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Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers

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中国药理学与毒理学杂志 2015年第S1期29卷 80-80页

作者： Feng Li Muthu K. Shanmugam Kodappully Sivaraman Siveen Fan Wang Tina H. Ong Ser Yue Loo Mahadeva M.M. Swamy Somnath Mandal Alan Prem Kumar Boon Cher Goh Tapas Kundu Kwang Seok Ahn Ling Zhi Wang Kam Man Hui Gautam Sethi Department of Pharmacology Yong Loo Lin School of Medicine National University of Singapore Singapore 117957 Cancer Science Institute of Singapore Centre for Translational Medicine Singapore 117957 Division of Cellular and Molecular Research Humphrey Oei Institute of Cancer Research National Cancer Centre Singapore 169610 Genome Institute of Singapore Agency for Science Technology and Research (A*STAR) Singapore Jawaharlal Nehru Centre for advanced Scientific Research Molecular Biology and Genetics Unit Transcription and Disease Laboratory Bangalore 560064 India School of Biomedical Sciences Faculty of Health Sciences Curtin University Western Australia 6009 Australia Department of Biological Sciences University of North Texas Denton Texas 76203 Department of Haematology-Oncology National University Health System Singapore 117957 College of Korean Medicine Kyung Hee University Seoul 130-701 Republic of Korea

OBJECTIVE Platinum compounds such as cisplatin and carboplatin are frequently used as the first-line chemotherapy for the treatment of the head and neck squamous cell carcinoma(HNSCC).In the present study,we investigated whether garcinol,apolyisoprenylated benzophenone can chemosensitize HNSCC to *** The effect of garcinol and cisplatin on HNSCC was assessed by MTT,Western blotting,real time PCR,FACS,immunohistochemistry,DNA binding assay and xenograft mouse *** We found that garcinol inhibited the viability of a panel of diverse HNSCC cell lines,enhanced the apoptotic effect of cisplatin,suppressed constitutive as well as cisplatin-induced NF-κB activation,and downregulated the expression of various oncogenic gene products(cyclin D1,Bcl-2,survivin and VEGF).In vivo study showed that administration of garcinol alone(0.5 mg·kg-1,ip five times/week)significantly suppressed the growth of the tumor,and this effect was further increased by *** the markers of proliferation index(Ki-67)and microvessel density(CD31)were downregulated in tumor tissues by the combination of cisplatin and *** pharmacokinetic results of garcinol indicated that good systemic exposure was achievable after ip administration of garcinol at 0.5and 2mg·kg-1 with mean peak concentration(cmax)of 1825.4 and 6635.7nmol·L-1 in the mouse serum,*** Overall,our results suggest that garcinol can indeed potentiate the effects of cisplatin by negative regulation of various inflammatory and proliferative biomarkers.

关键词： HNSCC chemoresistance NF-κB proliferation garcinol

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2020 Roadmap on gas-involved photo-and electro-catalysis

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Chinese Chemical Letters 2019年第12期30卷 2089-2109页

作者： Yulu Yang Yang Tang Haomin Jiang Yongmei Chen Pingyu Wan Maohong Fan Rongrong Zhang Sana Ullah Lun Pan Ji-Jun Zou Mengmeng Lao Wenping Sun Chao Yang Gengfeng Zheng Qiling Peng Ting Wang Yonglan Luo Xuping Sun Alexander S.Konev Oleg V.Levin Panagiotis Lianos Zhuofeng Hu Zhurui Shen Qinglan Zhao Ying Wang Nadia Todorova Christos Trapalis Matthew V.Sheridan Haipeng Wang Ling Zhang Songmei Sun Wenzhong Wang Jianmin Ma School of Physics and Electronics Hunan UniversityChangsha 410082China College of Chemistry Beijing University of Chemical TechnologyBeijing 100029China School of Civil and Environmental Engineering Georgia Institute of TechnologyAtlantaGA 30332United States College of Engineering and Applied Sciences and School of Energy ResourcesUniversity of WyomingLaramieWY 82071United States Key Laboratory for Green Chemical Technology of the Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Collaborative Innovative Center of Chemical Science and Engineering(Tianjin) Tianjin 300072China Institute for Superconducting and Electronic Materials Australian Institute for Innovative MaterialsUniversity of WollongongNSW 2522Australia Laboratory of advanced Materials Department of ChemistryFudan UniversityShanghai 200438China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province College of Chemistry and Chemical EngineeringChina West Normal UniversityNanchong 637002China Institute of Chemistry St.Petersburg State University7/9 Universitetskaya emb.St.Petersburg 199034Russian Federation Department of Chemical Engineering University of PatrasPatras 26500Greece School of Environmental Science and Engineering Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation TechnologySun Yat-sen UniversityGuangzhou 510275China School of Materials Science and Engineering Nankai UniversityTianjin 300350China Department of Chemistry Chinese University of Hong KongHong KongChina Institute of Nanoscience and Nanotechnology NCSR"Demokritos"Athens 15341Greece State Key Laboratory of School of Radiation Medicine and Protection and School for Radiological and interdisciplinary Sciences(RAD-X) Soochow UniversitySuzhou 215123China State Key Laboratory of High Performance Ceramics and Superf

Green reactions not only provide us chemical products without any pollution,but also offer us the viable technology to realize difficult tasks in normal ***-,photoelectro-,and electrocatalytic reactions are indeed powerful tools to help us to embrace bright ***,some gas-involved reactions are extremely useful to change our life environments from energy systems to liquid fuels and cost-effective products,such as H2 evolution(H2 production),02 evolution/reduction,CO2 reduction,N2 reduction(or N2 fixation) *** can provide fuel cells clean H2 for electric vehicles from H2 evolution reaction(HER),at the same time,we also need highly efficient 02 reduction reaction(ORR) in fuel cells for improving the reaction ***,we can get the clean oxidant O2 from water through O2 evolution reaction(OER),and carry out some reactions without posing any pollution to reaction ***,we can translate the greenhouse gas CO2 into useful liquid fuels through CO2 reduction reaction(CRR).Last but not the least,we can get ammonia from N2 reduction reaction(NRR),which can decrease energy input compared to the traditional Hubble *** reactions,such as HER,ORR,OER,CRR and NRR could be realized through solar-,photoelectro-and electro-assisted *** them,the catalysts used play crucial roles in determining the efficiency and kinds of products,so we should consider the efficiency of ***,the cost,synthetic methods of catalysts should also be ***,significant progress has been achieved,however,many challenges still exist,reaction systems,catalysts underlying mechanisms,and so *** extremely active fields,we should pay attention to *** the background,it has motivated us to contribute with a roadmap on ’GasInvolved Photo-and Electro-Catalysis’.

关键词： H2 evolution reaction O2 reduction reaction O2 evolution reaction CO2 reduction reaction N2 reduction reaction Electrocatalysis Photocatalysis Photoelectrocatalysis

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Over-the-scope clips in the treatment of gastrointestinal tract iatrogenic perforation: A multicenter retrospective study and a classification of gastrointestinal tract perforations

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World Journal of Gastrointestinal Surgery 2016年第4期8卷 315-320页

作者： Benedetto Mangiavillano Angelo Caruso Raffaele Manta Roberto Di Mitri Alberto Arezzo Nico Pagano Giuseppe Galloro Filippo Mocciaro Massimiliano Mutignani Carmelo Luigiano Enrico Antonucci Rita Conigliaro Enzo Masci Gastroenterology and Gastrointestinal Endoscopy Borea Hospital Gastroenterology and Gastroin-testinal Endoscopy Sant’Agostino Estense Gastrointestinal Endoscopy Operative Endoscopy Unit Niguarda-Ca Granda Hospital Gastroenterology and Endo-scopy Unit ARNAS Civico Hospital Department of Surgical Sciences University of Torino Unit of Gastroenterology S.Orsola-Malpighi Univer-sity Hospital Department of Clinical Medicine and Surgery Special Unit of Surgical Digestive Endoscopy University of Naples Federico Ⅱ - School of Medicine Gastrointestinal Endoscopy San Paolo Univer-sitary Hospital Division of Surgical and Gastrointetsinal products Euromedical s.r.l Gastroenterology and Gastrointestinal Endoscopy National Tumori Institute

AIM: To determine the outcome of the management of iatrogenic gastrointestinal tract perforations treated by over-the-scope clip(OTSC) ***: We retrospectively enrolled 20 patients(13 female and 7 male; mean age: 70.6 ± 9.8 years) in eight high-volume tertiary referral centers with upper or lower iatrogenic gastrointestinal tract perforation treated by OTSC placement. Gastrointestinal tract perforation could be with oval-shape or with round-shape. Ovalshape perforations were closed by OTSC only by suction and the round-shape by the "twin-grasper" plus suction. RESULTS: Main perforation diameter was 10.1 ± 4.3 mm(range 3-18 mm). The technical success rate was 100%(20/20 patients) and the clinical success rate was 90%(18/20 patients). Two patients(10%) who did not have complete sealing of the defect underwent surgery. Based upon our observations we propose two types of perforation: Round-shape "type-1 perforation" and oval-shape "type-2 perforation". Eight(40%) out of the 20 patients had a type-1 perforation and 12 patients a type-2(60%). CONCLUSION: OTSC placement should be attempted after perforation occurring during diagnostic or therapeutic endoscopy. A failed closure attempt does not impair subsequent surgical treatment.

关键词： Over-the-scope clip OVESCO Perforation Gastrointestinal tract

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Risk Analysis Comparison between the Mission NANOSATC-BR1 and NANOSATC-BR2

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Journal of Mechanics Engineering and Automation 2015年第2期5卷 88-94页

作者： Marcos Antonio Laurindo Dal Piaz Lucas Lourencena Caldas Franke Mauricio Ricardo Balestrini Iago Camargo Silveira Guilherme Paul Jaenisch Tiago Travi Farias Otavio Santos Cupertino Durao Nelson Jorge Schuch advanced Mechanics Laboratory Southern Regional Space Research Center National Institute for Space Research Santa Maria97.105-970 Brazil Radiofrequeney and Communications Laboratory Southern Regional Space Research Center National Institute for SpaceResearch Santa Maria 97.105o970 Brazil National Institute for Space Research S6o Josd dos Campos 12.245-970 Brazil Southern Regional Space Research Center National Institute for Space Research in collaboration with the Santa Maria SpaceScience Laboratory Technological Center from Federal University of Santa Maria Santa Maria 97.105-900 Brazil

The goal of this work is to perform the risks analysis of the mission NANOSATC-BR1 and NANOSATC-BR2 and then compare them linearly. The NANOSATC-BR1 and NANOSATC-BR2 are the first and the second satellite, respectively. They belonged to the project NANOSATC-BR—-development of CubeSats, which is performed in the facilities built by the partnership between the National Institute of Space Research and the Technological Center from Federal University of Santa Maria. The project focuses on the development of a scientific instrumentation and, simultaneously, the design development, construction, qualification and launch of a national scientific nanosatellite, in a cube shape with 100 mm of edge and near to 1.33 kg of mass, per unit (U). The risk analysis was held to identify and minimize the project"s risks of failure, due to its complexity, assuring the mission success, preventing extra pays and rework. The software, CubeSat Mission Design Software Tool for Risk Estimating, which uses statistical regression methods, was used. So, we were capable to measure the project"s most critical steps assuring its success. The NANOSATC-BR1 was launched in June 19 and it is orbiting the Earth in a nominal regime and the NANOSATC-BR2 has been scheduled to be launched in 2016.

关键词：风险分析超小型卫星合作伙伴关系统计回归方法软件工具技术中心科学仪器风险估计

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Observation of e^+e^-→D_s^+■^((*)0)K^- and study of the P-wave D_s mesons

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Chinese Physics C 2019年第3期43卷 5-16页

作者：麦迪娜 M.N.Achasov S.Ahmed M.Albrecht M.Alekseev A.Amoroso 安芬芬安琪白羽 O.Bakina R.Baldini Ferroli 班勇 K.Begzsuren D.W.Bennett J.V.Bennett N.Berger M.Bertani D.Bettoni F.Bianchi I.Boyko R.A.Briere 蔡浩蔡啸 A.Calcaterra 曹国富 S.A.Cetin J.Chai 常劲帆 W.L.Chang G.Chelkov 陈刚陈和生陈江川陈玛丽陈申见陈元柏成伟帅 G.Cibinetto F.Cossio 代洪亮代建平 A.Dbeyssi D.Dedovich 邓子艳 A.Denig I.Denysenko M.Destefanis F.De Mori 丁勇董超董静董燎原董明义豆正磊杜书先范荆州方建房双世方易 R.Farinelli L.Fava F.Feldbauer G.Felici 封常青 M.Fritsch 傅成栋付颖高清高鑫磊高原宁高勇贵高榛 B.Garillon I.Garzia A.Gilman K.Goetzen 龚丽龚文煊 W.Gradl M.Greco 谷立民顾旻皓顾珊顾运厅郭爱强郭立波郭如盼郭玉萍 A.Guskov Z.Haddadi 韩爽郝喜庆 F.A.Harris 何康林 F.H.Heinsius T.Held 衡月昆侯治龙胡海明胡继峰胡涛胡誉黄光顺黄金书黄性涛黄晓忠黄智玲 N.Huesken T.Hussain W.Ikegami Andersson W.Imoehl M.Irshad 纪全姬清平季晓斌季筱璐姜侯兵江晓山蒋兴雨焦健斌焦铮金大鹏金山金毅 T.Johansson N.Kalantar-Nayestanaki 康晓珅 M.Kavatsyuk 柯百谦 I.K.Keshk T.Khan A.Khoukaz P.Kiese R.Kiuchi R.Kliemt L.Koch O.B.Kolcu B.Kopf M.Kuemmel M.Kuessner A.Kupsc M.Kurth W.Kühn J.S.Lange P.Larin L.Lavezzi H.Leithoff 李翠李澄李德民李飞李峰云李刚李海波李惠静李家才李井文李科李龙科李蕾李佩莲李培荣李启云李卫东李卫国李晓玲李小男李学潜李志兵梁昊梁勇飞梁羽铁廖广睿廖龙洲 J.Libby 林创新林德旭刘冰刘北江刘春秀刘栋刘殿宇刘福虎刘芳刘峰刘宏邦刘恒君刘怀民刘欢欢刘汇慧刘建北刘晶译刘魁勇刘凯刘珂刘倩刘树彬刘翔刘玉斌刘振安刘智青龙云飞娄辛丑吕海江陆嘉达吕军光卢宇卢云鹏罗成林罗民兴罗朋威罗涛罗小兰 S.Lusso 吕晓睿马凤才马海龙马连良马明明马秋梅马旭宁马新鑫马骁妍马玉明 F.E.Maas M.Maggiora S.Maldaner Q.A.Malik A.Mangoni 冒亚军毛泽普 S.Marcello 孟召霞 J.G.Messchendorp G.Mezzadri 闵建闵天觉 R.E.Mitchell 莫晓虎莫玉俊 C.Morales Morales N.Yu.Muchnoi H.Muramatsu A.Mustafa S.Nakhoul Y.Nefedov F.Nerling I.B.Nikolaev 宁哲 S.Nisar 牛顺利 S.L.Olsen 欧阳群 S.Pacetti 潘越 M.Papenbrock P.Patteri M.Pelizaeus 彭海平 K.Peters J.Pettersson 平加伦平荣刚 A.Pitka R.Poling V.Prasad 祁鸣齐天钰钱森乔从丰覃拈 X.S.Qin 秦中华邱进发屈三强 K.H.Rashid C.F.Redmer M.Richter M.Ripka A.Rivetti M.Rolo 荣刚 Ch.Rosner M.Rump A.Sarantsev M.Savrié K.Schoenning 单葳单心钰邵明沈成平沈培迅沈肖雁盛华义史欣宋娇娇宋欣颖 S.Sosio C.Sowa S.Spataro 隋风飞孙功星孙俊峰孙亮孙胜森孙新华孙勇杰孙艳坤孙永昭孙志嘉孙振田谭雅星唐昌建唐光毅唐晓 M.Tiemens B.Tsednee I.Uman 王斌王滨龙王成伟王大勇王豪豪王科王亮亮王灵淑王萌王蒙王平王佩良王茹敏王维平王雄飞王越王贻芳王铮王志刚王至勇王宗源 T.Web Institute of High Energy Physics Beijing 100049China Beihang University Beijing 100191China Beijing Institute of Petrochemical Technology Beijing 102617China Bochum Ruhr-University D-44780 BochumGermany Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China China Center of advanced Science and Technology Beijing 100190China COMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200443China G.I.Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Helmholtz Institute Mainz Johann-Joachim-Becher-Weg 45D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University of Science and Technology Luoyang 471003China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati I-00044FrascatiItaly INFN Sezione di Ferrara I-44122FerraraItaly Institute of Physics and Technology Peace Ave.54BUlaanbaatar 13330Mongolia Johannes Gutenberg University of Mainz Johann-Joachim-Becher-Weg 45D-55099 MainzGermany Joint Institute for Nuclear Research 141980 DubnaMoscow regionRussia Justus-Liebig-Universitaet Giessen II.Physikalisches InstitutHeinrich-Buff-Ring 16D-35392 GiessenGermany KVI-CART University of GroningenNL-9747 AA GroningenThe Netherlands Lanzhou University Lanzhou 730000China Liaoning University Shenyang 110036China Nanjing Normal University Nanjing 210023China Nanjing University Nanjing 210093China Nankai University Tianjin 300071China Peking University Beijing 100871China Shandong University Jinan 250100China Shanghai

Studies of e^+e~→D_s^+■^((*)0)K^-and the P-wave charmed-strange mesons are performed based on an e^+e^-collision data sample corresponding to an integrated luminosity of 567 pb^(-1) collected with the BESIII detector at s^(1/2)=4.600 GeV. The processes of e^+e^-→D_s^+■^(*0)K^- and D_s^+■~0K^- are observed for the first time and are found to be dominated by the modes D_s^+D_(s1)(2536)^-and D_s^+D_(s2)~*(2573)^-, respectively. The Born cross sections are measured to be σ~B(e^+e^-→D_s^+■^(*0)K^-) =(10.1±2.3±0.8) pb and σ~B(e^+e^-→D_s^+■~0K^-) =(19.4±2.3± 1.6) pb, and the products of Born cross section and the decay branching fraction are measured to be σ~B(e^+e^-→D_s^+D_(s1)(2536)^-+c.c.)·B(D_(s1)(2536)^-→■^(*0)K^-)=(7.5±1.8±0.7) pb and σ~B(e^+e^-→D_s^+D_(s2)~*(2573)^-+ c.c.)·B(D_(s2)~*(2573)^-→■~0 K^-)=(19.7 ± 2.9 ±2.0) pb. For the D_(s1)(2536)^-and D_(s2)~*(2573)^-mesons, the masses and widths are measured to be M(D_(s1)(2536)^-)=(2537.7±0.5 ±3.1) MeV/c2, Γ(D_(s1)(2536)^-) =(1.7 ±1.2 ±0.6)MeV, and M(D_(s2)~*(2573)^-)=(2570.7±2.0 ±1.7) MeV/c^2, Γ(D_(s2)~*(2573)^-)=(17.2 ±3.6 ±1.1) MeV. The spin-parity of the D_(s2)~*(2573)^-meson is determined to be J^p= 2^+. In addition, the processes e^+e^-→D_s^+■^((*)0)K^-are searched for using the data samples taken at four(two) center-of-mass energies between 4.416(4.527) and 4.575 GeV, and upper limits at the 90% confidence level on the cross sections are determined.

关键词： cross section P-wave D_s mesons resonance parameters spin-parity BESIII

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