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Effect of gamification applications on success of dentistry students

World Journal of Methodology 2025年第1期15卷 80-87页

作者： Hatice Ahsen Deniz Elif Polat Balkan Burak İncebeyaz Kıvanç Kamburoğlu Department of Dentomaxillofacial Radiology Ankara University Faculty of DentistryAnkara 06500Türkiye

BACKGROUND Gamification,the use of game materials in education,has been used in several scientific fields,and studies have demonstrated its effectiveness in student *** To evaluate whether the success of 4th-and 5th-grade dentistry students increases when using the gamification applications Kahoot!and *** An experimental design was used to measure the effect of gamification applications on students who were taught using the traditional *** this purpose,Mentimeter and Kahoot!applications were used in this experimental *** groups of 4th-and 5th-grade students were formed:Mentimeter,Kahoot!,and control *** effect of gamification applications on achievement was evaluated by administering a post-test to these groups after the instructional ***-way analysis of variance and t-tests were used for statistical *** A total of 35.5%of the students were in the Mentimeter group,29.8%in the Kahoot!group,and 34.6%in the control *** the total number of students,54.8%were female and 45.2%were male,while 52.2%were 5th-grade students and 47.8%were 4th-grade *** overall grade point average was found to be 66.65(range,24-100).There was a statistically significant difference in average success scores between students of different groups(P=0.003<0.05)and grades(P=0.036<0.05).The average success score was the highest in the Mentimeter group(71.64)and the lowest in the Kahoot!group(62.15).In the control group,this score was *** average success score was higher for students in the 5thgrade(68.16)and for female students(68.84).CONCLUSION Gamification has a great potential in the education of dentomaxillofacial radiology *** outperformed both the Kahoot!and the traditional method in terms of average student success rates.

关键词： Gamification Mentimeter Kahoot! Education dentistry

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An early report: a modified porphyrin-linked metronidazole targeting intracellular Porphyromonas gingivalis in cultured oral epithelial cells

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International Journal of Oral Science 2017年第3期9卷 167-173页

作者： Ping Ye Jiho Chang Lin Feng Foo Benjamin C-M Yap Institute of Dental Research Centre for Oral Health Westmead Hospital affiliation of faculty of dentistry the University of Sydney

Porphyromonas gingivalis （P. gingivalis） has a strong association with the pathogenesis of periodontal disease. Recurrence of periodontal disease following therapy is attributed to numerous factors, and of growing interest is the potential problem of intracellular bacteria that are able to persist and multiply within the host cell, thereby facilitating relapse of infection. The effect of antibiotic therapy in controlling P. gingivalis is questionable. Accordingly, while metronidazole is very effective against anaerobic extracellular P. gingivalis by disrupting the DNA of anaerobic microbial cells, this antibiotic does not effectively penetrate into mammalian cells to inhibit intracellular bacteria. Therefore in the present study, a modified porphyrin-linked metronidazole adducts, developed in our laboratory, was used to kill intracellular P. gingivalis. A series of experiments were performed, including cytotoxicity assays and cellular uptake of adducts by flow cytometry coupled with live cell imaging analysis, P. gingivalis invasion and elimination assays, and the analysis of colocalization of P. gingivalis and porphyrin-linked metronidazole by confocal laser scanning microscopy. Findings indicated that P. gingivalis and porphyrin-linked metronidazole were colocalized in the cytoplasm, and this compound was able to kill P. gingivalis intracellular with a sufficient culture time. This is a novel antimicrobial approach in the elimination of P. gingivalis from the oral cavity.

关键词： porphyrin-linked metronidazole Porphyromonas gingivalis periodontitis oral epithelial cells

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Non-Thermal Atmospheric Plasma:Can it Be Taken as a Common Solution for the Surface Treatment of Dental Materials?

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Plasma Science and Technology 2016年第4期18卷 417-423页

作者： Emre SEKER Mehmet Ali KILICARSLAN Serdar POLAT Emre OZKIR Suat PAT Department of Prosthodontics Faculty of DentistryEskisehir Osmangazi University Department of Prosthodontics Faculty of DentistryAnkara University Department of Prosthodontics Faculty of DentistryGazi University Department of Prosthodontics Faculty of DentistryAfyon Kocatepe University faculty of Art and Science Eskisehir Osmangazi University

This study aimed to evaluate the surface roughness and wetting properties of various dental prosthetic materials after different durations of non-thermal atmospheric plasma（NTAP）*** hundred and sixty discs of titanium（Ti）（n：40）,cobalt chromium（Co-Cr）（n：40）,yttrium stabilized tetragonal zirconia polycrystals（Y-TZP）（n：40）and polymethylmethacrylate（PMMA）（n：40）materials were machined and smoothed with silicon carbide *** surface roughness was evaluated in a control group and in groups with different plasma exposure times [1-3-5 s].The average surface roughness（Ra）and contact angle（CA）measurements were recorded via an atomic force microscope（AFM）and tensiometer,*** changes were examined with a scanning electron microscope（SEM）.Data were analyzed with two-way analysis of variance（ANOVA）and the Tukey HSD test α=0.05）.According to the results,the NTAP surface treatment significantly affected the roughness and wettability properties（P 〈 0.05）.SEM images reveal that more grooves were present in the NTAP *** an increase in the NTAP application time,an apparent increment was observed for Ra,except in the PMMA group,and a remarkable reduction in CA was observed in all *** is concluded that the NTAP technology could enhance the roughening and wetting performance of various dental materials.

关键词： dental material atmospheric plasma surface treatment roughness contact angle

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Effect of Different Bleaching Applications on the Surface Properties and Staining Susceptibility of Dental Composites

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Journal of Wuhan University of Technology(Materials Science) 2016年第3期31卷 677-683页

作者： Pinlar Gul Osman Tolga Harorli Nilgün Ak Mustafa Gündogdu Department of Restorative dentistry Faculty of DentistryAtaturk University25240-ErzurumTurkey Department of Restorative dentistry Faculty of DentistryAkdeniz University07058-AntalyaTurkey Department of Prosthetic dentistry faculty of dentistry Ataturk University25240-ErzurumTurkey

The aim of this study was to investigate the effects of two bleaching systems on micro hardness, surface roughness and color stability of two novel dental composites. Ormocer based restorative Admira and nano-filled composite Clearfil Majesty Esthetic were bleached with 10% carbamide peroxide （Opalescence PF） or 35% hydrogen peroxide （Beyond Max 5） and subsequently immersed in four different staining solutions （coffee, tea, red wine, and cola）. Distilled water was used as a control. Color measurements were performed with a spectrophotometer. Vickers micro hardness and roughness data were analyzed with two- way analysis of variance for repeated measures. The analysis of variance was used to compare the color change values. Duncan＇s multiple comparison test was applied to compare the results （a = 5%）. AE~＂ values over 3.3 were considered clinically unacceptable. Micro hardness and surface roughness values of the tested composites were decreased significantly after bleaching applications. Red wine and tea storage caused perceptible discolorations in the composite resin materials after 30 days of 3-hour immersion. Home or office bleaching applications can affect the surface properties of resin composites and accelerate the staining process.

关键词： composite resin bleaching surface roughness micro hardness discoloration

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Efficacy of two calcium phosphate pastes on the remineralization of artificial caries: a randomized controlled double-blind in situ study

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International Journal of Oral Science 2013年第4期5卷 224-228页

作者： Somkamol Vanichvatana Prim Auychai Department of Pediatric dentistry Faculty of DentistryChulalongkorn University

To test the efficacy of two calcium phosphate pastes compared to that of fluoride toothpaste on remineralizing artificial caries in situ, this study had a double-blind crossover in situ design, involving three experimental phases of 14 days each, with an 8-day washout period between phases. Nine healthy subjects participated in the study. The subjects wore removable palatal appliances mounted with six human enamel slabs with artificial caries lesions, and in each of the experimental phases, used one of the following methods two times/day： group A, brushing with 1.0 g of Colgate Regular Flavor, followed by applying 0.25 g of Tooth Mousse Plus; group B, brushing with 0.25 g of Clinpro Tooth Crbme; and group C, brushing with 1.0 g of Colgate Regular Flavor. After 14 days, the enamel slabs （54 slabs/ group） were embedded in resin, sectioned and examined with a polarized-light microscope, and the lesion areas were quantified using Image-Pro Plus. All experimental groups showed a significant reduction in lesion area compared to the initial lesion area （paired t-test, P〈O.O01）. The mean reduction in lesion area of Groups A, B and C were （0.029__.0.010）, （0.030_＋0.009） and （0.027_＋0.009） mm2, respectively. There were no statistical differences between groups （KruskaI-Wallis test, P〉0.05）. All three groups remineralized the enamel slab lesions, indicating model sensitivity to fluoride. Given the differences in usage amounts and treated regimens, Clinpro Tooth Crbme provided similar benefits to the fluoride toothpaste; however, no additional benefit of Tooth Mousse Plus was observed when used in conjunction with the fluoride toothpaste.

关键词： Clinpro casein phosphopeptide-amorphous calcium phosphate fluoride functionalized tricalcium phosphate remineralization

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Immunohistochemical expression of matrix metalloproteinase-9 and 13 in oral squamous cell carcinoma and their role in predicting lymph node metastasis

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World Journal of Methodology 2025年第2期15卷 108-116页

作者： Bhari Sharanesha Manjunatha Keshav T Handge Vandana Sandeep Shah Yasser Eid Al-Thobaiti Deepak Gowda Sadashivappa Pateel Department of Basic Oral Medicine and Allied Dental Sciences Taif UniversityAt`Taif 26571MakkahSaudi Arabia Department of Oral and Maxillofacial Pathology Dr.Vasantrao Pawar Medical CollegeHospital and Research CentreNashik 423101MaharashtraIndia Department of Oral Pathology and Microbiology KM Shah Dental College and HospitalSumandeep VidyapeethVadodara 391760GujaratIndia Department of Oral and Maxillofacial Surgery and Diagnostic Sciences Faculty of DentistryTaif UniversityAl-Haweiah 26571 MakkahSaudi Arabia Department of Oral Pathology and Microbiology Faculty of DentistryMAHSA UniversitySelangor 42610Malaysia

BACKGROUND One of the main characteristics of oral squamous cell carcinoma(OSCC)is that it metastasizes to cervical lymph nodes frequently with a high degree of local invasiveness.A primary feature of malignant tumors is their penetration of neighboring tissues,such as lymphatic and blood arteries,due to the tumor cells'capacity to break down the extracellular matrix(ECM).Matrix metalloproteinases(MMPs)constitute a family of proteolytic enzymes that facilitate tissue remo-deling and the degradation of the ***-9 and MMP-13 belong to the group of extracellular matrix degrading enzymes and their expression has been studied in OSCC because of their specific ***-13,a collagenase family member,is thought to play an essential role in the MMP activation cascade by breaking down the fibrillar collagens,whereas MMP-9 is thought to accelerate the growth of *** MMP-13 expression has been associated with tumor behavior and patient prognosis in a number of malignant *** authors wish to thank Jadhav KB for his valuable opinion during the preparation of the manuscript.

关键词： Matrix metalloproteinases Oral squamous cell carcinoma Tumor staging Immunohistochemistry Invasion Lymph node metastasis TNM stage

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The oral commensal Streptococcus mitis activates the aryl hydrocarbon receptor in human oral epithelial cells

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International Journal of Oral Science 2017年第3期9卷 145-150页

作者： stian a engen gro h rørvik olav schreurs inger js blix karl schenck department of oral biology faculty of dentistryuniversity of osloOsloNorway institute of clinical dentistry faculty of dentistryuniversity of osloOsloNorway

Streptococcus mitis （S. mitis） is a pioneer commensal bacterial species colonizing many of the surfaces of the oral cavity in healthy individuals. Yet, not much information is available regarding its interaction with the host. We used examination of its transcriptional regulation in oral keratinocytes to elucidate some of its potential roles in the oral cavity. Transcription factor analysis of oral keratinocytes predicted S. *** activation of aryl hydrocarbon receptor （AhR）, Activation and functionality of AhR was confirmed through nuclear translocation determined by immunofluorescence microscopy and real-time polymerase chain reaction with reverse transcription analysis of CYPIA1, the hallmark gene for AhR activation. Addition of Streptococcus mutans or Streptococcus gordonfi did not induce CYPIA1 transcription in the keratinocyte cultures. Introduction of an AhR-specific inhibitor revealed that S. mitis-mediated transcription of CXCL2 and CXCL8 was regulated by AhR. Elevated levels of pmstaglandin E2 （enzyme-linked immunosorbent assay） in supernatants from S. mitis-treated oral epithelial cells were also attenuated by inhibition of AhR activity. The observed AhR-regulated activities point to a contribution of S. mitis in the regulation of inflammatory responses and thereby to wound healing in the oral cavity. The concept that the oral commensal microbiota can induce AhR activation is important, also in view of the role that AhR has in modulation of T-cell differentiation and as an anti-inflammatory factor in macrophaees.

关键词： aryl hydrocarbon receptor commensal inflammation oral epithelium prostaglandin E2 Streptococcus

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A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon C.Daeschler Katelyn J.W.So Konstantin Feinberg Marina Manoraj Jenny Cheung Jennifer Zhang Kaveh Mirmoeini JPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

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3D TECA hydrogel reduces cellular senescence and enhances fibroblasts migration in wound healing

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Asian Journal of Pharmaceutical Sciences 2018年第4期13卷 317-325页

作者： Luay Thanoon Younis Mohamed Ibrahim Abu Hassan Tara Bai Taiyeb Ali Tommy Julianto Bustami faculty of dentistry Universiti Teknologi MARA faculty of dentistry Universiti Teknologi MARAMAHSA University faculty of Pharmacy

This study was designed to investigate the effect of 3 D TECA hydrogel on the inflammatory-induced senescence marker, and to assess the influence of the gel on the periodontal lig-ament fibroblasts(PDLFs) migration in wound healing in vitro. PDLFs were cultured with20 ng/ml TNF-α to induce inflammation in the presence and absence of 50 μM 3 D TECA gelfor 14 d. The gel effect on the senescence maker secretory associated-β-galactosidase(SA-β-gal) activity was measured by a histochemical staining. Chromatin condensation and DNAsynthesis of the cells were assessed by 4,6-diamidino-2-phenylindole and 5-ethynyl-2-deoxyuridine fluorescent staining respectively. For evaluating fibroblasts migration, scratchwound healing assay and Pro-Plus Imaging software were used. The activity of senescencemarker, SA-β-gal, was positive in the samples with TNF-α-induced inflammation. SA-β-galpercentage is suppressed( > 65%, P < 0.05) in the treated cells with TECA gel as compared tothe non-treated cells. Chromatin foci were obvious in the non-treated samples. DNA syn-thesis was markedly recognized by the fluorescent staining in the treated compared to non-treated cultures. Scratch wound test indicated that the cells migration rate was significantlyhigher(14.9 μm^2/h, P < 0.05) in the treated versus(11 μm^2/h) for control PDLFs. The new for-mula of 3 D TECA suppresses the inflammatory-mediated cellular senescence and enhancedfibroblasts proliferation and migration. Therefore, 3 D TECA may be used as an adjunct to ac-celerate repair and healing of periodontal tissues.

关键词： 3D TECA Cellular senescence SA-β-gal TNF-α Fibroblast migration

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Evaluation of periodontal healing in class II furcation defects following guided tissue regeneration with two different types of poly lactic acid membranes

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Chinese Medical Journal 2004年第2期17卷 270-274页

作者： Deniz Cetiner Berrinnsal Ates Parlar ElifGültekin BülentKurtis Department of Periodontology faculty of dentistry Gazi University Ankara TurkeyDepartment of Periodontology Faculty of Dentistry Gazi University Ankara TurkeyDepartment of Periodontology Faculty of Dentistry Gazi University Ankara TurkeyDepartment of Pathology Faculty of Dentistry Gazi University Ankara TurkeyDepartment of Periodontology Faculty of Dentistry Gazi University Ankara Turkey

Background Guided tissue regeneration procedures provide predictable reconstruction of periodontal tissues in the treatment of furcation involvements in animals and huamns. This study was to compare long-term effectiveness of two different types of polylactic acid (PLA) membranes on periodontal regeneration in surgically created class II furcation defects in dogs.Methods Full thickness mucoperiosteal flap was raised on the buccal aspects of the experimental teeth and class II furcation defects having 5 mm vertical dimensions were created on mandibular premolar III and IV on each quadrant. The exposed root surfaces were thoroughly planed and PLA membranes were placed over the experimental defects on both sites. One site received liquid polymer membrane (LPM), and resorbable periodontal mesh (RPM) membranes were applied to the other site. The animals were sacrificed at 7 months after surgery and the specimens were processed for histological evaluation.Results The average length of new attachment formed on the treated roots in both groups ranged from 3. 02 mm to 4. 5 mm. Complete bone filling was observed at the furcation sites. No statistically significant differences were found between two membranes in any of the parameters (P>0. 05).Conclusion This study demonstrates favorable regenerative outcomes by the use of two different types of PLA membranes that could be used as alternatives for guided tissue regeneration (GTR).

关键词： guided tissue regeneration polyfactic acid membranes furcation/surgery experimental studies

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