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Wild pink bayberry free phenolic extract induces mitochondria-dependent apoptosis and G0/G1 cell cycle arrest through p38/MAPK and PI3K/Akt pathway in MDA-MB-231 cancer cells

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Food Science and Human Wellness 2023年第5期12卷 1510-1518页

作者： Wen Xia Ersheng Gong Yanyun Lin Bisheng Zheng Wenhan Yang Tong Li Sheng Zhang Peng Li Ruihai Liu Overseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health(111 Center) School of Food Science and EngineeringSouth China University of TechnologyGuangzhou 510641China School of Public Health and Health Management Gannan Medical UniversityGanzhou 341000China Key Laboratory of tropical Crop products processing of Ministry of Agriculture and Rural Affairs Agricultural Products Processing Research InstituteChinese Academy of Tropical Agricultural SciencesZhanjiang 524001China Department of Food Science Cornell UniversityIthaca 14853USA Stem Cell research and Cellular Therapy Center Affi liated Hospital of Guangdong Medical UniversityZhanjiang 524001China

Polyphenol-rich foods have been shown to be good for cancer prevention as powerful antioxidants. In this study, the mechanisms of wild pink bayberry free phenolic extract(WPBFE)inhibiting the proliferation and inducing apoptotic of MDA-MB-231 breast cancer cells was examined. The main phenolic acids and flavonols in WPBFE were gallic acid((18.83 ± 0.44)μg/g FW)and myricetin((1.52 ± 0.05)μg/g FW), respectively. The maximum inhibition rate of WPBFE at non-cytotoxicity dose(below 80 mg/mL)was 81%. Western blotting analysis showed that WPBFE could cause the arrest of cell cycle in G0/G1 phase by down-regulating expression levels of PCNA, CDK4, cyclin D1 and up-regulating the expression level of p21. Meanwhile, WPBFE induced apoptosis through initiating the mitochondrial death pathway by up-regulating cleaved caspase-3 and enhancing the ratio of Bax/Bcl-2, with the maximum expression levels of 1.29 and 2.03 folds that of control group, respectively. Further study of the upstream protein, we found that WPBFE down-regulated TRAF2, while upregulated p-ASK1, p-p38 and p-p53. Furthermore, WPBFE could down-regulate the expression of p-PI3K and p-Akt. These observations indicated that WPBFE might play an anticancer role through regulating the p38 MAPK together with PI3K/Akt pathway.

关键词： Phenolic extract Breast cancer Cell cycle Apoptosis Cell proliferation

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Increasing China's agricultural Labor productivity: Comparison and Policy Implications from Major Agrarian Countries

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Journal of Resources and Ecology 2018年第6期9卷 575-584页

作者： CHEN Yangfen LI Xiande LIU Yu institute of agricultural Economics and Development Chinese Academy of Agricultural SciencesBeijing 100081China National Engineering research Center for Information Technology in Agriculture Beijing 100097China

China's low agricultural labor productivity has become the key weakness of its agricultural competitive- ness and sustainable development,and strategies for improving China's agricultural labor productivity lack clear and consistent theory and empirical *** address this issue,the current study uses the methods of convergence index,correlation coefficient,and nonparametric test,to analyze the characteristics and influencing factors of agricultural labor productivity among 32 major agrarian countries during *** analysis shows that the development gap among countries has been *** USA takes the leading position among all the countries, while some countries with scarce land like Japan have succeeded in achieving transcendence,and other countries like India have experienced relatively slow *** agricultural labor productivity is significantly driven by agricultural labor surplus,agricultural product processing,and agricultural industrial *** effects of land resource endowment,agricultural mechanization,and biochemical inputs have been declining and in some cases are no longer even *** is therefore necessary to shift attention to marketization,diversification,and high quality,instead of the former focus on agricultural intensification,concentration and large-scale operations,and this shift is probably more closely aligned with current *** are more people and less land in China,and the agricultural labor force in China still accounts for nearly 30% of the total *** these national conditions,it is very important to simultaneously improve the efficiency of agricultural production of small farmers and promote the successful urbanization of the agricultural labor *** the medium and long term,it is imperative to improve the competitiveness of chinese agriculture by adopting related policy arrangements such as induced agricultural technological innovation,production factor substitution,and m

关键词： agricultural development agricultural labor productivity international comparison agricultural policies agricultural industry in China

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MRUNet:A two-stage segmentation model for small insect targets in complex environments

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Journal of Integrative Agriculture 2023年第4期22卷 1117-1130页

作者： WANG Fu-kuan HUANG Yi-qi HUANG Zhao-cheng SHEN Hao HUANG Cong QIAO Xi QIAN Wan-qiang College of Mechanical Engineering Guangxi UniversityNanning 530004P.R.China Lingnan Guangdong Laboratory of Modern Agriculture Genome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120P.R.China Wuzhou product Quality Inspection institute Wuzhou 543000P.R.China

Online automated identification of farmland pests is an important auxiliary means of pest *** practical applications,the online insect identification system is often unable to locate and identify the target pest accurately due to factors such as small target size,high similarity between species and complex *** facilitate the identification of insect larvae,a two-stage segmentation method,MRUNet was proposed in this ***,MRUNet borrows the practice of object detection before semantic segmentation from Mask R-CNN and then uses an improved lightweight UNet to perform the semantic *** reliably evaluate the segmentation results of the models,statistical methods were introduced to measure the stability of the performance of the models among samples in addition to the evaluation indicators commonly used for semantic *** experimental results showed that this two-stage image segmentation strategy is effective in dealing with small targets in complex *** with existing state-of-the-art semantic segmentation methods,MRUNet shows better stability and detail processing ability under the same *** study provides a reliable reference for the automated identification of insect larvae.

关键词： insect larvae deep learning semantic segmentation object detection

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Lipid analysis of three special nervonic acid resources in China

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Oil Crop Science 2020年第4期5卷 180-186页

作者： Xinghao Tu Jingya Wan Ya Xie Fang Wei Siewyoung Quek Xin Lv Liqing Du Hong Chen Oil Crops research institute of the chinese academy of agricultural sciences Key Laboratory of Oilseeds Processing of Ministry of Agriculture and Rural AffairsKey Laboratory of Biology and Genetic Improvement of Oil Crops of Ministry of Agriculture and Rural AffairsHubei Key Laboratory of Lipid Chemistry and NutritionWuhanChina South Subtropical Crop research institute Chinese Academy of Tropical Agricultural Science/Key Laboratory of Tropical Fruit BiologyMinistry of Agriculture and Rural AffairsZhanjiangChina Faculty of Life Science Hubei UniversityWuhanChina School of Chemical sciences University of AucklandAuckland1142New Zealand

Nervonic acid plays an important role in nutrition and function of the human *** oleifera,Acer truncatum and Xanthoceras sorbifolium are China’s unique woody plant rich in nervonic acid in seed *** study aims to investigate the lipid composition of these 3 special *** fatty acids were detected by gas chromatography coupled with flame detector(GC-FID).Triglycerides(TAGs)and phospholipids(PLs)were detected by shotgun-mass spectrometry(shotgun-MS).Results showed that *** oil presented the highest level of nervonic acid(46.20±0.22%)among the 3 *** oil of *** and *** had 3.53±0.20%and 1.83±0.21%nervonic acid respectively.53 species of TAGs and 15 species of PLs were identified in *** oil,with PLs content of 499.94±22.34μg/*** *** oil,PL and TAG species were twice more than those in *** oil,and its’content of PLs was 76.27±3.21μg/*** *** oil,75 TAGs and 34 PLs were detected,with the lowest PLs at 23.84±0.17μg/*** results demonstrated that these 3 vegetable oils have great potential to become nervonic acid supplements for human health.

关键词： Nervonic acid Malania oleifera Acer truncatum Xanthoceras sorbifolium Lipid analysis

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Indoleamine 2,3-dioxygenase as biomarker for classification of macrophages and to study immunomodulating activity of dietary fibers

Indoleamine 2,3-dioxygenase as biomarker for classification ...

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第十二届全国营养科学大会

作者： YONGFU TANG Coen Govers Harry J.Wichers Jurriaan J.Mes Food & Biobased research Wageningen University and Research Centre Key Laboratory of tropical Crop products processing of Ministry of Agriculture Agriculture Products Processing Research InstituteChinese Academy of Tropical Agricultural Sciences

Objectives Macrophages can modify their phenotype rapidly as response to environmental *** differentiated primary macrophages to classic macrophages or alternative macrophages and analysed cell-type specific markers a...

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A comprehensive review of bioactive compounds and processing technology of sesame seed

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Oil Crop Science 2022年第2期7卷 88-94页

作者： Xuan Ma Zhi Wang Chang Zheng Changsheng Liu Oil Crops research institute of the chinese academy of agricultural sciences Oil Crops and Lipids Process Technology National&Local Joint Engineering LaboratoryKey Laboratory of Oilseeds ProcessingMinistry of Agriculture and Rural AffairsHubei Key Laboratory of Lipid Chemistry and NutritionWuhan430062China

Sesame seeds are promulgated as traditional high-quality edible oil crops,rich in lipid(40–65%),protein(19–35%),and bioactive *** review starts with bioactive components(fatty acid,tocopherol,phytosterol,sesamin,sesamolin,and sesamol)of sesame *** considers processing techniques for extracting oil(aqueous extraction and pressing)from *** technologies,such as enzyme-assisted aqueous,supercritical CO_(2),and microwave-assisted solvent extraction,are also *** methods of utilization of sesame seed cake are also *** the future,the processing technology of sesame seed will be further developed in the direction of improving comprehensive utilization rate to meet new consumption demand.

关键词： Sesame seed Bioactive compound Nutritional properties processing technology By-product

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Problems in Construction of Subsidy System for agricultural product Identification and Countermeasures——A Case Study of Xingjiang

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Asian agricultural research 2012年第11期4卷 18-20,24页

作者： CHENG Yan Xinjiang institute of Engineering institute of agricultural Economics and Development Chinese Academy of Agricultural Sciences

In line with current situations of extension of Xinjiang's agricultural products,the paper put forward and analyzed existing problems in extension works of agricultural product *** problems mainly include:(i) general identification of agricultural products is basically blank and both producers and consumers lack awareness of identification;(ii) creating(famous) brand is a weak point of agriculture in Xinjiang;(iii) certification of non-hazard,green and organic agricultural products lags behind;(iv) it neglects problem of agricultural product *** the basis of these problems,the paper present our recommendations:(i) government provides financial subsidy to actively guide certification of agricultural products;(ii) it should increase financial fund input in brand construction and support(famous) brand construction of agricultural products;(iii) it should provide subsidy for those enterprises creating famous brand,to encourage agricultural producing and processing enterprises to strive for famous brands;(vi) it should stress agricultural product packaging from the source and provide subsidy for agricultural producers who have affixed the identification;(v) it should gradually promote agricultural product identification,to constantly improve the farmers' awareness of agricultural product identification.

关键词： agricultural product identification Subsidy system

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Indoleamine 2,3-dioxygenase as biomarkers for classification of macrophages and to study immunomodulatingactivity of dietary fibers

Indoleamine 2,3-dioxygenase as biomarkers for classification...

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第十二届全国营养科学大会

作者： Yongfu Tang Coen Govers Harry J.Wichers Jurriaan J.Mes Food &Biobased research Wageningen University and Research Centre Key Laboratory of tropical Crop products processing of Ministry of Agriculture Agriculture Products Processing Research InstituteChinese Academy of Tropical Agricultural Sciences524001 ZhanjiangChina

Objectives Scope Due to the plasticity, macrophage as a heterogeneous population of immune cells could modify their phenotype rapidly as response to environmental factors. We differentiated primary macrophages to classic macrophages or alternative macrophages and analysed cell typespecific markers as well as those markers that response to dietary fibers. Some of these fibers for example given the beta-glucan Lentinan from Shiitake mushroom, have shown immunomodulating properties towards macrophages whichmight be expected to be revealed by these analysis. Methods Macrophages were obtained after 7 days culturing of monocytes in RPMI-1640 medium supplemented with 50 ng/ml MCSF(referred to as M(MCSF) and followed polarization by 20 ng/ml TNF-α plus 20 ng/ml IFN-γ or 20 ng/ml IL-4 for M(TNF-α + IFN-γ) and M(IL4) separately. Gene expression profiles of macrophages were analysed by Affymetrix GeneC hips(Human gene 1.1 ST Array) and verified mR NA expression by q ***,M(MCSF)were incubated with Lentinan containing Shiitake extract at 500μg/ml for the same 18 hours. Results Comparing M(TNF-α + IFN-γ) to M(IL4), we identified 8639 significant differencially expressing genes. According to those genes, IDO1, IRG1, ANKRD22, GBP5 and GBP3 were the top 5 markers for M(TNF-α + IFN-γ). Meanwhile, IL17 RB, ALOX5, CD180, ST8SIA6 and CHDH were the top 5 markers for M(IL4). Interestingly, indoleamine 2,3-dioxygenase(IDO) is an immunomodulatory protein expressed in various antigen presenting cells such as macrophages and dendritic cells, which can suppress adaptive immunity and showed T cells suppression and immune tolerance activity. Further, we verified IDO1 m RNA expression by q PCR, normalized to medium control, which confirmed that M(TNF-α + IFN-γ)highly express IDO1 while M(IL4) do not. IDO1 expression was also increased by incubation with theL entinancontaining extract of Shiitake mushroom.. Conclusion Our findings indicate that IDO1 is a potential biomarker for ident

关键词： IDO1 macrophage immunomodulatory

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Anti-Obesity, Anti-Atherosclerotic and Anti-Oxidant Effects of Pu-Erh Tea on a High Fat Diet-Induced Obese Rat Model

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Journal of Biosciences and Medicines 2019年第2期7卷 120-130页

作者： Changyun Xiong Yuanju Peng Benying Liu Wenrui Cui Xuncheng Liu College of tropical Crops Yunnan Agricultural University Pu’er China Tea research institute Yunnan Academy of Agricultural Science Menghai China South China Botanical Garden Chinese Academy of Sciences Guangzhou China

Pu-erh tea, a traditional chinese beverage, has been believed to have many benefits to human health and without side effects. In this study, we systematically analyzed the main active components of Pu-erh tea and investigated its anti-obesity, anti-atherosclerotic and anti-oxidant effects using an obese rat model. Obesity was induced by feeding a high-fat diet and subsequently the experimental obese mice were fed with high-fat diet supplemented with low (2.5%), medium (5%) or high (7.5%) doses of Pu-erh tea powder for 6 weeks respectively. As result, the body weight gain of the rats was decreased by medium and high doses of Pu-erh tea treatments. Furthermore, the levels of serum total cholesterol (TC), triglyceride (TG) and atherosclerosis index (AI) were significantly lowered by Pu-erh tea compared to the control group. Conversely, high density lipoproteincholesterol (HDL-C) level of the rats was significantly elevated by Pu-erh tea treatments. In addition, Pu-erh tea treatments increased the activities of anti-oxidative enzymes such as superoxide dismutase (SOD) and glutathione peroxides (GSH-Px), whereas reduced the level of lipid peroxidation product malondialdehyde (MDA) in obese rats. Collectively, our find-ings revealed that Pu-erh tea exerts comprehensive benefits in anti-obesity, anti-atherosclerotic and anti-oxidant effects, therefore can be used as a promising functional food in obesity management.

关键词： Pu-Erh Tea Anti-Obesity Anti-Atherosclerotic Anti-Oxidant Obese Rat Model

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Volatile Compounds Fingerprints for White Duck down and White Goose down Determined by Gas Chromatography-Ion Mobility Spectrometry

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agricultural sciences 2023年第3期14卷 432-445页

作者： Fei Wang Qihui Zhang Yiwen Lin Wenjian Chen Hui Wang Kuntai Li Jihua Li Yuliang Chen Leiyu Wang agricultural products processing research institute Chinese Academy of Tropical Agricultural Sciences Zhanjiang China College of Biological sciences and Engineering Jiangxi Agricultural University Nanchang China Zhanjiang Zikang Fiderdown production Company Ltd. Zhanjiang China School of Food Science & Technology Guangdong Ocean University Zhanjiang China

This work first describes a simple approach for the untargeted profiling of volatile compounds for distinguishing between white duck down (WDD) and white goose down (WGD) based on resolution-optimized GC-IMS combined with optimized chemometric techniques, namely PCA. The detection method for down samples was established by using GC-IMS. Meanwhile, the reason of unpleasant odors caused by WDD was explained on the basis of the characteristic volatile compounds identification. GC-IMS fingerprinting can be considered a revolutionary approach for a truly fully automatable, cost-efficient, and in particular highly sensitive method. A total of 22 compounds were successfully separated and identified through GC-IMS method, and the significant differences in volatile compounds were observed in three parts of WDD and WGD samples. The most characteristic volatile compounds of WGD belong to aldehydes, whereas carboxylic acids from WDD were detected generated by autoxidation reaction. Meanwhile, the main reason of unpleasant odor generation was possibly attributed to the high concentration of volatile carboxylic acids of WDD. Therefore, the constructed model presents a simple and efficient method of analysis and serves as a basis for down processing and quality control.

关键词： Gas Chromatography-Ion Mobility Spectrometry (GC-IMS) Principal Components Analysis (PCA) Down Characteristic Volatiles Fingerprints Carboxylic Acids

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