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作者：张永君严川伟王福会宋光铃楼翰一中国科学院金属研究所腐蚀与防护国家重点实验室中国科学院金属研究所腐蚀与防护国家重点实验室中国科学院金属研究所腐蚀与防护国家重点实验室 Cooperative Research Centre for Cast Metals Manufacturing（CAST） Department of MiningMinerals and Materials EngineeringThe University of QueenslandBrisbaneQld 4072Australia 中国科学院金属研究所腐蚀与防护国家重点实验室

对镁及镁合金基体金属上以各种不同工艺所得膜层的微观结构及其综合防护性能（包括耐蚀性、耐磨性及结合力）进行了比较研究。发现不同工艺条件形成的阳极氧化膜层在微观结构上存在显著区别;环保型阳极氧化工艺所得膜层的综合防护性能... 详细信息

对镁及镁合金基体金属上以各种不同工艺所得膜层的微观结构及其综合防护性能（包括耐蚀性、耐磨性及结合力）进行了比较研究。发现不同工艺条件形成的阳极氧化膜层在微观结构上存在显著区别;环保型阳极氧化工艺所得膜层的综合防护性能较经典工艺好,对基体金属能提供更为有效的保护。

关键词：镁阳极氧化膜层

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国际糖尿病足工作组:糖尿病足溃疡预防指南——《国际糖尿病足工作组:糖尿病足防治国际指南(2019)》的一部分

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感染．炎症．修复 2019年第3期20卷 140-157页

作者： Sicco A.Bus Larry A.Lavery Matilde Monteiro-Soares Anne Rasmussen Anita Raspovic Isabel C.N.Sacco Jaap J.van Netten 无罗颖琪李炳辉(译) 许樟荣(审校) Amsterdam UMC Department of Rehabilitation MedicineAcademic Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands Department of Plastic Surgery University of Texas Southwestern Medical CenterDallasTexasUSA MEDCIDES:Departamento de Medicina da Comunidade Informacao e Decisao em Saude&CINTESIS–Center for Health Technology and Services Research Faculdade de Medicina da Universidade do PortoPortoPortugal Steno Diabetes Center Copenhagen GentofteDenmark Discipline of Podiatry School of Allied HealthHuman Services and SportLa Trobe UniversityMelbourneVictoriaAustralia Physical Therapy Speech and Occupational Therapy DepartmentSchool of MedicineUniversity of Sao PauloSao PauloBrazil School of Clinical sciences Queensland University of TechnologyBrisbaneAustralia Diabetic Foot Clinic Department of SurgeryZiekenhuisgroep TwenteAlmelo and HengeloThe Netherlands International Working Group on the Diabetic Foot(IWGDF) 华中科技大学同济医学院附属梨园医院湖北武汉430077

国际糖尿病足工作组(IWGDF)1999年发布了关于预防和管理糖尿病足病的循证指南。该指南旨在预防糖尿病患者的足部溃疡,并在2015年,IWGDF对预防指南进行了更新。我们遵循GRADE(grading of recommendations assessment development and eva... 详细信息

国际糖尿病足工作组(IWGDF)1999年发布了关于预防和管理糖尿病足病的循证指南。该指南旨在预防糖尿病患者的足部溃疡,并在2015年,IWGDF对预防指南进行了更新。我们遵循GRADE(grading of recommendations assessment development and evaluation)的评分方法,采用以患者为观察对象、有干预措施、与对照组进行比较、观察结局(patient-intervention-comparison-outcome,PICO)的方法来设计临床问题和关键成果,对医学科学文献进行系统评价,并撰写推荐意见及其理由。这些推荐基于系统评价中发现的证据质量、专家意见,以及益处及危害的权重、患者偏好、可行性和适用性以及与干预相关成本的权衡。我们建议对处于极低溃疡风险的患者每年做一次筛查,了解其是否有周围神经病变和外周血管病变,对高风险人群检查的频率要更高,以筛查其他危险因素。为了预防足溃疡,要对有危险因素的患者进行健康教育,教育患者适当地对足部进行自我护理以及对溃疡前症状进行有效治疗。指导中高危患者穿着合适的治疗鞋,并对其足部皮肤温度进行监测。处方治疗鞋在行走过程中具有明显的减轻足底压力的效果,能够防止足底溃疡复发。急性足溃疡或即将发生的足溃疡保守治疗失败,应考虑手术干预。我们不建议使用神经松解减压术。对高危患者给予综合足部医疗护理,以防溃疡复发。贯彻这些推荐将有助于医疗专业人员对有足溃疡风险的糖尿病患者提供更好的护理,降低糖尿病足溃疡的发生率,使足部健康维持更长的时间即增加无足病的天数,显著减少糖尿病患者和医疗机构的负担。

关键词：糖尿病足足溃疡指南预防鞋具自我护理自我管理教育

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Cancer Res:HDAC抑制剂可促进单抗药物对HER2阳性肿瘤的治疗效果

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现代生物医学进展 2017年第18期17卷 I0001-I0002页

作者： Mikolaj Medon Eva Vidacs Stephin J Vervoort Jason Li Misty R. Jenkins Kelly M. Ramsbottom Joseph A. Trapani Mark J. Smyth Phillip K. Darcy Peter W. Atadja Michael A. Henderson Ricky W. Johnstone Nicole M. Haynes Cancer Therapeutics Program Peter MacCallum Cancer Centre Victorian Comprehensive Cancer Centre (VCCC) Melbourne Victoria Australia.Division of Surgical Oncology Peter MacCallum Cancer Centre VCCC Melbourne Victoria Australia. Cancer Therapeutics Program Peter MacCallum Cancer Centre Victorian Comprehensive Cancer Centre (VCCC) Melbourne Victoria Australia. Cancer Therapeutics Program Peter MacCallum Cancer Centre Victorian Comprehensive Cancer Centre (VCCC) Melbourne Victoria Australia. Bioinformatics Consulting Core Facility Cancer Research Division Peter MacCallum Cancer Centre VCCC Melbourne Victoria Australia. Cancer Immunology Research Program Peter MacCallum Cancer Centre VCCC Melbourne Victoria Australia.Sir Peter MacCallum Department of Oncology The University of Melbourne Parkville Victoria Australia. Cancer Immunology Research Program Peter MacCallum Cancer Centre VCCC Melbourne Victoria Australia. Cancer Immunology Research Program Peter MacCallum Cancer Centre VCCC Melbourne Victoria Australia.Sir Peter MacCallum Department of Oncology The University of Melbourne Parkville Victoria Australia. Immunology in Cancer and Infection Laboratory QIMR Berghofer Medical Research Institute Herston Queensland Australia. Cancer Immunology Research Program Peter MacCallum Cancer Centre VCCC Melbourne Victoria Australia.Sir Peter MacCallum Department of Oncology The University of Melbourne Parkville Victoria Australia. China Novartis Institute for Biomedical Research Shanghai China. Division of Surgical Oncology Peter MacCallum Cancer Centre VCCC Melbourne Victoria Australia. Cancer Therapeutics Program Peter MacCallum Cancer Centre Victorian Comprehensive Cancer Centre (VCCC) Melbourne Victoria Australia.Sir Peter MacCallum Department of Oncology The University of Melbourne Parkville Victoria Australia. Cancer Therapeutics Program Peter MacCallum Cancer Centre Victorian Comprehensive Cancer Centre (VCCC) Melbourne Victoria Australi

最近来自澳大利亚墨尔本的研究人员发现组蛋白去乙酰化酶抑制剂可以发动宿主免疫作为其抗肿瘤效应的一个基础。该研究为增强一些肿瘤免疫治疗药物的杀伤作用提供了新的方向。在这项发表在国际学术期刊Cancer Research上的研究中，研究... 详细信息

最近来自澳大利亚墨尔本的研究人员发现组蛋白去乙酰化酶抑制剂可以发动宿主免疫作为其抗肿瘤效应的一个基础。该研究为增强一些肿瘤免疫治疗药物的杀伤作用提供了新的方向。在这项发表在国际学术期刊Cancer Research上的研究中，研究人员发现组蛋白去乙酰化酶抑制剂panobinostat可以通过宿主免疫增强trastuzumab这种单抗治疗药物的抗肿瘤效果。

关键词：组蛋白去乙酰化酶抑制剂抗肿瘤效应治疗药物治疗效果 HDAC 单抗 Res 阳性

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奥司他韦治疗成人和儿童流感：临床研究报告和药品监管评论概要系统性综述

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英国医学杂志中文版 2014年第4期17卷 209-209页

作者： Tom Jefferson Mark Jones Peter Doshi Elizabeth A Spencer Igho Onakpoya Carl J Heneghan 李辉曹彬 Cochrane Acute Respiratory Infections Group Via Puglie 23 00187 Rome Italy School of Population Health University of Queensland Brisbane Australia Department of Pharmaceutical Health Services Research University of Maryland School of Pharmacy Baltimore MD 21201 USA Nuffield Department of Primary Care Health sciences University of Oxford Oxford UK 首都医科大学附属北京朝阳医院感染和临床微生物科

目的通过分析所有的临床随机对照试验（或者相似的研究）和药品监管评论，来描述奥司他韦治疗流感的潜在益处和风险。

关键词：系统监管临床儿童成人流感

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亚太地区慢性乙型肝炎治疗共识(2012最新版)

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临床肝胆病杂志 2012年第8期28卷 I0001-I0021页

作者：廖运范 Jia-HorngKao Teerha Piratvisuth Henry Lik Yuen Chan Rong-Nan Chien Chun-Jen Liu Ed Gane Stephen Locarnini Seng-Gee Lim Kwang-Hyub Han Deepak Amarapurkar Graham Cooksley Wasim Jafri Rosmawati Mohamed Wan-Long Chuang Laurentius A.Lesmana Jose D.Sollano Dong-Jin Suh Masao Omata 刘颖徐莹李芸黄祖雄樊蓉李小溪吕国涛周彬孙剑侯金林 Liver Research Unit Chang Gung Memorial HospitalChang Gung University College of Medicine Graduate Institute of Clinical Medicine National Taiwan University College of Medicine and Hospital NKC Institute of Gastroenterology and Hepatology Songklanagarind HospitalPrince of Songkla University Department of Medicine and Therapeutics and Institute of Digestive Disease The Chinese University of Hong Kong Graduate Institute of Clinical Medicine Department of Internal Medicine and Hepatitis Research CenterNational Taiwan University College of Medicine and Hospital New Zealand Liver Transplant Unit Auckland City Hospital Research & Molecular Development Victorian Infectious Diseases Reference LaboratoryWHO Regional Reference Laboratory for Hepatitis B Dept of Gastroenterology and Hepatology National University Health SystemYong Loo Lin School of MedicineSingapore Department of Internal Medicine Yonsei University College of MedicineLiver Cirrhosis Clinical Research Center Bombay Hospital & Medical Research Centre University of queensland Royal Brisbane Hospital Department of Medicine Aga Khan University University Malaya Medical Centre Hepatobiliary Division Department of Internal MedicineKaohsiung Medical University HospitalKaohsiung Medical University Department of Medicine University of Indonesia University of Santo Tomas Espaa Blvd.ManilaPhilippines Asan Medical Center University of Ulsan College of Medicine Yamanashi-ken Hospital Organization(Central and Kita Hospitals) University of Tokyo 广州南方医科大学南方医院肝病中心

自2008年至今,有大量关于慢性HBV感染的自然史和治疗的最新数据不断涌现。其中包括慢性HBV感染的无症状感染者,以社区为基础的队列研究,HBV基因型的作用,非药物诱导的自然HBV变异型毒株,无创性肝纤维化评估方法的应用,HBsAg定量在临床... 详细信息

自2008年至今,有大量关于慢性HBV感染的自然史和治疗的最新数据不断涌现。其中包括慢性HBV感染的无症状感染者,以社区为基础的队列研究,HBV基因型的作用,非药物诱导的自然HBV变异型毒株,无创性肝纤维化评估方法的应用,HBsAg定量在临床中的应用,更有效的新治疗药物和新治疗方案等等。来自亚太地区的专家审查和评估了相关数据,并共同商讨了近年来报道的最有意义的发现,基于此,对2008年版的亚太地区慢性乙型肝炎治疗共识进行修订,同时对2008年版治疗指南定义的关键词组进行了修订。修订后的指南包括以下几方面内容:一般治疗,肝纤维化评价适应证,何时开始治疗或停药,初始抗病毒治疗药物的选择,如何监测治疗中和治疗后的患者。关于特殊人群的治疗建议中包括了对妊娠妇女,已发生耐药,合并其他病毒感染,肝功能失代偿,接受免疫抑制治疗、化疗,肝移植或肝细胞癌患者的具体治疗建议。

关键词：肝炎乙型慢性治疗指南

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Ventilation practices in burn patients—an international prospective observational cohort study

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Burns & Trauma 2021年第1期9卷 47-57页

作者： Gerie J.Glas Janneke Horn Markus W.Hollmann Benedikt Preckel Kirsten Colpaert Manu Malbrain Ary Serpa Neto Karim Asehnoune Marcello Gamma de Abreu Ignacio Martin-Loeches Paolo Pelosi Folke Sjoerg Jan M.Binnekade Berry Cleffken Nicole P.Juffermans Paul Knape Bert G.Loef David P.Mackie Perenlei Enkhbaatar Nadia Depetris Anders Perner Eva Herrero Lucia Cachafeiro Marc Jeschke Jeffrey Lipman Matthieu Legrand Johannes Horter Athina Lavrentieva Alex Kazemi Anne Berit Guttormsen Frederik Huss Mark Kol Helen Wong Therese Starr Luc De Crop Wilson de Oliveira Filho Joa Manoel Silva Junior Cintia M.C.Grion Marjorie Burnett Frederik Mondrup Francois Ravat Mathieu Fontaine Renan Le Floch Mathieu Jeanne Morgane Bacus Maite Chaussard Marcus Lehnhardt Bassem Daniel Mikhail Jochen Gille Aidan Sharkey Nicole Trommel Auke C.Reidinga Nadine Vieleers Anna Tilsley Henning Onarheim Maria Teresa Bouza Alexander agrifoglio Filip Fredén Tina Palmieri Lynda E.Painting Marcus J.Schultz LAMiNAR investigators Academic Medical Center University of AmsterdamAmsterdamAZ 1105The Netherlands Department of Anaesthesia and Intensive Therapy Medical University of Lublin Aleje Racklawickie 1–20-059 Lublin–Poland AZ JAN PALFIJN GENT Watersportlaan 5–9000 Gent–Belgium ABC Medical School SaPauloBangúSP 5001Brazil Service d’Anesthésie Réanimation Chirurgicale Nantes 44093France University Hospital Carl Gustav Carus Dresden 01307Germany St James University Hospital Dublin D08 NHY1Ireland University of Genoa GenoaGE 16128Italy Linkoing University Hospital Linkoing 58185Sweden Maasstad Hospital RotterdamDZ 3079The Netherlands Red Cross Hospital BeverwijkLE 1942The Netherlands Martini Hospital GroningenNT 9728The Netherlands University of Texas Medical Branch GalvestonTX 77555USA Turin CTO Burn Center TurinTO 10126Italy Rigshospitalet Copenhagen 2100Denmark La Paz University Hospital Madrid 28046Spain Ross Tilley Burn Centre Sunnybrook Health Sciences CentreToronto M4N 3M5Canada Royal Brisbane and Women’s Hospital Queensland UniversityHerstonQLD 4029Australia Australian and New Zealand Intensive Care Research Centre.Monash University MelbourneVIC 3004Australia GH St-Louis-Lariboisière APHPParis 75010France BG Klinik Ludwigshafen Ludwigshafen 67071Germany Papanikoalou Hospital Thessaloniki 54621Greece Middlemore Hospital OtahuhuAuckland 2025New Zealand Haukeland University Hospital Bergen 5021Norway Uppsala University Hospital Uppsala 75185Sweden Concord Repatriation General Hospital NSW University of SydneyConcord 2139Australia Ziekenhuis Netwerk Antwerpen-Stuivenberg Antwerpen 2060Belgium Universidade de Sao Paulo Sao Paulo 01246-903Brazil Universidade Estadual de Londrina Londrina 86057-970Brazil Sunnybrook Health sciences Centre Toronto M4N 3M5Canada CHU Lyon St Luc Lyon 69007France CHU Nantes Service dánesthesie reanimation chirugicale Nantes 44093France Hopital Roger Salengro CHRU LilleLille 59037France Saint-Louis Hospital Paris 75010France BG University Hospital Bergmannsheil Bo

Background:It is unknown whether lung-protective ventilation is applied in burn patients and whether they benefit from it.This study aimed to determine ventilation practices in burn intensive care units(ICUs)and investigate the association between lung-protective ventilation and the number of ventilator-free days and alive at day 28(VFD-28).Methods:This is an international prospective observational cohort study including adult burn patients requiring mechanical ventilation.Low tidal volume(V_(T))was defined as V_(T)≤8 mL/kg predicted body weight(PBW).Levels of positive end-expiratory pressure(PEEP)and maximum airway pressures were collected.The association between V_(T) and VFD-28 was analyzed using a competing risk model.Ventilation settings were presented for all patients,focusing on the first day of ventilation.We also compared ventilation settings between patients with and without inhalation trauma.Results:A total of 160 patients from 28 ICUs in 16 countries were included.Low V_(T) was used in 74%of patients,median V_(T) size was 7.3[interquartile range(IQR)6.2–8.3]mL/kg PBW and did not differ between patients with and without inhalation trauma(p=0.58).Median VFD-28 was 17(IQR 0–26),without a difference between ventilation with low or high V_(T)(p=0.98).All patients were ventilated with PEEP levels≥5 cmH_(2)O;80%of patients had maximum airway pressures<30 cmH_(2)O.Conclusion:In this international cohort study we found that lung-protective ventilation is used in the majority of burn patients,irrespective of the presence of inhalation trauma.Use of low V_(T) was not associated with a reduction in VFD-28.Trial registration:Clinicaltrials.gov NCT02312869.Date of registration:9 December 2014.

关键词： Mechanical ventilation Inhalation trauma Lung-protective Critical care

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Genetic mechanisms of critical illness in Covid-19

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四川生理科学杂志 2020年第4期42卷 455-455页

作者： Erola Pairo-Castineira Roslin Institute University of Edinburgh Edinburgh UK MRC Human Genetics Unit Institute of Genetics and Molecular Medicine University of Edinburgh Western General Hospital Edinburgh UK Genomics England London UK Centre for Inflammation Research The Queen’s Medical Research Institute University of Edinburgh Edinburgh UK Centre for Genomic and Experimental Medicine Institute of Genetics and Molecular Medicine University of Edinburgh Western General Hospital Edinburgh UK Edinburgh Clinical Research Facility Western General Hospital University of Edinburgh Edinburgh UK Intensive Care National Audit & Research Centre London UK Institute for Molecular Bioscience The University of Queensland Brisbane Australia Biostatistics Group School of Life Sciences Sun Yat-sen University Guangzhou China The Crick Institute London UK Intensive Care Unit Royal Infirmary of Edinburgh Edinburgh UK School of Life sciences Westlake University Hangzhou China Westlake Laboratory of Life sciences and Biomedicine Hangzhou China Wellcome Centre for Human Genetics University of Oxford Oxford UK Department of Medicine University of Cambridge Cambridge UK Department of Intensive Care Medicine Guy’s and St Thomas’ NHS Foundation Trust London UK School of Immunology and Microbial sciences King’s College London London UK NIHR Health Protection Research Unit for Emerging and Zoonotic Infections Institute of Infection Veterinary and Ecological Sciences University of Liverpool Liverpool UK MRC-University of Glasgow Centre for Virus Research Institute of Infection Immunity and Inflammation College of Medical Veterinary and Life Sciences University of Glasgow Glasgow UK William Harvey Research Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK Centre for Tropical Medicine and Global Health Nuffield Department of Medicine University of Oxford Oxford UK Clinical Research Centre at St Vincent’s University Hospital University Col

Host-mediated lung inflammation is present,1 and drives mortality,2 in critical illness caused by Covid-19.Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development.3 Here we report the results of the GenOMICC(Genetics Of Mortality In Critical Care)genome-wide association study(GWAS)in 2244 critically ill Covid-19 patients from 208 UK intensive care units(ICUs).We identify and replicate novel genome-wide significant associations,on chr12q24.13(rs10735079,p=1.65[Formula:see text]10-8)in a gene cluster encoding antiviral restriction enzyme activators(OAS1,OAS2,OAS3),on chr19p13.2(rs2109069,p=2.3[Formula:see text]10-12)near the gene encoding tyrosine kinase 2(TYK2),on chr19p13.3(rs2109069,p=3.98[Formula:see text]10-12)within the gene encoding dipeptidyl peptidase 9(DPP9),and on chr21q22.1(rs2236757,p=4.99[Formula:see text]10-8)in the interferon receptor gene IFNAR2.We identify potential targets for repurposing of licensed medications:using Mendelian randomisation we found evidence in support of a causal link from low expression of IFNAR2,and high expression of TYK2,to life-threatening disease;transcriptome-wide association in lung tissue revealed that high expression of the monocyte/macrophage chemotactic receptor CCR2 is associated with severe Covid-19.Our results identify robust genetic signals relating to key host antiviral defence mechanisms,and mediators of inflammatory organ damage in Covid-19.Both mechanisms may be amenable to targeted treatment with existing drugs.Large-scale randomised clinical trials will be essential before any change to clinical practice.

关键词： lung drugs critical

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