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Epigenetic regulation of the inflammatory response in stroke

Neural Regeneration research 2025年第11期20卷 3045-3062页

作者： Jingyi Liang Fei Yang Zixiao Li Qian Li School of Basic Medical Sciences Capital Medical UniversityBeijingChina Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Laboratory for Clinical Medicine Beijing Key Laboratory of Neural Regeneration and RepairCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Healthcare quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Chinese Institute for Brain research BeijingChina research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering research Center of Digital Healthcare for Neurological Diseases BeijingChina Department of Biochemistry and Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Beijing Key Laboratory of Cancer Invasion and Metastasis research Capital Medical UniversityBeijingChina

Stroke is classified as ischemic or hemorrhagic,and there are few effective treatments for either *** mechanisms play a critical role in secondary brain injury following a stroke,which manifests as cytokine release,blood–brain barrier disruption,neuronal cell death,and ultimately behavioral *** the inflammatory response has been shown to mitigate this cascade of events in experimental stroke ***,in clinical trials of anti-inflammatory agents,longterm immunosuppression has not demonstrated significant clinical benefits for *** may be attributable to the dichotomous roles of inflammation in both tissue injury and repair,as well as the complex pathophysiologic inflammatory processes in *** acute harmful inflammatory responses or inducing a phenotypic shift from a pro-inflammatory to an anti-inflammatory state at specific time points after a stroke are alternative and promising therapeutic *** agents that can modulate inflammation requires a detailed understanding of the inflammatory processes of ***,epigenetic reprogramming plays a crucial role in modulating post-stroke inflammation and can potentially be exploited for stroke *** this review,we summarize current findings on the epigenetic regulation of the inflammatory response in stroke,focusing on key signaling pathways including nuclear factor-kappa B,Janus kinase/signal transducer and activator of transcription,and mitogen-activated protein kinase as well as inflammasome *** also discuss promising molecular targets for stroke *** evidence to date indicates that therapeutic targeting of the epigenetic regulation of inflammation can shift the balance from inflammation-induced tissue injury to repair following stroke,leading to improved post-stroke outcomes.

关键词： DNA methylation histone modification intracerebral hemorrhage ischemic stroke neuroinflammation neuroprotection non-coding RNA RNA methylation subarachnoid hemorrhage treatment

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Human activities are intensifying the spatial variation of landslides in the Yellow River Basin

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Science Bulletin 2025年第2期70卷 263-272页

作者： Naiman Tian Hengxing Lan Langping Li Jianbing Peng Bojie Fu John J.Clague State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China College of Geological Engineering and Geomatics Chang’an UniversityXi’an 710054China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Ecological Geology and Disaster Prevention Ministry of Natural ResourcesXi’an 710054China State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China State Key Laboratory of Earth Surface processes and Resource Ecology Faculty of Geographical ScienceBeijing Normal UniversityBeijing 100875China Department of Earth Sciences Simon Fraser UniversityBurnaby BCV5A 1S6Canada

Human activities are a triggering factor for landslides in the Yellow River Basin(YRB,China).However,the extent to which the spatial distribution of landslides is affected by human activities is *** constructed a human activity intensity index(HAII)based on nighttime light data and land cover *** and dominance analyses were used to compare the effects of the HAII,precipitation,distance to river,distance to fault,topographic relief and slope on the landslides spatial density(LSD).The results showed that in the YRB,the HAII,as a dominance influencing factor,had a significant positive influence on the ***,regional differences in the human disturbance of nature intensify the spatial variation of *** quantify the intensity of human disturbance to nature,a human-nature conflict index(HNCI)is constructed by quantifying the difference between the slope distributions of artificial and natural *** results show that in the middle section of the YRB,humans are developing more steep mountainous areas,leading to more dense *** study provides a reference for landslide risk management and land use planning in the YRB.

关键词： Landslide Human activities Spatial variation Human-nature conflict Yellow River Basin

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Spatiotemporal evolution of Ediacaran-Cambrian(ca.551–523 Ma)sponges in South China and their simulated contributions to marine oxygenation

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Science China Earth Sciences 2025年第2期68卷 549-563页

作者： Yan YE Lei ZHANG Can CHEN Shan CHANG Yuhao YI Qinglai FENG State Key Laboratory of Geological processes and Mineral Resources China University of GeosciencesWuhan 430074China School of Earth Science China University of GeosciencesWuhan 430074China Department of Geology Lund UniversityLund 22362Sweden Institute of Sedimentary Geology Chengdu University of TechnologyChengdu 610059China Key Laboratory of Deep-time Geography and Environment Reconstruction and Applications of Ministry of Natural Resources Chengdu University of TechnologyChengdu 610059China Second Geological Brigade of Hubei Geological Bureau Enshi 445000China College of Urban and Environmental Sciences Hubei Normal UniversityHuangshi 435002China Exploration and Development research Institute SINOPEC Jianghan Oilfield CompanyWuhan 430223China

The origin and evolution of sponges have attracted interest,not only because they are among the most basal metazoans,but also because they act as important ecological engineers in the *** research suggested that sponge groups diversified quickly during the Cambrian Series 2,while Terreneuvian sponge fossils are conspicuously rare and poorly ***,an increasing number of sponge spicules have been reported from the Ediacaran-Cambrian(E-C,ca.551–523 Ma)transitional carbonates/cherts worldwide,particularly in South China,which calls for updated *** oxygenation has been widely proposed to play a critical role in organismal evolution,but its relationship with sponges is unclear and falls into a“chicken-egg”*** this study,we summarize reported sponge spicule distributions from five E-C sections in South China to investigate the early evolutionary pattern of siliceous *** to current stratigraphic correlation,monaxons first appear in the late Ediacaran in the intrashelf basin-slope area,and then potentially expand to the continental shelf and deep basin in the lower *** these sections,the abundance,size,and diversity of monaxons increase upwards,followed by the appearance of diaxons,triaxons and then *** the uncertain affinity of the sponge fossils,it is possible that siliceous hexactinellids evolved later than siliceous demosponges,given that the earliest spicule assemblages are exclusively composed of monaxons,which commonly form bundles comparable to modern *** geochemical data from the Sifangjing section,Guizhou Province and the Yanziqiao section,Hunan Province,South China show that the appearance of sponges usually corresponds to anoxic *** addition,we applied the recently proposed Biological Pump,Oxygen and Phosphorus(BPOP)model to trace the evolution of oceanic oxygen concentrations with the radiation of *** results indicate that the possible contribution o

关键词： Cambrian Sponge Oxygenation Silicon concentration Box model

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A vehicle-mounted dual-smog chamber:Characterization and its preliminary application to evolutionary simulation of photochemical processes in a quasi-realistic atmosphere

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Journal of Environmental Sciences 2023年第10期132卷 98-108页

作者： Wenlu Wang Yang Xiao Shijie Han Yang Zhang Daocheng Gong Hao Wang Boguang Wang Institute for Environmental and Climate research Jinan UniversityGuangzhou 511443China Australia-China Centre for air quality Science and Management(Guangdong) Guangzhou 511443China Guangdong-Hongkong-Macao Joint Laboratory of Collaborative Innovation for Environmental quality Guangzhou 511443China

Smog chambers are the effective tools for studying formation mechanisms of air *** by traditional smog chambers differ to a large extent from real atmospheric conditions,including light,temperature and atmospheric ***,the existing parameters for mechanism interpretation are derived from the traditional smog *** address the gap between the traditional laboratory simulations and the photochemistry in the real atmosphere,a vehicle-mounted indoor-outdoor dual-smog chamber(JNUVMDSC)was developed,which can be quickly transferred to the desired sites to simulate quasi-realistic atmosphere simultaneously in both chambers using“local air”.Multiple key parameters of the smog chamber were characterized in the study,demonstrating that JNUVMDSC meets the requirements of general atmospheric chemistry simulation ***,the preliminary results for the photochemical simulations of quasi-realistic atmospheres in Pearl River Delta region and Nanling Mountains are consistent with literature reports on the photochemistry in this ***-VMDSC provides a convenient and reliable experimental device and means to study the mechanism of atmospheric photochemical reactions to obtain near-real results,and will make a great contribution to the control of composite air pollution.

关键词： Vehicle-mounted dual-smog chamber photochemical processes quasi-realistic atmosphere composite air pollution Pearl River Delta region

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Physico-Mechanical Characterisation of an Earth Bar and Bamboo Fiber Composite Material for Road Construction

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Open Journal of Composite Materials 2025年第1期15卷 31-43页

作者： Yvette Tankpinou Kiki Koffi Judicaël Agbelele Fernando Kpomahou Georgette Monleme processes and Technological Innovation Laboratory (LaPIT) National University of Science Technology Engineering and Mathematics (UNSTIM) Lokossa Benin Multidisciplinary research Laboratory for Technical Education (LARPET) National University of Technological Sciences Engineering and Mathematics Lokossa Benin Civil Engineering Test and Study Laboratory (L2EGC) National University of Technological Sciences Engineering and Mathematics Abomey Benin

Road construction in Africa is faced with a shortage of quality materials, leading to delays and increased costs. Traditional materials, such as clay soils of the bar soil type, have inadequate properties for pavement sub-base layers, particularly in terms of bearing capacity. This study explores a composite material combining bar soil and bamboo fibers to improve the mechanical performance of bar soil, offering a sustainable and cost-effective solution. The Tori-Bossito bar soil was characterised by particle size analysis, Atterberg limits, Proctor compaction tests and the California Bearing Ratio (CBR). The results show that this material is a class A2 sandy-clay soil with a CBR of 18, which is insufficient for foundation layers requiring a CBR of over 30. To improve its performance, Sèmè-Kpodji bamboo fibers, 30 to 100 microns in diameter and 3 to 5 cm long, were incorporated at rates of 0.9% to 2.7%. The optimum mix, with 2.4% fiber, has a CBR of 35, a dry density of 1.92 t/m3 and a moisture content of 12.4%. This reinforced material is suitable as a base course for low-traffic roadways.

关键词： Bamboo Fibers Bar Soil Sub-Base Low Traffic Mechanical Properties

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The phytohormone jasmonic acid is involved in rice resistance to Southern rice black-streaked dwarf virus

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The Crop Journal 2025年第1期13卷 23-30页

作者： Chaorui Huang Qing Liu Qingling Qi Chenfei Gao Lulu Li Yanjun Li Jianping Chen Zongtao Sun Jianlong Xu Hehong Zhang State Key Laboratory for Managing Biotic and Chemical Threats to the quality and Safety of Agro-products Key Laboratory of Biotechnology in Plant Protection of MOA of China and Zhejiang ProvinceInstitute of Plant VirologyNingbo UniversityNingbo 315211ZhejiangChina Institute of Crop Sciences National Key Facility for Crop Gene Resources and Genetic lmprovementChinese Academy of Agricultural SciencesBeijing 100081China

Viruses are significant pathogens causing severe plant infections and crop losses *** resistance mechanisms of rice to viral diseases,particularly Southern rice black-streaked dwarf virus(SRBSDV),remain poorly *** this study,we assessed SRBSDV susceptibility in 20 Xian/indica(XI)and 20 Geng/japonica(GJ)rice ***-1B accessions in the Xian subgroup displayed higher resistance than GJ *** transcriptome analysis revealed changes in processes like oxidoreductase activity,jasmonic acid(JA)metabolism,and stress *** sensitivity assays further linked antiviral defense to the JA *** findings highlight a JA-mediated resistance mechanism in rice and offer insights for breeding SRBSDV-resistant varieties.

关键词： Oryza sativa(rice) Jasmonic acid Southern rice black-streaked dwarf virus(SRBSDV) Variety resistance Defense response

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Role of copper chelating agents: between old applications and new perspectives in neuroscience

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Neural Regeneration research 2025年第3期20卷 751-762页

作者： Rosalba Leuci Leonardo Brunetti Vincenzo Tufarelli Marco Cerini Marco Paparella Nikola Puvača Luca Piemontese Department of Pharmacy-Pharmaceutical Science University of Bari Aldo MoroBariItaly Department of Precision and Regenerative Medicine and Jonian Area(DiMePRe-J) Section of Veterinary Science and Animal ProductionUniversity of Bari Aldo MoroBariItaly Department of Engineering Management in Biotechnology Faculty of Economics and Engineering Management in Novi SadUniversity Business Academy in Novi SadNovi SadSerbia

The role of copper element has been an increasingly relevant topic in recent years in the fields of human and animal health, for both the study of new drugs and innovative food and feed supplements. This metal plays an important role in the central nervous system, where it is associated with glutamatergic signaling, and it is widely involved in inflammatory processes. Thus, diseases involving copper(Ⅱ) dyshomeostasis often have neurological symptoms, as exemplified by Alzheimer's and other diseases(such as Parkinson's and Wilson's diseases). Moreover, imbalanced copper ion concentrations have also been associated with diabetes and certain types of cancer, including glioma. In this paper, we propose a comprehensive overview of recent results that show the importance of these metal ions in several pathologies, mainly Alzheimer's disease, through the lens of the development and use of copper chelators as research compounds and potential therapeutics if included in multi-target hybrid drugs. Seeing how copper homeostasis is important for the well-being of animals as well as humans, we shortly describe the state of the art regarding the effects of copper and its chelators in agriculture, livestock rearing, and aquaculture, as ingredients for the formulation of feed supplements as well as to prevent the effects of pollution on animal productions.

关键词： agriculture Alzheimer's disease chelators copper feed supplements multi-target

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Levels and trends of current-use pesticides(CUPs)in the arctic:An updated review,2010-2018

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Emerging Contaminants 2019年第1期5卷 70-88页

作者： Jennifer E.Balmer Adam D.Morris Hayley Hung Liisa Jantunen Katrin Vorkamp Frank Riget Marlene Evans Magali Houde Derek C.G.Muir Arctic Monitoring and Assessment Programme Fram CentrePO Box 6606Langnes9296TromsøNorway Department of Biology The Citadel171 Moultrie StreetCharlestonSCUSA Environment and Climate Change Canada National Wildlife Research CenterOttawaCanada air quality processes research section Environment and Climate Change CanadaTorontoOntarioCanada air quality processes research section Environment and Climate Change CanadaEgbertOntarioCanada Aarhus University Department of Environmental ScienceArctic Research CentreRoskildeDenmark Aarhus University Department of BioscienceRoskildeDenmark Aquatic Ecosystem Protection research Division Environment Canada11 Innovation BlvdSaskatoonSKS7N 3H5Canada Environment and Climate Change Canada St.Lawrence CenterMontrealQuebecCanada Environment and Climate Change Canada Canada Centre for Inland WatersBurlingtonOntarioCanada

Global regulations and many regional and national controls restrict the use of substances that exhibit the potential for environmental persistence and long-range ***,many current-use pesticides(CUPs)continue to be newly discovered in remote regions,including the *** present review serves as an update,summarizing newly available information for CUPs in the Arctic environment and biota published from 2010 to *** 2010,at least seven new CUPs have been measured in Arctic media:2-methyl-4-chlorophenoxyacetic acid(MCPA),metribuzin,pendimethalin,phosalone,quizalofop-ethyl,tefluthrin and *** the large number of pesticides in current use,the number measured in the Arctic is very limited,however,modelling studies have identified additional CUPs as potential Arctic contaminants that have yet to be investigated in the *** to their recent detection,reports of CUPs in the Arctic are limited,but *** have been reported in a wide range of abiotic Arctic matrices,including air,snow,ice,freshwater and seawater,indicating their capacity for long-range atmospheric transport,however,concentrations are generally low in comparison to legacy pesticides and other persistent organic pollutants(POPs).Recent food-web studies indicate CUPs can enter Arctic terrestrial and marine food chains,however,in contrast to POPs,the highest concentrations of many CUPs were found in lower trophic-level organisms,and the lowest concentrations detected in animals at the highest trophic levels(i.e,ringed seals,polar bear,caribou,and wolves)indicating significant trophic *** detection of CUPs in the remote Arctic ecosystem reinforces the need for continued monitoring of both known and potential Arctic pollutants to prevent impacts on human and environmental health as the global arsenal of pesticides used in agriculture continuously changes.

关键词： POPs Contaminants air Biota Long-range transport Persistence

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The mechanism of protein kinase C regulation

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Frontiers in Biology 2011年第4期6卷 328-336页

作者： Julhash U.KAZI Laboratory of Computational Biochemistry KN Biomedical Research InstituteBagura RoadBarisalBangladesh quality Control section Opsonin Pharma LtdBagura RoadBarisalBangladesh

Protein kinase C (PKC) is a family of serine/threonine protein kinases that plays a central role in transducingextracellular signals into a variety of intracellular responses ranging from cell proliferation to apoptosis. Nine PKCgenes have been identified in the human genome, which encode 10 proteins. Each member of this protein kinase familydisplays distinct biochemical characteristics and is enriched in different cellular and subcellular locations. Activation ofPKC has been implicated in the regulation of cell growth and differentiation. This review summarizes works of the pastyears in the field of PKC biochemistry that covers regulation and activation mechanism of different PKC isoforms.

关键词： PKC biochemistry PKC kinase PKC phosphatases PKC structure

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Optimization of Processing Parameters for Laser Powder Deposition using Finite Element Method

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Journal of Wuhan University of Technology(Materials Science) 2010年第5期25卷 832-837页

作者：付垚 State Key Laboratory of Non-ferrous Metals and processes General Research Institute for Non-ferrous Metals

In order to investigate the effects of powder materials and processing parameters on thermal and stress field during laser powder deposition （LPD）, a finite element model was developed with the help of ANSYS software. The finite element model was verified by the comparison between the experimental results and computed results. Then LPD processes with different powder materials and processing parameters were simulated by using the FE model. The results show that less difference of thermal conductivity and thermal expansion coefficient between powder material and substrate material produces lower residual stress; higher laser power, laser scanning speed and smaller laser beam diameter can lead higher peak temperature and higher residual stress. The research opens up a way to rational selection of the powder materials and processing parameters for ensured quality.

关键词： laser powder deposition thermal field stress field powder material processing parameters

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