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Dynamical framework with blocking topography coordinates for atmospheric GCM and its validation

Chinese Science Bulletin 2003年第S2期48卷 9-17页

作者： LIN Zhaohui~1, ZHANG Ming~(1,2), LIANG Danqing~(1,2) WANG Aihui~1, ZHANG Dongling~1 & ZENG Qingcun~1 1. ICCES, Institute of Atmospheric Physics, Chinese Academy of Sciences. Beijing 100029. China 2. coll.ge of Meteorology. PLA University of Science and Technology, Nanjing 211101. China Chinese Acad Sci Inst Atmospher Phys ICCES Beijing 100029 Peoples R China PLA Univ Sci & Technol Coll Meteor PLA Nanjing 211101 Peoples R China

The dynamical framework with Blocking To-pography Coordinates (hereafter, BTC), which is suited tohandle the steep topography for the atmospheric generalcirculation models, is presented in this paper, together withits validation results. The integral properties of both the dif-ferential and finite-difference equations for the BTC dy-namical core are: gross mass conservation, quadratic con-servation for advection terms, Coriolis force does not changethe kinetic energy, conservation of total available energy. Theimproved nonlinear iteration scheme is utilized for thetime-integration. The energy conservation for BTC dynami-cal core is validated by using the integration results from9-layer and 21-layer version respectively. Comparison resultsshow that, the changes of the kinetic energy and total avail-able potential energy during the integration are quite closefor both the BTC dynamical framework and the dynamicalframework of IAP 9-level and IAP 21-level AGCM, and thismay suggest that the BTC dynamical core can be used forlong-term integration with good computational ***, the BTC dynamical core has the advantageover the terrain following (sigma) coordinates in its betterrepresentation of the influence of the large-scale topographyon the atmospheric general circulation. Finally, the correct-ness and reasonableness of the BTC dynamical core has beenfurther proved by the numerical simulation of the topogra-phy influence on the quasi-stationary planetary wave with21-layer version of BTC dynamical framework.

关键词： blocking topography coordinates atmospheric general circulation model dynamical framework.

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PNAS:科学家发现新的精子运动调节器

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现代生物医学进展 2017年第27期17卷 I0001-I0002页

作者： Castaneda, Julio M. Hua, Rong Miyata, Haruhiko Oji, Asami Guo, Yueshuai Cheng, Yiwei Zhou, Tao Guo, Xuejiang Cui, Yiqiang Shen, Bin Wang, Zibin Hu, Zhibin Zhou, Zuomin Sha, Jiahao Prunskaite-Hyyrylainen, Renata Yu, Zhifeng Ramirez-Solis, Ramiro Ikawa, Masahito Matzuk, Martin M. Liu, Mingxi Baylor coll.Med Dept Pathol & Immunol Houston TX 77030 USA Osaka Univ Res Inst Microbial Dis Suita Osaka 5650871 Japan Nanjing Med Univ State Key Lab Reprod Med Nanjing 210029 Jiangsu Peoples R China Nanjing Med Univ Dept Histol & Embryol Nanjing 210029 Jiangsu Peoples R China Osaka Univ Grad Sch Pharmaceut Sci Suita Osaka 5650871 Japan Nanjing Med Univ Anim Core Facil Nanjing 210029 Jiangsu Peoples R China Baylor coll.Med Ctr Reprod Med Houston TX 77030 USA Univ Oulu Fac Biochem & Mol Med FI-90014 Oulu Finland Baylor coll.Med Ctr Drug Discovery Houston TX 77030 USA Wellcome Trust Sanger Inst Hinxton CB10 1SA England Univ Tokyo Inst Med Sci Minato Ku Tokyo 1088639 Japan Baylor coll.Med Dept Mol & Cellular Biol Houston TX 77030 USA Baylor coll.Med Dept Mol & Human Genet Houston TX 77030 USA Baylor coll.Med Dept Pharmacol Houston TX 77030 USA

南京医科大学生殖医学国家重点实验室、基础医学院组织胚胎学系刘明兮课题组与贝勒医学院***课题组、大阪大学MasahitoIkawa课题组等共同解析了一个精子运动调节基因TCTE1，结果发表于《美国科学院院刊》（PNAs）。

关键词：精子运动调节器科学家国家重点实验室组织胚胎学课题组生殖医学医科大学

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Insights into the Discrepancy between Single Molecule Experiments

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Communications in Theoretical Physics 2019年第6期71卷 753-763页

作者： Qian Zhou Min Zhang Yang-Tao Fan Yu-Kang Wang Lin Bao Guang-Ju Zhao Hu Chen Yan-Hui Liu Guizhou Univ Coliege Phys Guiyang 550025 Guizhou Peoples R China Guizhou Univ Coll Big Data & Informat Engn Guiyang 550025 Guizhou Peoples R China Xiamen Univ Dept Phys Xiamen 361005 Fujian Peoples R China Xiamen Univ Pen Tung Sah Inst Micronano Sci & Technol Xiamen 361005 Fujian Peoples R China

Sharp bending as one of the mechanical properties of double-stranded DNA(dsDNA) on the nanoscale is essential for biological functions and processes. force sensors with optical readout have been designed to measure the forces inside short, strained loops composed of both dsDNA and single-stranded DNA(ssDNA). Recent FRET singlemolecule experiments were carried out based on the same force sensor design, but provided totally contrary results. In the current work, Monte Carlo simulations were performed under three conditions to clarify the discrepancy between the two experiments. The criterion that the work done by the force exerted on dsDNA by ssDNA should be larger than the nearest-neighbor(NN) stacking interaction energy is used to identify the generation of the fork at the junction of dsDNA and ssDNA. When the contour length of dsDNA in the sensor is larger than its critical length, the fork begins to generate at the junction of dsDNA and ssDNA, even with a kink in dsDNA. The forces inferred from simulations under three conditions are consistent with the ones inferred from experiments, including extra large force and can be grouped into two different states, namely, fork states and kink states. The phase diagrams constructed in the phase space of the NN stacking interaction energy and excited energy indicate that the transition between the fork state and kink state is difficult to identify in the phase space with an ultra small or large number of forks, but it can be detected in the phase space with a medium number of forks and kinks.

关键词： force sensor Monte Carlo simulation kink structure fork structure nearest-neighbouring stacking interaction energy

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梯级式溢洪道上的楔形砌块受力分析

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江苏农学院学报 1992年第1期13卷 35-42页

作者：钱义达 BakerR. Dept.of Hydr.and Agric.Eng. Jiangsu Agric.Coll.Yangzhou 225001 Dept.of Civ.Eng. Univ.of SalfordEngland.U.K.

为了正确地掌握梯级式溢洪道的设计,本文主要对楔形保护砌块上的3种主要作用力进行了分析.从理论上分析并推导了梯级水流下冲力的计算公式,得到了试验证实,这是一种新的计算方法,比目前各国采用的离心力计算法更为合理与正确;利用实测... 详细信息

为了正确地掌握梯级式溢洪道的设计,本文主要对楔形保护砌块上的3种主要作用力进行了分析.从理论上分析并推导了梯级水流下冲力的计算公式,得到了试验证实,这是一种新的计算方法,比目前各国采用的离心力计算法更为合理与正确;利用实测所得的Chezy系数,对均匀流状态下梯级溢洪道上的水流阻力进行分析并提出计算公式;提供了排水孔面积与渗压降幅之间的实测关系曲线,并证实5％是较为适宜的排水孔面积。

关键词：梯级式楔形砌块力学分析溢洪道

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