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Production of Functional Materials Derived from Regenerated Silk Fibroin by Utilizing 3D Printing and Biomimetic Enzyme-induced Mineralization

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Chinese Journal of Polymer Science 2024年第3期42卷 299-310,I0005页

作者： Ni Chen Fei-Yu Luo Gong-Wen Yang Jin-Rong Yao Xin Chen Zheng-Zhong Shao State Key laboratory of molecular Engineering of Polymers Laboratory of Advanced Materials and Department of Macromolecular ScienceFudan UniversityShanghai 200433China

Critical-sized bone defects, commonly encountered in clinical orthopedic surgery, present a significant challenge. One of the promising solutions is to prepare synthetic bone substitute materials with precise structural control, mechanical compatibility, and enhanced osteogenic induction performance, nevertheless the successful preparation of such materials remains difficult. In this study, a two-step technique,integrating an extrusion-based printing process with biomimetic mineralization induced by alkaline phosphatase(ALP), was developed. Initially,a pre-cured hydrogel of regenerated silk fibroin(RSF) with a small quantity of hydroxypropyl cellulose(HPC) and ALP was prepared through heating the mixed aqueous solution. This pre-cured hydrogel demonstrated thixotropic property and could be directly extruded into predetermined structures through a 3D-printer. Subsequently, the 3D-printed RSF-based materials with ALP underwent biomimetic in situ mineralization in calcium glycerophosphate(Ca-GP) mineralizing solution, utilizing the polymer chains of RSF as templates and ALP as a trigger for cleaving phosphate bonds of Ca-GP. The resulting 3D-printed RSF-mineral composites including hydrogel and sponge possessed adjustable compression modulus of megapascal grade and variable hydroxyapatite content, which could be controlled by manipulating the duration of the mineralization ***, these 3D-printed RSF-mineral composites demonstrated non-cytotoxicity towards rat bone marrow mesenchymal stem cells. Therefore, they may hold great potential for applications involving the replacement of tissues characterized by osteoinductivity and intricate structures.

关键词： Silk protein Alkaline phosphatase Extrusion-based printing Biomineralization

Engineering the electronic structure on MXenes via multidimensional component interlayer insertion for enhanced electromagnetic shielding

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Journal of Materials Science & Technology 2023年第7期138卷 149-156页

作者： Mengqiu Huang Lei Wang Biao Zhao Guanyu Chen Renchao Che laboratory of advanced Materials Shanghai Key Lab of Molecular Catalysis and Innovative MaterialsDepartment of Materials ScienceFudan UniversityShanghai 200438China Joint-Research Center for Computational Materials Zhejiang LaboratoryHangzhou 311100China

MXene-based functional electromagnetic interference(EMI)shielding films are highly desirable for mod-ern integrated electronic and telecommunication systems in aerospace,military,artificial intelligence,and smart and wearable electronics *** this work,3D freestanding Ti_(3)C_(2)T_(x)/CNTs/Ni film assembled by 1D multi-walled carbon nanotubes(MWCNTs)/Ni and 2D Ti_(3)C_(2)T_(x)MXene sheets was synthesized by a facile vacuum filtration *** electrostatic incorporation,hexagonal nickel plates embed on the CNTs and then the CNTs/Ni insert into the Ti_(3)C_(2)T_(x)layers to form magnetized Ti_(3)C_(2)T_(x)-based functional film with a compact and laminated *** to the outstanding electron migration capacity in the highly conductive Ti_(3)C_(2)T_(x)sheet and multiple internal reflections from porous and segregated structures,the op-timized Ti_(3)C_(2)T_(x)/CNTs/Ni composite films show excellent EMI shielding effectiveness of 67.4 dB with elec-trical conductivity of 744 S cm^(-1).Surprisingly,a magnetization compensation strategy is built to boost the EMI shielding effectiveness with decreased ***,the visual magnetic coupling phenomenon and charge distribution in the heterogeneous interfaces could be observed in the recon-structed electron holography *** encouraging results shed light on novel magnetized MXene-based functional films for high-performance EMI shielding.

关键词： Ti_(3)C_(2)T_(x)MXene Magnetic modulation Electromagnetic-interference shielding Nickel flakes Freestanding film

Nanopore ultra-long sequencing and adaptive sampling spur plant complete telomere-totelomere genome assembly

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molecular Plant 2024年第11期17卷 1773-1786页

作者： Dongdong Lu Caijuan Liu Wenjun Ji Ruiyan Xia Shanshan Li Yanxia Liu Naixu Liu Yongqi Liu Xing Wang Deng Bosheng Li Shandong Key laboratory of Precision molecular Crop Design and Breeding Peking University Institute of Advanced Agricultural SciencesShandong Laboratory of Advanced Agricultural Sciences in WeifangShandong 261325China

The pursuit of complete telomere-to-telomere(T2T)genome assembly in plants,challenged by genomic complexity,has been advanced by Oxford Nanopore Technologies(ONT),which offers ultra-long,realtime *** its promise,sequencing length and gap filling remain significant *** study optimized DNA extraction and library preparation,achieving DNA lengths exceeding 485 kb;average N50 read lengths of 80.57 kb,reaching up to 440 kb;and maximum reads of 5.83 ***,we demonstrated that combining ultra-long sequencing and adaptive sampling can effectively fill gaps during assembly,evidenced by successfully filling the remaining gaps of a near-complete Arabidopsis genome assembly and resolving the sequence of an unknown telomeric region in watermelon ***,our strategies improve the feasibility of complete T2T genomic assemblies across various plant species,enhancing genome-based research in diverse fields.

关键词： complete T2T genome ultra-long sequencing nanopore sequencing adaptive sampling filling gaps

Enhanced N-doping in mesoporous carbon for efficient electrocatalytic CO2 conversion

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Nano Research 2019年第9期12卷 2324-2329页

作者： Min Kuang Anxiang Guan Zhengxiang Gu Peng Han Linping Qian Gengfeng Zheng laboratory of advanced Materials Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsFudan UniversityShanghai 200438China

The capability of electrocatalytic reducti on of carbon dioxide(CO2)using nitrogen(N)-doped carb on strongly depe nds on the N-dopi ng level and their *** this work,we developed a strategy to generate mesoporous N-doped carb on frameworks with tun able configurati ons and contents of N dopants,by using a secondary doping process via the treatment of N,N-dimethylformamide(DMF)*** obtained mesoporous N-doped carbon(denoted as MNC-D)served as an efficient electrocatalyst for electroreduction of CO2 to CO.A high Faradaic efficiency of^92%and a partial current density for CO of-6.8 mA·cm^-2 were achieved at a potential of-0.58 V *** analyses further revealed that the active sites within the N-doped carb on catalysts were the pyridinic N and defects gen erated by the DMF treatme nt,which enhan ced the activati on and adsorpti on CO2 *** study suggests a new approach to develop efficie nt carb on-based catalysts for potential scalable CO2 reduction reaction(CO2RR)to fuels and chemicals.

关键词： electrocatalyst CO2 reduction reaction nitrogen-doped carbon pyridinic Faradaic efficiency

High capacity lithium-manganese-nickel-oxide composite cathodes with low irreversible capacity loss and good cycle life for lithium ion batteries

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Science China Chemistry 2016年第11期59卷 1479-1485页

作者： Jingwen Zhang Xun Guo Sumei Yao Xinping Qiu Key lab of Organic Optoelectronics and molecular Engineering Department of ChemistryTsinghua University

We report a method to eliminate the irreversible capacity of 0.4Li_2MnO_3·0.6LiNi_(0.5)Mn_(0.5)O_2(Li_(1.17)Ni_(0.25)Mn_(0.583)O_2) by decreasing lithium content to yield integrated layered-spinel *** patterns,High-resolution TEM image and electrochemical cycling of the materials in lithium cells revealed features consistent with the presence of spinel phase within the *** discharged to about 2.8 V,the spinel phase of LiM_2O_4(M=Ni,Mn) can transform to rock-salt phase of Li_2M_2O_4(M=Ni,Mn) during which the tetravalent manganese ions are reduced to an oxidation state of *** the spinel phase can act as a host to insert back the extracted lithium ions(from the layered matrix) that could not embed back into the layered lattice to eliminate the irreversible capacity loss and increase the discharge *** electrochemical properties at room temperature showed a high capacity(about 275 mAh g^(-1) at 0.1 C) and exhibited good cycling performance.

关键词： Lithium ion electrode composite materials Lithium-rich material spinel phase layered phase

Nanopore sensing system for high-throughput single molecular analysis

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Science China Chemistry 2018年第12期61卷 1483-1485页

作者： Zhen Gu Yi-Lun Ying Yi-Tao Long Key laboratory for Advanced Materials & School of Chemistry and Molecular EngineeringEast China University of Science and Technology Shanghai 200237China

Nanopore technique enables a sensitive, label free, low cost and high throughput method for single-molecule analysis[1–4]. Usually, the nanopore is fabricated on an insulating membrane with electrolyte solution in two sides, which can act as the only pathway for the ionic flow. When a single molecule enters the pore under the applied biased potential, it will temporarily block the ionic current flow through the nanopore. By analyzing the amplitude, duration, shape and frequency spectra of ionic current modulations, nanopore detection could provide the characteristics of the analytes.

关键词： Nanopore sensing system high-throughput single molecular analysis

Recent advances in hard carbon anodes with high initial Coulombic efficiency for sodium-ion batteries

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Nano Materials Science 2023年第2期5卷 189-201页

作者： Yanhua Wan Yao Liu Dongliang Chao Wei Li Dongyuan Zhao Department of Chemistry Laboratory of Advanced MaterialsShanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsState Key Laboratory of Molecular Engineering of PolymersFudan UniversityShanghai200433China

Initial Coulombic efficiency(ICE)has been widely adopted in battery research as a quantifiable indicator for the lifespan,energy density and rate performance of *** carbon materials have been accepted as a promising anode family for sodium-ion batteries(SIBs)owing to their outstanding ***,the booming application of hard carbon anodes has been significantly slowed by the low ICE,leading to a reduced energy density at the cell *** offers a challenge to develop high ICE hard carbon anodes to meet the applications of high-performance ***,we discuss the definition and factors of ICE and describe several typical strategies to improve the ICE of hard carbon *** strategies for boosting the ICE of such anodes are also systematically categorized into several aspects including structure design,surface engineering,electrolyte optimization and *** key challenges and perspectives in the development of high ICE hard carbon anodes are also outlined.

关键词： Sodium-ion battery Hard carbon Initial Coulombic efficiency Interface engineering Anode

Amplifiable protein identification via residue-resolved barcoding and composition code counting

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National Science Review 2024年第7期11卷 205-217页

作者： Weiming Guo Yuan Liu Yu Han Huan Tang Xinyuan Fan Chu Wang Peng R.Chen Synthetic and Functional Biomolecules Center Beijing National Laboratory for Molecular SciencesKey Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationCollege of Chemistry and Molecular Engineering Peking University Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary Studies Peking University

Ultrasensitive protein identification is of paramount importance in basic research and clinical diagnostics but remains extremely challenging. A key bottleneck in preventing single-molecule protein sequencing is that, unlike the revolutionary nucleic acid sequencing methods that rely on the polymerase chain reaction(PCR) to amplify DNA and RNA molecules, protein molecules cannot be directly amplified. Decoding the proteins via amplification of certain fingerprints rather than the intact protein sequence thus represents an appealing alternative choice to address this formidable challenge. Herein, we report a proof-of-concept method that relies on residue-resolved DNA barcoding and composition code counting for amplifiable protein fingerprinting(AmproCode). In AmproCode, selective types of residues on peptides or proteins are chemically labeled with a DNA barcode, which can be amplified and quantified via quantitative PCR. The operation generates a relative ratio as the residue-resolved ‘composition code’ for each target protein that can be utilized as the fingerprint to determine its identity from the proteome database. We developed a database searching algorithm and applied it to assess the coverage of the whole proteome and secretome via computational simulations, proving the theoretical feasibility of AmproCode. We then designed the residue-specific DNA barcoding and amplification workflow, and identified different synthetic model peptides found in the secretome at as low as the fmol/L level for demonstration. These results build the foundation for an unprecedented amplifiable protein fingerprinting method. We believe that, in the future,AmproCode could ultimately realize single-molecule amplifiable identification of trace complex samples without further purification, and it may open a new avenue in the development of next-generation protein sequencing techniques.

关键词： protein identification amplifiable fingerprinting residue-specific chemistry DNA barcoding composition code counting

Structural and Magnetic Properties of [Fe/Ni]N Multilayers

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Chinese Physics Letters 2010年第7期27卷 256-259页

作者：唐佳马斌张宗芝金庆原 Key lab of advanced Photonic Materials and Devices Laboratory of Advanced Materials and Department of Optical Science and Engineering Fudan University Shanghai 200433

[Fe/Ni]N multilayered structure grows epitaxially on the single crystalline MgO substrate. Due to the different directions of magnetic easy axes of Fe and Ni and the strong strain, large anisotropy dispersion is assumed. According to the layer model, the magnetization of Fe and Ni layers cannot follow each easy axis because of exchange coupling, and then the anisotropies are averaged out. The reduction of the effective anisotropy enhances with the decrease of periodic thickness. Thus, the coercivity of [Fe/Ni]N multilayers reduces with decreasing periodic thickness.

关键词： Iron Thickness Layering Nickel Dispersants Periodicity