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A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration research 2025年第7期20卷 2029-2037页

作者： Xiao Liang Xingping Quan Xiaorui Geng Yujing Huang Yonghua Zhao Lei Xi Zhen Yuan Ping Wang Bin Liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

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Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke:a special outlook on mitochondrial delivery

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Neural Regeneration research 2025年第8期20卷 2181-2198页

作者： Jiali Chen Yiyang Li Xingping Quan Jinfen Chen Yan Han Li Yang Manfei Zhou Greta Seng Peng Mok Ruibing Wang Yonghua Zhao institute of Chinese Medical Sciences State Key Laboratory of Quality Research in Chinese MedicineUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmacy Hunan Provincial People’s Hospitalthe First Affiliated Hospital of Hunan Normal UniversityChangshaHunan ProvinceChina Department of Electrical and Computer Engineering University of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmaceutical Sciences Faculty of Health SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina

Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on *** vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic ***,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery *** utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly ***,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic *** extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke *** this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification *** the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment ***,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.

关键词： delivery engineering extracellular vesicles identification ischemic stroke isolation mitochondria targeting strategy therapeutic effects

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Neuropeptide cholecystokinin:a key neuromodulator for hippocampal functions

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Neural Regeneration research 2025年第7期20卷 1991-1992页

作者： Fengwen Huang Stephen Temitayo Bello Department of Neuroscience City University of Hong KongKowloon TongHong Kong Special Administrative RegionChina Center for Regenerative Medicine and Health Hong Kong Institute of Science&InnovationChinese Academy of SciencesHong Kong Special Administrative RegionChina

Spatial memory is crucial for survival within external surroundings and wild *** hippocampus,a critical hub for spatial learning and memory formation,has received extensive investigations on how neuromodulators shape its functions(Teixeira et al.,2018;Zhang et al.,2024).However,the landscape of neuromodulations in the hippocampal system remains poorly understood because most studies focus on classical monoamine neuromodulators,such as acetylcholine,serotonin,dopamine,and *** neuropeptides,comprising the most abundant neuromodulators in the central nervous system,play a pivotal role in neural information processing in the hippocampal ***(CCK),one of the most abundant neuropeptides,has been implicated in regulating various physiological and neurobiological statuses(Chen et al.,2019).CCK-A receptor(CCK-AR)and CCK-B receptors(CCK-BR)are two key receptors mediating the biological functions of CCK,both of which belong to class-A sevenfold transmembrane G protein-coupled receptors(Nishimura et al.,2015).CCK-AR preferentially reacts to sulfated CCK,whereas CCK-BR binds both CCK and gastrin with similar affinities(Ding et al.,2022).The expression patterns of CCK-AR and CCK-BR are distinct,implying that CCK has various functions in target *** instance,CCK-AR is widely expressed in the GI and brain subregions and is hence implicated in the control of digestive function and satiety ***,CCK-BR is abundantly and widely distributed in the central nervous system,which majorly regulates anxiety,learning,and memory(Ding et al.,2022).However,the roles of endogenous CCK and CCK receptors in regulating hippocampal function at electrophysiological and behavioral levels have received less attention.

关键词： abundant functions modulator

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CRISPR-Cas9-mediated editing of the OsHPPD 30 UTR confers enhanced resistance to HPPDinhibiting herbicides in rice

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Plant Communications 2023年第5期4卷 83-85页

作者： Yunyu Wu Ning Xiao Yue Cai Qian Yang Ling Yu Zichun Chen Wei Shi Jianju Liu Cunhong Pan Yuhong Li Xiaoxiang Zhang Changhai Zhou Niansheng Huang Hongjuan Ji Shuhao Zhu Aihong Li institute of agricultural Sciences for lixiahe region in Jiangsu Jiangsu Key Laboratory of Crop Genomics and Molecular BreedingYangzhou 225009China

Dear Editor,Loss of yield because of competition from weeds restricts the production of rice(Oryza sativa L.)(Maeda et al.,2019).Application of chemical herbicides is currently the most effective method for controlling weeds during rice production,especially in modern simplified cultivation ***,long-term and extensive use of herbicides,such as inhibitors of the enzymes 5-enolpyruvylshikimate-3-phosphate synthase,acetolactate synthase,and acetyl-coenzyme A carboxylase,has resulted in the emergence of herbicide-resistant weed species as well as soils with high levels of herbicide residues,which limit crop ***,there is an urgent need for alternative herbicides and breeding of corresponding herbicideresistant rice varieties.

关键词： breeding resistance herbicide

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Boosting hydrocarbon conversion via Cu-doping induced oxygen vacancies on CeO2 in CO2 electroreduction

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Journal of Energy Chemistry 2025年第1期100卷 66-76页

作者： Lei Xue Tong Shi Chenhui Han Heng Zhang Fenrong Liu Haorun Li Yan Wang Xiaojun Gu Shanghong Zeng Inner Mongolia Key Laboratory of Chemistry and Physics of Rare Earth Materials School of Chemistry and Chemical Engineering Inner Mongolia University State Key Laboratory of Coal Conversion Institute of Coal Chemistry Chinese Academy of Sciences institute of Catalysis Department of Chemistry Zhejiang University National Key Laboratory of Baiyunobo Rare Earth Resource research and Comprehensive Utilization Baotou Research Institute of Rare Earths

Conversion of CO2back to hydrocarbons is the most direct way of closing the“carbon cycle”,and its significance is further enlarged if this process is driven by renewable energies such as ***,precisely controlling the product selectivity towards hydrocarbons against the competitive hydrogen evolution remains challenging,especially for Cu-based ***,we report a novel defect engineering strategy,by which Cu-doping-induced oxygen vacancies on CeO2nanorods were effectively created,with adjustable vacancy/Cu *** resulting optimum catalyst shows up to 79% catalytic current density to hydrocarbons （excluding CO）,with 49% faradaic efficiency to *** and density functional theory unveil that the ratio between oxygen vacancy and Cu affects significantly the formation of*CHO and activation of H2O,which leads to the following deep hydrogenation to *** findings may spur new insights for designing and developing more controllable chemical process relevant to CO2utilization.

关键词： Oxygen vacancy Hydrocarbon production Reaction mechanism

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Pseudogamous Apomixis in Maize and Sorghum in Diploid-Tetraploid Crosses

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Phyton-International Journal of Experimental Botany 2019年第4期88卷 389-401页

作者： Marina Tsvetova Lev Elkonin Yulia Italianskaya agricultural research institute of South-East region Department of BiotechnologySaratov410010Russia

Apomictic seed development is a complex process including formation of unreduced embryo sac,parthenogenetic embryo development from the egg cell,and endosperm formation either autonomously,or due to fertilization of polar nuclei by the sperm(under pseudogamous form of apomixis).In the latter case,an obstacle to the normal endosperm development is disturbance of maternal(m)-to-paternal(p)genomic ratio 2m:1p that occurs in the cases of pollination of unreduced embryo sac with haploid *** of tetraploid pollinators can overcome this problem because in such crosses maternal-to-paternal genomic ratio is 4m:2p that provides formation of kernels with plump *** tetraploid lines as pollen parents we observed formation of plump kernels on the ears and panicles of diploid maize and sorghum *** kernels had hybrid endosperm and diploid maternal-type embryo or hybrid embryo with different ploidy level(2n,3n,4n).The frequencies of plump kernels on the ear ranged from 0.2-0.3%to 5.7-6.2%counting from the number of ***-type plants were found in two maize lines,their frequency varying from 10.7 to 37.5%of the progeny *** CMS-lines of sorghum pollinated with tetraploid sorghum accessions,the frequency of plump kernels ranged from 0.6 to 14.0%counting from the number of ovaries;the frequency of maternal-type plants varied from 33.0 up to 96.1%.The hybrid nature of endosperm of the kernels that gave rise to maternal-type plants has been proved by marker gene expression and by SDS-electrophoresis of endosperm *** data testify to variable modes of seed formation under diploid×tetraploid crosses in maize and sorghum both by amphi-and by ***,usage of tetraploid pollinators might be a promising approach for isolation of apomixis in maize and sorghum accessions.

关键词： Interploidy crosses genomic balance unreduced embryo sac pseudogamous apomixis Zea mays L Sorghum bicolor(L.)Moench

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Scenario analysis for reduction of pollutant load discharged from a watershed by recycling of treated water for irrigation

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Journal of Environmental Sciences 2010年第6期22卷 878-884页

作者： Eisaku Shiratani Yoshiyuki Munakata Ikuo Yoshinaga Tomijiro Kubota Koji Hamada Tadayoshi Hitomi National institute for Rural Engineering Kokusai Kogyo Co.Ltd. National agricultural research Centre for Kyushu Okinawa region

A model in which a river model was layered on a distributed model （double-layered model） was developed to analyse the transport of water and pollutants （nitrogen, phosphorus, and BOD as organic matter） in watersheds and rivers. The model was applied to the watershed of Abragafuchi Lake, Japan, where serious water pollution has occurred over three decades, and the applicability of the model was demonstrated. Scenarios of recycling of sewage treated-water into agriculture to reduce pollutant load discharged into the lake were analysed. The results showed that irrigating paddy fields with the sewage-treated water could contribute to conserving water and reducing pollutant load, with reduction rate in BOD, nitrogen, and phosphorus ranging from 6%-36%, 16%-46%, and 18%-51%, respectively. Particularly, the results indicated that, irrigating paddy fields with the treated water during non-cropping periods and the accompanying reduction in withdrawn water from the river were more effective in reducing pollutant loads discharged into the lake. Further study is required on the effect of recycled water on crop cultivation and soil conditions for safe implementation.

关键词： watershed management paddy field sewage treatment water reuse

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Effect of Waxy Wheat Flour Blends on the Quality of Chinese Steamed Bread

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agricultural Sciences in China 2007年第10期6卷 1275-1282页

作者： QIN Peng CHENG Shun-he MA Chuan-xi lixiahe region agricultural research institute of Jiangsu Province Yangzhou 225007 P.R.China Agronomy College Anhui Agricultural University Hefei 230036 P.R.China Agronomy College Yunnan Agricultural University Kunming 650201 P.R.China

Steamed bread is very popular in the East and Southeast Asian regions, and its quality is affected by some physicochemical properties. Chinese steamed bread was made by adding waxy flour into normal wheat flour in the present study. The results showed that specific volume was not affected by the proportions of waxy flour, whereas, adding waxy flour decreased the appearance, color, texture, elasticity, stickiness, and the total score of Chinese steamed bread. However, there were no significant differences in all values when the proportions of waxy flour were below 10%. All evaluations but specific volume of Chinese steamed bread were positively influenced by the peak viscosity, resistance, and maximum resistance. When the waxy flour proportions were below 25%, the firmness of Chinese steamed bread stored at -18℃ for 3 days gradually decreased with the increase of waxy flour. It was revealed that the qualities of Chinese steamed bread cannot be improved by waxy flour but it can be widely used in frozen storing food in the future.

关键词： waxy wheat Chinese steamed bread quality

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Causes of Poor Grain Plumpness of Two-Line Hybrids and Their Relationships to the Contents of Hormones in the Rice Grain

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agricultural Sciences in China 2007年第8期6卷 930-940页

作者： ZHAO Bu-hong ZHANG Hong-xi ZHU Qing-sen YANG Jian-chang Key Laboratory of Crop Genetics and Physiology of Jiangsu Province Yangzhou University Yangzhou 225009 P.R. China lixiahe region agricultural research institute of Jiangsu Province Yangzhou 225007 P.R.China

This study was designed to elucidate the grain filling characteristics and the causes of poor grain plumpness of some two-line hybrid rice combinations and their hormonal mechanism. Six varieties, including three two-line hybrid rice combinations, that show differences in seed-setting and grain filling, were used. And the contents of starch, sucrose, zeatin （Z）＋ zeatin riboside （ZR）, indole-3-acetic acid （IAA）, and abscisic acid （ABA）, the ethylene evolution rate, activities of sucrose synthase （SuSase） and starch synthase （StSase） in grains, the seed-setting and grain filling rate were investigated. The correlations amongst these were analyzed. The results showed that the poor grain filling of two-line hybrids was mainly attributed to the higher unfilled grain rate and the lower filling degree of inferior grains. During the early and mid grain filling periods, the sucrose content in inferior grains was greater than that in superior grains for the combinations with poor grain filling, indicating that the substrate concentration was not the principal factor for their slow grain filling and poor grain plumpness of the inferior grains of two-line hybrids. Z ＋ ZR, IAA, and ABA in superior grains were obviously greater than those in inferior grains at early grain filling stage. The maximum and mean contents of Z ＋ ZR, IAA, and ABA were positively very significantly correlated with the maximum and mean grain-filling rate, filling degree, and grain weight. The evolution rate of ethylene was greater in inferior grains than in superior grains and greater for the combinations with poor grain plumpness than those with good grain plumpness at the early or mid filling stages. The evolution rate of ethylene was negatively and significantly correlated with the grain filling rate, the grain filling degree, and the grain weight. Spraying ethephon （ethylene-releasing agent） at the early grain filling stage increased the evolution rate of ethylene, reduced the ABA content and activit

关键词： two-line hybrid rice grain-filling hormonal regulation physiological mechanism

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Effect of Waxy Wheat Flour Blends on the Quality of Fresh and Stale Bread

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agricultural Sciences in China 2009年第4期8卷 401-409页

作者： QIN Peng MA Chuan-Xi WU Rong-lin KONG Zhi-you ZHANG Bo-qiao College of Agronomy and Biotechnology Yunnan Agricultural University Kunming 650201 P.R.China agricultural research institute of lixiahe region Yangzhou 225007 P.R. China College of Agronomy Anhui Agricultural University Hefei 230036 P.R. China Department of Biology and Chemistry Baoshan Teachers College Baoshan 678000 P.R.China

Starch is the major component in the wheat kernel, which is mainly composed of amylose and amylopectin. The wheat without amylose in its endosperm was called ＂waxy wheat＂. Waxy wheat can be used to adjust the amylose content and improve the wheat-based food quality by adding to non-waxy wheat flour. In order to investigate the effect of waxy wheat flour on the quality of fresh and stale bread, waxy wheat flour was added into the flour of Canadian Spring Wheat 2 at 0.0, 5.0, 10.0, 15.0, 20.0, 25.0, 30.0, and 35.0% to make breads. The physicochemical properties were adjusted to suitability by adding Yangmai 158 flour, and breads were evaluated for sensory quality, crumb firmness, loaf volume and weight loss over a period of 0, 2, 4, and 6 days. The result showed that the best total score of fresh bread was 82.9 by adding waxy flour at 7.0%, though no significant difference was found among blends with 0.0-15.0% of waxy flour. Breads with the addition of 22.0% waxy flour had lower firmness, and decreasing loss of weight. Waxy wheat flour blend at 15.0% was optimal in retarding staling without significant decreasing fresh bread quality in comparison to the control.

关键词： waxy wheat fresh bread stale bread quality

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