicate that the existence of hydrogen atoms on specific bump sites significantly decreases the friction coefficient(μ)of textured a-C film,which is highly dependent on the surface hydrogen *** repulsion between hydrogen atoms and lubricant molecules prompts the formation of a dense lubricant film on the surface of the mating ***,with the enhancement of the surface hydrogen content,the passivation of the friction interface and the repulsion between hydrogen atoms and lubricants play dominant roles in reducing the friction coefficient instead of hydrodynamic lubrication.

关键词： textured amorphous carbon(a-C) selective hydrogenation oil lubrication friction mechanism reactive molecular dynamics(RMD)

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Structural engineering of hard carbon through spark plasma sintering for enhanced sodium-ion storage

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Rare Metals 2024年第9期43卷 4274-4285页

作者： Hao-Ming Xiao Heng Zheng Ping Yuan Jun-Hui Luo Lin-Lin Shen Jie-Feng Tan Xian-You Luo De Li Yong Chen Guangdong Key laboratory for Hydrogen Energy Technologies School of Materials Science and Hydrogen EnergyFoshan University State Key laboratory of marine Resource Utilization in South China Sea Hainan Provincial Key Laboratory of Research on Utilization of Si-Zr-Ti ResourcesHainan University

Hard carbon （HC） has emerged as one of the superior anode materials for sodium-ion batteries （SIBs）,with its electrochemical performance significantly influenced by the presence of oxygen functional groups and its closed pore ***,current research on the structural adjustment of these oxygen functional groups and the closed pore architecture within HC remains ***,energy-efficient and contamination-free spark plasma sintering technology was employed to tune the structure of coconut-shell HC,resulting in significant adjustments to the content of carboxyl （decreasing from 5.71 at%to 2.12 at%） and hydroxyl groups （decreasing from 7.73 at % to 6.26 at%）.Crucially,these modifications reduced the irreversible reaction of oxygen functional groups with Na+.Simultaneously,a substantial number of closed pores with an average diameter of 1.22 nm were generated within the HC,offering an ideal environment for efficient Na+*** structural changes resulted in a remarkable improvement in the electrochemical performance of the modified *** reversible specific capacity of the modified HC surged from 73.89 mAh·g-1to an impressive 251.97 m Ah·g-1at a current density of 50 mA·*** at 400 mA·g-1,the reversible specific capacity increased significantly from 14.55 to 85.44 mAh·***,this study provides a novel perspective for designing tailored HC materials with the potential to develop high-performance SIBs.

关键词： Closed pores Hard carbon Oxygen functional groups Sodium-ion batteries Spark plasma sintering

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