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Adaptive Control of Lower-Limb Exoskeletons for Walking Assistance Based on Inter-Joint Coordination

Journal of Bionic Engineering 2024年第4期21卷 1775-1787页

作者： Chaoyang Li Lincong Luo Zhi Liu Tianchi Chen Songxiang Liu Ye He Xiaoan Chen Lei Li Wei Tech Ang School of Mechanical Engineering Chongqing UniversityChongqing400044China Rehabilitation Research Institute of Singapore Singapore308232Singapore Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China School of Mechanical and aerospace Engineering Nanyang Technological UniversitySingapore639798Singapore

Unilateral motor impairment can disrupt the coordination between the joints,impeding the patient’s normal *** assist such patients to walk normally and naturally,an adaptive control algorithm based on inter-joint coordination was proposed in this work for lower-limb *** control strategy can generate the reference trajectory of the affected leg in real time based on a motion coordination model between the joints,and adopt an adaptive controller with virtual windows to track the reference *** Short-Term Memory(LSTM)network was also adopted to establish the coordination model between the joints of both lower limbs,which was optimized by preprocessing angle information and adding gait phase *** the adaptive controller,the virtual windows were symmetrically distributed around the reference trajectory,and its width was adjusted according to the gait phase of the auxiliary *** addition,the impedance parameters of the controller were updated online to match the motion capacity of the affected leg based on the spatiotemporal symmetry factors between the bilateral *** LSTM coordination model demonstrated good accuracy and generality in the gait database of seven individuals,with an average root mean square error of 3.5 and 4.1 for the hip and knee joint angle estimation,*** further evaluate the control algorithm,four healthy subjects walked wearing the exoskeleton while additional weights were added around the ankle joint to simulate an asymmetric *** the experimental results,it was shown that the algorithm improved the gait symmetry of the subjects to a normal level while exhibiting great adaptability to different subjects.

关键词： Lower-limb exoskeleton Adaptive control Gait symmetry Inter-joint coordination Motion estimation

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Automatic detection of breast lesions in automated 3D breast ultrasound with cross-organ transfer learning

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虚拟现实与智能硬件（中英文） 2024年第3期6卷 239-251页

作者： Lingyun BAO Zhengrui HUANG Zehui LIN Yue SUN Hui CHEN You LI Zhang LI Xiaochen YUAN Lin XU Tao TAN Affiliated Hangzhou First People's hospital School of MedicineWestlake UniversityHangzhou 330100China Faculty of Applied Sciences Macao Polytechnic UniversityMacao 999078China Pathology Department Changsha First HospitalChangsha 410073China Radiology Department Changsha First HospitalChangsha 410073China College of aerospace Science and Engineering National University of Defense TechnologyChangsha 410073China Hunan Provincial Key Laboratory of Image Measurement and Vision Navigation Changsha 410073China School of Information Science and Technology Shanghaitech UniversityShanghai 201210China

Background Deep convolutional neural networks have garnered considerable attention in numerous machine learning applications,particularly in visual recognition tasks such as image and video *** is a growing interest in applying this technology to diverse applications in medical image *** three dimensional Breast Ultrasound is a vital tool for detecting breast cancer,and computer-assisted diagnosis software,developed based on deep learning,can effectively assist radiologists in ***,the network model is prone to overfitting during training,owing to challenges such as insufficient training *** study attempts to solve the problem caused by small datasets and improve model detection *** We propose a breast cancer detection framework based on deep learning(a transfer learning method based on cross-organ cancer detection)and a contrastive learning method based on breast imaging reporting and data systems(BI-RADS).Results When using cross organ transfer learning and BIRADS based contrastive learning,the average sensitivity of the model increased by a maximum of 16.05%.Conclusion Our experiments have demonstrated that the parameters and experiences of cross-organ cancer detection can be mutually referenced,and contrastive learning method based on BI-RADS can improve the detection performance of the model.

关键词： Breast ultrasound Automated 3D breast ultrasound Breast cancers Deep learning Transfer learning Convolutional neural networks Computer-aided diagnosis Cross organ learning

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Bioinspired nanomaterials for wearable sensing and human–machine interfacing

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Nano Research 2024年第2期17卷 445-461页

作者： Vishesh Kashyap Junyi Yin Xiao Xiao Jun Chen Department of Bioengineering University of CaliforniaLos AngelesLos AngelesCA 90095USA Department of Mechanical and aerospace Engineering University of CaliforniaLos AngelesLos AngelesCA 90095USA

The inculcation of bioinspiration in sensing and human–machine interface(HMI)technologies can lead to distinctive characteristics such as conformability,low power consumption,high sensitivity,and unique properties like self-healing,self-cleaning,and *** sensing and HMI are fields rife with opportunities for the application of bioinspired nanomaterials,particularly when it comes to wearable sensory systems where biocompatibility is an additional *** review discusses recent development in bioinspired nanomaterials for wearable sensing and HMIs,with a specific focus on state-of-the-art bioinspired capacitive sensors,piezoresistive sensors,piezoelectric sensors,triboelectric sensors,magnetoelastic sensors,and electrochemical *** also present a comprehensive overview of the challenges that have hindered the scientific advancement in academia and commercialization in the industry.

关键词： bioinspired nanomaterials human–machine interface wearable sensors wearable bioelectronics

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Flexible piezoelectret film sensor for noncontact mechanical signal capture by multiple transmission media

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Nano Research 2024年第8期17卷 7643-7657页

作者： Xingchen Ma Qianqian Hu Lian Zhou Xinhao Xiang Yi Qin Ke Zhang Pengfei He Ying Dai Wenxin Niu Xiaoqing Zhang Shanghai Key Laboratory of Special Artificial Microstructure Materials and Technology School of Physics Science and EngineeringTongji UniversityShanghai 200092China Shanghai Yangzhi Rehabilitation hospital(Shanghai Sunshine Rehabilitation Center) School of MedicineTongji UniversityShanghai 201619China Department of Rehabilitation Sciences Tongji University School of MedicineShanghai 200092China School of aerospace Engineering and Applied Mechanics Tongji UniversityShanghai 200092China

Mechanical signal capture without physical contact has emerged as a highly promising research field and attracted tremendous attention due to its prosperous applications in household medical care,lifestyle monitoring and remote operation,offering users high level of safety,convenience and ***,noncontact sensing is ideal to maximize the immersive user experience in the human–machine interaction(HMI),eliminating interference to human activities and mechanical fatigue to the sensor,***,we report a self-powered flexible sensor integrated with irradiation cross-linked polypropylene(IXPP)piezoelectret film for noncontact sensing,featuring multi-functions to detect mechanical signals transmitted through solid,liquid and gaseous media and would facilitate their versatile practical *** folded-structure configuration of the sensor facilitates the improvement of the noncontact sensing *** solid media,such as the rectangular wooden stick used in this study,the sensor can detect mechanical stimulus exerted at a distance of 100 cm.A system detection sensitivity up to 57 pC/kPa with a low detection limit of 0.6 kPa is achieved at a noncontact distance of 10 *** when partly or completely immersed in water,the sensor effectively traces movement signals of human bodies underwater,demonstrating great advantages for non-inductive aquatic fitness training ***,due to the low acoustic impedance of piezoelectret film,speech recognition through gaseous medium is also *** further introduce application demonstrations of the developed film sensors to monitor exercise postures and physiological signals without direct contact between human body and the sensor,displaying great potential to be incorporated into future smart *** study commendably expands the application scope of piezoelectret materials,which will have profound implications for exploring novel intelligent human–machine interactions.

关键词： noncontact sensing piezoelectret multiple transmission media mechanical signal capture

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Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions

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Neural Regeneration Research 2025年第7期20卷 2116-2128页

作者： Yuxue Mu Ning Zhang Dongyu Wei Guoqing Yang Lilingxuan Yao Xinyue Xu Yang Li Junhui Xue Zuoming Zhang Tao Chen aerospace Clinical Medical Center School of Aerospace MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Aviation Medicine Xijing HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Emergency Medicine Wuhan No.1 HospitalWuhanHubei ProvinceChina Third Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Fourth Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina

A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain ***,we established an animal model of weightlessness via tail suspension to examine the pathological changes and molecular mechanisms of retinal damage under *** 4 weeks of tail suspension,there were no notable alterations in retinal function and morphology,while after 8 weeks of tail suspension,significant reductions in retinal function were observed,and the outer nuclear layer was thinner,with abundant apoptotic *** investigate the mechanism underlying the degenerative changes that occurred in the outer nuclear layer of the retina,proteomics was used to analyze differentially expressed proteins in rat retinas after 8 weeks of tail *** results showed that the expression levels of fibroblast growth factor 2(also known as basic fibroblast growth factor)and glial fibrillary acidic protein,which are closely related to Müller cell activation,were significantly *** addition,Müller cell regeneration and Müller cell gliosis were observed after 4 and 8 weeks,respectively,of simulated *** findings indicate that Müller cells play an important regulatory role in retinal outer nuclear layer degeneration during weightlessness.

关键词： glial fibrous acidic protein gliosis Müller cells nerve growth factor neural differentiation neurodegeneration proteomic retinal degeneration retinal outer nuclear layer simulated weightlessness

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Development of international guidelines by Tuina practitioners for specific acupoints of paediatrics Tuina(2022 version)

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Journal of Traditional Chinese Medicine 2024年第5期44卷 1044-1051页

作者： LAN Xiaoxue SUN Yanan WENG Zhiwen WANG Yue ZHANG Ying LIANG Yuanwen GU Sirui ZHOU Rong CHEN Qianji JIA Baolin BO Han WANG Fangying HE Qiang ZHANG Jie TAN Jiang YE Xingzhu WANG Xiyou YU Changhe CHEN Hong Department of Tuina and Pain Management the First Clinical DepartmentBeijing University of Chinese Medicine Department of Traditional Chinese Medicine Xuanwu HospitalCapital Medical University Department of Tuina and Pain Management Dongzhimen Hospital of Beijing University of Chinese Medicine Department of Encephalopathy Beijing Huairou Hospital of Traditional Chinese Medicine Yungang Community Health Service Center China Aerospace Science & Industry Corporation of 731 Hospital Department of Pediatrics China-Japan Friendship Clinical SchoolBeijing University of Chinese Medicine Department of Pediatrics the Second Clinical Medical College of Beijing University of Chinese Medicine Shenzhen Luohu hospital of Traditional Chinese Medicine Department of Chinese Medicine Raffles Medical Group Department of Traditional Chinese Medicine Beiing Children's HospitalCapital Medicine UniversityNational Center for Children's Health Anzhen Community Health Service Center L. Ac. Ancient Healing Center Frederick Department of Tuina and Pain Management Dongzhimen HospitalBeijing University of Chinese Medicine

OBJECTIVE: To establish a standardized framework encompassing the precise locations, manipulations,functions and indications of specific acupoints in the field of paediatric Tuina. METHODS: The development of consensus involved three distinct stages. Initially, a list of paediatric Tuina specific acupoints was compiled based on an extensive literature review, which was subsequently supplemented through expert interviews. In the second stage, the Delphi method was employed to assess the significance of acupoint locations, manipulations, functions, and indications. In situations where the questionnaire survey failed to yield agreement or when the experts held reservations, the nominal group approach was utilized during the expert consensus meeting. The final version of the technical standardized material was ultimately determined during an expert consensus conference. After undergoing external peer review and evaluation, the completed draft was prepared for public dissemination RESULTS: The comprehensive list identified a total of 66 specific acupoints. The location and manipulation questionnaire consisted of 156 items based on the literature database, while the function and indication questionnaire contained 116 items. Two rounds of Delphi surveys were conducted for the location and manipulation category, and another two rounds of Delphi surveys were conducted for the function and indication category. During the experts consensus meeting The panel of experts conducted in-depth discussions on 61 questions, resulting in the formulation of technical guidelines for the locations, manipulations, functions, and indications of 64 paediatric Tuina acupoints. Subsequently, the research team compiled and edited the draft of the technical guidelines for acupoints of paediatric Tuina, which was finalized after external review and feedback. CONCLUSION: This study successfully established the recognized technical standards for practitioners of paediatric Tuina, thereby standardizi

关键词： Child Delphi technique Tuina acupoint guideline international paediatrics

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润湿性对脑白质水力渗透率的影响

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Acta Mechanica Sinica 2024年第2期40卷 244-258页

作者：苏丽君雷杰超李振兴马驰原刘少宝 State Key Laboratory of Mechanics and Control for aerospace Structures Nanjing University of Aeronautics and AstronauticsNanjing210016China MIIT Key Laboratory of Multifunctional Lightweight Materials and Structures Nanjing University of Aeronautics and AstronauticsNanjing210016China Department of Neurosurgery Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing210002China

脑白质可被视为由神经轴突和组织液组成的周期性多孔介质,其水力渗透率反映了组织液在细胞外空间流动的阻力,在水分子运输和药物传递中起着关键作用.细胞外空间的典型宽度为纳米级,组织液流动是具有微尺度的润湿性问题,然而润湿性对渗... 详细信息

脑白质可被视为由神经轴突和组织液组成的周期性多孔介质,其水力渗透率反映了组织液在细胞外空间流动的阻力,在水分子运输和药物传递中起着关键作用.细胞外空间的典型宽度为纳米级,组织液流动是具有微尺度的润湿性问题,然而润湿性对渗透性的影响仍然不清楚.本研究将脑白质理想简化为一种周期性纤维多孔介质,考虑流体黏度和滑移边界,以量化润湿性对其水力渗透性的影响.发现流体有效黏度的减小和滑移长度的增加,会导致水力渗透率增大.还发现,对于方形排列的轴突纤维,润湿性对垂直水力渗透率的影响比对平行水力渗透率大;而对于六边形排列的轴突,影响则相反.研究结果可为脑水肿等脑水平衡紊乱疾病治疗及大脑药物传递提供理论指导.

关键词：药物传递脑白质神经轴突润湿性滑移边界脑水肿有效黏度组织液

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Effect of ramipril on progression of nonculprit lesions in patients with ST-elevation myocardial infarction after primary percutaneous coronary intervention

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Journal of Geriatric Cardiology 2019年第9期16卷 695-700页

作者： Jian WANG Song-Yuan HE Department of Cardiology Aerospace Central Hospital Aerospace Clinical Medical College of Peking University

Objective To investigate the effect of ramipril on progression of nonculprit lesions in patients with ST-elevation myocardial infarction(STEMI) after primary percutaneous coronary intervention(PPCI). Methods A total of 200 patients(60.1 ± 11.3 years) with STEMI who underwent successful PPCI from January 2010 to December 2013 were enrolled in this study. All patients underwent PPCI as treatment for culprit lesions. Patients were divided into two groups according to the dosage of ramipril used at hospital discharge as follows: high dosage group(2.5–10 mg, q.d.) and low dosage group(1.25–2.5 mg, q.d.). Clinical and angiographic follow-up was performed for 12 months. The primary endpoint was clinically-driven percutaneous coronary intervention(PCI) for nonculprit lesions. The clinical and angiographic features were analyzed. Results Clinical and angiographic follow-up was performed with 87 patients in the high dosage group and 113 patients in the low dosage group. The numbers of patients who underwent additional PCI were six and 20 in the high and low dosage groups, respectively. The rate of having additional PCI performed was lower in the high dosage group than in the low dosage group(6.90% vs. 17.70%, P = 0.03). Conclusions A high dosage of ramipril may prevent progression of nonculprit lesions, which could be the major cause of recurrent PCI in patients with STEMI after PPCI.

关键词： Nonculprit lesion Primary percutaneous coronary intervention Ramipril ST-elevation myocardial infarction

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Research on the Application of Evidence-Based Quality Control Circle to Improve the Implementation Rate of Airway Management Measures in Adult Critically Ill Patients

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Yangtze Medicine 2024年第1期8卷 8-19页

作者： Yujiao Yan Jing Wu Juan Liu Yanting Yuan Lixin Liu Huaxin Ye Juan Ding Nursing Department of Hubei aerospace hospital Xiaogan China School of Stomatology Hubei Vocational and Technical College Xiaogan China Department of Medicine Yangtze University Jingzhou China

Objective: To explore the effect of evidence-based quality control circle (QCC) in improving the implementation rate of airway management measures in adult critically ill patients. Methods: Based on the Joanna Briggs Institute (JBI) evidence-based health care model, the best evidence of airway management in adult critically ill patients was obtained and applied to the clinic. Results: The total implementation rate of airway management measures in adult critically ill patients increased from 23.62% before the implementation of quality control circle to 88.82%, and the pulmonary infection rate in critically ill patients decreased from 42.31% to 21.74%, with statistical significance between the two groups (P 0.05). Conclusion: Evidence-based quality control circle activities can standardize the practice standards of airway management in critically ill patients, reduce the occurrence of patients’ airway related complications, and improve clinical outcomes.

关键词： Critically Ill Patients Airway Management Be Evidence-Based Quality Control Circle Intensive Care Unit (ICU)

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The utilization of chitosan/Bletilla striata hydrogels to elevate anti-adhesion,anti-inflammatory and pro-angiogenesis properties of polypropylene mesh in abdominal wall repair

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Regenerative Biomaterials 2024年第4期3卷 111-124页

作者： Yuntao Di Lu Wang Wei He Shuyan Liu Yuqi He Jie Liao Ruihong Zhang Lan Yin Zhiwei Xu Xiaoming Li Department of Neurosurgery The Fourth Central Hospital of Baoding CityBaoding 072350China Research Center for Biomedical Engineering Medical Innovation&Research DivisionChinese PLA General HospitalKey Laboratory of Biomedical Engineering and Translational MedicineMinistry of Industry and Information TechnologyBeijing 100853China Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China College of Lab Medicine Hebei North UniversityZhangjiakou 075000China Key Laboratory of Advanced Materials of Ministry of Education Tsinghua UniversityBeijing 100084China

Polypropylene(PP)mesh is commonly used in abdominal wall repair due to its ability to reduce the risk of organ damage,infections and other ***,the PP mesh often leads to adhesion formation and does not promote functional tissue *** this study,we synthesized one kind of aldehyde Bletilla striata polysaccharide(BSPA)modified chitosan(CS)hydrogel based on Schiff base *** hydrogel exhibited a porous network structure,a highly hydrophilic surface and good *** wrapped the PP mesh inside the hydrogel and evaluated the performance of the resulting composites in a bilateral 1×1.5cm abdominal wall defect model in *** results of gross observation,histological staining and immunohistochemical staining demonstrated the positive impact of the CS hydrogel on anti-adhesion and wound healing ***,the addition of BSPA to the CS hydrogel further improved the performance of the composites in vivo,promoting wound healing by enhancing collagen deposition and capillary *** study suggested that the BSPA-modified CS hydrogel significantly promoted the anti-adhesion,anti-inflammatory and pro-angiogenesis properties of PP meshes during the healing ***,this work offers a novel approach to the design of abdominal wall repair patches.

关键词： abdominal wall wound healing hydrogel Bletilla striata anti-adhesion

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