检索结果-南通市图书馆

第九届全国遗传病诊断与产前诊断学术交流会暨产前诊断和医学遗传学新技术研讨会

作者：吕昔琴 affymetrix

＜正＞～～

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Quantifying Dynamical Predictability:the Pseudo-Ensemble Approach

引用

Chinese Annals of Mathematics,Series B 2009年第5期30卷 569-588页

作者： Jianbo GAO Wenwen TUNG Jing HU PMB Intelligence LLC PO Box 2077 West Lafayette IN 47996 USA. Purdue Climate Change Research Center Department of Earth and Atmospheric Sciences Purdue University 550 Stadium Mall Dr. West Lafayette IN 47907-2051 USA. PMB Intelligence LLC PO Box 2077 West Lafayette IN 47996 USA affymetrix Inc. 3380 Central Expressway Santa Clara CA 95051 USA.

The ensemble technique has been widely used in numerical weather prediction and extended-range *** approaches to evaluate the predictability using the ensemble technique can be divided into two major *** is dynamical,including generating Lyapunov vectors,bred vectors,and singular vectors,sampling the fastest error-growing directions of the phase space,and examining the dependence of prediction efficiency on ensemble *** other is statistical,including distributional analysis and quantifying prediction utility by the Shannon entropy and the relative ***,with simple models,one could choose as many ensembles as possible,with each ensemble containing a large number of *** the forecast models become increasingly complicated,however,one would only be able to afford a small number of ensembles,each with limited number of members,thus sacrificing estimation accuracy of the forecast *** uncover connections between different information theoretic approaches and between dynamical and statistical approaches,we propose an (∈;T)-entropy and scale-dependent Lyapunov exponent——based general theoretical framework to quantify information loss in ensemble *** importantly,to tremendously expedite computations,reduce data storage,and improve forecasting accuracy,we propose a technique for constructing a large number of "pseudo" ensembles from one single solution or scalar *** pseudo-ensemble technique appears to be applicable under rather general conditions,one important situation being that observational data are available but the exact dynamical model is unknown.

关键词： Dynamical predictability Ensemble forecasting Relative entropy Kolmogorov entropy Scale-dependent Lyapunov exponent

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

CYP2D6PCR基因型与DXT表型和基因芯片检测的比较(英文)

引用

中国临床药理学与治疗学 2002年第2期7卷 100-105页

作者：严奉祥廖端芳 CHOU Wen-Hwei WEDLUND Peter-J ROBBINS-WEILER Dorris-K RYDER Thomas-B PERBOST ClotildeQuintiles Inc FAIRCHILD Maureen KOCH Walter-H 南华大学药物药理研究所衡阳421001 College of Pharmacy University of Kentucky Quintiles Inc affymetrix Santa Clara CA Roche Molecular Inc Alameda CA

目的 :为了评价CYP2D6的基因型和表型的联系以及基因芯片在CYP2D6多基因分析中的应用。方法 :2 4 2健康志愿者 ,口服dextromethorphan后收集尿液测定其代谢率 ,收集 2 0ml血提取DNA ,并通过基因特异性PCR和 / (或 )基因芯片分析CYP2D6 ... 详细信息

目的 :为了评价CYP2D6的基因型和表型的联系以及基因芯片在CYP2D6多基因分析中的应用。方法 :2 4 2健康志愿者 ,口服dextromethorphan后收集尿液测定其代谢率 ,收集 2 0ml血提取DNA ,并通过基因特异性PCR和 / (或 )基因芯片分析CYP2D6 2——— 11, 17和多拷贝CYP2D6基因 ,其中 5个基因 ( 3、 4、 6、 7和 9)用PCR和CYD4 5 0基因芯片同时分析。结果 :CYP2D6基因型比表型更富有信息和更能反映CYP2D6酶的表达。CYP2D6 3、 4、 6、 7和 9的基因检测在CYP4 5 0基因芯片和基因特异性PCR中显示高度的一致性。结论 :基因芯片在检测基因多位点的多基因中是一个有发展前途和可靠的方法。

关键词： CYP2D6 表型基因型 PCR 寡核苷酸微陈列杂交

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

CTGF, intestinal stellate cells and carcinoid fi brogenesis

引用

World Journal of Gastroenterology 2007年第39期13卷 5208-5216页

作者： M Kidd IM Modlin MD Shapiro RL Camp SM Mane W Usinger JR Murren Departments of Surgery Yale University School of Medicine New Haven Connecticut 06520-8062 United States Departments of Pathology Yale University School of Medicine New Haven Connecticut 06520-8062 United States Departments of affymetrix Resource Keck Biotechnology Resource Laboratory Yale University School of Medicine New Haven Connecticut 06520-8062 United States Fibrogen Inc San Francisco CA United States Departments of Medical Oncology Yale University School of Medicine New Haven Connecticut 06520-8062 United States

AIM： To investigate the role of small intestinal carcinoid tumor-derived fibrotic mediators, TGFβ1 and CTGF, in the mediation of fibrosis via activation of an ＂intestinal＂ stellate cell. METHODS： GI carcinoid tumors were collected for Q RT-PCR analysis of CTGF and TGFβ1. Markers of stellate cell desmoplasia were identified in peritoneal fibrosis by immunohistochemistry and stellate cells cultured from fresh resected fibrotic tissue. CTGF and TGFβ1 were evaluated using quantitative tissue array profiling （AQUA analysis） in a GI carcinoid tissue microarray （TMA） with immunostaining and correlated with clinical and histologically documented fibrosis. Serum CTGF was analyzed using a sandwich ELISA assay. RESULTS： Message levels of both CTGF and TGFβ1 in SI carcinoid tumors were significantly increased （〉 2-fold, P 〈 0.05） versus normal mucosa and gastric （non-fibrotic） carcinoids. Activated stellate cells and markers of stellate cell-mediated fibrosis （vimentin, desmin） were identified in histological fibrosis. An intestinal stellate cell was immunocytochemically and biochemically characterized and its TGFβ1 （10-7M） initiated CTGF transcription response （〉 3-fold, P 〈 0.05） demonstrated. In SI carcinoid tumor patients with documented fibrosis, TMA analysis demonstrated higher CTGF immunostaining （AQUA Score： 92 ± 8, P 〈0.05）, as well as elevated TGFβ1 （90.6 ± 4.4, P 〈 0.05）. Plasma CTGF （normal 12.5 ± 2.6 ng/mL） was increased in SI carcinoid tumor patients （31 ± 10 ng/mL, P 〈 0.05） compared to non-fibrotic GI carcinoids （〈 15 ng/mL） CONCLUSION： SI carcinoid tumor fibrosis is a CTGF/ TGFβl-mediated stellate cell-driven fibrotic response. The delineation of the biology of fibrosis will facilitate diagnosis and enable development of agents to obviate its local and systemic complications.

关键词： Carcinoid Connective tissue growth factor fibrosis Small intestine Stellate cell TGFI

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：