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Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

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Neural Regeneration research 2025年第10期20卷 2955-2968页

作者： Wei Zhang Yubao Lu Ruoqi Shen Yingjie Wu Chenrui Liu Xingxing Fang Liangming Zhang Bin Liu Limin Rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)Key Laboratory for Quality research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina Guangdong Provincial center for Quality Control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial center for Engineering and Technology research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury

Warpage prediction of the injection-molded strip-like plastic parts

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Chinese Journal of Chemical Engineering 2016年第5期24卷 665-670页

作者： Chaofang Wang Ming Huang Changyu Shen Zhenfeng Zhao National Engineering research center for advanced Polymer Processing Technology Zhengzhou University

For most strip-like plastic injection molded parts, whose cross section size is much smaller than their length, the traditional Hele-Shaw model and three-dimensional model do not work well in the prediction of the warpage be- cause of their special shape. A new solution was suggested in this work. The strip-like plastic part was regarded as a little-curved beam macrnscopically, and was divided into a few one-dimensional elements. On the section of each elemental node location, two-dimensional thermal finite element analysis was made to obtain the non- uniform thermal stress caused by the time difference of the solidification of the plastic melt in the mold. The stress relaxation, or equivalently, strain creep was dealt with by using a special computing model. On the bases of in-mold elastic stress, the final bending moment to the beam was obtained and the warpage was predict- ed in good a^reement with practical cases.

关键词： Strip-like plastic part Warpage prediction Injection molding Numerical simulation

Evaluation of Microstructure and Magnetic Properties in Non-oriented Electrical Steel Strained by Tension

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Journal of Iron and Steel research International 2016年第2期23卷 166-170页

作者： J.SALINAS B. A.SALINAS R. Engineering Metallurgical Research Center and Advanced Studies of National Polytechnic Institute

The effects of deformation on the microstructure and magnetic properties of non oriented electrical steels were investigated. Box annealed electrical steel sheets were deformed by tension at four different strains： 3%, 8%, 12 % and 25 % The internal grain misorientation caused by tensile deformation was measured by electron backscat- tering diffraction （EBSD） with grain orientation spread （GOS） as an indicator of the lattice distortion. The experi- mental results showed that the average GOS value increases with the strain. The microstructure and crystallographic texture of deformed samples did not show a significant change in samples strained below 25 %. However, the mag- netic properties were strongly affected： coercivity was directly proportional to the square root of the GOS value and energy losses increased as the strain level was increased.

关键词： non-oriented electrical steel tensile deformation internal misorientation magnetic property EBSD

Local microstructure and photoluminescence of Er-doped 12CaO·7Al_2O_3 powder

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Journal of Rare Earths 2008年第3期26卷 433-438页

作者：王丹刘玉学徐长山刘益春王国瑞李兴华 center for advanced Opto-Electronic Functional Materials research Northeast Normal University

Er-doped 12Ca0.7Al2O3 （C12A7：Er） powders were prepared using the sol-gel method followed by annealing inorganic precursors. X-ray diffraction （XRD）, Raman and absorption spectra revealed that Er ions existed and substituted Ca^2＋ lattice site in C12A7. The photoluminescence of C12A7：Er at room temperature was observed in the visible and infrared region using 488 nm （2.54 eV） Ar^＋ line as excitation source, respectively. The sharp and intense green emission bands with multi-peaks around 520 nm and 550 nm correspond to the transitions from the excited states ^2H11/2 and ^4S3/2 tO the ground state ^4I15/2, respectively. Furthermore, red emission band around 650 nm was also observed. It was attributed to the electronic transition from excited states ^4F9/2 to the ground state ^4I15/2 inside 4f-shell of Er^3＋ ions. The intensive infrared emission at 1.54 μm was attributed to the transition from the fast excited states of ^4I13/2 to the ground state （^4I15/2）. The temperature dependent photoluminescence of infrared emission showed that the integrated intensity reached a maximum value at near room temperature. The forbidden transitions of intra-4f shell electrons in free Er^3＋ ions were allowed in C12A7 owing to lack of the inversion symmetry in the Er^3＋ position in C12A7 crystal field. Our results suggested that C12A7：Er was a candidate for applications in Er-doped laser materials, and full color display.

关键词： C12A7:Er sol-gel photoluminescence raman absorption rare earths

X-ray phase-sensitive microscope imaging with a grating interferometer:Theory and simulation

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Chinese Physics B 2022年第9期31卷 652-657页

作者： Jiecheng Yang Peiping Zhu Dong Liang Hairong Zheng Yongshuai Ge research center for Medical Artificial Intelligence Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Platform of advanced Photon Source Technology R&D Laboratory of X-ray Optics and TechnologyBeijing Synchrotron Radiation FacilityInstitute of High Energy PhysicsChinese Academy of SciencesBeijing100049China Beijing advanced Innovation center for Imaging Theory and Technology Capital Normal UniversityBeijing 100048China Paul C Lauterbur research center for biomedical Imaging Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China4.Paul C Lauterbur Research Center for Biomedical ImagingShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

A general theoretical framework is presented to explain the formation of the phase signal in an x-ray microscope integrated with a grating interferometer,which simultaneously enables the high spatial resolution imaging and the improved image *** using this theory,several key parameters of phase contrast imaging can be predicted,for instance,the fringe visibility and period,and the conversion condition from the differential phase imaging(DPI)to the phase difference imaging(PDI).Additionally,numerical simulations are performed with certain x-ray optical components and imaging *** with the available experimental measurement[***.113063105(2018)]demonstrates the accuracy of this developed quantitative analysis method of x-ray phase-sensitive microscope imaging.

关键词： x-ray phase contrast imaging x-ray microscope grating interferometer

Texture and stretch formability of rolled Mg–Zn–RE(Y, Ce, and Gd) alloys at room temperature

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Rare Metals 2013年第5期32卷 441-447页

作者： Zheng-Xu Cai Hai-Tao Jiang Di Tang Zhao Ma Qiang Kang National Engineering research center of advanced Rolling University of Science and Technology Beijing

To develop a new magnesium alloy with excellent formability at room temperature, the effect of Y, Ce, and Gd addition on texture and stretch formability of Mg-1.5Zn alloys was carried out. The result shows that Y, Ce, and Gd addition in Mg-1.5Zn alloys can effectively weaken and modify the basal plane texture, characterized by TD-split texture in which the position of basal is titled from normal direction （ND） toward transverse direction （TD）. When Mg-1.5Zn alloy with Gd addition appears low texture intensity and TD-split texture, where the position of basal poles is tilted by about 4-35° from ND toward to TD, the largest Erichsen value of 7.0 and the elongation rate reaches 29.1% in TD direction. However, Y and Ce addition in Mg-1.5Zn alloys promote a large number of second phase particles, which cancel the contribution of the unique basal texture to stretch formability and ductility.

关键词： Magnesium Texture Size effects Stretch formability Mechanical property Rare earth elements

research of magnetic self-balance used in a repetitive high voltage rectangular waveform pulse adder

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Plasma Science and Technology 2018年第1期20卷 47-53页

作者：周乾宇童立青刘克富 Engineering research center of advanced Lighting Technology Ministry of Education Fudan University

Compared with a sinusoidal operation, pulsed operation has more homogeneity and more efficiency in dielectric barrier discharge. In this paper, an improved pulse adder is designed and assembled to create repetitive high voltage rectangular pulses when resistive loads or capacitive loads exist. Beyond the normal pulse adder based on solid-state switches, additional metal- oxide-semiconductor field effect transistors are used in each stage for a faster falling edge. Further, the voltage difference between stages is eliminated by balancing windings. In this paper, we represent our theoretical derivation, software simulations and hardware experiments on magnetic self-balance. The experiments show that the voltage difference between stages is eliminated by balancing windings, which matches the result of simulations with almost identical circuits and parameters.

关键词： pulse adder fast falling edge balancing windings magnetic self-balance dielectricbarrier discharge

Inspires effective alternatives to backpropagation:predictive coding helps understand and build learning

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Neural Regeneration research 2025年第11期20卷 3215-3216页

作者： Zhenghua Xu Miao Yu Yuhang Song School of Health Sciences and biomedical Engineering Hebei University of TechnologyTianjinChina Department of Computer Science University of OxfordOxfordUK

Artificial neural networks are capable of machine learning by simulating the hiera rchical structure of the human *** enable learning by brain and machine,it is essential to accurately identify and correct the prediction errors,referred to as credit assignment(Lillicrap et al.,2020).It is critical to develop artificial intelligence by understanding how the brain deals with credit assignment in neuroscience.

关键词： assignment learning enable

Preparation of Filling Porous Osteoconduction Materials and Its Animal Experiment Study

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Journal of Wuhan University of Technology(Materials Science) 2011年第2期26卷 232-235页

作者：陈晓明 biomedical Materials and Engineering research center Wuhan University of Technology

Titanium rods were processed into implant samples with cavity and groove in which was filled with HAP/β-TCP porous osteoconduction composite materials in order to increase the mechanical stability of the implant in *** phase compositions of the composite was characterized by X-ray diffraction （XRD） and scanning electron microscopy（SEM）.Histological evaluation showed that the biogradable composite could enhanced the ability of new bone *** composite can conduct new bone tissue growing into the cavities gradually after implanted into animal,and then achieve mechanical *** filling biogradable compound exhibited excellent biocompatibility,which combined with the new bone tissues tightly without inflammation and loosing.

关键词： β-tricalcium phosphate hydroxyapate filling osteoconduction titanium animal experiment