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Relationship between left-behind status and cognitive function in older Chinese adults: a prospective 3-year cohort study

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General Psychiatry 2023年第3期36卷 148-157页

作者： Hong-Guang Zhang Fang Fan Bao-Liang Zhong Helen Fung-Kum Chiu Department of Psychiatry Affiliated Wuhan Mental Health CenterTongji Medical College of Huazhong Universityof Science&TechnologyWuhanHubeiChina Department of Psychiatry Wuhan Mental Health CenterWuhanHubeiChina Department of Clinical Psychology Wuhan Hospital for PsychotherapyWuhanHubeiChina Department of Psychiatry The Chinese University of Hong KongHong KongChina

Background Due to the inaccuracy of the traditional geographical distance-based definition of left-behind status,data on the negative effect of left-behind status on cognitive function among older adults are controversial.Aims This study examined the cross-sectional and longitudinal associations of left-behind status with cognitive function in older Chinese adults.The left-behind status definition was based on the frequency of face-to-face parent-child meetings.Methods Data from a nationally representative sample of 8682 older adults(60+years)in 2015(5658 left behind and 3024 non-left behind),of which 6933 completed the follow-up in 2018,were obtained from the China health and Retirement Longitudinal Study.Left-behind older adults werebroadlydefined as those aged 60+years who had living adult children and saw their children less than once per month.The cognitive function was assessed with a composite cognitive test with higher total scores indicating better cognitive function.Results Left-behind older adults had significantly lower cognitive test scores than non-left-behind older adults in both 2015(11.1(6.0)vs 13.2(5.9),t=15.863,p<0.001)and 2018(10.0(6.6)vs 12.4(6.7),t=14.177,p<0.001).After adjusting for demographic factors,lifestyle factors,chronic medical conditions and the baseline cognitive test score(in the longitudinal analysis only),on average,the cognitive test score of left-behind older adults was 0.628 lower than their non-left-behind counterparts in 2015(t=5.689,p<0.001).This difference in cognitive test scores attenuated to 0.322 but remained significant in 2018(t=2.733,p=0.006).Conclusions Left-behind older Chinese adults have a higher risk of poor cognitive function and cognitive decline than their non-left-behind counterparts.Specific efforts targeting left-behind older adults,such as encouraging adult children to visit their parents more regularly,are warranted to maintain or delay the progression of cognitive decline.

关键词： function cognitive maintain

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Clinical characteristics of hospitalised patients with schizophrenia who were suspected to have coronavirus disease(COVID-19)in Hubei Province,China

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General Psychiatry 2020年第2期33卷 73-79页

作者： Xuebing Liu Hong Lin Haifeng Jiang Ruihua Li Na Zhong Hang Su Yi Li Min Zhao wuhan mental health center WuhanChina Yichang Special Care Hospital YichangChina Shanghai Jiao Tong University School of Medicine affiliated Shanghai mental health center ShanghaiChina

Background Since the outbreak of C0VID-19,no data have been available for hospitalised psychiatric patients who are suspected to have COVID-19.We performed a comprehensive investigation of the clinical features of hospitalised patients with schizophrenia with or without suspected COVID-19 in Hubei Province,China.Aim To explore the clinical characteristics of hospitalised patients with schizophrenia with suspected COVID-19 in Hubei Province,China.M ethods 21 hospitalised patients with schizophrenia with suspected COVID-19(COVID-19 suspected group)in the isolation ward of a mental health hospital in wuhan and 30 hospitalised patients with schizophrenia(clean group)in the general ward of another mental health hospital in Yichang were recruited.We retrospectively reviewed their clinical characteristics,laboratory findings and chest CT results before 21 February 2020.We also compared the emotional and mental symptoms between the two groups.Results Medical records revealed that 21 COVID-19 suspected patients were transferred to the isolation ward between 30 January 2020 and 15 February 2020.The mean age(SD)of COVID-19 suspected patients was 43.1(2.6).12(57.1%)patients showed abnormalities on chest CT before onset of respiratory symptoms.14(66.7%)patients had psychiatric medications adjustment after detection of abnormal chest CT findings.By 21 February,one patient was confirmed to have COVID-19.Even though the remaining 20(95.2%)were negative for at least two reverse transcription PCR tests,11(52.4%)patients met the diagnostic criteria for clinically confirmed cases.Compared with patients in the clean group,patients in the suspected COVID-19 group showed significantly higher stress,depression and anxiety levels and poorer sleep quality.Conclusion Setting up an independent isolation ward for hospitalised psychiatric patients who are suspected to have symptoms of COVID-19 helped control the spread of the epidemic.Patients with schizophrenia suspected to have COVID-19 showed increased stress and mood and sleep disturbance

关键词： characteristics finding Hubei

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The Risk and Prevention of Novel Coronavirus Pneumonia Infections Among Inpatients in Psychiatric Hospitals

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Neuroscience Bulletin 2020年第3期36卷 299-302页

作者： Yuncheng Zhu Liangliang Chen Haifeng Ji Maomao Xi Yiru Fang Yi Li Shanghai mental health center Shanghai Jiao Tong University School of MedicineShanghai 200030China Shanghai Changning mental health center(affiliated to East China Normal University) Shanghai 200335China Institute of Burns Tongren Hospital of Wuhan University(Wuhan Third Hospital)Wuhan 430000China Affiliated Wuhan Mental Health Center Tongji Medical College of Huazhong University of Science and TechnologyWuhan 430012China CAS center for Excellence in Brain Science and Intelligence Technology Shanghai 200031China Shanghai Key Laboratory of Psychotic Disorders Shanghai 201108China

Dear Editor,Since the middle of December 2019,human-to-human transmission of novel coronavirus pneumonia(NCP,also called COVID-19)has occurred among close contacts[1].After the outbreak on January 21,2020,it was swiftly included among the Class B infectious diseases stipulated in the Law of the People’s Republic of China on the Prevention and Control of Infectious Diseases,and measures for prevention and control of Class A infectious diseases were adopted.At 21:27 on February 12,2020,the China News Network updated information to include epidemic data from the National health Commission and official channels in Hong Kong,Macao,and Taiwan regions:the highest death rate was in wuhan City(Table 1).Overload of inpatients at hospitals may play a negative role in the overall therapeutic effect and contribute to the death rate.

关键词： prevention Taiwan measures

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Identification and predictive analysis for participants at ultra-high risk of psychosis:A comparison of three psychometric diagnostic interviews

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World Journal of Clinical Cases 2022年第8期10卷 2420-2428页

作者： Peng Wang Chuan-Dong Yan Xiao-Jie Dong Lei Geng Chao Xu Yun Nie Sheng Zhang Department of Psychological Rehabilitation the Affiliated Wuhan Mental Health CenterTongji Medical College of Huazhong University of Science&TechnologyWuhan 430022Hubei ProvinceChina

BACKGROUND An accurate identification of individuals at ultra-high risk(UHR)based on psychometric tools to prospectively identify psychosis as early as possible is required for indicated preventive intervention.The diagnostic comparability of several psychometric tools,including the comprehensive assessment of at risk mental state(CAARMS),the structured interview for psychosis-risk syndrome(SIPS)and the bonn scale for the assessment of basic symptoms(BSABS),is unknown.AIM To address the psychometric comparability of CAARMS,SIPS and BSABS for subjects who are close relatives of patients with schizophrenia.METHODS In total,189 participants aged 18-58 years who were lineal relative by blood and collateral relatives by blood up to the third degree of kinship of patients with schizophrenia were interviewed in the period of May 2017 to January 2019.Relatives of the participants diagnosed schizophrenia were excluded.All the participants were assessed for a UHR state by three psychometric tools(CAARMS,SIPS and BSABS).The psychometric diagnosis results included at risk of psychosis(UHR+),not at risk of psychosis(UHR-)and psychosis.Demographic and clinical characteristics were also measured.The inter-rater agreement was assessed for evaluation of the coherence of the three scales.Transition rates for UHR+subjects to psychosis within 2 years were also recorded.RESULTS The overall agreement percentages were 93.12%,92.06%and 93.65%of CAARMS and SIPS,SIPS and BSABS and CAARMS and BSABS,respectively.The overall agreement percentage of the relative functional impairment of the three groups(UHR+,not at risk of psychosis and psychosis)were 89.24%,86.36%and 88.12%,respectively.The inter-rater reliability of the CAARMS,SIPS and BSABS total score was 0.90,0.89 and 0.85.The inter-rater reliability was very good to excellent for all the subscales of these three instruments.For CAARMS,SIPS and BSABS,the kappa coefficient about UHR criteria agreement was 0.87,0.84 and 0.82,respectively(P<0.001).The transition rates of UHR+to psychosis wi

关键词： Psychosis Ultra-high risk Psychosis-Risk syndrome Psychometric diagno-stic Predictive analysis

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低水平低密度脂蛋白胆固醇与认知功能下降

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Science Bulletin 2021年第16期66卷 1684-1690,M0004页

作者：花蓉马燕军李承龙钟宝亮解武祥 Heart and Vascular health Research center Peking University Clinical Research InstitutePeking University First HospitalBeijing 100191China Key Laboratory of Molecular Cardiovascular Sciences(Peking University) Ministry of EducationBeijing 100191China Department of Geriatric Psychiatry Affiliated Wuhan Mental Health CenterTongji Medical College of Huazhong University of Science&TechnologyWuhan 430030China

低水平的低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)与认知功能下降的关系仍不明确.本研究基于当前指南的积极降脂建议(心血管事件高风险者LDL-C应低于70 mg/d L,极高风险者LDL-C应低于55 mg/d L),使用美国健康与... 详细信息

低水平的低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)与认知功能下降的关系仍不明确.本研究基于当前指南的积极降脂建议(心血管事件高风险者LDL-C应低于70 mg/d L,极高风险者LDL-C应低于55 mg/d L),使用美国健康与退休研究第13次(2016年)与第14次(2018年)调查的数据,根据目前指南推荐的降脂目标值,将第13次调查的LDL-C数据划分为5个水平,评估低水平LDL-C与认知功能下降的纵向相关性.结果发现,在7129名研究对象中,与LDL-C为70~99.9 mg/d L的人相比,LDL-C<55mg/d L的人随访两年期间的认知功能综合得分下降速度变慢(慢0.244分/年;95%置信区间:0.065,0.422,P=0.008);LDL-C为55~69.9 mg/d L的人,其认知得分下降速度也变慢.该研究表明在中老年人群里,与中等水平LDL-C(70~99.9 mg/d L)相比,低水平LDL-C(<70 mg/d L,尤其是<55 mg/d L)的认知下降速度变慢.未来有必要进一步开展随机对照试验,以确定目前指南推荐的积极降脂目标对于认知功能的安全性和益处.

关键词：认知功能下降低密度脂蛋白胆固醇中老年人群心血管事件置信区间随机对照试验数据划分

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Biomarkers for early diagnosis of autism obtained through bioinformatics analysis of human blood sample

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Journal of Translational Neuroscience 2021年第4期6卷 7-18页

作者： Liuyin Jin Linman Wu Zhilan Yang Junyi Xiang Wenqian Xu Chang Shu Gaohua Wang center for mental health Renmin Hospital of Wuhan UniversityWuhan 430000China School of mental health Wenzhou Medical UniversityWenzhou 325006China The affiliated mental Hospital of Kunming Medical University Kunming 650000China

Objective:autism spectrum disorder(ASD),a serious disorder that begins early in life,con-tinues throughout the lifespan.Children with ASD who are diagnosed early are more responsive to therapeutic interventions and have less social and language impair-ment than children diagnosed later;however,current di-agnostic measures are mostly applied to children older than one year and lack the appropriate biological markers for early diagnosis of ASD.Using bioinformatic analy-sis,this study explores the molecular information mech-anism of ASD.Method:in this study,we used dataset GSE6575 from Gene Expression Omnibus(GEO)to an-alyze the mRNA expression profile of ASD,including 35 ASD samples and 12 normal control samples looking for different genes and we did enrichment analysis of those genes.We then used the STRING database to construct a protein-protein interaction(PPI)network of differential genes.Finally,Cytoscape plug-in cytoHubba was used to search for hub genes.The diagnostic value of the hub genes was verified by subject operating characteristic curves.Result:we looked for 50 different genes and did an enrichment analysis of those genes.The results of the enrichment analysis showed that these differential genes were mainly concentrated in the response to viruses,the immune regulation of inflammation and energy metabo-lism.Using Cytoscape plug-in cytoHubba,we found ten different genes.We drew ROC curves for all ten genes among which two genes,interleukin 2 receptor subunit beta(IL2Rβ)and perforin 1(PRF1),had good sensitivity and specificity for the early diagnosis of autism.The ar-eas under the ROC curves were 0.855,0.830 for IL2Rβ,PRF1.Conclusion:data analysis using the GEO data-base can provide new insights into the etiology of ASD as well as some possible biomarkers and therapeutic targets for early diagnosis and treatment of ASD.

关键词： autism spectrum disorder(ASD) differentially expressed gene early diagnosis energy metabolism immune regulation

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Aripiprazole in the treatment of acute episode of schizophrenia: a real-world study in China

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Chinese Medical Journal 2023年第9期136卷 1126-1128页

作者： Qian Li Yun’ai Su Xuemei Liao Maosheng Fang Jianliang Gao Jia Xu Mingjun Duan Haiying Yu Yang Yang Zhiyu Chen Jintong Liu Shaoxiao Yan Peifen Yao Shuying Li Changhong Wang Bin Wu Congpei Zhang Tianmei Si Department of Psychopharmacology Peking University Sixth Hospital(Institute of Mental Health)NHC Key Laboratory of Mental Health(Peking University)National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital)Beijing 100191China Department of Psychiatry Wuhan Mental Health CenterWuhanHubei 430012China Department of Child and Adolescent Psychology the Fourth People’s Hospital of HefeiHefeiAnhui 230022China mental health center the First Psychiatric Hospital of HarbinHarbinHeilongjiang 150056China Department of Science and Education the Fourth People’s Hospital of ChengduChengduSichuan 610036China Department of Psychiatry the Chinese People’s Liberation Army 904th HospitalChangzhouJiangsu 213003China Department of Psychiatry Beijing Anding HospitalBeijing 100029China Department of Psychiatry Hangzhou Seventh People’s HospitalHangzhouZhejiang 310063China Department of Adolescent and Child Psychological Behavior Shandong Mental Health CenterJinanShandong 250014China Department of Integrated Chinese and Western Medicine Beijing Huilongguan HospitalBeijing 102208China Department of Psychiatry Shanghai Mental Health CenterShanghai 201109China Department of Psychiatry the First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Department of Psychiatry the Second Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan 456750China Department of Psychiatry Xi’an Mental Health CenterXi’anShaanxi 710067China

To the Editor:Schizophrenia is a progressive,debilitating disease.[1]Safe and effective treatment performed during the acute phase is the first step to improve prognosis,and it is critically important.Aripiprazole is known as a dopamine system stabilizer,and it exerts partial agonism with high affinity at dopamine D2 and serotonin-1A(5-HT1A)receptors as well as antagonism at serotonin-2A(5-HT2A)receptors.[2]It has been shown to be efficacious in amelioration of both positive and negative symptoms of acute schizophrenia,and it shows better tolerance than most antipsychotics.[3]We conducted a real-world study to further confirm the efficacy and safety of aripiprazole in patients with acute episodes of schizophrenia in China and tried to explore the clinical variables,including various drug regimens,which may be correlated with the efficacy of aripiprazole,and provide a basis for the optimization of aripiprazole treatment for patients with acute schizophrenia.

关键词： schizophrenia acute dopamine

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Alterations of Thymic Epithelial Cells in Lipopolysaccharide-induced Neonatal Thymus Involution

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Chinese Medical Journal 2016年第1期129卷 59-65页

作者： Yong-Jie Zhou Hua Peng Yan Chen Ya-Lan Liu affiliated mental health center Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430012 China Department of Pediatrics Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430022 China

Background： Vascular endothelial growth factor （VEGF） in the thymus was mainly produced by the thymic epithelial cells （TECs）, the predominant component of the thymic microenvironment. The progression of TECs and the roles of VEGF in the neonatal thymus during sepsis have not been reported. This study aimed to explore the alterations of TECs and VEGF level in the neonatal thymus involution and to explore the possible mechanisms at the cellular level. Methods： By establishing a model of clinical sepsis, the changes of TECs were measured by hematoxylin-eosin staining. confocal microscopy, and flow cytometry. Moreover, the levels of VEGF in serum and thymus were assessed based on enzyme-linked immunosorbent assay and Western blotting. Results： The number ofthymocytes and TECs was significantly decreased 2411 after lipopolysaccharide （LPS） challenge. （2.40 ± 0,46）× 10^7 vs. （3.93 ± 0.66）× 10^7 and （1.16 ± 0.14）× 10^5 vs. （2.20 ± 0.19）× 10^5, P 〈 0.05, respectively. Cortical TECs and medullary TECs in the LPS-treated mice were decreased 1.5-fold and 3.9-fold, P 〈 0.05, respectively, lower than those in the controls. The number of thymic epithelial progenitors was also decreased. VEGF expression in TECs was down-regulated in a time-dependent manner. Conclusion： VEGF in thymic cells subsets might contribute to the development of TECs in neonatal sepsis.

关键词： Lipopolysaccharide Thymic Epithelial Cells Thymus Involution： Vascular Endothelial Growth Factor

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电针改善躯体形式障碍患者睡眠脑电及事件相关电位的临床研究

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Journal of Acupuncture and Tuina Science 2024年第1期22卷 58-64页

作者：刘占文张郦张敏敏胡学谦陈兴时苏杰洪珏 Shanghai Changning mental health center/affiliated mental health center East China Normal UniversityShanghai 200335China Shanghai mental health center Shanghai 200030China 不详

目的:观察电针治疗对躯体形式障碍(SFD)患者睡眠脑电及事件相关电位(ERP)的影响。方法:选择75例SFD患者为电针组,予以电针神庭和百会治疗,每次30 min,每日1次,连续治疗6 d为1个疗程,疗程间休息1 d,共治疗4个疗程。治疗前采用躯体症状检... 详细信息

目的:观察电针治疗对躯体形式障碍(SFD)患者睡眠脑电及事件相关电位(ERP)的影响。方法:选择75例SFD患者为电针组,予以电针神庭和百会治疗,每次30 min,每日1次,连续治疗6 d为1个疗程,疗程间休息1 d,共治疗4个疗程。治疗前采用躯体症状检查报告单对患者的主要症状进行调查。治疗前和治疗后进行睡眠脑电Quisi监测,检测ERP失匹配负波(MMN)和P300。对40名正常人进行相同的睡眠脑电Quisi监测和ERP检测,作为正常对照组数据。结果:研究过程中电针组13例患者因资料不全被剔除,最终有62例纳入统计分析。在62例SFD患者中,困扰患者的主要症状依次是认知功能障碍、睡眠障碍、呼吸系统、消化系统、五官及心血管系统症状。与正常对照组比较,治疗前电针组患者ERP的MMN及P300潜伏期延长,波幅下降,组间差异均有统计学差异(P0.05);Quisi指标中电针组的TST增加,RL延长,SL缩短,AT减少;睡眠结构的主要改变是S1占比减少,S2占比增加,SE提高,与本组治疗前差异均有统计学意义(P0.05)。除TST、RT、S1占比及SWS外,其他Quisi指标(包括RL、NRP、SL、AT、SE及S2占比)的组间差异均无统计学意义(P>0.05)。结论:SFD患者的临床症状表现多样,多数患者存在睡眠脑电及ERP异常;电针治疗可纠正SFD患者异常的睡眠脑电指标及ERP的MMN和P300。

关键词：针刺疗法电针穴,百会穴,神庭躯体形式障碍事件相关电位多导睡眠描记术失匹配负波

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Change of Disease Spectrum Characteristics of Psychiatric Inpatients Before and After Lockdown Lifted During the COVID-19 Pandemic—wuhan City,Hubei Province,China,2021

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China CDC weekly 2022年第18期4卷 389-392,I0002-I0004页

作者： Jingfang Liu Xuan Gong Xiaofen Li Zhiying Wan Hongqiang Sun Lijun Kang Zhongchun Liu Department of Psychiatry Renmin Hospital of Wuhan UniversityWuhan CityHubei ProvinceChina Peking University Sixth Hospital Peking University Institute of Mental HealthNHC Key Laboratory of Mental Health(Peking University)National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital)National Center for Mental HealthChinese Center for Disease Control and PreventionBeijingChina

Summary What is already known about this topic?The coronavirus disease 2019(COVID-19)pandemic poses a significant threat to mental health globally and may change the proportion of hospitalized patients.What is added by this report?This report analyzed and compared the disease characteristics of psychiatric inpatients one year before and after wuhan lifted lockdown during COVID-19.About 50%of the inpatients were diagnosed with bipolar disorder;females and adolescents had a higher prevalence of mental disorders.What are the implications for public health practice?More attention should be paid to the mental health of children,adolescents,and females.

关键词： wuhan globally COV

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